Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to CXCR5. The antibodies can be afucosylated and exhibit increased ADCC compared with the otherwise identical fucosylated antibodies. The invention includes uses, and associated methods of using the antibodies.
Type:
Grant
Filed:
November 20, 2020
Date of Patent:
April 16, 2024
Assignees:
Pfizer Inc., The Regents of the University of California
Inventors:
Rachel Groth, William Brian Snyder, Xianjun Cao, Robert Joseph Dunn, Joseph Dal Porto, Michael Karin
Abstract: Provided herein are devices comprising one or more cells, and methods for fabrication thereof. The devices may be electrochemical devices. The devices may include three-dimensional supercapacitors. The devices may be microdevices such as, for example, microsupercapacitors. In some embodiments, the devices are three-dimensional hybrid microsupercapacitors. The devices may be configured for high voltage applications. In some embodiments, the devices are high voltage microsupercapacitors. In certain embodiments, the devices are high voltage asymmetric microsupercapacitors. In some embodiments, the devices are integrated microsupercapacitors for high voltage applications.
Type:
Grant
Filed:
May 27, 2021
Date of Patent:
April 16, 2024
Assignees:
The Regents of the University of California, Nanotech Energy, Inc.
Inventors:
Maher F. El-Kady, Richard B. Kaner, Jack Kavanaugh
Abstract: Provided are methods of treating various forms of hearing loss caused by aberrant calcium fluxes in auditory cells. The methods encompass the administration of agents which prevent abnormal calcium fluxes, stabilize SERCA2b activity, or prevent ER UPR apoptotic responses. The methods include therapeutic treatments of subjects suffering from hearing loss as well as preventative treatments which protect auditory cells from cell death, for example as caused by exposure to loud noise.
Type:
Grant
Filed:
October 22, 2016
Date of Patent:
April 16, 2024
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: Aspects of the subject disclosure may include, for example, training a cell-level machine learning model to predict a likelihood of a cell site in a cellular network having service issues that impact customers of the cellular network, training a user equipment (UE) level machine learning model using output information from the cell-level machine learning model and historical information about UE-level performance metrics, receiving, from a customer associated with a UE device operating on the cellular network, information about a service degradation experienced by the customer on the UE device, providing the information about the service degradation to the UE-level machine learning model; and receiving, from the UE-level machine learning model, information identifying a source of the service degradation. Other embodiments are disclosed.
Type:
Application
Filed:
September 30, 2022
Publication date:
April 11, 2024
Applicants:
AT&T Intellectual Property I, L.P., The Regents of the University of California
Inventors:
Jia Wang, Amit Kumar Sheoran, Xiaofeng Shi, Chen Qian, Matthew Osinski
Abstract: Aspects of the subject disclosure may include, for example, categorizing users of a cellular network according to a plurality of user categories, identifying, by a machine learning model, a service degradation in the cellular network, identifying at least one affected user, the at least one affected user being affected by the service degradation, identifying one or more affected user categories including the at least one affected user, identifying potentially affected users, the potentially affected users being categorized according to the one or more affected user categories, and taking action to isolate the potentially affected users from the service degradation. Other embodiments are disclosed.
Type:
Application
Filed:
September 30, 2022
Publication date:
April 11, 2024
Applicants:
AT&T Intellectual Property I, L.P., The Regents of the University of California
Inventors:
Jia Wang, Xiaofeng Shi, Amit Kumar Sheoran, Matthew Osinski, Chen Qian
Abstract: A metalens and a metalens array having a bounded angular field of view are disclosed. The metalens includes a substrate and a two-dimensional (2D) grid over the substrate to divide the substrate into a 2D array of meta-units. Each meta-unit in the 2D array includes a nanostructure and a portion of the substrate that supports the nanostructure. Moreover, each meta-unit is configured with an angular-dependent transmission or reflection coefficient that decreases with an increasing incident angle of an illumination. Moreover, the metalens passes an incident light having an incident angle less than a cutoff angle and rejects an incident light having an incident angle greater than the cutoff angle. The metalens can be used a base unit for constructing a metalens array by tiling copies of the metalens into a 2D array of the metalens to achieve a significantly larger field-of-view.
Type:
Application
Filed:
February 11, 2022
Publication date:
April 11, 2024
Applicant:
The Regents of the University of California
Abstract: Methods for treating diabetes are described. The methods include administration of a serotonin receptor 1F (HTR1F) antagonist, such as a substituted piperidine, methysergide, or methiothepin, to a subject in need thereof. Administration of the HTR1F antagonist can increase survival of pancreatic beta cells in conjunction with pancreatic islet transplantation. Methods for transplanting pancreatic islets to subjects such as diabetes patients are also described.
Type:
Application
Filed:
January 11, 2022
Publication date:
April 11, 2024
Applicant:
The Regents of the University of California
Abstract: The present disclosure relates generally to methods for preparing a tissue sample for detection of the expression of a transmembrane protein in the tissue sample. The present disclosure also provides antibodies and treatments targeting tumor samples expressing the PLXDC1 or the PLXDC2 proteins.
Type:
Application
Filed:
October 16, 2020
Publication date:
April 11, 2024
Applicant:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: Systems and method for wireless recording system-on-chips for distributed neural interface systems with inductive power delivery and UWB data transmission are described. In an embodiment, the system includes an implantable neural interface including: an electrode array having several electrodes; front end circuitry including: one or more digital components, and at least one amplifier coupled to a first electrode and a second electrode of the electrode array, wherein the amplifier and the first electrode and the second electrode form a sensing channel configured to sense electrical activity; and a transceiver including: several digital components; a power harvesting system that receives RF energy through a wireless power link; and a wireless clock receiver that provides a clock signal to the one or more digital components of the front end circuitry and the several digital components of the transceiver.
Type:
Application
Filed:
December 20, 2021
Publication date:
April 11, 2024
Applicant:
The Regents of the University of California
Abstract: The present disclosure provides compounds and compositions capable of treating cancer or an autoimmune disease, such as Crohn's disease, and methods of use thereof.
Type:
Grant
Filed:
July 22, 2019
Date of Patent:
April 9, 2024
Assignee:
The Regents of the University of California
Inventors:
Dimitrios Iliopoulos, Michael E. Jung, Jonghoon Kim, Jill M. Hoffman, Iordanes Karagiannides
Abstract: Trehalose-based nanogels for stabilizing and controlled releasing biomolecules such as glucagons are disclosed. Specifically, trehalose-based nanogels comprise (a) a copolymer comprising first methacrylate units and second methacrylate units, wherein (i) the first methacrylate units comprise trehalose side chains; and (ii) the second methacrylate units comprise disulfide side chains; (b) dithiol cross-linkers; wherein the dithiol cross-linkers cross link the copolymer through the disulfide side chains of the second methacrylate units.
Type:
Grant
Filed:
November 30, 2018
Date of Patent:
April 9, 2024
Assignee:
The Regents of the University of California
Abstract: A computer vision pipeline is provided for fully automated interpretation of cardiac function, using a combination of machine learning strategies to enable building a scalable analysis pipeline for echocardiogram interpretation. Videos from patients with heart failure can be analyzed and processed as follows: 1) preprocessing of echo studies; 2) convolutional neural networks (CNN) processing for view identification; 3) segmentation of chambers and delineation of cardiac boundaries using CNNs; 4); particle tracking to compute longitudinal strain; and 5) targeted disease detection.
Type:
Grant
Filed:
March 14, 2019
Date of Patent:
April 9, 2024
Assignee:
The Regents of the University of California
Abstract: A thermoresponsive suspension composition for use in additive manufacturing includes an aqueous suspension of a thermosetting resin, a crosslinking agent configured to react with the thermosetting resin, and a mineral particulate, wherein the thermosetting resin and crosslinking agent react at or above a trigger temperature.
Type:
Grant
Filed:
November 18, 2021
Date of Patent:
April 9, 2024
Assignees:
The Regents of the University of California, Technical University of Munich, Master Builders Solutions Admixtures US, LLC
Inventors:
Gaurav Sant, Sharu Bhagavathi Kandy, Torben Gädt, Iman Mehdipour, Thiyagarajan Ranganathan, Samanvaya Srivastava, Paul Seiler
Abstract: Systems, device configurations, and processes are provided for navigation and determination of navigation observables based on low Earth orbit (LEO) satellite signals. A method for navigation includes using differential carrier phase measurement of LEO signals including correction of position estimates using integer ambiguity resolution and double difference carrier phase determinations. Frameworks described herein can use a computationally efficient integer ambiguity resolution to reduce the size of the integer least squares (ILS) determination. The framework may include a joint probability density function (pdf) of the megaconstellation LEO satellites' azimuth and elevation angle to characterize a LEO system. Embodiments are also directed to correction of ambiguities of carrier phase differential (CD)-low Earth orbit (LEO) (CD-LEO) measurements that may utilize a base and a rover without requiring prior knowledge of rover position.
Type:
Grant
Filed:
July 2, 2021
Date of Patent:
April 9, 2024
Assignee:
The Regents of the University of
California
Inventors:
Zak Kassas, Joe Khalife, Mohammad Neinavaie
Abstract: The disclosure provides for pathogenic biomarkers and serum extracellular vesicular biomarkers that are associated with vascular anomalies and malformation of endothelial cells, and uses thereof, including for diagnosis, prognosis and therapy.
Type:
Grant
Filed:
June 3, 2019
Date of Patent:
April 9, 2024
Assignee:
The Regents of the University of California
Inventors:
Wenbin Tan, John Stuart Nelson, Dongbao Chen
Abstract: Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.
Type:
Grant
Filed:
December 12, 2018
Date of Patent:
April 9, 2024
Assignees:
The Regents of the University of California, The United States Government as Represented by the Department of Veterans Affairs
Inventors:
Casey Ward, Qizhi Tang, Peter Stock, Gaetano Faleo, Gopika Nair, Matthias Hebrok, Wenhan Chang, Thuy Vo, Jeffrey A. Bluestone, Eleonora De Klerk
Abstract: Provided herein are klotho polypeptide compositions and methods for improving cognitive function in an individual comprising treatment of with klotho polypeptides.
Type:
Application
Filed:
June 28, 2023
Publication date:
April 4, 2024
Applicant:
The Regents of the University of California
Abstract: A membrane desalination system includes a housing, an electrically conductive membrane disposed within the housing, wherein the electrically conductive membrane includes a porous support and an electrically conductive layer disposed on the porous support, and the electrically conductive layer includes nanostructures, and an alternating current power source connected to the electrically conductive membrane.
Type:
Application
Filed:
December 1, 2021
Publication date:
April 4, 2024
Applicant:
The Regents of the University of California
Inventors:
David Jassby, Unnati Rao, Eric Hoek, Bongyeon Jung
Abstract: Aspects of the subject disclosure may include, for example, receiving, from a machine learning model, information about an event causing a service degradation in a cellular network, wherein the event is external to the cellular network, determining one or more event categories associated with the event causing the service degradation, determining, based on the one or more event categories, likely affected customers, the likely affected customers being likely to experience the service degradation, determining, by the machine learning model, proper resources for resolution of the service degradation, wherein the determining proper resources is based on the one or more event categories, and dispatching the proper resources for resolution of the service degradation. Other embodiments are disclosed.
Type:
Application
Filed:
September 30, 2022
Publication date:
April 4, 2024
Applicants:
AT&T Intellectual Property I, L.P., The Regents of the University of California
Inventors:
Jia Wang, Amit Kumar Sheoran, Xiaofeng Shi, Matthew Osinski, Chen Qian
Abstract: A new prune cultivar designated ‘UC G2S-8’ has been developed. The fruit of this cultivar are medium, yellow in color and covered with a grayish waxy bloom. The ‘UC G2S-8’ tree is productive and a regular bearer.
Type:
Grant
Filed:
April 12, 2023
Date of Patent:
April 9, 2024
Assignee:
The Regents of the University of California
Inventors:
Theodore M. DeJong, Sarah Castro, James F. Doyle, Carolyn DeBuse