Patents Assigned to Pharma Mar, S.A.
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Patent number: 7576188Abstract: Aplidine and aplidine analogues are of use for the treatment of cancer, in particular in the treatment of leukemias and lymphomas, especially in combination therapies.Type: GrantFiled: March 12, 2004Date of Patent: August 18, 2009Assignee: Pharma Mar, S.A.U.Inventors: Joseph R. Bertino, Debabrata Barnejee, Saydam Guray, José Jimeno, Glynn Thomas Faircloth
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Publication number: 20090197901Abstract: Variolin derivatives of formula (5) are provided, wherein the substituent groups defined by X2, R1, R2, R3, R6, R7, and R12 are each independently selected from the group consisting of H, OH, OR?, SH, SR?, SOR?, SO2R?, NO2, NH2, NHR?, N(R?)2, NHCOR?, NHSO2R?, CN, halogen, ?O, C(?O)H, C(?O)R?, CO2H, CO2R?, carboxyalkyl, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; wherein each of the R? groups is independently selected from the group consisting of H, OH, SH, NO2, NH2, CN, halogen, ?O, C(?O)H, C(?O)CH3, CO2H, CO2CH3, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, aryl, aralkyl and heteroaromatic; wherein the pairs of groups of R1 and R2, R2 and R3, R3 and R12, R12 and R6, or R6 and R7 may be joined into a carbocyclic or heterocyclic ring system.Type: ApplicationFiled: January 7, 2009Publication date: August 6, 2009Applicant: PHARMA MAR, S.A.Inventors: Modesto Remuinan, Juan Jose Gonzalez, Carlos del Pozo, Andres Francesh, Carmen Cuevas, Simon Munt, Ignacio Manzanares, Regan James Anderson, Jonathan Charles Morris
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Publication number: 20090186938Abstract: Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.Type: ApplicationFiled: June 15, 2007Publication date: July 23, 2009Applicant: PHARMA MAR, S.A.Inventors: Ma Jesus Martin Lopez, Laura Coello Molinero, Jose Fernando Reyes Benitez, Alberto Rodriguez Vicente, Maria Garranzo Garcia-Ibarrola, Carmen Murcia Perez, Andres Francesch Solloso, Francisco Sanchez Sancho, Maria del Carmen Cuevas Marchante, Rogelio Fernandez Rodriguez
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Publication number: 20090170860Abstract: A method for improving the cytotoxic effect of Ecteinascidin-743 (ET-743) or an analog thereof on a tumor cell population in a patient the method including administering to the patient, sequentially or simultaneously, a therapeutically effective combination of a composition including ET-743 and an amount of a composition including a PARP-1 inhibitor effective to increase the cytotoxic effect of ET-743 on the tumor cell population. Anti-tumor compositions containing a therapeutically effective amount of ET-743 and an amount of a PARP-1 inhibitor effective to increase the tumor cytotoxicity of the ET-743 are also presented.Type: ApplicationFiled: November 27, 2006Publication date: July 2, 2009Applicant: PHARMA MAR, S.A., SOCIEDAD UNIPERSONALInventors: Kathleen Scotto, Michael Mandola
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Publication number: 20090163507Abstract: Ecteinascidin compounds with a quinone ring for ring E are active as anti-cancer agents. Related processes and compounds are provided.Type: ApplicationFiled: November 19, 2008Publication date: June 25, 2009Applicant: PHARMA MAR, S.A.Inventors: Valentin Martinez Barrasa, Pilar Gallego, Carmen Cuevas, Simon Munt, Ignacio Manzanares, Roberto Menchaca, Natividad Rodriguez, Alberto Rodriguez
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Publication number: 20090130675Abstract: The invention relates to genes involved in the biosynthesis of thiocoraline and to the heterologous production of same. According to the invention, the cluster of genes responsible for the biosynthesis of thiocoraline was identified and cloned. Said cluster of genes can be used in the heterologous production of thiocoraline which has an antitumor and antibacterial activity.Type: ApplicationFiled: August 1, 2006Publication date: May 21, 2009Applicant: PHARMA MAR, S.A.Inventors: Angelina Ramos Castro, Alfredo Fernandez Brana, Felipe Lombo Brugos, Carmen Mendez Fernandez, Jose Antonio Salas Fernandez, Ana Velasco Iglesias, Carmen Schleissner Sanchez
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Publication number: 20090124647Abstract: Antitumoural compounds of general formula (I); wherein Ar is an heterocyclic group of formula (a) and R1, R2, R3, R4, R5, R6, R7, n and the dotted line take permitted meanings can be obtained from a tunicate of the family Polyclinidae, genus Aplidium, species cyaneum, and the invention further provides derivatives thereof.Type: ApplicationFiled: November 13, 2006Publication date: May 14, 2009Applicant: PHARMA MAR, S.A.Inventors: Jose Fernando Reyes Benitez, Andres Francesch Solloso, Carmen Cuevas Marchante, Marta Altuna Urquijo, Daniel Pla Queral, Mercedes Alvarez Domingo, Fernando Albericio Palomera
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Patent number: 7531506Abstract: Trunkamide A and other cycloheptapeptides can be made by solid phase synthesis of a linear precursor.Type: GrantFiled: April 2, 2002Date of Patent: May 12, 2009Assignee: Pharma Mar, S.A.Inventors: Fernando Albericio Palomera, Josep Maria Caba Naudi, Ernest Giralt Lledó, Ignacio Manzanares, Ignacio Rodriquez
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Publication number: 20090117176Abstract: A method of treating the human body for cancer comprises administering an effective therapeutic amount of a Pegylated Liposomal form of the anthracycline Doxorubicin (“PLD”), in combination with an effective therapeutic amount of ET-743Type: ApplicationFiled: October 26, 2005Publication date: May 7, 2009Applicant: Pharma Mar, S.A. Sociedad UnipersonalInventors: Erard Gilles, Lars-Axel Sternas, Ovid Trifan, Helgi van de Velde, April Teitelbaum
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Patent number: 7524956Abstract: Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically; R1 is an amidomethylene group or an acyloxymethylene group; R5 and R8 are independently chosen from —H, —OH or —OCOCH2OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring; R14a and R14b are both —H ozone is —H and the other is —OH, —OCH3 or —OCH2CH3, or R14a and R14b together form a keto group; and R15 and R18 are independently chosen from —H or —OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring. In modified starting materials, the 21-cyano group can be replaced by other groups introduced using nucleophilic reagents.Type: GrantFiled: July 9, 2007Date of Patent: April 28, 2009Assignee: Pharma Mar, S.A.Inventors: Carmen Cuevas, Marta Perez, Andres Francesch, Carolina Fernandez, Jose Luis Chicharro, Pilar Gallego, Maria Zarzuelo, Fernando de Calle, Ignacio Manzanares
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Patent number: 7521478Abstract: Compounds of the general formula (I) or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each independently selected from the group consisting of H, SiR?3, SOR?, SO2X, C(?O)R?, C(?O)OR?, C(?O)NR?, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aryl, heteroaryl or aralkyl; the group R? is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aminoalkyl, aryl, aralkyl and heterocyclic groups; and the group R? is selected from the group consisting of H, OH, OR?, OCOR?, SH, SR?, SOR?, SO2R?, NO2, NH2, NHR?, N(R?)2, NHCOR?, N(COR?)2, NHSO2R?, CN, halogen, C(?O)H, C(?O)R?, CO2H, CO2R?, CH2OR, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkylidene, substituted or unsubstituted alkynyl, substitType: GrantFiled: July 30, 2003Date of Patent: April 21, 2009Assignee: Pharma Mar, S.A.U.Inventors: Carlos del Pozo Losada, Andres Francesch, Carmen Cuevas Marchante, Marta Perez Alvarez
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Patent number: 7507766Abstract: Carnitine and other muscle protectors are useful to prevent side effects of aplidine and aplidine analogues.Type: GrantFiled: October 12, 2001Date of Patent: March 24, 2009Assignee: Pharma Mar, S.A.Inventors: Luis Lopez Lazaro, Jose Maria Fernandez-Sousa, Jean-Pierre Armand, Eric Raymond
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Patent number: 7507708Abstract: The present invention is directed to new kahalalide antitumoral compounds, in particular to analogues of kahalalide F, useful as antitumoral, antiviral, antifungal agents and in the treatment of psoriasis.Type: GrantFiled: October 20, 2003Date of Patent: March 24, 2009Assignee: Pharma Mar, S.A.U.Inventors: Glynn Thomas Faircloth, Maria del Carmen Cuevas Marchante
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Publication number: 20090076016Abstract: Jorumycin, renieramycin, safracin and saframycin related compounds formulations, methods of preparing the same, articles of manufacture and kits with such formulations, and methods of treating proliferative diseases with the same formulations are provided.Type: ApplicationFiled: October 30, 2006Publication date: March 19, 2009Applicant: PHARMA MAR, S.A.Inventors: Pilar Calvo Salve, Maria Tobio Barreira
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Patent number: 7495000Abstract: Variolin derivatives of formula (5) are provided, wherein the substituent groups defined by X2, R1, R2, R3, R6, R7 and R12 are each independently selected from the group consisting of H, OH, OR?, SH, SR?, SOR?, SO2R?, NO2, NH2, NHR?, N(R?)2, NHCOR?, NHSO2R?, CN, halogen, ?O, C(?O)H, C(?O)R?, CO2H, CO2R?, carboxyalkyl, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; wherein each of the R? groups is independently selected from the group consisting of H, OH, SH, NO2, NH2, CN, halogen, ?O, C(?O)H, C(?O)CH3, CO2H, CO2CH3, C1-C12 alkyl, C2-C12 alkenyl, C2-C12alkynyl, aryl, aralkyl and heteroaromatic; wherein the pairs of groups R1 and R2, R2 and R3, R3 and R12, R12 and R6, or R6 and R7 may be joined into a carbocyclic or heterocyclic ring system.Type: GrantFiled: July 11, 2002Date of Patent: February 24, 2009Assignee: Pharma Mar, S.A.Inventors: Modesto Remuiñan, Juan Jose Gonzalez, Carlos Del Pozo, Carmen Cuevas, Simon Munt, Regan James Anderson, Andres Francesh, Jonathan Charles Morris, Ignacio Manzanares
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Publication number: 20090030068Abstract: The invention relates to novel antitumor compounds of general formula as well as their corresponding pharmaceutically acceptable salts, derivatives, prodrugs and stereoisomers. These compounds can be obtained by isolating a sponge from family Theonellidae, genus Theonella and species swinhoei, and forming derivatives from the isolated compounds. These compounds have cytotoxic activity and can be used for the treatment of the cancer.Type: ApplicationFiled: December 14, 2006Publication date: January 29, 2009Applicant: PHARMA MAR, S.A.Inventors: Ma Jesus Martin Lopez, Jose Fernando Reyes Benitez, Rogelio Fernandez Rodriguez, Andres Francesch Solloso, Maria del Carmen Cuevas Marchante, Laura Coello Molinero
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Patent number: 7482429Abstract: A process is provided for preparing kahalalide F and which leads to other kahalalide mimic compounds having useful biological activity.Type: GrantFiled: February 9, 2001Date of Patent: January 27, 2009Assignee: Pharma Mar, S.A.Inventors: Fernando Albericio, Ernest Giralt, Jose Carlos Jimenez, Angel Lopez, Ignacio Manzanares, Ignacio Rodrigues, Miriam Royo
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Patent number: 7473681Abstract: Formulations and uses of kahalalide F.Type: GrantFiled: October 31, 2001Date of Patent: January 6, 2009Assignee: Pharma Mar, S.A.Inventors: Glynn Thomas Faircloth, Bastiaan Nuijen, Steve Weitman
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Publication number: 20080318848Abstract: The present invention is directed to new kahalalide antitumoral compounds, in particular to analogs of kahalalide F, useful as antitumoral, antiviral, and antifungal agents.Type: ApplicationFiled: January 25, 2008Publication date: December 25, 2008Applicant: Pharma Mar S.A.U.Inventors: Glynn Faircloth, Maria del Carmen Cuevas Marchante
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Publication number: 20080318849Abstract: A process is provided for preparing kahalalide F and which leads to other kahalalide mimic compounds having useful biological activity.Type: ApplicationFiled: August 25, 2008Publication date: December 25, 2008Applicant: PHARMA MAR, S.A.Inventors: Fernando Albericio, Ernest Giralt, Jose Carlos Jimenez, Angel Lopez, Ignacio Manzanares, Ignacio Rodrigues, Miriam Royo