Patents Assigned to NOF Corporation
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Publication number: 20240117094Abstract: Provided is a modifier for an ophthalmic device capable of imparting high wettability and lubricity to a silicone hydrogel, specifically, a modifier for an ophthalmic device capable of expressing such effect when contained in a small amount. Also provided are a silicone hydrogel obtained by curing a silicone hydrogel composition containing the modifier for an ophthalmic device, and an ophthalmic device using the silicone hydrogel. It has been found that a water-soluble silicone-containing water-soluble copolymer obtained by copolymerizing a phosphorylcholine group-containing monomer and a specific silicone monomer can impart high wettability and lubricity to a silicone hydrogel when contained in a small amount.Type: ApplicationFiled: November 24, 2021Publication date: April 11, 2024Applicant: NOF CORPORATIONInventors: Hirotaka SUZUKI, Norio IWAKIRI
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REACTION COMPOSITION FOR NUCLEIC ACID AMPLIFICATION AND NUCLEIC ACID AMPLIFICATION METHOD USING SAME
Publication number: 20240110235Abstract: A method for improving repeatability of a nucleic acid amplification method is provided by the present invention, the method including performing a nucleic acid amplification reaction using a reaction composition containing water, an amplification target nucleic acid at a concentration of not more than 10,000 copies/mL, and one or more polymers selected from the following group A at a concentration of 0.005 to 0.5 w/v %: [group A] (A1) a polymer consisting of a constitutional unit derived from 2-(meth)acryloyloxyethylphosphorylcholine (A2) a copolymer containing a constitutional unit derived from 2-(meth)acryloyloxyethylphosphorylcholine and a constitutional unit derived from (meth)acrylic acid.Type: ApplicationFiled: August 30, 2023Publication date: April 4, 2024Applicant: NOF CORPORATIONInventors: Hirotaka SUZUKI, Masaru MATSUDA -
Publication number: 20240101734Abstract: The present invention provides a sensitizer for nucleic acid amplification which is a polymer containing a constitutional unit derived from a monomer represented by the following formula (1): wherein symbols are as defined in the specification.Type: ApplicationFiled: January 21, 2022Publication date: March 28, 2024Applicant: NOF CORPORATIONInventors: Hirotaka SUZUKI, Seina KONDO, Masaru MATSUDA
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Publication number: 20240101742Abstract: A living radical polymer that has a low molecular weight distribution and has a specific functional group at least at one end, and a resin-coated pigment has high dispersibility of a resin composition including the living radical polymer, is excellent in properties such as preservation stability, discharge stability, and color developability in a dispersed state, and is suitably used in a pigment dispersion. A living radical polymer has a specific functional group structure, the living radical polymer includes a polymerization initiator-derived specific organic compound moiety at one end or in a backbone of the living radical polymer and is obtained by reacting a radical generator having a specific functional group with at least any end, for example, an iodine end ascribable to a precursor. A living radical polymer composition includes the same; a resin-coated pigment is obtained by coating with the living radical polymer composition; and a method produces the living radical polymer.Type: ApplicationFiled: January 21, 2022Publication date: March 28, 2024Applicants: NOF CORPORATION, NATIONAL UNIVERSITY CORPORATION YAMAGATA UNIVERSITYInventors: Masumi TAKAMURA, Tatsuhiro TAKAHASHI, Shigeki TAKAHASHI, Shinri SAKAI
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Patent number: 11912964Abstract: The present invention is a contact lens treatment solution containing the following copolymer A and copolymer B in a ratio of A/B=1000/1 to 2/1 (by weight). According to the present invention, there can be provided a contact lens treatment solution capable of removing dirt having adhered to contact lens surfaces and capable of imparting persisting hydrophilicity to contact lens surfaces, by simple immersion treatment. Copolymer A: a copolymer obtained by copolymerization of a monomer (a) represented by formula (1) and a monomer (b) represented by formula (2), in which the copolymerization ratio of the monomer (a) to the monomer (b), a/b=7/3 to 9/1 (by mol), and having a weight-average molecular weight of 400,000 to 700,000.Type: GrantFiled: September 11, 2019Date of Patent: February 27, 2024Assignee: NOF CORPORATIONInventors: Hirotaka Suzuki, Hiroko Kawasaki, Shunsuke Sakurai
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Patent number: 11905366Abstract: A method for producing a multi-arm type polyethylene glycol derivative, which includes carrying out the following in order: Step (A): protecting an even number of hydroxyl groups, while leaving only the hydroxyl group at the 1-position of a polyhydric alcohol having an odd number of hydroxyl groups, other than the hydroxyl group at the 1-position by cyclic benzylidene acetalization, Step (B): linking two molecules of the compound obtained in step (A) to a compound for introducing a specific linker by etherification reaction, Step (C): deprotecting the cyclic benzylidene acetal structure at the terminal of the compound obtained in step (B), Step (D): polymerizing 3 to 600 mol of ethylene oxide to each hydroxyl group of the compound obtained in step (C) to obtain a multi-arm type polyethylene glycol derivative, and Step (E): functionalizing the hydroxyl group at the terminal of the multi-arm type polyethylene glycol derivative obtained in step (D).Type: GrantFiled: March 27, 2019Date of Patent: February 20, 2024Assignee: NOF CORPORATIONInventors: Akihide Onozawa, Hiroki Yoshioka, Masaki Kamiya
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Patent number: 11905367Abstract: A branched monodispersed polyethylene glycol represented by the formula (1): wherein X1 is a functional group that forms a covalent bond upon a reaction with a functional group present in a biofunctional molecule; n is an integer of 4 to 50, which represents number of repeating units of ethylene oxide units; and L1 represents a single bond, —NH—, -L2-(CH2)m1- or -L2-(CH2)m1-L3-(CH2)m2-, L2 represents an ether bond, an amide bond, an urethane bond or a single bond, L3 represents an ether bond, an amide bond or an urethane bond, and m1 and m2 represent each independently an integer of 1 to 5.Type: GrantFiled: March 19, 2019Date of Patent: February 20, 2024Assignee: NOF CORPORATIONInventors: Mika Hamura, Yuki Matsuno, Hiroki Yoshioka
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Publication number: 20240043613Abstract: A method for producing a maleimide polyethylene glycol derivative, may including a reaction step of heating a maleimide polyethylene glycol derivative having a protective group, in a solvent in the presence of silica gel to cause deprotection. A maleimide polyethylene glycol derivative can be produced at a high maleimidization rate while restraining deterioration of a maleimide group on deprotecting the maleimide polyethylene glycol derivative having a protective group.Type: ApplicationFiled: December 8, 2021Publication date: February 8, 2024Applicant: NOF CORPORATIONInventors: Daiki OZONE, Shota MORI, Masaki OTA
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Publication number: 20240043674Abstract: A rubber composition for hot air cross-linking containing 100 parts by mass of one or more rubber components (A) selected from an ethylene-propylene rubber and an ethylene-propylene-diene rubber, 1.0 parts by mass or more and 15.0 parts by mass or less of an organic peroxide (B), and 0.01 parts by mass or more and 9.0 parts by mass or less of a reducing agent (C). Also disclosed is a cross-linked rubber formed from the rubber composition for hot air cross-linking and a method of producing the cross-linked rubber.Type: ApplicationFiled: December 10, 2021Publication date: February 8, 2024Applicant: NOF CORPORATIONInventors: Kanako TAKUMA, Masaki HAYASHI
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Publication number: 20240026052Abstract: A monomer composition including (A) a phosphorylcholine group-containing polysiloxane monomer represented by the following formula (1), (B) a siloxanyl group-containing silicone monomer having at least one or more hydroxy groups in a molecule, represented by the following formula (2) or (3), (C) one or more hydrophilic monomers selected from hydroxyethyl (meth)acrylate, hydroxypropyl (meth)acrylate, and hydroxybutyl (meth)acrylate, (D) methacrylic acid, and (E) a hydrophilic monomer other than the component (C), a represents an integer of 20 to 500, b represents an integer of 1 to 70, c represents an integer of 1 to 70, d represents 0 or 1, p and q each represent 0 or 1, X represents —CH2— or —CH2CH2—, and R represents an alkyl group having 2 to 18 carbon atoms,Type: ApplicationFiled: December 9, 2021Publication date: January 25, 2024Applicant: NOF CORPORATIONInventors: Shu TAKASHIMA, Yoshiki TANAKA, Norio IWAKIRI
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Publication number: 20240010777Abstract: Provided is a surface treatment agent for an ophthalmic device that can impart wettability and lubricity to the surface of a silicone hydrogel, more specifically, a surface treatment agent for an ophthalmic device that can subject the silicone hydrogel to surface treatment even when the silicone hydrogel is not caused to present any specific complementary functional group. Also provided are a surface-treated silicone hydrogel whose surface has been treated with the surface treatment agent for an ophthalmic device, and an ophthalmic device using the surface-treated silicone hydrogel. It has been found that the above-mentioned objects can be achieved by using a water-soluble copolymer obtained by copolymerizing a phosphorylcholine group-containing monomer, a specific silicone monomer, and a thermally reactive monomer or a photoreactive monomer, the copolymer having water solubility controlled to a specific level. Thus, the present invention has been completed.Type: ApplicationFiled: November 24, 2021Publication date: January 11, 2024Applicant: NOF CORPORATIONInventors: Hirotaka SUZUKI, Shunsuke OZAKI, Norio IWAKIRI
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Patent number: 11867875Abstract: Provided is a contact lens that can exhibit excellent breaking elongation and surface hydrophilicity even when produced using a hydrophobic mold made of polypropylene or the like without performing a surface hydrophilic treatment. Further provided are a monomer composition and a polymer that can be suitably used for obtaining the contact lens. This monomer composition contains (A) a siloxanyl group-containing itaconic acid diester monomer, (B) an amide group-containing monomer, (C) a hydroxy group-containing monomer, (D) a siloxanyl group-containing (meth)acrylate, and (E) a cross-linking agent in a specific ratio.Type: GrantFiled: September 10, 2019Date of Patent: January 9, 2024Assignee: NOF CORPORATIONInventors: Ryuya Gotanda, Koh Kobayashi, Shu Takashima, Norio Iwakiri, Yosuke Matsuoka, Eiji Harata
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Patent number: 11851516Abstract: Provided is a monomer suitable for application to an ophthalmic device, the monomer showing high surface hydrophilicity, a high oxygen transmissibility, and appropriate mechanical strength when copolymerized with a polymerizable monomer, such as a hydrophilic monomer. It has been recognized that a phosphorylcholine group-containing polysiloxane monomer can solve the problems.Type: GrantFiled: April 4, 2019Date of Patent: December 26, 2023Assignee: NOF CORPORATIONInventors: Yosuke Matsuoka, Akane Katori, Norio Iwakiri, Shu Takashima, Ryuya Gotanda, Nobuyuki Sakamoto
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Patent number: 11827592Abstract: A composition of zinc salts of carboxylic acids. The carboxylic acids of the zinc salts include 0.5 to 6.0 mass % of a component (A), 0.05 to 1.2 mass % of a component (B) and 88.0 to 98.0 mass % of a component (C) described below. A ratio [(A)/(B)] of a mass of the component (A) with respect to a mass of the component (B) is 99/1 to 75/25, where (A) is a straight chain and saturated carboxylic acid having a carbon number of 12 to 22; (B) is a strait chain and unsaturated carboxylic acid having one unsaturated bond and a carbon number of 18, said unsaturated bond comprising a trans-form double bond; and (C) is a straight-chain and unsaturated carboxylic acid having one unsaturated bond and a carbon number of 18, said unsaturated bond comprising a cis-form double bond.Type: GrantFiled: April 23, 2020Date of Patent: November 28, 2023Assignee: NOF CORPORATIONInventors: Takeshi Yoshimura, Hiroyuki Ogi, Mako Iwasaki
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Publication number: 20230365750Abstract: The present invention provides a method for producing a maleimide polyethylene glycol lipid, and the method includes a reaction step of deprotecting a maleimide polyethylene glycol lipid having a protective group by heating the maleimide polyethylene glycol lipid having a protective group in a solvent in the presence of silica gel. According to the present invention, a production method of preventing deterioration of a maleimide group and improving a maleimidation rate can be provided.Type: ApplicationFiled: September 17, 2021Publication date: November 16, 2023Applicant: NOF CORPORATIONInventors: Shota MORI, Masaki OTA
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Publication number: 20230355512Abstract: Provided are an ocular surface drug-retaining agent that enables an excellent improvement in retainability of a medicament on an ocular surface and an eye drop containing the agent. An ocular surface drug-retaining agent containing a copolymer having three different kinds of constituent units at a specific ratio can express an excellent effect of retaining a medicament on an ocular surface (in particular, a corneal surface) to allow the effect or action of the drug to be sustained over a long period of time.Type: ApplicationFiled: September 6, 2022Publication date: November 9, 2023Applicants: NOF CORPORATION, KINKI UNIVERSITYInventors: Noriaki NAGAI, Shunsuke Sakurai, Eiji Harata
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Patent number: 11754936Abstract: Provided is a wax which is used in a toner, whereby the toner is excellent in low-temperature fixability and heat-resistant shelf stability, the glossiness is improved as compared with the prior art, and the generation of ultrafine particles and the bleeding of the wax are not likely to occur. The wax for toners, wherein the wax is an ester wax generated by esterification of a pentaerythritol and a monocarboxylic acid; wherein the monocarboxylic acid used for the esterification contains a behenic acid, an arachidic acid and a stearic acid; and wherein, with respect to 100% by mass of the monocarboxylic acid, a content ratio of the behenic acid is from 60% by mass to 80% by mass; a content ratio of the arachidic acid is from 5% by mass to 15% by mass; and a content ratio of the stearic acid is from 15% by mass to 25% by mass.Type: GrantFiled: October 7, 2019Date of Patent: September 12, 2023Assignees: ZEON CORPORATION, NOF CORPORATIONInventors: Masashi Watanabe, Takeshi Yoshimura, Norifumi Itako
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Patent number: 11746308Abstract: Provided is a treating solution for soft contact lenses capable of imparting hydrophilicity and sustainability thereof to a soft contact lens surface. It has been found that a treating solution for soft contact lenses containing a copolymer that contains two kinds of monomers different from each other as constituent units at a specific ratio, and that has a specific weight-average molecular weight can impart excellent hydrophilicity and sustainability thereof.Type: GrantFiled: December 3, 2018Date of Patent: September 5, 2023Assignee: NOF CORPORATIONInventors: Shunsuke Sakurai, Masatomo Takahashi, Norio Iwakiri, Koji Miyamoto, Takanori Fujita
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Patent number: 11746225Abstract: Disclosed herein is a resin composition including an ethylene-acrylic acid alkyl ester copolymer (L), a graft copolymer (M), and a styrene-based elastomer (N), wherein the graft copolymer (M) is obtained by a reaction among an ethylene-acrylic acid alkyl ester copolymer (A), a monomer component (B) containing at last one monomer selected from the group consisting of a (meth)acrylic acid alkyl ester monomer and an aromatic vinyl monomer, and t-butyl peroxymethacryloyloxyethyl carbonate (C), and a weight ratio between the ethylene-acrylic acid alkyl ester copolymer (A) and the monomer component (B) ((A)/(B)) is 50/50 to 98/2. The resin composition is capable of reducing squeaking noises generated by contact between a thermoplastic resin molded body and leather.Type: GrantFiled: February 5, 2020Date of Patent: September 5, 2023Assignee: NOF CORPORATIONInventors: Hiroki Arai, Kazuaki Mima
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Patent number: 11744792Abstract: A solid soap containing, (A) 77 to 91 mass % of an alkali metal salt of a saturated fatty acid having an even number of carbon atoms from 12 to 18, (B) 0.005 to 1 mass % of an alkali metal salt of a saturated fatty acid having an odd number of carbon atoms from 13 to 17, (C) 0.5 to 5 mass % of glycerol, and (D) 5 to 18 mass % of water.Type: GrantFiled: January 16, 2020Date of Patent: September 5, 2023Assignee: NOF CORPORATIONInventors: Dai Murakami, Tomohiro Wakita