Abstract: The present invention is a contact lens treatment solution containing the following copolymer A and copolymer B in a ratio of A/B=40/1 to 5/1 (by weight). According to the present invention, there can be provided a contact lens treatment solution capable of removing dirt having adhered to contact lens surfaces, capable of improving lubricity of contact lens surfaces and capable of imparting persisting hydrophilicity to contact lens surfaces, by simple immersion treatment. Copolymer A: a copolymer obtained by copolymerization of a monomer (a) represented by formula (1) and a monomer (b) represented by formula (2), in which the copolymerization ratio of the monomer (a) to the monomer (b), a/b=7/3 to 9/1 (by mol), and having a weight-average molecular weight of 400,000 to 800,000.

Abstract: A biodegradable polyethylene glycol derivative in which a polyethylene glycol chain is linked by an acetal linker capable of accurately controlling the hydrolysis rate under different pH environments in the living body, and whose division rate into a polyethylene glycol chain of low molecular weight in the living body can be accurately controlled. The biodegradable polyethylene glycol derivative is represented by formula (1) or formula (2) as described.

Abstract: A hydrophilic polymer derivative having a cyclic benzylidene acetal linker represented by the following formula (1): wherein R1 and R6 are each independently a hydrogen atom or a hydrocarbon group; R2, R3, R4 and R5 are each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; X1 is a chemically reactive functional group; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 8; and Z1 and Z2 are each independently a selected divalent spacer.

Abstract: Disclosed is an additive for lubricating oil, which comprises a phosphite ester compound (A) having a specific structure and a phosphite ester compound (B) having a specific structure, wherein a mass ratio of the phosphite ester compound (A) to the phosphite ester compound (B) (phosphite ester compound (A):phosphite ester compound (B)) is 99:1 to 80:20. According to the present invention, it is possible to provide an additive for lubricating oil, capable of imparting wear resistance and demulsibility with respect to a base oil for lubricating oil, and to impart durability even in the presence of water.

Abstract: A bio-related substance bonded to a branched and degradable polyethylene glycol derivative that is degraded in the cells represented by the following formula (A): wherein each symbol is as defined in the present specification, is provided by the present invention.

Abstract: A method for purifying a branched polyethylene glycol, which includes adding, to a branched polyethylene glycol compound represented by the following formula [1] and having a weight average molecular weight of 40000 or more: where Z, Y1, Y2, A, Polymer, l, m and b are as defined herein, at least one solid acid selected from magnesium silicate, aluminum silicate, and aluminum magnesium silicate and having a specific surface area of 50 to 250 m2/g in the presence of an aprotic organic solvent to obtain a mixture; stirring the mixture; and subsequently separating the solid acid.

Abstract: A heterobifunctional monodisperse polyethylene glycol with two adjacent monodisperse polyethylene glycol side chains, in which a peptide linker is degraded by intracellular enzymes to release a drug slowly and effectively mask the hydrophobicity of the drug, and an antibody-drug conjugate in which the antibody and the drug are bound using same is provided. A heterobifunctional monodisperse polyethylene glycol represented by the formula (1): wherein each symbol in the formula (1) is as defined in the DESCRIPTION.

Abstract: A lyophilized composition capable of encapsulating any nucleic acid with high efficiency and easily is provided. A lyophilized composition of lipid nanoparticles not containing a nucleic acid but containing an ionic lipid, a sterol, a PEG lipid, an acidic buffer component that shows a buffering action at pH 1-6, and a cryoprotectant, wherein a weight ratio of the cryoprotectant and a total lipid is 10:1-1000:1.

Abstract: Provided is a novel technique for treating cancer using structurally-reinforced S-TuD. Provided are: a composition for the prevention or treatment of tumors, said composition comprising an miRNA inhibitory complex including RNA of analog thereof; and a method for preventing or treating tumors using said composition. The miRNA inhibitory complex preferably includes at least one double-stranded structure and an miRNA-binding sequence. Two strands of the miRNA binding sequence preferably bind individually to two strands on at least one end of the double-stranded structure. According to some of the aspects of the present invention, there is provided a delivery system for delivering such an miRNA inhibitory complex.

Abstract: The present invention relates to a plant proteoglycan obtained from gum arabic obtained from a trunk or branch of Acacia plant (Acacia Senegal Willdenow or Acacia Seyal Delile), having a weight average molecular weight of 900,000-3,500,000, and having a total aldehyde content of not more than 2.0 ?mol equivalent/g. A plant proteoglycan having physiological activity equal to or higher than that of animal proteoglycan can be provided by the present invention.

Abstract: A compound is provided which is effectively adsorbed to a substrate surface, such as an immune reaction vessel, has extremely high protein adsorption inhibitory effect that inhibits non-specific adsorption of protein or the like, and has excellent washability to retain the inhibitory effect before and after washing operation of the substrate. Also provided are a protein adsorption inhibitor using the compound, a phosphorylcholine-modified substrate, and a method for inhibiting protein adsorption. The compound is a phosphorylcholine group-containing polyethylene glycol derivative represented by formula (1). The method for inhibiting protein adsorption of the present invention includes the step of forming an adsorbed layer of the derivative on a substrate surface.

Abstract: A heterobifunctional monodispersed polyethylene glycol represented by formula (1) which has two adjacent monodispersed polyethylene glycol side chains and does not have a chiral center in the molecular structure: wherein X1 and Y1 are each an atomic group containing a functional group capable of forming a covalent bond upon a reaction with a functional group present in a biofunctional molecule. R1 is a hydrocarbon group or the like. n is an integer of 3 to 72. A1 represents -L1-(CH2)m1— or the like, L1 and L2 represent each an ether bond or the like, and m1 and m2 each independently represent an integer of 1 to 5. B1 represents -L3-(CH2)m3— or the like, L3 and L4 represent an amide bond or the like, and m3 and m4 each independently represent an integer of 1 to 5. Also disclosed is an antibody-drug conjugate including the heterobifunctional monodispersed polyethylene glycol.

Abstract: The present invention provides an O/W type emulsion having a volume median diameter of not more than 100 nm and containing a compound represented by the formula (1) wherein Xa and Xb are each independently X1, X2 or a 1,4-piperazinediyl group; s is 1 or 2, R4 is an alkyl group having 1-6 carbon atoms, na and nb are each independently 0 or 1, R1a, R1b, R2a and R2b are each independently an alkylene group having 1-6 carbon atoms, Ya and Yb are each independently an ester bond, or the like, and R3a and R3b are each independently a liposoluble vitamin residue or the like.

Abstract: Provided is a monomer composition for contact lenses, which uses a polysiloxane monomer to produce a polymer that shows satisfactory surface hydrophilicity and oxygen permeability, and that is excellent in modulus and elongation at break. It has been found that a monomer composition containing a phosphorylcholine group-containing polysiloxane monomer, a monovinyl ether monomer, and the like can achieve the above-mentioned object.

Abstract: A surfactant composition for a formed sand including 80 to 99.8 mass % of a compound (A) represented by formula (1); 0.1 to 10 mass % of a compound (B) represented by formula (2); and 0.1 to 10 mass % of an amphoteric surfactant (C): R1O-(EO)n—SO3M1??(1) wherein R1 represents a hydrocarbon group having 6 to 22 carbons, EO represents oxyethylene group, n is 1 to 10, and M1 represents an alkali metal, an alkaline earth metal, ammonium or an organic ammonium; R2O—SO3M2??(2) wherein R2 represents a hydrocarbon group having 6 to 22 carbons, and M2 represents an alkali metal, an alkaline earth metal, ammonium or an organic ammonium.

Abstract: An object is to provide a wax dispersant capable of improving the resin composition in the fluidity in a molten state, the transparency and the storage stability, when adding the wax to a thermoplastic resin. The wax dispersant is a copolymer (A) which has a copolymerization composition comprising structural units respectively derived from: an aromatic monomer (A1) within 40 to 94% by mass; a (meth)acrylic acid long chain alkyl ester (A2) represented by the formula (1) (an alcohol residue R2 is C9 to C22 alkyl) within 5 to 40% by mass; and a (meth)acrylic acid alkyl ester (A3) represented by the formula (2) (an alcohol residue R4 is C1 to C8 alkyl) within 1 to 20% by mass, and also has a weight average molecular weight within 3,000 to 50,000.

Abstract: The invention provides a cationic lipid, a lipid membrane structure containing same, and use thereof. The cationic lipid is represented by the formula (1) wherein R1a, R1b, R2a, R2b, R3a, R3b, Xa, Xb, Yb, Za, and Zb are as defined in the specification.

Abstract: A method for producing a terminal carboxyl group-containing polyethylene glycol, which includes the following steps 1 and 2. Step 1: In a solution containing a polyethylene glycol having a hydroxyl group, an inorganic base 0.5 to 4 times the polyethylene glycol in mass, an aprotic solvent and water, mass of the water being 5 to 20 meq with respect to the inorganic base and mass of the water in the solution being 2,000 ppm or less, a compound of the formula (1) is reacted with the polyethylene glycol to obtain a polyethylene glycol ester: wherein X represents a leaving group, a represents an integer of 4 to 9, and R1 represents a hydrocarbon group having 1 to 4 carbon atoms; Step 2: The polyethylene glycol ester is hydrolyzed to obtain a terminal carboxyl group-containing polyethylene glycol.

Abstract: The invention provides a modified bio-related substance that shows further prolonged half-life in blood and further improved stability in the blood of living organisms. In particular, the invention provides a conjugate of a block polymer and a bio-related substance, which conjugate is represented by the following formula (I), wherein each symbol is as described herein.

Abstract: An intracellularly degraded branched and degradable polyethylene glycol derivative represented by the following formula (1): wherein each symbol is as defined in the present specification, that is used for modifying bio-related substances is provided by the present invention.