Patents Assigned to Novo Nordisk Biotech, Inc.
  • Purified coprinus laccases and nucleic acids encoding the same
    Patent number: 6008029
    Abstract: The present invention relates to polypeptides having laccase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: December 28, 1999
    Assignee: Novo Nordisk Biotech Inc.
    Inventors: Debbie Sue Yaver, Kimberley M. Brown, Sakari Kauppinen, Torben Halkier
  • Nucleic acids encoding polypeptides having tripeptide aminopeptidase activity
    Patent number: 5989889
    Abstract: The present invention relates to isolated nucleic acid sequences encoding polypeptides having tripeptide aminopeptidase activity. The invention also relates; to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as recombinant methods for producing the polypeptides.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: November 23, 1999
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Michael Rey, Elizabeth Golightly
  • Haloperoxidases from Curvularia verruculosa and nucleic acids encoding same
    Patent number: 5965418
    Abstract: The present invention relates to Curvularia verruculosa haloperoxidases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the haloperoxidases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods for recombinant production of the haloperoxidase. The invention further relates to compositions comprising the haloperoxidases and methods of using the compositions for killing microbial cells or inhibiting growth of microbial cells.
    Type: Grant
    Filed: April 16, 1997
    Date of Patent: October 12, 1999
    Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.
    Inventors: Claus Fuglsang, Karen Oxenb.o slashed.ll, Torben Halkier, Randy M. Berka, Joel Cherry
  • Aspergillus oryzae 5-aminolevulinic acid synthases and nucleic acids encoding same
    Patent number: 5958747
    Abstract: The present invention relates to Aspergillus oryzae 5-aminolevulinic acid synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the 5-aminolevulinic acid synthases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods of producing the 5-aminolevulinic acid synthases.
    Type: Grant
    Filed: February 5, 1998
    Date of Patent: September 28, 1999
    Assignee: Novo Nordisk Biotech, Inc
    Inventors: Susan L. Elrod, Joel R. Cherry
  • Methods for modifying the production of a polypeptide
    Patent number: 5958727
    Abstract: The present invention relates to methods for modifying the production of a polypeptide, comprising: (a) introducing a nucleic acid construct into a cell, wherein the cell comprises a DNA sequence encoding a polypeptide, under conditions in which the nucleic acid construct integrates into the genome of the cell at a locus not within the DNA sequence encoding the polypeptide to produce a mutant cell, wherein the integration of the nucleic acid construct modifies the production of the polypeptide by the mutant cell relative to the cell when the mutant cell and the cell are cultured under the same conditions; and (b) identifying the mutant cell with the modified production of the polypeptide.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: September 28, 1999
    Assignee: Novo Nordisk Biotech, Inc
    Inventors: Howard Brody, Deborah S. Yaver, Michael Lamsa, Kim Hansen
  • Methods for producing a polypeptide in a bacillus cell
    Patent number: 5955310
    Abstract: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a Bacillus host cell in a medium conducive for the production of the polypeptide, wherein the Bacillus cell comprises a nucleic acid construct comprising (i) a tandem promoter in which each promoter sequence of the tandem promoter is operably linked to a single copy of a nucleic acid sequence encoding the polypeptide and (ii) an mRNA processing/stabilizing sequence located downstream of the tandem promoter and upstream of the nucleic acid sequence encoding the polypeptide; and (b) isolating the polypeptide from the cultivation medium.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: September 21, 1999
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: William Widner, Alan Sloma, Michael D. Thomas
  • Enzymatic methods for dyeing with reduced vat and sulfur dyes
    Patent number: 5948122
    Abstract: The present invention relates to methods for dyeing a material, comprising (a) treating the material with a dyeing system which comprises one or more reduced vat dyes and/or one or more reduced sulfur dyes; and (b) oxidizing the one or more reduced vat dyes or one or more reduced sulfur dyes adsorbed onto the treated material with an oxidation system comprising (i) an oxygen source and one or more enzymes exhibiting oxidase activity or (ii) a hydrogen peroxide source and one or more enzymes exhibiting peroxidase activity, to convert the one or more reduced dyes to their original oxidized insoluble colored forms; wherein the material is a fabric, yarn, fiber, garment or film made of cotton, diacetate, flax, fur, hide, leather, linen, lyocel, polyacrylic, polyamide, polyester, ramie, rayon, silk, tencel, triacetate, viscose or wool.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: September 7, 1999
    Assignees: Novo Nordisk Biotech, Inc., Novo Nordisk BioChem North America Inc., Novo Nordisk A/S
    Inventors: Feng Xu, Sonja Irene Salmon
  • Gene encoding carboxypeptidase of aspergillus niger
    Patent number: 5939305
    Abstract: The present invention relates to a gene encoding an ascomycete or deuteromycete carboxypeptidase Y gene, and host cells modified so as to produce reduced amounts of carboxypeptidase.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: August 17, 1999
    Assignee: Novo Nordisk Biotech Inc
    Inventors: Debbie Sue Yaver, Sheryl Ann Thompson
  • Genes encoding signal recognition particle of Aspergillus niger
    Patent number: 5922561
    Abstract: The present invention relates to a nucleic acid construct containing a nucleic acid sequence encoding an element of a filamentous fungal signal recognition particle.
    Type: Grant
    Filed: October 3, 1994
    Date of Patent: July 13, 1999
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Sheryl Ann Thompson, Debbie Sue Yaver
  • Nucleic acids encoding a polypeptide having protease activity
    Patent number: 5891701
    Abstract: The present invention relates to isolated nucleic acid sequences encoding polypeptides having protease activity, in which the polypeptides are obtainable from an alkalophilic Bacillus species having enhanced stability towards bleaching agents of the peroxy type. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as recombinant methods for producing the polypeptides.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: April 6, 1999
    Assignee: Novo Nordisk BioTech Inc.
    Inventors: Alan Sloma, Lynne Christianson
  • Recombinant expression of a glucose oxidase from a cladosporium strain
    Patent number: 5879921
    Abstract: The invention is directed to alkaline glucose oxidases comprising novel peptide sequences. Furthermore, the invention relates to methods for producing and using said glucose oxidases.
    Type: Grant
    Filed: November 7, 1996
    Date of Patent: March 9, 1999
    Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.
    Inventors: Joel R. Cherry, Randy M. Berka, Torben Halkier
  • Polypeptides having mutanase activity and nucleic acids encoding same
    Patent number: 5874275
    Abstract: The present invention relates to polypeptides having mutanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to oral cavity compositions and methods for degrading mutan.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: February 23, 1999
    Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.
    Inventors: Randy M Berka, Stephan Christgau, Torben Halkier, Jeff Shuster, Claus Crone Fuglsang
  • Aspergillus oryzae 5-aminolevulinic acid synthases and nucleic acids encoding same
    Patent number: 5871991
    Abstract: The present invention relates to Aspergillus oryzae 5-aminolevulinic acid synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the 5-aminolevulinic acid synthases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods of producing the 5-aminolevulinic acid synthases.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: February 16, 1999
    Assignee: Novo Nordisk BioTech, Inc.
    Inventors: Susan L. Elrod, Joel R. Cherry
  • Polypeptides having 3g6-phytase activity from thermomyces and nucleic acids encoding same
    Patent number: 5866118
    Abstract: The present invention relates to isolated polypeptides having phytase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to composite feeds and methods of reducing phytate levels.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: February 2, 1999
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Randy M. Berka, Michael W. Rey, Alan V. Klotz
  • Haloperoxidases from curvularia verruculosa and nucleic acids encoding same
    Patent number: 5866393
    Abstract: The present invention relates to Curvularia verruculosa haloperoxidases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the haloperoxidases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods for recombinant production of the haloperoxidase. The invention further relates to compositions comprising the haloperoxidases and methods of using the compositions for killing microbial cells or inhibiting growth of microbial cells.
    Type: Grant
    Filed: July 9, 1996
    Date of Patent: February 2, 1999
    Assignees: Novo Nordisk A/S, Novo Nordisk BioTech, Inc.
    Inventors: Claus Fuglsang, Karen Oxenb.o slashed.ll, Torben Halkier, Randy M. Berka, Joel Cherry
  • Aspergillus porphobilinogen synthases and nucleic acids encoding same
    Patent number: 5866391
    Abstract: The present invention relates to Aspergillus porphobilinogen synthases and isolated nucleic acid fragments comprising nucleic acid sequences encoding the porphobilinogen synthases as well as nucleic acid constructs, vectors, and recombinant host cells comprising the nucleic acid sequences. The invention also relates to methods of producing the porphobilinogen synthases.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: February 2, 1999
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Aubrey Jones, Joel R. Cherry
  • Penicillium purpurogenum mutanases and nucleic acids encoding same
    Patent number: 5853702
    Abstract: The present invention relates to polypeptides having mutanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The present invention further relates to oral cavity compositions and methods for degrading mutan.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: December 29, 1998
    Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.
    Inventors: Randy M. Berka, Stephan Christgau, Torben Halkier, Jeff Shuster, Claus Crone Fuglsang
  • Metalloprotease having increased activity
    Patent number: 5843753
    Abstract: The present invention relates to a novel metalloprotease obtainable from a fungus having increased proteolytic activity. Additionally, the invention related to isolated nucleic acid fragments encoding said metalloprotease as well as vectors, DNA constructs, and recombinant host cells comprising said nucleic acid fragments.
    Type: Grant
    Filed: March 3, 1995
    Date of Patent: December 1, 1998
    Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.
    Inventors: Jeffrey R. Shuster, Mark Madden, Donna L. Moyer, Claus Fuglsang, Sven Branner
  • Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein
    Patent number: 5837847
    Abstract: The invention is related to a non-toxic, non-toxigenic, non-pathogenic recombinant Fusarium, e.g., Fusarium graminearum host cell comprising a nucleic acid sequence encoding a heterologous protein operably linked to a promoter. The invention further relates to a method for the production of recombinant proteins using such Fusarium host cells. The invention also relates to a promoter and terminator sequence which may be used in such cells.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: November 17, 1998
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: John C. Royer, Donna L. Moyer, Yoder T. Wendy, Jeffrey R. Shuster
  • Nucleic acids encoding polyeptides having absidia lipase activity
    Patent number: 5821102
    Abstract: The present invention relates to isolated nucleic acid sequences encoding polypeptides having Absidia lipase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. The invention further relates to compositions comprising the polypeptides.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: October 13, 1998
    Assignees: Novo Nordisk Biotech Inc., Novo Nordisk A/S
    Inventors: Randy M. Berka, Karuppan Chettiar Boominathan, Thomas Sandal