Abstract: For use in premature babies and infants, in particular for administering surfactant to the lungs, the inhalation therapy device described herein comprises an aerosol generating device 1, a respiratory air flow generating means 3 and a nebulising chamber 5 into which the generated liquid droplets 2 and the respiratory air flow 4 are supplied. The nebulising chamber 5 comprises a tapering area 52 which ends in a tubular intubation means 6. The intubation means 6 is designed such that the intubation end 6b can be positioned in such a manner that the liquid droplet/respiratory air mixture conveyed via the intubation means is released behind those areas of the respiratory tract that filter out to a great extent the liquid droplets from the mixture.

Abstract: The inhalation therapy device comprises an aerosol generator (2) and a mixing chamber (3). The introduction of ambient air is achieved by means of supply channels (9) under the control of an inspiration valve (20), including an aerosol passage (22), a region with inspiration air through openings (23) and a valve element (21). The aerosol passage (22) surrounds the membrane (6) of the aerosol generator (2), whereby a front face edge of the tubular aerosol passage (22) lies along a sealing line (20a) on a surface of the aerosol generator (2).

Abstract: An aerosol generating device includes a membrane for atomizing a liquid; an actuating device, which is coupled to the membrane so that this membrane is set in oscillatory motion when activated by electric signals; and a flexible substrate, which has electric lines for supplying electric signals to the actuating device and is designed for fastening the aerosol generating device to a fastening area of an inhalation therapy unit, and on which the membrane and the actuating device are held.

Abstract: The invention describes an aerosol generator for inhalation therapy devices, in which an oscillatable assembly, consisting of at least a membrane and an oscillation generator, is mounted in an encapsulating means such that at least the membrane is exposed for the supply of liquid and the generation of an aerosol, whereas the remaining parts of the oscillatable assembly are protected. Mounting occurs by means of a flexible passage such that the oscillatory motions of the oscillatable assembly are not negatively affected.

Abstract: The invention describes an aerosol generator for inhalation therapy devices, in which an oscillatable assembly, consisting of at least a membrane and an oscillation generator, is mounted in an encapsulating means such that at least the membrane is exposed for the supply of liquid and the generation of an aerosol, whereas the remaining parts of the oscillatable assembly are protected. Mounting occurs by means of a flexible passage such that the oscillatory motions of the oscillatable assembly are not negatively affected.

Abstract: The invention relates to an aerosol delivery device (10, 100, 100?) comprising an aerosol generator (12, 106) for generating an aerosol in the device and a fluid conveying unit (14, 16, 18; 102, 104, 130) configured to induce a first fluid flow (26, 120) having a first flow rate in the device for transporting at least a portion of the generated aerosol outside the device and to induce a second fluid flow (32, 122) having a second flow rate in the device for conveying a fluid into the device, wherein the fluid conveying unit comprises a vibrator (18, 104) for vibrating the aerosol and the first flow rate is equal to or smaller than the second flow rate.

Abstract: The invention provides aqueous liquid pharmaceutical compositions comprising arbekacin and chloride ions. The compositions are well tolerable for use in a method for treatment or prevention of a disease of the upper or lower respiratory tract, wherein the composition is aerosolized and inhaled by the patient. Furthermore, the invention provides arbekacin hydrochloride.

Abstract: A pharmaceutical aerosol is disclosed which is suitable for delivering an active compound to the mucosa of the nose, the osteomeatal complex or a paranasal sinus. The pressure of the aerosol is not constant, but pulsates at a frequency from about 10 to 90 Hz. The aerosol is further characterized in that it exhibits a low effective flow rate of less than about 5 liters per minute. The aerosol is, inter alia, suitable for the prevention, management, or treatment of a disease, symptom, or condition affecting the nose or the paranasal sinuses, such as acute and chronic sinusitis.

Abstract: An aerosol generator for generating an aerosol from a fluid, comprising: a vibratable membrane (22) having a first side (24) for being in contact with the fluid and an opposite second side (25), the membrane having a plurality of through holes (26) penetrating the membrane in an extension direction (E) from the first side to the second side, whereby the fluid passes the through holes from the first side to the second side when the membrane is vibrated for generating the aerosol at the second side, each through hole (26) having along its extension direction (E) a smallest diameter (Ds), a larger diameter (DL) that is larger than the smallest diameter and defined by that diameter that is closest to triple, preferably twice said smallest diameter, each through hole having a nozzle portion (32) defined by that continuous portion of the through hole in the extension direction comprising the smallest diameter of the through hole and bordered by the larger diameter of the through hole, characterized in that the rati

Abstract: An ampoule for insertion into an aerosol generator, in order to atomize a substance (40) contained in the ampoule, comprising: a container portion (10), which forms a chamber (11, 23) for receiving at least one constituent of the substance (40); and an interface portion (20), which is designed for receiving and fixing the ampoule receiving portion of the aerosol generator and has, in a direction in which the ampoule is intended to be inserted into the aerosol generator, a push-up bottom (15, 31), characterized in that the container portion (10) and the interface portion (20) arc formed by separate parts and the interface portion is of a closable design.

Abstract: An inhalation nebulizer includes an aerosol generator that can be removed from the inhalation therapy device or inserted therein, and a control device that sends a control signal to the aerosol generator. The aerosol generator has a characterization device containing information about the aerosol generator, that can be determined by an identification device of the inhalation therapy device, in order to influence the operation of the inhalation therapy device.

Abstract: Atomizer for a ventilation machine with a ventilator, including a body with a first connection for connecting the atomizer to a ventilator and a second connection for connecting the atomizer to a line leading to a patient, wherein the body forms a flow channel from the first connection to the second connection; and an atomizing device for atomizing a fluid; wherein the atomizing device is disposed between the first connection and the second connection in the flow channel and adapted so that the fluid can be atomized substantially parallel to, and preferably in, the flow direction from the first connection to the second connection.

Abstract: Aerosol generator having a liquid reservoir (10) defining in a sealed state a volume VR configured to hold an initial volume of liquid VL; a membrane (5) having openings, the liquid reservoir (10) being connected to the membrane (5) to feed the liquid to one side of the membrane, the membrane being oscillatable to transport the liquid through the openings whereby the liquid is emitted in the form of an aerosol on the other side of the membrane, wherein the volume VR of the liquid reservoir (10) before the membrane (5) is oscillated is configured to contain more than 5 ml of gas at an initial volume of the liquid VL of at least 5 ml.

Abstract: The invention relates to an aerosol therapy device comprising a membrane nebulizer (1) and a personal digital assistant (PDA (2)), which are interconnected via communication devices (10, 11) in such a way that therapy data, which has been prepared in relation to signals, is transmitted from the membrane nebulizer (1) to the PDA and control data is transmitted from the latter (2) to the membrane nebulizer (1).

Abstract: A fluid dispersion device comprises a substrate having an outer section and an inner section, said inner section of the substrate having an aperture, a dispersion element positioned at said aperture of said substrate, and an actuator arranged to coaxially surround said aperture of said substrate, wherein the outer edge of said inner section of said substrate is coupled to said outer section of said substrate by a plurality of resilient members.

Abstract: The invention relates to liquid pharmaceutical compositions containing: a) a therapeutically effective dose of a cyclosporin; b) an aqueous carrier liquid; c) a first solubilizing substance selected among the group of phospholipids; and d) a second solubilizing substance selected among the group of non-ionic surfactants. Preferably, the cyclosporin is liposome solubilized. The inventive composition is suitable for oral, parenteral, nasal, mucosal, topical, and particularly pulmonary application in the form of an aerosol.

Abstract: Atomizer for a ventilation machine with a ventilator, comprising a body with a first connection for connecting the atomizer to a ventilator and a second connection for connecting the atomizer to a line leading to a patient, wherein the body forms a flow channel from the first connection to the second connection; and an atomizing device for atomizing a fluid; characterized in that the atomizing device is disposed between the first connection and the second connection in the flow channel and adapted so that the fluid can be atomized substantially parallel to, and preferably in, the flow direction from the first connection to the second connection.

Abstract: The invention relates to a method for operating an aerosol delivery device (10), comprising the steps of generating a predetermined amount of an aerosol in the device (10) and inducing a transport flow in the device (10) for transporting at least a portion of the predetermined amount of the aerosol outside the device (10). During the aerosol generating step, the transport flow is first induced, then stopped after a predetermined first period of time and then induced again after a predetermined second period of time.

Abstract: The invention describes an aerosol generator for inhalation therapy devices, in which an oscillatable assembly, consisting of at least a membrane and an oscillation generator, is mounted in an encapsulating means such that at least the membrane is exposed for the supply of liquid and the generation of an aerosol, whereas the remaining parts of the oscillatable assembly are protected. Mounting occurs by means of a flexible passage such that the oscillatory motions of the oscillatable assembly are not negatively affected.

Abstract: The aerosol generator of an inhalation therapy device according to a preferred embodiment of the invention continuously produces an aerosol at a generation rate of about 0.2 ml/min to about 1.5 ml/min, preferably 0.4 ml/min to about 1.2 ml/min and the mixing chamber has a volume of about 60 ml to about 150 ml, preferably about 80 ml to about 120 ml, and even more preferably about 90 to about 110 ml. While the patient inhales through the inhalation therapy device, the generated aerosol is inhaled by the patient. While the patient exhales into the inhalation therapy device, the generated aerosol is collected in the mixing chamber. Due to the specific size of the mixing chamber, the continuously generated aerosol can accumulate therein without losses even when the exhalation phase is longer than the inhalation phase like in the case of emphysema.