Patents Assigned to Nisshin Flour Milling Co., Ltd.
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Patent number: 5845855Abstract: A mechanical grinding apparatus of the present invention, which includes a rotor supported by a rotary shaft and having a plurality of grooves defined on the outer peripheral surface thereof and a liner inserted to the outside of the rotor so as to form a desired gap between the liner and the rotor and having a plurality of grooves defined on the inner peripheral surface thereof for grinding a substance to be ground in the gap, is characterized in that the grooves of at least one of the rotor and the liner incline in a direction preventing the flow of the substance to be ground with respect to a direction parallel with a rotary shaft. Since the mechanical grinding apparatus of the present invention can make a ground substance having a small particle size, no large particles mixed therein and a sharp particle size distribution width at a high efficiency, the grinding apparatus is preferably applicable to powder composed of resin or mainly composed of resin to be finely ground.Type: GrantFiled: November 18, 1996Date of Patent: December 8, 1998Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Yukiyoshi Yamada, Satoshi Akiyama, Takahiro Ichikawa, Hideo Okabe
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Patent number: 5827878Abstract: 9-Cis-retinoic acid-.alpha.-tocopherol esters, pharmaceutical compositions containing the same and use of the same as a medicine for the treatment of leukemia, in particular, the remission of leukemia are provided and a combined use of a 9-cis-retinoic acid-.alpha.-tocopherol ester and either 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid exhibits a synergistic effect in the treatment of leukemia without any side effects caused by 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid.Type: GrantFiled: June 27, 1997Date of Patent: October 27, 1998Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Makoto Makishima, Yasuhiro Kanatani, Yoshio Honma, Kohei Inomata, Takao Kishiye
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Patent number: 5801143Abstract: A cyclic depsipeptide having the general formula (I) ##STR1## (wherein n is an integer of 5-15) or a pharmacologically acceptable salt thereof. The present compound can be prepared by cultivation of a cyclic depsipeptide-producing microorganism belonging to the genus of Bacillus. The present compounds are useful as a therapeutic agent for hyperlipemia, an agent for inhibiting the secretion of lipids or an agent for inhibiting the production of apolipoprotein B.Type: GrantFiled: November 25, 1996Date of Patent: September 1, 1998Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Shigeru Hiramoto, Yukio Saito, Shigeo Hatanaka, Akiko Shingai
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Patent number: 5789380Abstract: An agent for inhibiting an accumulation of visceral fat is disclosed which comprises an amylase inhibitor of wheat origin as an active ingredient. The agent is effective for inhibiting the accumulation of visceral fat in the viscus, thus preventing the visceral fat obesity which may be one of the causes of adult diseases.Type: GrantFiled: January 14, 1997Date of Patent: August 4, 1998Assignees: Nisshin Flour Milling Co., Ltd., Nagata Sangyo Co., Ltd.Inventors: Toshiyuki Miyazaki, Toshihisa Morimoto, Ryuji Murayama, Sachiko Takase, Toshinao Goda
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Patent number: 5786009Abstract: A process for preparing a low-viscous pasta sauce contained in a container, comprising using 10 to 65% by weight of the water to be used in the formulation of a pasta sauce, 0.5 to 5.5% by weight of a waxy starch, and, if necessary, 0.5 to 3% by weight of wheat starch, based on the total weight of the pasta sauce immediately before being loaded into a container, together with other raw materials for the pasta sauce to prepare a condensed pasta sauce having a viscosity of 1,000 to 20,000 cp at 70.degree. to 90.degree. C., loading the condensed pasta sauce into the container, and loading the remaining water into the container after, simultaneously with, or before the loading of the condensed pasta sauce into the container, followed by a sterilization treatment by heating to make a pasta sauce having a viscosity of 500 cp or less at normal temperatures (25.degree. C.).Type: GrantFiled: March 12, 1996Date of Patent: July 28, 1998Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Hiroshi Goto, Mamoru Kanada
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Patent number: 5756475Abstract: Isoprene derivatives of formula (I) ##STR1## wherein m is an integer of 0 to 3,n is an integer of 5 to 12,A is cyclo(C.sub.3 -C.sub.6)alkylene, phenylene, fluorenylene, pyrrolidinylene, piperazinylene, 9-aza-3-oxabicyclo?3.3.1!-nonylene,R.sub.1 and R.sub.2 are each independently benzyl, of which a phenyl ring may be substituted by 1 to 5 substituents selected from the group consisting of hydroxy, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy and halogen,X is a single bond or a divalent radical of --(CH.sub.2).sub.p NH--,p is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof. Those compounds are useful as multidrug resistance inhibitors for overcoming multidrug resistance of cancer and agents for enhancing an activity of anti-cancer agents.Type: GrantFiled: January 30, 1997Date of Patent: May 26, 1998Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Kohei Inomata, Toshihiro Takahashi, Hitoshi Inoue, Makoto Yanai, Hiroyuki Yamazaki, Masashi Suzuki, Tsutomu Takasawa, Kouji Kawamura, Norio Oshida, Hiroyuki Ikemoto, Takao Kishiye
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Patent number: 5753691Abstract: The pharmaceutical use of 1-cinnamoyl-2-pyrrolidinone derivatives having the activities to inhibit the production of IL-1.beta. and the release of TNF.alpha.. Those derivatives are useful in the treatment or prophylaxis of the diseases such as chronic rheumatism and sepsis.Type: GrantFiled: December 22, 1995Date of Patent: May 19, 1998Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Koichi Katsuyama, Masato Ariga, Yukio Saito, Shigeo Hatanaka, Kenichi Momose
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Patent number: 5753654Abstract: Novel diaminomethylidene derivatives represented by formula (I) ##STR1## wherein R.sup.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group and others, R.sup.2 is a group of the following formula ##STR2## and others, R.sup.3 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group and others, X is O, S, CHNO.sub.2, C(COOR.sup.4).sub.2, C(COOR.sup.4)CN or C(CN).sub.2) or pharmacologically acceptable salts thereof.The above-mentioned compounds are useful as a gastrointestinal prokinetic agent to be used for the treatment of digestive tract diseases.Type: GrantFiled: November 7, 1996Date of Patent: May 19, 1998Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Haruhiko Kikuchi, Hiroaki Satoh, Ruta Fukutomi, Kohei Inomata, Masashi Suzuki, Koichiro Hagihara, Takeo Arai, Setsuko Mino, Haruko Eguchi
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Patent number: 5736550Abstract: Pyrimidine derivatives useful as a gastrointestinal prokinetic agent, represented by formula ##STR1## wherein X is O or NR.sup.5, Y is O, S or NR.sup.5 wherein R.sup.5 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or the like;R.sup.1 and R.sup.2 may be the same or different and each is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or the like;R.sup.3 is CN, or COOR.sup.6 wherein R.sup.6 is a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group, an aryl group or the like;R.sup.4 is --SR.sup.7 or --NR.sup.8 R.sup.9 wherein R.sup.7 is a C.sub.1 -C.sub.6 alkyl group;R.sup.8 is a C.sub.1 -C.sub.6 alkyl group or the like;R.sup.9 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or the like, or R.sup.8 and R.sup.9 may represent, together with the nitrogen atom to which they are attached, an N-substituted piperazine ring of formula (X) ##STR2## wherein R.sup.10 represents a C.sub.1 -C.sub.6 alkyl group or the like or a pharmacologically acceptable salt thereof.Type: GrantFiled: November 15, 1996Date of Patent: April 7, 1998Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Haruhiko Kikuchi, Hiroaki Satoh, Ruta Fukutomi, Kohei Inomata, Masashi Suzuki, Koichiro Hagihara, Takeo Arai, Setsuko Mino, Haruko Eguchi
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Patent number: 5726291Abstract: An amylase inhibitor consisting of a protein constructed of 244 amino acid residues having two subunits each identified as SEQ ID NO:1, in which a single band is observed at a mobility of 0.26 by polyacrylamide gel electrophoresis, and having a high inhibitory activity against human pancreatic .alpha.-amylase to inhibit an increase in blood glucose level, control an insulin secretion or maintain the duration in a feeling of satiety for diet. The amylase inhibitor can be used alone or in combination with other known amylase inhibitors.Type: GrantFiled: January 14, 1997Date of Patent: March 10, 1998Assignees: Nisshin Flour Milling Co., Ltd., Nagata Sangyo Co., Ltd.Inventors: Toshiyuki Miyazaki, Toshihisa Morimoto, Ryuji Murayama
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Patent number: 5712105Abstract: The present invention describes a monoclonal antibody which recognizes the C-terminal region of human glicentin. The antibody is useful for assaying for the presence of glicentin in a sample.Type: GrantFiled: October 25, 1995Date of Patent: January 27, 1998Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Noboru Yanaihara, Takeya Sato, Kiyoshi Fukuchi
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Patent number: 5702749Abstract: Disclosed is a process for preparing a powdered seasoning, which comprises adding to and dissolving in a seasoning liquor or soy sauce, 100-250% by weight in total of a dextrin of DE value 6-15 and a dextrin of DE value 1-5 and 3-20% by weight of gelatin, and then spray-drying the resultant solution, a content of the DE 1-5 dextrin being 5-60% by weight of the total dextrin, all the percent weights being based on the weight of a solid in the seasoning liquor or soy sauce.Type: GrantFiled: February 28, 1996Date of Patent: December 30, 1997Assignee: Nisshin Flour Milling Co., LTD.Inventors: Masahisa Sugiura, Kazuhiro Okada, Sadao Nagata
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Patent number: 5702922Abstract: In the method for the extraction of glicentin or a glicentin analogous substance from the cells of a transformed microorganism having incorporated therein an expressible gene encoding glicentin or a glicentin analogous substance, the extraction is carried out using an aqueous solution of an inorganic acid and/or an organic acid. The glicentin is human glicentin or a human glicentin analogous substance.Type: GrantFiled: November 22, 1995Date of Patent: December 30, 1997Assignee: Nisshin Flour Milling Co., Ltd.Inventor: Shinjirou Imai
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Patent number: 5700776Abstract: Agents for stimulating insulin secretion and for treating diabetes which comprise glicentin as an active ingredient.Type: GrantFiled: April 3, 1995Date of Patent: December 23, 1997Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Akira Ohneda, Kazuyuki Sasaki, Yohei Natori, Tomohisa Nagasaki
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Patent number: 5698564Abstract: Diphenyl disulfide compounds having an inhibiting activity against the production of Interleukin-1.beta. (IL-1.beta.) or the release of Tumor Necrosis Factor.alpha. (TNF.alpha.), which are useful in the treatment or prophylaxis of the diseases such as chronic rheumatism and sepsis are described.Type: GrantFiled: December 21, 1995Date of Patent: December 16, 1997Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Koichi Katsuyama, Masato Ariga, Yukio Saito, Shigeo Hatanaka, Toshihiro Takahashi
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Patent number: 5684003Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof are selective agonists for 5-HT.sub.4 receptors. ##STR1## wherein Ak is a C.sub.3 -C.sub.6 alkyl group, and R is a C.sub.2 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 alkenyl group, a C.sub.3 -C.sub.6 alkynyl group, a C.sub.3 -C.sub.7 cycloalkyl group or a C.sub.3 -C.sub.6 cycloalkylmethyl group.Type: GrantFiled: October 12, 1995Date of Patent: November 4, 1997Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Haruhiko Kikuchi, Hiroaki Satoh, Masashi Suzuki, Ruta Fukutomi, Masahiro Ueno, Koichiro Hagihara, Takeo Arai, Setsuko Mino, Yumiko Noguchi
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Patent number: 5665407Abstract: A process for the production of a light-colored seasoning liquor, which comprises forming a koji-making and fermenting material from a blend material of (A) 90-70% by weight of a material consisting of 25-100% by weight of gluten and 75-0% by weight of wheat and (B) 10-30% by weight of soybeans, and then carrying out subsequent koji-making and fermentation steps by a conventional method to form a fermented koji product, which is then squeezed to obtain the seasoning liquor.Type: GrantFiled: October 11, 1995Date of Patent: September 9, 1997Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Sadao Nagata, Shigeru Endo, Keiichi Kishi
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Patent number: 5664686Abstract: A sifter frame is composed of a pair of frame elements including an outer frame and an inner frame, and the outer frame is formed from a frame member having the same height and includes a pair of fine powder dropping ports, a rough powder dropping port and a rectangular fine powder receiving plate disposed in a region surrounded by these openings and one of the outer block frame members and the inner frame is fitted with the space above the receiving plate.Type: GrantFiled: June 12, 1996Date of Patent: September 9, 1997Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Yasunobu Hosogoshi, Toshio Maruo, Yasuo Sakata, Katsumasa Morita, Takefumi Ibori, Harumi Kubota, Toshio Douzono, Kanemitsu Nakagawa, Kunio Sugihara, Yukio Yoshizawa, Yoshiaki Aridome, Shoji Yamanaka
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Patent number: 5660633Abstract: A powder supplying apparatus supplies, for example, a powder spraying apparatus with fine powder particles such as of ceramics having particle sizes of several .mu.m to 10 .mu.m at an extremely small rate of several grams to several tens of grams per hour, in the form of micronized discrete particles dispersed at a high degree of uniformity. The powder spraying apparatus is capable of spraying the fine powder particles on an object surface with a high degree of uniformity of distribution. The disclosed apparatus is used typically in uniformly spraying the above-mentioned fine powder particles which serve as spacers between a pair of transparent substrates of a liquid crystal display panel, for the purpose of maintaining a uniform and constant gap to be filled with a liquid crystal between these transparent substrates.Type: GrantFiled: August 17, 1995Date of Patent: August 26, 1997Assignees: Nisshin Flour Milling Co., Ltd., Nisshin Engineering Co., Ltd.Inventors: Hiroshi Murata, Kimio Miyagawa, Eiji Shinoda, Hideo Moriyama
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Patent number: 5652004Abstract: Disclosed is a process for the production of a fermenting material which comprises using 5-100% by weight of a dried gluten product and 95-0% by weight of wheat as a raw material, adding steam to the material so as to adjust the moisture content of the material to within a range of 12-18%, and granulating followed by steaming.Type: GrantFiled: October 13, 1995Date of Patent: July 29, 1997Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Sadao Nagata, Shigeru Endo, Keiichi Kishi