Patents Assigned to Pharma Mar, S.A.
  • Antitumoral compounds
    Patent number: 11713325
    Abstract: A compound of general formula I and pharmaceutical compositions, kits, methods of making, and methods for treating cancer using the same.
    Type: Grant
    Filed: April 5, 2022
    Date of Patent: August 1, 2023
    Assignee: Pharma Mar, S.A.
    Inventors: Maria del Carmen Cuevas Marchante, Andres Francesch Solloso, Valentin Martinez Barrasa
  • Combination therapy with an antitumor alkaloid
    Patent number: 11590129
    Abstract: The present invention relates to the combination of PM01183 with several anticancer drugs, in particular other anticancer drugs selected from antitumor platinum coordination complexes, antimetabolites, mitotic inhibitors, anticancer antibiotics, topoisomerase I and/or II inhibitors, proteasome inhibitors, histone deacetylase inhibitors, nitrogen mustard alkylating agents, nitrosourea alkylating agents, nonclassical alkylating agents, estrogen antagonists, androgen antagonists, mTOR inhibitors, tyrosine kinase inhibitors, and other agents selected from aplidine, ET-743, PM02734 and PM00104, and the use of these combinations in the treatment of cancer.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: February 28, 2023
    Assignee: PHARMA MAR, S.A.
    Inventors: Victoria Moneo Ocaña, Gema Santamaría Núñez, Luis Francisco García Fernández, Carlos María Galmarini, María José Guillén Navarro, Pablo Manuel Avilés Marín
  • Antitumoral compounds
    Patent number: 11339180
    Abstract: A compound of general formula I and pharmaceutical compositions, kits, methods of making, and methods for treating cancer using the same.
    Type: Grant
    Filed: April 2, 2021
    Date of Patent: May 24, 2022
    Assignee: PHARMA MAR, S.A.
    Inventors: María del Carmen Cuevas Marchante, Andrés Francesch Solloso, Valentín Martínez Barrasa
  • Antitumoral compounds
    Patent number: 11332480
    Abstract: A compound of general formula I, wherein X, R1-R4 take various meanings, for use in the treatment of cancer.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: May 17, 2022
    Assignee: PHARMA MAR, S.A.
    Inventors: María del Carmen Cuevas Marchante, Andrés Francesch Solloso, Valentín Martínez Barrasa
  • Antibody drug conjugates
    Patent number: 11224663
    Abstract: Drug conjugates of formula [D-(X)b-(AA)w-(L)-]n-Ab wherein: D is a drug moiety having the following formula (I) or a pharmaceutically acceptable salt, ester, solvate, tautomer or stereoisomer thereof, wherein: A is selected from (II) and (III) R1, R2 and R3 is H, ORa, OCORa, OCO—ORa, alkyl, alkenyl, alkynyl, etc.; R3? is, CORa, COORa, CONRaRb, etc; each of R4 to R10 and R12 is alkyl, alkenyl or alkynyl; R11 is H, CORa, COORa, alkyl, alkenyl or alkynyl, or R11 and R12+N+C atoms to which they are attached may form a heterocyclic group; each of R13 and R14 is H, CORa, COORa, alkyl, alkenyl or alkynyl; each Ra and Rb is H, alkyl, alkenyl, alkynyl, etc.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: January 18, 2022
    Assignee: PHARMA MAR, S.A.
    Inventors: Cármen Cuevas Marchante, Juan Manuel Domínguez Correa, Andrés Francesch Solloso, María Garranzo García-Ibarrola, María José Munoz Alonso, Francisco Sánchez Madrid, Juan Manuel Zapata Hernández, Alicia García Arroyo, Maria Ángeles Ursa Pecharromán
  • Antitumoral compounds
    Patent number: 10538535
    Abstract: A compound of general formula I, wherein X, R1-R4 take various meanings, for use in the treatment of cancer.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: January 21, 2020
    Assignee: PHARMA MAR, S.A.
    Inventors: María del Carmen Cuevas Marchante, Andrés Francesch Solloso, Valentín Martínez Barrasa
  • Antitumoral compounds
    Patent number: 10442820
    Abstract: A compound of general formula I, wherein X, R1-R4 take various meanings, for use in the treatment of cancer.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: October 15, 2019
    Assignee: PHARMA MAR, S.A.
    Inventors: María del Carmen Cuevas Marchante, Andrés Francesch Solloso, Valentín Martínez Barrasa
  • Pharmaceutical formulations of ecteinascidin compounds
    Patent number: 10322183
    Abstract: Ecteinascidin formulations, methods of preparing the same, articles of manufacture and kits with such formulations, and methods of treating proliferative diseases with the same formulations are provided.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: June 18, 2019
    Assignee: PHARMA MAR, S.A., SOCIEDAD UNIPERSONAL
    Inventors: Jacob Hendrik Beijnen, Bastiaan Nuijen, Pilar Calvo Salve, Maria Tobio Barreira
  • Antitumoral compounds
    Patent number: 9827257
    Abstract: A compound of general formula (I) wherein A, Y, R1, R2, R3, R4, R5, and R6 take various meaning or use in the treatment of cancer.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: November 28, 2017
    Assignee: PHARMA MAR, S.A.
    Inventors: Alberto Rodriquez Vicente, Maria Garranzo Garcia-Ibarrola, Carmen Murcia Perez, Francisco Sanchez Sancho, Maria del Carmen Cuevas Marchante, Cristina Mateo Urbano, Isabel Digon Juarez
  • Antitumoral compounds
    Patent number: 9750759
    Abstract: A compound of general formula (I) wherein A, Y, R1, R2, R3, R4, R5, and R6 take various meaning or use in the treatment of cancer.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: September 5, 2017
    Assignee: Pharma Mar, S.A.
    Inventors: Alberto Rodriquez Vicente, Maria Garranzo Garcia-Ibarrola, Carmen Murcia Perez, Francisco Sanchez Sancho, Maria del Carmen Cuevas Marchante, Cristina Mateo Urbano, Isabel Digon Juarez
  • Synthetic process for the manufacture of ecteinascidin compounds
    Patent number: 9428524
    Abstract: This invention relates to compounds of formula II: wherein R1, R2, ProtSH, and ProtNH are as defined, to processes for the synthesis of ecteinascidins of formula I from compounds of formula II, and to processes for the synthesis of compounds of formula II.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: August 30, 2016
    Assignee: PHARMA MAR, S.A.
    Inventors: Ma Jesús Martin López, Andrés Francesch Solloso, Maria del Carmen Cuevas Marchante
  • Formulations comprising jorumycin-, renieramycin-, safracin- or saframycin-related compounds for treating proliferative diseases
    Patent number: 9192568
    Abstract: Jorumycin, renieramycin, safracin and saframycin related compounds formulations, methods of preparing the same, articles of manufacture and kits with such formulations, and methods of treating proliferative diseases with the same formulations are provided.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: November 24, 2015
    Assignee: Pharma Mar, S.A.
    Inventors: Pilar Calvo Salve, Maria Tobio Barreira
  • Antitumoral compounds
    Patent number: 9187445
    Abstract: A compound of general formula (I) wherein A, Y, W, R1, R2, R3, R4, R5, and R6 take various meanings for use in the treatment of cancer.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: November 17, 2015
    Assignee: PHARMA MAR, S.A.
    Inventors: Alberto Rodríguez Vicente, María Garranzo García-Ibarrola, Carmen Murcia Pérez, Francisco Sánchez Sancho, María del Carmen Cuevas Marchante, Cristina Mateo Urbano, Isabel Digón Juárez
  • Anticancer steroidal lactones unsaturated in position 7 (8)
    Patent number: 8962602
    Abstract: A compound of general formula (I), wherein R1-R17 and the - - - - - - line take various meanings for use in the treatment of cancer.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: February 24, 2015
    Assignee: Pharma Mar, S.A.
    Inventors: Rogelio Fernández Rodríguez, José Fernando Reyes Benítez, Andrés Francesch Solloso, María del Carmen Cuevas Marchante
  • Pharmaceutical formulations of ecteinascidin compounds
    Patent number: 8895557
    Abstract: Ecteinascidin formulations, methods of preparing the same, articles of manufacture and kits with such formulations, and methods of treating proliferative diseases with the same formulations are provided.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: November 25, 2014
    Assignee: Pharma Mar, S.A., Sociedad Unipersonal
    Inventors: Jacob Hendrik Beijnen, Bastiaan Nuijen, Pilar Calvo Salve, Maria Tobio Barreira
  • Antitumoral compounds
    Patent number: 8748388
    Abstract: Antitumoral compounds of Formula I, and pharmaceutically acceptable salts, derivatives, tautomers, prodrugs or stereoisomers thereof useful as antitumour agents.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: June 10, 2014
    Assignee: Pharma Mar, S.A.
    Inventors: Judit Tulla-Puche, Eleonora Marcucci, Núria Bayó-Puxan, Fernando Albericio, Maria del Carmen Cuevas Marchante
  • Antitumoral compounds
    Patent number: 8710264
    Abstract: A compound of general formula (I) wherein, R11, R12, R13, R14, R15, W, Y, R1, R2, R3, R4, R5, and R6 take various meanings for use in the treatment of cancer.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: April 29, 2014
    Assignee: Pharma Mar, S.A.
    Inventors: Alberto Rodríguez Vicente, Maria Garranzo García-Ibarrola, Carmen Murcia Pérez, Francisco Sánchez Sancho, Maria del Carmen Cuevas Marchante, Cristina Mateo Urbano, Isabel Digón Juárez
  • Combination Therapy with an Antitumor Alkaloid
    Publication number: 20130266666
    Abstract: The present invention relates to the combination of PM01183 with several anticancer drugs, in particular other anticancer drugs selected from antitumor platinum coordination complexes, antimetabolites, mitotic inhibitors, anticancer antibiotics, topoisomerase I and/or II inhibitors, proteasome inhibitors, histone deacetylase inhibitors, nitrogen mustard alkylating agents, nitrosourea alkylating agents, nonclassical alkylating agents, estrogen antagonists, androgen antagonists, mTOR inhibitors, tyrosine kinase inhibitors, and other agents selected from aplidine, ET-743, PM02734 and PM00104, and the use of these combinations in the treatment of cancer.
    Type: Application
    Filed: November 11, 2011
    Publication date: October 10, 2013
    Applicant: PHARMA MAR, S.A.
    Inventors: Victoria Moneo Ocaña, Gema Santamaría Núñez, Luis Francisco García Fernández, Carlos Maria Galmarini, María José Guillén Navarro, Pablo Manuel Avilés Marín
  • Multiple myeloma treatments
    Patent number: 8435992
    Abstract: Methods for treating cancer by using compound PM00104, in particular, for treating multiple myeloma are provided.
    Type: Grant
    Filed: May 18, 2009
    Date of Patent: May 7, 2013
    Assignee: Pharma Mar S.A.
    Inventors: Enrique Ocio, Atanasio Pandiella, Jesús San Miguel, Pablo Manuel Avilés Marín
  • Pharmaceutical formulation of a didemnin compound
    Patent number: 8420130
    Abstract: A stable pharmaceutical composition of a didemnin compound, comprises firstly a lyophilized didemnin preparation including water-soluble material and secondly a reconstitution solution of mixed solvents.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: April 16, 2013
    Assignee: Pharma Mar S.A.
    Inventors: Bastiaan Nuijen, Jacob Hendrik Beijnen, Roland Elizabeth Cornelis Henrar, Andres Gomez, Jose Jimeno