Patents Assigned to Novo Nordisk Biotech, Inc.
  • Nucleic acid constructs for the production of a Bacillus alkaline protease
    Patent number: 5621089
    Abstract: The invention is directed to an isolated nucleic acid construct(s) comprising a nucleic acid sequence encoding an alkaline protease having a molecular weight of about 34 kD and is obtainable from a strain of Bacillus sp. Group I, as well as recombinant vectors and host cells comprising such constructs. Additionally, the invention is directed to a method for obtaining the protease. The invention is also directed to promoter and signal sequences derived from said alkaline protease as well as methods of using the promoter and signal sequences in the expression of heterologous nucleic acid sequences encoding heterologous proteins in bacteria.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: April 15, 1997
    Assignees: Novo Nordisk Biotech, Inc., Novo Nordisk A/S
    Inventors: Alan P. Sloma, Helle Outtrup, Claus Dambmann, Dorrit A. Aaslyng
  • Thermophilic fungal expression system
    Patent number: 5604129
    Abstract: The present invention relates to recombinant thermophilic host cells comprising a nucleic acid sequence encoding a heterologous protein, and a method of producing recombinant protein utilizing same. The recombinant hosts of the present invention provide a better morphology in tank fermentations than many known fungal host cells, such as Aspergillus, which morphology results in lower viscosity levels, and therefore improved productivity.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: February 18, 1997
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Ejner B. Jensen, Karuppan C. Boominathan
  • Thermophilic fungal expression system
    Patent number: 5602004
    Abstract: The present invention relates to recombinant thermophilic host cells comprising a nucleic acid sequence encoding a heterologous protein, and a method of producing recombinant protein utilizing same. The recombinant hosts of the present invention provide a better morphology in tank fermentations than many known fungal host cells, such as Aspergillus, which morphology results in lower viscosity levels, and therefore improved productivity.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: February 11, 1997
    Assignee: Novo Nordisk Biotech, Inc.
    Inventors: Ejner B. Jensen, Karuppan C. Boominathan