Patents Assigned to Peking University
-
Patent number: 11760641Abstract: A method for preparing suspended graphene support film by selectively etching growth substrate is disclosed in present invention. The transfer process of graphene is avoided. The process of present invention is efficient and low in cost, suspended graphene support film can be prepared in a single etching step. The prepared graphene support film does not need any support by polymer film and polymer fiber. The prepared graphene support film has controllable number of layers and high intactness (90%-97%), large suspended area (diameter is 10-50 ?m), wide clean area (>100 nm) and can be mass-produced. In addition, the graphene support film can be directly used as transmission electron microscope support film, and can be used to achieve high resolution imaging of nanoparticles.Type: GrantFiled: October 14, 2019Date of Patent: September 19, 2023Assignee: PEKING UNIVERSITYInventors: Hailin Peng, Liming Zheng, Bing Deng
-
Patent number: 11753650Abstract: The application discloses a wheat fertility-related gene TaMS7 and an application method thereof, and belongs to the field of biotechnology. By analyzing a genome-wide expression profile of wheat anthers at different development stages, we obtain the wheat fertility-related gene TaMS7, and regulate the fertility of a plant by adjusting expression of the gene to produce and maintain wheat male sterility lines and to prepare hybrid seeds, wherein the discovery of this gene has important theoretical and practical significance for establishing an efficient technology system of wheat hybrid seed production, and for studying wheat male sterility mechanism and heterosis.Type: GrantFiled: November 8, 2017Date of Patent: September 12, 2023Assignees: BEIJING NEXT GENERATION HYBRID WHEAT BIOTECHNOLOGY CO., LTD, PEKING UNIVERSITY INSTITUTE OF ADVANCED AGRICULTURAL SCIENCESInventors: Jian Li, Zheng Wang, Ligeng Ma, Xingwang Deng
-
Patent number: 11748927Abstract: A system for synthesizing a real-time image by using optical surface motion signals includes: an acquisition unit configured to acquire an image of a patient before treatment and real-time optical surface data of the patient during treatment; and a synthesis unit configured to synthesize the acquired image of the patient before treatment and the real-time optical surface data of the patient during treatment into a real-time image that is synchronized with a change of the optical surface motion signals according to a certain mapping relationship. The synthesized real-time image achieves precise, real-time, non-invasive, visual dynamic tracking of the moving target volumes without concomitant dose during radiotherapy on the existing traditional accelerator platform.Type: GrantFiled: September 29, 2020Date of Patent: September 5, 2023Assignee: BEIJING CANCER HOSPITAL(PEKING UNIVERSITY CANCER HOSPITAL)Inventors: Yibao Zhang, Chenguang Li, Yuliang Huang, Hao Wu, Hongjia Liu
-
Patent number: 11746350Abstract: Compositions and methods for treating a subject are provided. The compositions may include a short interfering RNA (siRNA) molecule comprising a sense RNA strand and an anti-sense RNA strand, the sense and anti-sense RNA strands forming an RNA duplex. The method may include administering a medical composition including an agent to the subject, wherein the agent is configured to reduce uridine 5?-diphospho-glucuronosyltransferase (UGT) levels in the subject. The sense RNA strand or the anti-sense RNA strand may be 15 to 25 nucleotides in length. The sense RNA strand and the anti-sense RNA strand may be 70%-100% complementary.Type: GrantFiled: May 17, 2022Date of Patent: September 5, 2023Assignee: PEKING UNIVERSITYInventors: Liangyi Chen, Wenzhen Zhu, Yi Wang
-
Publication number: 20230265496Abstract: A method for low frequency somatic cell mutation identification and quantification, relating specifically to a method for transposon copy number and genome location identification. Specific sites of different transposon families are used, transposon insertion sequences are specifically enriched via library construction, high-throughput sequencing and bioinformatics analysis are used, and genome locations, copy numbers and types of transposons within samples are accurately identified. The method economically and accurately identifies copy numbers and genome locations of transposons.Type: ApplicationFiled: July 23, 2018Publication date: August 24, 2023Applicant: PEKING UNIVERSITYInventors: Liping WEI, Boxun ZHAO, Yue HUANG, Qixi WU, Yongxin YE, Xianing ZHENG
-
Patent number: 11736224Abstract: This application provides a data transmission method. The method includes: An electronic device first establishes an MPTCP connection to an application server, where the MPTCP connection includes two TCP connections. Then, the electronic device receives indication information from an application server, where the indication information includes a type identifier and a parameter. When the type identifier indicates a low data transmission delay requirement, the electronic device receives, in a first time period after the electronic device receives the indication information, the data stream by using a first TCP connection. When an accumulated data amount actually received by the electronic device in the first time period is less than a product of the parameter and duration corresponding to the first time period, the electronic device receives the data stream in a second time period by using both the two TCP connections.Type: GrantFiled: December 10, 2019Date of Patent: August 22, 2023Assignees: Huawei Technologies Co., Ltd., Peking UniversityInventors: Hao Wang, Chenren Xu, Shuo Chen, Jianfeng Qi, Henghui Liang, Xiaojin Li, Lili Liu, Guan Wang
-
Patent number: 11734154Abstract: A delta debugging method and system based on a probability model which includes: acquiring an initial probability model and historical test data; optimizing and iterating the initial probability model through the historical test data to obtain an optimized and iterated probability model; and performing delta debugging on a target program containing multiple lines of code based on the optimized and iterated probability model to obtain a debugging result that meets a first preset condition. Therefore, by adopting the embodiment of the present application, the initial probability model can be continuously optimized and iterated through the historical test data, and the target program can be debugged based on the optimized and iterated probability model, so that the debugging result can be improved, or the compression amount of the size of the target program can reach a target compression amount, or the debugging time can be greatly reduced.Type: GrantFiled: August 31, 2021Date of Patent: August 22, 2023Assignee: PEKING UNIVERSITYInventors: Guancheng Wang, Ruobing Shen, Yingfei Xiong, Lu Zhang
-
Patent number: 11714921Abstract: Provided are an image processing method, an image matching method, a device, and a storage medium. The image processing method includes: obtaining an image feature of an input image; determining a plurality of local image features of the image feature; determining a plurality of local feature vectors corresponding to the plurality of local image features respectively; determining a hash code of the input image based on the plurality of local feature vectors.Type: GrantFiled: June 30, 2020Date of Patent: August 1, 2023Assignees: BOE TECHNOLOGY GROUP CO., LTD., PEKING UNIVERSITYInventors: Yigeng Fang, Xiaojun Tang, Yadong Mu
-
Patent number: 11702658Abstract: The present application provides methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA. The present application further provides deaminase-recruiting RNAs used in the RNA editing methods and compositions comprising the same.Type: GrantFiled: October 14, 2021Date of Patent: July 18, 2023Assignees: EDIGENE THERAPEUTICS (BEIJING) INC., PEKING UNIVERSITYInventors: Pengfei Yuan, Yanxia Zhao, Nengyin Liu, Zexuan Yi, Gangbin Tang, Wensheng Wei, Liang Qu, Zongyi Yi, Shiyou Zhu, Chunhui Wang, Zhongzheng Cao, Zhuo Zhou
-
Patent number: 11703537Abstract: Disclosed are method and an apparatus for analysis of an interface state of a MIS-HEMT device.Type: GrantFiled: April 2, 2020Date of Patent: July 18, 2023Assignee: PEKING UNIVERSITY SHENZHEN GRADUATE SCHOOLInventors: Xinnan Lin, Shuhao Xiong
-
Publication number: 20230186091Abstract: Disclosed are a method and a device for determining a task-driven pruning module, and a computer readable storage medium. The method includes: obtaining an input task and a task quantity of a neural network to be pruned, and output information of a component module of the neural network to be pruned; determining a task correlation degree of the component module according to the input task, the task quantity and the output information; determining an input information retention degree of the component module according to the task quantity and the output information; determining an importance index value of the component module according to the task correlation degree and the input information retention degree; and determining the pruning module in the neural network to be pruned according to the importance index value.Type: ApplicationFiled: February 25, 2022Publication date: June 15, 2023Applicant: PEKING UNIVERSITY SHENZHEN GRADUATE SCHOOLInventors: Wei GAO, Yang GUO, Ge LI
-
Publication number: 20230168218Abstract: A sensor array device includes a substrate and electrodes. The electrodes include a power electrode located in a first region of the substrate and a plurality of working electrodes located in a second region of the substrate. Surfaces of the working electrodes have various specific enzymes, respectively, and the specific enzymes on the surfaces of the working electrodes are different. The plurality of working electrodes are located in different sub-regions of the second region, respectively. The sensor array device further includes a guide layer or a hydrophilic layer. The guide layer is located above the electrodes and covers the first region and the second region. An edge of the guide layer extends to an edge of the substrate. The hydrophilic layer is arranged on the substrate and covers the first region and the second region, and an edge of the hydrophilic layer extends to the edge of the substrate.Type: ApplicationFiled: November 25, 2022Publication date: June 1, 2023Applicant: Peking UniversityInventor: Yue CUI
-
Publication number: 20230170307Abstract: A processing method of a flexible hybrid electronic system is provided and includes the following steps: etching out embedded grooves on a front surface of a silicon-based substrate embedding a plurality of heterogeneous chips into corresponding embedded grooves, wherein front surfaces of the embedded chips are flush with the front surface of the silicon-based substrate; then gradually realize the polymer flexible connection, electrical interconnection, insulation protection, and polymer flexible coverage between chips. The processing method processes the flexible hybrid electronic system based on the method of embedding chips, which can reduce material loss and processing steps, and is beneficial to realizing large-scale manufacturing.Type: ApplicationFiled: April 30, 2021Publication date: June 1, 2023Applicant: PEKING UNIVERSITYInventors: Wei WANG, Lang CHEN
-
Patent number: 11661596Abstract: Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA, deaminase-recruiting RNAs used in the RNA editing methods, compositions and kits comprising the same.Type: GrantFiled: January 11, 2022Date of Patent: May 30, 2023Assignee: PEKING UNIVERSITYInventors: Wensheng Wei, Zongyi Yi, Liang Qu, Feng Tian, Chunhui Wang, Shiyou Zhu, Zhuo Zhou
-
Patent number: 11662484Abstract: The present disclosure provides a neutral atom imaging unit, a neutral atom imager, a neutral atom imaging method, and a space detection system. The neutral atom imaging unit includes at least one set of detection units, the at least one set of detection units includes: at least one semiconductor detector line array, each semiconductor detector line array includes a semiconductor detector strip composed of a plurality of semiconductor detectors; and at least one modulation grid. The modulation grid includes a slit and a slat forming the slit; the modulation grid includes a plurality of grid periods, each of the grid periods includes n slits, the width of the semiconductor detector strip is d, and the width (wi) of the i-th slit of the modulation grid satisfies the following relationship: w i = n i × d .Type: GrantFiled: July 9, 2021Date of Patent: May 30, 2023Assignee: PEKING UNIVERSITYInventors: Qiugang Zong, Yongfu Wang, Linghua Wang, Hong Zou, Hongfei Chen, Xiangqian Yu, Weihong Shi, Lyu Zhou
-
Publication number: 20230157996Abstract: The present application provides a small-molecule inhibitor targeting an EB virus nuclear antigen protein, and/or a pharmaceutical composition containing the same, which can be used for the treatment of a disease caused by EBNA1 activity, such as, but not limited to, cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and/or rheumatoid arthritis. The present application further provides a small-molecule inhibitor targeting an EB virus nuclear antigen protein, and/or a pharmaceutical composition containing the same, which can be used for the treatment of a disease caused by EBV infection in a lytic and/or latent phase.Type: ApplicationFiled: December 2, 2022Publication date: May 25, 2023Applicants: Shenzhen Bay Laboratory, Peking University Shenzhen Graduate SchoolInventors: Zhendong ZHU, Zhengshuang XU, Ting LI, Chao CHE, Qingzhou ZHANG, Sigui CHEN, Huangcan CHEN, Dehu XIANG, Zhen YANG
-
Publication number: 20230143813Abstract: A compound of Formula I compound—Ovatodiolide which is safe and effective to use in a pharmaceutical composition for inhibition of SARS-CoV-2 is provided. The pharmaceutical composition comprising a safe and effective amount of a compound of Formula I compound—Ovatodiolide or pharmaceutically acceptable salts thereof, together with a pharmaceutically acceptable carrier, which has great potential to treat SARS-CoV-2 induced COVID-19 based on a safe and effective amount of a compound of Formula I compound—Ovatodiolide.Type: ApplicationFiled: April 17, 2020Publication date: May 11, 2023Applicants: Peking University Shenzhen Graduate School, CNS Biotek Corp., Gansu Evergreen Pharmaceuticals, Co., Ltd.Inventors: Zhen Yang, Yew-Min Tzeng, Linqi Zhang, Junmin Quan, Qing Chang, Qi Zhang, Chien-Ming Lee
-
Publication number: 20230135021Abstract: A method for training a feature quantization model includes: obtaining a plurality of source data domains; obtaining feature information and labeling information of each of the plurality of source data domains; decomposing the feature information of each of the plurality of source data domains, so as to obtain common feature information and domain-specific feature information of the plurality of source data domains, the common feature information being feature information common to the plurality of source data domains; and training a feature quantization model according to the common feature information of all the source data domains, and domain-specific feature information and the labeling information of each of the plurality of source data domains, so as to obtain a common feature quantization model.Type: ApplicationFiled: March 12, 2021Publication date: May 4, 2023Applicants: BOE TECHNOLOGY GROUP CO., LTD., Peking UniversityInventors: Yigeng FANG, Yadong MU, Xiaojun TANG
-
Patent number: 11638839Abstract: A device and a method for measuring proton beam source position and beamline center are disclosed. The device includes N quadrupole magnets, a laser, a target and a scintillation screen; the target and the scintillation screen are arranged in front of and behind the N-quadrupole lens, respectively; the N-quadrupole lens can be converted to a M-quadrupole lens; the position of proton beam after being focused by the N- or M-quadrupole lens on the scintillation screen is measured; according to the amplification factor and the proton beam position, the offset of the proton beam source from the beamline center, as well as the position of the beamline center on the scintillation screen are calculated; the disclosure can accurately determine the position of the beamline center and the proton beam source by the use of N quadrupole magnets, combined with a scintillation screen.Type: GrantFiled: November 4, 2020Date of Patent: May 2, 2023Assignee: Peking UniversityInventors: Jungao Zhu, Xueqing Yan, Chen Lin
-
Publication number: 20230130402Abstract: Disclosed are a method and an apparatus for designing a magnetic shielding apparatus and a magnetic shielding apparatus. The method includes: determining a region of interest inside the magnetic shielding apparatus, the region of interest being a region where a magnetic shielding effect is expected to be achieved, and the magnetic shielding apparatus including N layers of shields disposed in a nested manner; determining a complete parameter set; and obtaining, based on the complete parameter set, a set of result parameters for describing the geometric structure, the set of result parameters that enables magnetic flux density in the region of interest to meet a preset threshold. This method not only greatly improves optimized magnetic shielding performance compared with an equal-spacing solution, but also resolves a problem that an analytical method cannot be used to optimize a magnetic shielding apparatus with a non-concentric structure.Type: ApplicationFiled: September 16, 2022Publication date: April 27, 2023Applicants: Peking University, Beijing QuanMag Healthcare Co. Ltd.Inventors: Jia-Hong GAO, Dongxu LI, Jingwei SHENG