Abstract: An aerosol delivery device includes an aerosol generator for generating an aerosol in the aerosol delivery device with a membrane and a vibrator which is configured to vibrate a fluid and to aerosolise the fluid by the membrane. The aerosol delivery device further includes a fluid reservoir for receiving the fluid to be aerosolised, the fluid reservoir being arranged in fluid communication with the membrane, a controller which is configured to sequentially operate the vibrator at a plurality of different vibration frequencies, a sensor which is configured to detect at least one electrical parameter of the vibrator for each of the plurality of different vibration frequencies, and a detector which is configured to detect the presence of fluid in contact with the membrane and/or in the fluid reservoir on the basis of the dependence of the detected values of the at least one electrical parameter on the vibration frequency.

Abstract: The invention relates to a method of manufacturing a vibratable head (1) for an aerosol generator (2), the vibratable head (1) comprising a support member (4), a vibratable membrane (6) supported by the support member (4) and a vibrator (8) configured to vibrate the vibratable membrane (6). The method comprises the steps of providing the support member (4), roughening a surface portion (10) of the support member (4) by laser structuring, applying an adhesive (9) to at least a part of the roughened surface portion (10) of the support member (4) and attaching at least one element to the support member (4) by at least a portion of the adhesive (9). Further, the invention relates to a vibratable head (1) manufactured by this method, an aerosol generator (2) comprising such a vibratable head (1) and a method of manufacturing such an aerosol generator (2).

Abstract: The present invention relates to a control device for controlling an operation of an aerosol nebulizer system (30), said aerosol nebulizer system (30) comprising an aerosol generator (31) for nebulizing a liquid and a plurality of sensor units (38a, 38b, 38c, 38d, 38e), said control device (20) comprising: a communication unit (21), configured to establish a wireless communication connection and to perform data transmission with the aerosol nebulizer system (30), a sensor data control unit (22), configured to trigger a selection of sensor data related to the sensor units (38a, 38b, 38c, 38d, 38e) to be wirelessly transmitted to the control device (20).

Abstract: Inhalator comprising an aerosol generator configured to generate an aerosol by nebulizing a fluid and a controller configured to control operation of the aerosol generator and a housing accommodating at least the aerosol generator and the controller, the housing having a base for supporting the housing on a horizontal surface, wherein a portion of the housing accommodating at least a portion of the controller is arranged further away from the base than the aerosol generator as seen in a vertical direction, when the base is supported on the horizontal surface.

Abstract: Inhalator (50) comprising an aerosol generator (64) configured to generate an aerosol by nebulizing a fluid and a controller (24) configured to control operation of the aerosol generator and a housing (11, 51) accommodating at least the aerosol generator and the controller, the housing having a base (12) for supporting the housing on a horizontal surface, wherein a portion (35) of the housing accommodating at least a portion of the controller is arranged further away from the base than the aerosol generator as seen in a vertical direction, when the base is supported on the horizontal surface.

Abstract: An opening element for opening an ampoule in an aerosol generation device includes a first member which has a conduit extending therethrough for guiding a fluid contained in the ampoule through the first member and a second member which is arranged at least partly inside or on the conduit. Further, an aerosol generation device includes such an opening element.

Abstract: A fluid reservoir is attachable to an aerosol generation device for guiding a fluid from a fluid container to the aerosol generation device. The fluid reservoir has an interface portion arranged at the fluid reservoir for attaching the fluid reservoir to the aerosol generation device. The interface portion has a locking element configured to non-detachably lock the fluid reservoir to the aerosol generation device after attachment of the fluid reservoir to the aerosol generation device. The locking element is breakable to enable detachment of the fluid reservoir from the aerosol generation device. A combination includes the fluid reservoir and a primary fluid package, wherein the primary fluid package has at least one chamber containing a fluid therein. An aerosol generation device is configured for use with the fluid reservoir has an attachment portion for receiving the interface portion of the fluid reservoir.

Abstract: The present invention relates to a medical evaluation device (10) for evaluating an adherence to a therapy protocol when using an aerosol nebulizer (30) having an aerosol generator (31) for nebulizing a liquid medication according to said therapy protocol, said medical evaluation device (10) comprising: a communication unit (100), configured to establish a communication connection with a communication device (20), said communication connection being configured for: providing first configuration data to a nebulizer control device (40) of said aerosol nebulizer (30) via said communication device (20), said first configuration data for configuring said aerosol nebulizer according to said therapy protocol; and receiving nebulizing data indicating an operation of said aerosol nebulizer from said communication device (20); further comprising an evaluation unit (110), configured to evaluate said adherence to said therapy protocol based on a comparison of said received nebulizing data with respective parameters defin

Abstract: An aerosol generator for generating an aerosol from a fluid, comprising: a vibratable membrane having a first side for being in contact with the fluid and an opposite second side, the membrane having a plurality of through holes penetrating the membrane in an extension direction from the first side to the second side, whereby the fluid passes the through holes from the first side to the second side when the membrane is vibrated for generating the aerosol at the second side, each through hole having along its extension direction a smallest diameter, a larger diameter that is larger than the smallest diameter and defined by that diameter that is closest to triple, preferably twice said smallest diameter, each through hole having a nozzle portion defined by that continuous portion of the through hole in the extension direction comprising the smallest diameter of the through hole and bordered by the larger diameter of the through hole, wherein the ratio of the total length of each through hole in the extension di

Abstract: The invention relates to a method of manufacturing a vibratable head (1) for an aerosol generator (2), the vibratable head (1) comprising a support member (4), a vibratable membrane (6) supported by the support member (4) and a vibrator (8) configured to vibrate the vibratable membrane (6). The method comprises the steps of providing the support member (4), roughening a surface portion (10) of the support member (4) by laser structuring, applying an adhesive (9) to at least a part of the roughened surface portion (10) of the support member (4) and attaching at least one element to the support member (4) by at least a portion of the adhesive (9). Further, the invention relates to a vibratable head (1) manufactured by this method, an aerosol generator (2) comprising such a vibratable head (1) and a method of manufacturing such an aerosol generator (2).

Abstract: The invention relates to an aerosol generator (1), comprising a housing (20, 22), having a first holding member (24, 24?, 24?) and a second holding member (38), and a vibratable element (4) for generating an aerosol. The vibratable element (4) is at least partially accommodated in the housing (20, 22). The vibratable element (4) is contacted by and held between the first and second holding members (24, 24?, 24?; 38). The first holding member (24, 24?, 24?) is less flexible than the second holding member (38). Further, the invention relates to an aerosol delivery device comprising the aerosol generator (1).

Abstract: The invention relates to a method for cleaning a membrane (3) of a membrane aerosol generator (4) of an inhalation therapy device (100), which membrane can vibrate, wherein a cleaning liquid is fed to the membrane (3) and the membrane (3) is caused to vibrate in such a way that the cleaning liquid is conveyed through the openings of the membrane (3), wherein the cleaning liquid contains at least one surfactant. The invention further relates to a combination of a cleaning device (1) and of a cleaning liquid, wherein the cleaning device (1) is designed for cleaning a membrane (3) of a membrane aerosol generator (4) of an inhalation therapy device (100), which membrane can vibrate. The cleaning device (1) comprises a liquid-feeding apparatus (2), which is designed to feed the cleaning liquid to the membrane (3), and a vibration activation apparatus (9), which is designed to activate membrane vibrations such that the cleaning liquid is conveyed through the openings of the membrane (3).

Abstract: An aerosol generator for generating an aerosol from a fluid, comprising: a vibratable membrane (22) having a first side (24) for being in contact with the fluid and an opposite second side (25), the membrane having a plurality of through holes (26) penetrating the membrane in an extension direction (E) from the first side to the second side, whereby the fluid passes the through holes from the first side to the second side when the membrane is vibrated for generating the aerosol at the second side, each through hole (26) having along its extension direction (E) a smallest diameter (Ds), a larger diameter (DL) that is larger than the smallest diameter and defined by that diameter that is closest to triple, preferably twice said smallest diameter, each through hole having a nozzle portion (32) defined by that continuous portion of the through hole in the extension direction comprising the smallest diameter of the through hole and bordered by the larger diameter of the through hole, characterized in that the rati

Abstract: An inhalation therapy device includes an atomizer for atomizing a drug which is advantageously present in the form of a fluid into an atomization chamber so that an aerosol or mist is provided in the atomization chamber. The patient or user can inhale the aerosol produced by the atomizer from the atomization chamber via a mouthpiece. The ampoule is inserted into an ampoule holder holding the fluid-containing ampoule. The inhalation therapy device also includes an opening unit for opening the fluid-containing ampoule. The ampoule holder advantageously includes a first part, disposed displaceably in relation to the opening unit, thereby allowing an ampoule present in the ampoule holder to be displaced in the direction of the opening unit.

Abstract: The invention relates to cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection. In particular, the invention provides a cyclosporine liquid formulation for use as an aerosol for inhalation in a method of preventing or treating pulmonarychronic graft rejection in single lung transplanted patients. The formulation is preferably administered once or twice daily. The formulation may be aerosolized with a nebulizer that comprises features for monitoring the time, date and duration of inhalation by the patient, in order to monitor patient adherence. The formulation according to the invention may be combined with standard immunosuppressants and corticosteroids.

Abstract: The invention relates to an aerosol delivery device (10) comprising an aerosol generator (3) for generating an aerosol in the aerosol delivery device (10), a sensor (5) configured to detect a use of the aerosol delivery device (10) for aerosol treatment, and a controller (7) configured to deactivate the aerosol generator (3) if no use of the aerosol delivery device (10) for aerosol treatment is detected by the sensor (5). Further, the invention relates to a method for operating an aerosol delivery device (10), comprising the steps of operating an aerosol generator (3) for generating an aerosol in the aerosol delivery device (10), detecting a use of the aerosol delivery device (10) for aerosol treatment by means of a sensor (5), and deactivating the aerosol generator (3) by means of a controller (7) if no use of the aerosol delivery device (10) for aerosol treatment is detected by the sensor (5).

Abstract: An inhalation therapy device includes an atomizer for atomizing a drug which is advantageously present in the form of a fluid into an atomization chamber so that an aerosol or mist is provided in the atomization chamber. The patient or user can inhale the aerosol produced by the atomizer from the atomization chamber via a mouthpiece. The ampoule is inserted into an ampoule holder holding the fluid-containing ampoule. The inhalation therapy device also includes an opening unit for opening the fluid-containing ampoule. The ampoule holder advantageously includes a first part, disposed displaceably in relation to the opening unit, thereby allowing an ampoule present in the ampoule holder to be displaced in the direction of the opening unit.

Abstract: A pharmaceutical aerosol is disclosed which is suitable for delivering an active compound to the mucosa of the nose, the osteomeatal complex or a paranasal sinus. The pressure of the aerosol is not constant, but pulsates at a frequency from about 10 to 90 Hz. The aerosol is further characterised in that it exhibits a low effective flow rate of less than about 5 liters per minute. The aerosol is, inter alia, suitable for the prevention, management, or treatment of a disease, symptom, or condition affecting the nose or the paranasal sinuses, such as acute and chronic sinusitis.

Abstract: The invention relates to a fluid reservoir (2) for an aerosol generator (50), the fluid reservoir (2) comprising a fluid chamber (4) for receiving a fluid (6), an opening (8) for guiding the fluid (6) received in the fluid chamber (4) outside the fluid chamber (4), and a collar portion (10) surrounding the opening (8) and extending into the fluid chamber (4). A first portion (12) of the fluid chamber (4) extends along the length of the collar portion (10) in a height direction (H) of the fluid chamber (4), A second portion (14) of the fluid chamber (4) is arranged adjacent to the first portion (12) in the height direction (H) of the fluid chamber (4). A lateral extension of the first portion (12) in the directions perpendicular to the height direction (H) of the fluid chamber (4) is smaller than a lateral extension of the second portion (14) in the directions perpendicular to the height direction (H) of the fluid chamber (4).

Abstract: The invention relates to liquid pharmaceutical compositions containing: a) a therapeutically effective dose of a cyclosporin; b) an aqueous carrier liquid; c) a first solubilizing substance selected among the group of phospholipids; and d) a second solubilizing substance selected among the group of non-ionic surfactants. Preferably, the cyclosporin is liposome solubilized. The inventive composition is suitable for oral, parenteral, nasal, mucosal, topical, and particularly pulmonary application in the form of an aerosol.