Patents Assigned to Perlegen Sciences, Inc.
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Patent number: 7127355Abstract: Several methods are described for assessing an individual's likelihood of developing or exhibiting a multifactorial trait. The methods include determining a plurality of genotypes for the individual at a plurality of biallelic polymorphic loci, using the genotypes to compute a score for the individual, and comparing the score to at least one threshold value.Type: GrantFiled: September 30, 2004Date of Patent: October 24, 2006Assignee: Perlegen Sciences, Inc.Inventors: David Cox, Mark McCamish
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Publication number: 20060234216Abstract: The present invention includes the use of any of the polymorphisms, SNP haplotype blocks or SNP haplotype patterns. In one embodiment, susceptibility to a phenotype resulting from an allele or marker in linkage disequilibrium with such polymorphic forms is evaluated. Novel therapeutic and diagnostic compounds and methods are also disclosed.Type: ApplicationFiled: August 22, 2002Publication date: October 19, 2006Applicant: Perlegen Sciences, Inc.Inventors: David Cox, Deana Arnold
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Patent number: 7124033Abstract: Methods, code, and apparatus are used to ensure that groups of experimental subjects selected for inclusion in a study are matched. Individuals are genotyped and the genotype data is used to determine the extent of mismatch between study groups. If groups show evidence of poor matching, then the genotype data is used to better match the study groups.Type: GrantFiled: April 30, 2003Date of Patent: October 17, 2006Assignee: Perlegen Sciences, Inc.Inventors: David Hinds, Renee Stokowski
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Publication number: 20060228728Abstract: A collection of polymorphic sites having resistance or susceptibility to Alzheimer's disease is provided. The sites are useful in methods of diagnosing and treating Alzheimer's disease and related conditions.Type: ApplicationFiled: January 31, 2006Publication date: October 12, 2006Applicant: Perlegen Sciences, Inc.Inventors: David Cox, Dennis Ballinger, Erica Beilharz, Karel Konvicka, Laura Stuve
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Publication number: 20060223058Abstract: Cell and tissue autonomous phenotypes are correlated with genotype information. Correlated genotype information is used to screen individual traits. Methods and systems for correlating cell and tissue autonomous phenotypes to genotype information are provided.Type: ApplicationFiled: March 9, 2006Publication date: October 5, 2006Applicant: Perlegen Sciences, Inc.Inventors: David Cox, Brad Margus
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Patent number: 7115726Abstract: The present invention includes the use of any of the polymorphisms, SNP haplotype blocks or SNP haplotype patterns. In one embodiment, susceptibility to a phenotype resulting from an allele or marker in linkage disequilibrium with such polymorphic forms is evaluated. Novel therapeutic and diagnostic compounds and methods are also disclosed.Type: GrantFiled: August 22, 2002Date of Patent: October 3, 2006Assignee: Perlegen Sciences, Inc.Inventors: David R. Cox, Deana A. Arnold
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Publication number: 20060211684Abstract: The present invention provides a strategy to compensate for deficiency in the alpha-2C receptor by administering an agonist of different receptors; the alpha-2A and/or dopamine d2 receptors. These receptors are fully functional and receptive to stimulation by an agonist. Agonism of the alpha-2A and/or dopamine d2 receptors by clonidine, Nolomirole or other suitable agonist may down regulate epinephrine production, and hence compensate for the deficiency in the alpha-2C receptor. Such methods are useful for treating a variety of cardiovascular disorders.Type: ApplicationFiled: January 13, 2006Publication date: September 21, 2006Applicant: Perlegen Sciences, Inc.Inventor: Mark McCamish
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Publication number: 20060188875Abstract: The invention provides nucleic acid segments of the human genome including polymorphic sites, SNP haplotype blocks, SNP haplotype patterns for each block and informative SNPs for each pattern. Allele-specific primers and probes hybridizing to regions flanking these sites are also provided. The nucleic acids, primers and probes are used in applications such as association studies and other genetic analyses.Type: ApplicationFiled: October 31, 2002Publication date: August 24, 2006Applicant: Perlegen Sciences, Inc.Inventors: David Cox, Nila Patil, Anthony Berno, David Hinds
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Publication number: 20060183132Abstract: Multiple unique selection probes are provided in a single medium. Each selection probe has a sequence that is complementary to a unique target sequence that may be present in a sample under consideration. For example, each selection probe may be complementary to a sequence that includes one of the SNPs used to genotype an organism. Single-stranded selection probes anneal or hybridize with sample sequences having the unique target sequences specified by the selection probe sequences. Sequences from the sample that do not anneal or hybridize with the selection probes are separated from the bound sequences by an appropriate technique. The bound sequences can then be freed to provide a mixture of isolated target sequences, which can be used as needed for the application at hand.Type: ApplicationFiled: February 14, 2005Publication date: August 17, 2006Applicant: Perlegen Sciences, Inc.Inventors: Glenn Fu, Laura Stuve, John Sheehan, Amy Ollmann, Naiping Shen, Andrew Sparks, Dennis Ballinger
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Publication number: 20060177847Abstract: Correlations between polymorphisms and metabolic syndrome, obesity, treatment-emergent weight gain and insulin resistance are provided. Methods of diagnosing and treating metabolic syndrome, obesity, treatment-emergent weight gain and insulin resistance are provided. Systems and kits for disgnosis and treatment of metabolic syndrome, treatment-emergent weight gain, obesity and insulin resistance are provided.Type: ApplicationFiled: December 8, 2005Publication date: August 10, 2006Applicant: Perlegen Sciences, Inc.Inventors: David Cox, Dennis Ballinger, Richard Hockett, Sandra Kirkwood
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Patent number: 7058657Abstract: An interactive and dynamic data analysis tool that helps interactive analysis in real time on medium size datasets having complex structure is described. In one aspect, the data analysis tool is capable of being configured to act as a data producer tool arranged to provide a data source. The data analysis tool can also be configured as a data consumer tool capable of receiving and processing a particular data source. The data source tool and the data consumer tool are connected together to form a framework that takes the form of a data mapping context that mediates the data provided by the data source and a particular data role.Type: GrantFiled: January 7, 2003Date of Patent: June 6, 2006Assignee: Perlegen Sciences, Inc.Inventor: Anthony J. Berno
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Publication number: 20060008834Abstract: Improved life sciences business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic developments.Type: ApplicationFiled: July 13, 2005Publication date: January 12, 2006Applicant: Perlegen Sciences, Inc.Inventors: Bradley Margus, David Cox
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Publication number: 20050272086Abstract: The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype blocks and patterns to dissect the genetic bases of disease and drug response. The methods of the present invention are useful in whole genome analysis.Type: ApplicationFiled: June 29, 2005Publication date: December 8, 2005Applicant: Perlegen Sciences, Inc.Inventors: Nila Patil, David Cox, Anthony Berno, David Hinds
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Patent number: 6969589Abstract: The present invention relates to methods for identifying variations that occur in the human genome and relating these variations to the genetic basis of disease and drug response. In particular, the present invention relates to identifying individual SNPs, determining SNP haplotype blocks and patterns, and, further, using the SNP haplotype blocks and patterns to dissect the genetic bases of disease and drug response. The methods of the present invention are useful in whole genome analysis.Type: GrantFiled: March 26, 2002Date of Patent: November 29, 2005Assignee: Perlegen Sciences, Inc.Inventors: Nila Patil, David R. Cox, Anthony J. Berno, David A. Hinds
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Patent number: 6963805Abstract: The present invention provides methods for determining sequence similarity (conserved sequences) between nucleic acids from a first organism and nucleic acids from a second, different organism without having to know a priori the nucleic acid sequence from the second, different organism. The first nucleic acid can be from any organism where the sequence of the nucleic acid is known and the second nucleic acid can be from any organism. The method involves determining which bases from the second nucleic acid are identical to the first nucleic acid, and allows one to determine the sequence of portions of the second nucleic acid. The invention is useful for identifying putative functional regions or putative organism-sequences in a genome.Type: GrantFiled: October 5, 2001Date of Patent: November 8, 2005Assignee: Perlegen Sciences, Inc.Inventors: Kelly A. Frazer, Nila Patil, John Sheehan
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Patent number: 6955883Abstract: Improved life sciences business systems and methods are disclosed. One or more genomes are scanned for single nucleotide polymorphisms. The polymorphisms are assigned to haplotype blocks, and representative SNPs from the haplotype blocks are used in association studies for pharmaceutical and diagnostic developments.Type: GrantFiled: March 26, 2003Date of Patent: October 18, 2005Assignee: Perlegen Sciences, Inc.Inventors: Bradley A. Margus, David R. Cox, Stephen P. A. Fodor
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Publication number: 20050196770Abstract: Several methods are described for assessing an individual's likelihood of developing or exhibiting a multifactorial trait. The methods include determining a plurality of genotypes for the individual at a plurality of biallelic polymorphic loci, using the genotypes to compute a score for the individual, and comparing the score to at least one threshold value.Type: ApplicationFiled: September 30, 2004Publication date: September 8, 2005Applicant: Perlegen Sciences, Inc.Inventors: David Cox, Mark McCamish
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Patent number: 6898531Abstract: The presently claimed invention provides methods for amplifying a DNA target sequence. One embodiment of the present invention provides robust methods for amplification of target sequences. In a first aspect of the invention, a method for designing primer pairs for the amplification reaction is provided. In a further aspect of the invention, reagents and cycling parameters for the amplification reaction are provided.Type: GrantFiled: January 9, 2002Date of Patent: May 24, 2005Assignee: Perlegen Sciences, Inc.Inventors: John B. Sheehan, Daryl J. Thomas, Wade A. Barrett
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Patent number: 6897025Abstract: Improved systems and methods for performing genetic analyses. Full genomic DNA scans are performed on the genetic DNA from a plurality of individuals to identify genetic variants. For those variants, but not based on a full genetic DNA scan, the variants alone are scanned in additional individuals to identify blocks of the variants that tend to be inherited together.Type: GrantFiled: January 7, 2002Date of Patent: May 24, 2005Assignee: Perlegen Sciences, Inc.Inventors: David R. Cox, Bradley A. Margus, Nila Patil
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Publication number: 20050100911Abstract: The invention provides several methods for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids on a nucleic acid probe array. The methods result in a subset of the initial population enriched for a desired property, or lacking nucleic acids having an undesired properly. The resulting nucleic acids in the subset are then applied to the array for various types of analysis. The methods are particularly useful for analyzing populations having a high decree of complexity, for example, chromosomal-derived DNA, or whole genomic DNA, or mRNA population. In addition, such methods allow for analysis of pooled samples.Type: ApplicationFiled: August 6, 2003Publication date: May 12, 2005Applicant: Perlegen Sciences, Inc.Inventors: Nila Patil, David Cox, Charit Pethiyagoda, Andrew Sparks, Huang-Tsu Chen