Abstract: Provided is a Pt(IV) complex. As a prodrug, the Pt(IV) complex is activated by irradiation to release a Pt(II) complex for the treatment of tumors. Also provided is a pharmaceutical composition including the Pt(IV) complex, and the use of the Pt(IV) complex in the preparation of a drug for treating tumors by means of irradiation activation. Further provided is a kit including the Pt(IV) complex and the description, wherein the description indicates that radiotherapy is performed after administration to treat tumors.

Abstract: A method, system, device and computer-readable storage medium for inverse quantization. The method comprises: determining an initial weighted inverse quantization matrix, wherein, the initial weighted inverse quantization matrix is the same as the quantized block in size; setting some matrix elements in the initial weighted inverse quantization matrix to zero to obtain a weighted inverse quantization matrix, wherein, determining the matrix elements that need to be zeroed according to the size of the quantized block; weighted inverse quantizing the quantized coefficients in the quantized block to generate corresponding inverse transform coefficients, wherein, the value of the matrix element corresponding to the position of the quantized coefficient in the weighted inverse quantization matrix is used as a weight coefficient of the weighted inverse quantization.

Abstract: Disclosed is a method for implementing an adaptive stochastic spiking neuron based on a ferroelectric field effect transistor, relating to the technical field of spiking neurons in neuromorphic computing. Hardware in the method includes a ferroelectric field effect transistor (fefet), an n-type mosfet, and an l-fefet formed by enhancing a polarization degradation characteristic of a ferroelectric material for the ferroelectric field-effect transistor, wherein a series structure of the fefet and the n-type mosfet adaptively modulates a voltage pulse signal transmitted from a synapse. The l-fefet has a gate terminal connected to a source terminal of the fefet to receive the modulated pulse signal, and simulates integration, leakage, and stochastic spike firing characteristics of a biological neuron, thereby implementing an advanced function of adaptive stochastic spike firing of the neuron.

Abstract: The present disclosure provides a complex of general formula (I), wherein M is tetravalent platinum; L is independently a neutral ligand or an anionic ligand when appearing each time; x is an integer of 1-5; P is a precursor ligand, the precursor ligand being a ligand of a tetravalent platinum ion which can be released from the complex after irradiation and converted into a functional molecule D to achieve functions such as medicine, fluorescence detection, or a functional material.

Abstract: The invention relates to a method for prognosing ACS in a subject, the method comprising determining plasma MIF and Nt-proBNP (or BNP) concentrations in a sample from the subject, diagnosing ACS when the subject plasma concentrations are greater than a reference MIF and Nt-proBNP (or BNP) plasma concentration, and prognosing the magnitude of ACS from the subject plasma MIF and Nt-proBNP (or BNP) concentrations. Also provided is a method of treating ACS in a subject, a device, a kit, and a cardiac biomarker related to the methods of prognosing ACS.

Abstract: A liquid crystal/polymer composite electrically controlled dimming film is provided, including a liquid crystal material, a polymer matrix, and two layers of conductive substrates. The polymer matrix is sandwiched between the two layers of conductive substrates, and the polymer matrix has a porous microstructure. The liquid crystal material is dispersed in the polymer matrix to form liquid crystal microdroplets, and the liquid crystal microdroplets have vertically oriented polymer networks. The liquid crystal/polymer composite electrically controlled dimming film has a unique composite microstructure. In this composite microstructure, the polymer matrix of the porous microstructure gives the film with good mechanical processing performance.

Abstract: The present invention pertains to pharmaceutical chemical field, and relates to a sterol derivative as well as preparation method and uses thereof. Specifically, the present invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, ester or ether thereof, wherein, R1 is selected from the group consisting of —OH, ?O(carbonyl), H, and C1-C3 alkyl; R2 is selected from the group consisting of —OH, H, and C1-C3 alkyl; R3 is selected from the group consisting of —OH, ?O, H, and C1-C3 alkyl; R4 is selected from the group consisting of —OH, H, and C1-C3 alkyl; and none, one, two, three or four of R1, R2, R3, and R4 are —OH. The compound of the present invention can inhibit HMG-CoA reductase, tumor cells and lipase effectively, and is a potential drug for reducing blood-fat, antitumors, or for losing weight.

Abstract: The present invention pertains to pharmaceutical chemical field, and relates to a sterol derivative as well as preparation method and uses thereof. Specifically, the present invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, ester or ether thereof, wherein, R1 is selected from the group consisting of —OH, ?O(carbonyl), H, and C1-C3 alkyl; R2 is selected from the group consisting of —OH, H, and C1-C3 alkyl; R3 is selected from the group consisting of —OH, ?O, H, and C1-C3 alkyl; R4 is selected from the group consisting of —OH, H, and C1-C3 alkyl; and none, one, two, three or four of R1, R2, R3, and R4 are —OH. The compound of the present invention can inhibit HMG-CoA reductase, tumor cells and lipase effectively, and is a potential drug for reducing blood-fat, antitumors, or for losing weight.

Abstract: The present disclosure relates to a method of synthesizing cyclosporine derivatives. The method includes: providing a precursor fluid of the cyclosporine derivative, an alkaline fluid and a ClCH2OCOCl solution; premixing the precursor fluid and the alkaline fluid to obtain a premixed solution; feeding the premixed solution into a first reaction chamber, reacting to prepare a first reaction liquid; feeding the first reaction liquid into a second reaction chamber, reacting the first reaction liquid with a CO2 fluid to prepare a second reaction liquid; and reacting the second reaction liquid with the ClCH2OCOCl solution.

Abstract: A thin film transistor and manufacturing method thereof, an electronic device are provided, which includes: a gate electrode, a gate insulation layer, an active layer, a first electrode and a second electrode are on a base substrate, the active layer made of a one-dimensional semiconductor nano material includes a first electrode region, a second electrode region, a first channel region, a second channel region; the first electrode region and the second electrode region are in contact with the first electrode and the second electrode respectively, the first channel region is directly connected with the first channel region and the second channel region respectively, the second channel region is a first doped region and between the first electrode region and the second electrode region; an energy level of the second channel region is different from that of the first channel region corresponding to the energy level of the second channel region.

Abstract: A device and method for testing an effective diffusion coefficient of helium in helium-bearing natural gas solves the problem that there is currently no systematic method or supporting experimental device to quantitatively characterize the diffusion behavior of helium in helium-bearing natural gas. The device includes a diffusion system and a gas sampling and analysis system. The diffusion system includes an upstream diffusion chamber, a downstream diffusion chamber, and a true triaxial apparatus, and is configured to simulate a gas diffusion process. The gas sampling and analysis system includes an upstream gas sample retention chamber, a downstream gas sample retention chamber, and a chromatographic analyzer, and is configured to sample a diffusing gas and analyze composition of the gas. By performing diffusion process simulation, gas sampling and analysis, and data calculation and fitting, the effective diffusion coefficient of helium in the helium-bearing natural gas is finally acquired.

Abstract: A method for constructing a real-geographic-space scene in real time based on a panoramic-video technique is provided. By using a measuring robot and the attitude sensors, accurately determining the geographic coordinates and the attitudes of the cameras, where the cameras may be installed in a fixed or stringing manner, where in the fixing type a plurality of neighboring videos at the same moment undergo orthographic correction and splicing, and in the stringing type the cameras are installed to a guiding device and may locally, independently and quickly move and shoot, and the videos of the neighboring cameras are spliced in real time; and fusing the videos, the geographic coordinates and the environment sounds that satisfy the delay time, to form a scene video streaming.

Abstract: Compositions and methods for treating a subject are provided. The compositions may include a short interfering RNA (siRNA) molecule comprising a sense RNA strand and an anti-sense RNA strand, the sense and anti-sense RNA strands forming an RNA duplex. The method may include administering a medical composition including an agent to the subject, wherein the agent is configured to reduce uridine 5?-diphospho-glucuronosyltransferase (UGT) levels in the subject. The sense RNA strand or the anti-sense RNA strand may be 15 to 25 nucleotides in length. The sense RNA strand and the anti-sense RNA strand may be 70%-100% complementary.

Abstract: A method for constructing a real-geographic-space scene in real time based on a panoramic-video technique is provided. By using a measuring robot and the attitude sensors, accurately determining the geographic coordinates and the attitudes of the cameras, where the cameras may be installed in a fixed or stringing manner, where in the fixing type a plurality of neighboring videos at the same moment undergo orthographic correction and splicing, and in the stringing type the cameras are installed to a guiding device and may locally, independently and quickly move and shoot, and the videos of the neighboring cameras are spliced in real time; and fusing the videos, the geographic coordinates and the environment sounds that satisfy the delay time, to form a scene video streaming.

Abstract: The present application relates to the technical field of deep learning and pose estimation, and more particularly, to a contextual instance decoupling (CID)-based multi-person pose estimation (MPPE) method and apparatus. The method includes: acquiring a preset number of images containing multiple persons; inputting the images containing multiple persons, as a training sample, into a CID-based MPPE model for training; and performing pose estimation on a target image using the trained CID-based MPPE model, the CID-based MPPE model being provided with an instance information abstraction module, a global feature decoupling module and a heatmap estimation module. The method and apparatus of the present application can explore context clues over a greater range, thus being robust to spatial detection errors and superior in both accuracy and efficiency.

Abstract: Provided are an on-chip miniature X-ray source and a method for manufacturing the same. The on-chip miniature X-ray source includes: an on-chip miniature electron source; a first insulating spacer provided on an electron-emitting side of the on-chip miniature electron source, where the first insulating spacer has a cavity structure; and an anode provided on the first insulating spacer, where a closed vacuum cavity is formed between the on-chip miniature electron source and the anode. The on-chip miniature X-ray source has the advantages of stable X-ray dose, low working requirements for vacuum, fast switch response, capability of integration and batch fabrication, and can be used in various types of small and portable X-ray detection, analysis and treatment devices.

Abstract: The present disclosure relates to the technical field of electroosmotic pumps (EOPs) and wearable medical equipment, and in particular, to an EOP, an insulin pump and an insulin pump system. The EOP of the present disclosure is cost-effective and has low power consumption, and can replace an existing mechanical pump device as a driving device in the insulin pump to achieve miniaturization of the insulin pump and lower the price of the insulin pump. In addition, when the EOP adopts a modified flexible membrane with penetrating pores, the EOP can pump and infuse a high-concentration insulin solution to achieve miniaturization and high efficiency of the insulin pump, which is conducive to the integration of wearable medical devices for treating diabetes.

Abstract: Embodiments of the present application provide a method and a device of inverse tone mapping and an electronic device. The method includes: obtaining one or more low dynamic range images; performing a decomposition operation to the low dynamic range image to acquire a detail layer and a basic layer of the low dynamic range image; restoring the detail layer and the basic layer by using a predetermined first restoration network and a second restoration network to acquire restored detail layer and basic layer; and adjusting the restored detail layer and basic layer by using a predetermined fusion network to acquire an adjusted high dynamic range image. With the technical solution of the present application, the conversion from a low dynamic range image to a high dynamic range image can be more robustly completed without complicated parameter settings.

Abstract: The present disclosure relates to a silicon-based fan out package structure including embedded manifold type microchannels, which includes: a chip, which includes a substrate and embedded microchannels located on a back of the substrate; a silicon-based adapter plate, which includes a groove for burying the chip, a manifold channel located below the groove and communicated with the groove, a liquid inlet and a liquid outlet; a low temperature sealing layer for sealingly communicating the embedded microchannels with the manifold channel, the low temperature sealing layer being located between the chip and the silicon-based adapter plate; and a rewiring layer at a top of the chip. The present disclosure also relates to a preparation method for a silicon-based fan out package structure including embedded manifold type microchannels. The silicon-based fan out package structure of the present disclosure has both low temperature process compatibility and packaging compatibility and high heat dissipation efficiency.

Abstract: Disclosed is a method for implementing an adaptive stochastic spiking neuron based on a ferroelectric field effect transistor, relating to the technical field of spiking neurons in neuromorphic computing. Hardware in the method includes a ferroelectric field effect transistor (fefet), an n-type mosfet, and an I-fefet formed by enhancing a polarization degradation characteristic of a ferroelectric material for the ferroelectric field-effect transistor, wherein a series structure of the fefet and the n-type mosfet adaptively modulates a voltage pulse signal transmitted from a synapse. The I-fefet has a gate terminal connected to a source terminal of the fefet to receive the modulated pulse signal, and simulates integration, leakage, and stochastic spike firing characteristics of a biological neuron, thereby implementing an advanced function of adaptive stochastic spike firing of the neuron.