Abstract: A thermoset precursor composition includes a backbone comprising an imine bond bonding at least one of: 1) aromatic compounds together, or 2) bonding an aromatic compound to an aliphatic chain, and at least one of: an epoxy group terminating the backbone or an aldehyde group terminating the backbone. The thermoset precursor can have at least two epoxy groups, one epoxy group and one aldehyde group, or two aldehyde groups.
Type:
Application
Filed:
December 7, 2023
Publication date:
March 28, 2024
Applicant:
The Regents of the University of California
Abstract: Aspects of the disclosure relate to antibodies and methods of use. Various antibodies are disclosed, including engineered antibodies targeting CD138, CD38, and TfR1. Certain aspects are directed to IgE antibodies and use in diagnosis and/or treatment of cancer. Also disclosed are kits and pharmaceutical compositions comprising one or more engineered antibodies.
Type:
Application
Filed:
September 1, 2021
Publication date:
March 28, 2024
Applicant:
The Regents of the University of California
Inventors:
Manuel L. PENICHET, Pierre V. CANDELARIA, Miguel NAVA, Tracy R. WELLS
Abstract: A composition of matter useful as a bioadhesive including a bistable adhesive polymer. The bistable adhesive polymer includes one or more polymer backbones; side-chains attached to each of the polymer backbones; and one or more transition temperatures between a crystalline state and an amorphous state. The one or more transition temperatures are such that the polymer transitions from the crystalline state to the amorphous state upon physical contact with biological tissue having a temperature higher than the transition temperature. The polymer adheres or attaches to the biological tissue in the amorphous state and can be peeled from the biological tissue when cooled below the transition temperature to the crystalline state.
Type:
Application
Filed:
January 31, 2022
Publication date:
March 28, 2024
Applicant:
The Regents of the University of California
Abstract: The present disclosure relates generally to ex vivo primary tumor models prepared from fresh tumor tissues which are useful for screening anti-cancer agents. The fresh tumor tissues are prepared and cultured under suitable conditions to grow an outgrowth of endothelial cells Killing of these endothelial cells by a candidate agent indicates the efficacy of the agent in inhibiting tumor angiogenesis.
Type:
Application
Filed:
October 16, 2020
Publication date:
March 28, 2024
Applicant:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: The present invention provides a method of treating frontotemporal dementia, or a childhood genetic neurodegenerative disease such as Ataxia Telangiectasia (A-T), or neurodegenerative diseases such as Parkinson's disease or neuropsychiatric diseases comprising administering to a subject in need thereof an effective amount of chlorite composition, such as sodium chlorite. The present invention thereby provides a method of modulating the immune system in a subject in need thereof. Described herein are methods of administration and treatment.
Type:
Grant
Filed:
January 10, 2023
Date of Patent:
March 26, 2024
Assignees:
NEUVIVO, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: The present invention provides a method of treating frontotemporal dementia, or a childhood genetic neurodegenerative disease such as Ataxia Telangiectasia (A-T), or neurodegenerative diseases such as Parkinson's disease or neuropsychiatric diseases comprising administering to a subject in need thereof an effective amount of chlorite composition, such as sodium chlorite. The present invention thereby provides a method of modulating the immune system in a subject in need thereof. Described herein are methods of administration and treatment.
Type:
Grant
Filed:
August 30, 2022
Date of Patent:
March 26, 2024
Assignees:
NEUVIVO, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: Disclosed are methods and devices for biomolecular detection, comprising a nanopipette, exemplified as a hollow inert, non-biological structure with a conical tip opening of nanoscale dimensions, suitable for holding an electrolyte solution which may contain an analyte such as a protein biomolecule to be detected as it is passed through the tip opening. Biomolecules are detected by specific reaction with peptide ligands chemically immobilized in the vicinity of the tip. Analytes which bind to the ligands cause a detectible change in ionic current. A sensitive detection circuit, using a feedback amplifier circuit, and alternating voltages is further disclosed. Detection of IL-10 at a concentration of 4 ng/ml is also disclosed, as is detection of VEGF.
Type:
Grant
Filed:
January 18, 2022
Date of Patent:
March 26, 2024
Assignee:
The Regents of the University of California
Inventors:
Miloslav Karhanek, Chris David Webb, Senkei Umehara, Nader Pourmand
Abstract: A neck supporting exoskeleton is configured to be worn by a person to support the person's head during backward extension motions of the person's neck. The neck supporting exoskeleton may comprise a torso frame configured to be coupled to the person's torso, a head pillow configured to contact the rear portion of the person's head during backward extension motions of the person's neck, a linkage allowing for relative motion between the head pillow and the torso frame in the sagittal plane of the person, and an actuator configured to impose a supporting force onto the head pillow. When the person's neck extension angle increases beyond an engagement angle, the actuator causes the linkage to impose a supporting force onto the head pillow resisting the backward extension motion of the head pillow and the person's head relative to the torso frame thereby providing a support for the person's head.
Type:
Grant
Filed:
October 18, 2019
Date of Patent:
March 26, 2024
Assignees:
The Regents of the University of California, suitX, Inc.
Inventors:
Logan Van Engelhoven, Homayoon Kazerooni, James Ren, Wayne Yi-Wei Tung, Valantyn Koziak
Abstract: A selective oxide-forming alloy, a coating formed from, and a machine component including the coating are provided. The selective oxide-forming alloy includes between atomic percent and 26 atomic percent silicon (Si), between 21 atomic percent and 27 atomic percent titanium (Ti), between 30 atomic percent and 39 atomic percent aluminum (Al), between 2 atomic percent and 10 atomic percent hafnium (Hf), and a balance of niobium (Nb).
Type:
Grant
Filed:
March 15, 2023
Date of Patent:
March 26, 2024
Assignees:
General Electric Company, The Regents of the University of California
Inventors:
Collin Scott Holgate, Tresa Marie Pollock, Carlos Gerardo Levi, Akane Suzuki
Abstract: The present invention provides a method of treating frontotemporal dementia, or a childhood genetic neurodegenerative disease such as Ataxia Telangiectasia (A-T), or neurodegenerative diseases such as Parkinson's disease or neuropsychiatric diseases comprising administering to a subject in need thereof an effective amount of chlorite composition, such as sodium chlorite. The present invention thereby provides a method of modulating the immune system in a subject in need thereof. Described herein are methods of administration and treatment.
Type:
Grant
Filed:
January 10, 2023
Date of Patent:
March 26, 2024
Assignees:
NEUVIVO, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: A method for analysis of complex spatio-temporal data within a dynamic system that includes spatial positions and fields, at least a portion of which are interacting, includes determining values of mean field at every spatial position, determining spatio-temporal eigenmodes in spatial-frequency space assuming interacting fields, and determining spatial and temporal interactions between the eigenmodes. The resulting display indicates space/time localization patterns that are indicative of connectivity within the dynamic system.
Type:
Grant
Filed:
January 31, 2021
Date of Patent:
March 26, 2024
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: The present invention provides for a fusion protein comprising: (a) a terpene synthase (TS), or a homolog thereof, (b) a peptide linker, and (c) a P450 enzyme, or a homolog thereof.
Type:
Grant
Filed:
March 19, 2021
Date of Patent:
March 26, 2024
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Abstract: A unibody transtibial prosthetic device includes a socket personalized for a specific patient's residual limb. A pylon extends from the socket, the pylon being a unitary polymer structure of interconnected elongated supports having open spaces therebetween. The device also includes a foot-ankle complex, the foot-ankle complex being a unitary polymer extending from the pylon, the foot and ankle unitary structure being shaped to provide multi-axial dynamic flex to enable dorsiflexion, plantar flexion, inversion and eversion motion for smooth symmetric gait performance and energy capture and return. The socket, pylon and foot-ankle complex are portions of a unibody.
Type:
Grant
Filed:
January 11, 2022
Date of Patent:
March 26, 2024
Assignee:
The Regents of the University of California
Inventors:
Joshua Pelz, Luca De Vivo, Falko Kuester, Herbert J. Barrack
Abstract: There is disclosed squaraine compounds of formula I: wherein each of Y1 and Y2 is independently chosen from an optionally substituted amino group and an optionally substituted aryl group. Also described are organic optoelectronic devices comprising a Donor-Acceptor heterojunction that is formed from one or more of the squaraine compounds. A method of making the disclosed device, which may include one or more sublimation step for depositing said squaraine compound, is also disclosed.
Type:
Grant
Filed:
June 24, 2019
Date of Patent:
March 26, 2024
Assignees:
The Regents of the University of Michigan, University of Southern California
Inventors:
Mark E. Thompson, Stephen R. Forrest, Guodan Wei, Siyi Wang, Lincoln Hall, Viacheslav V. Diev, Xin Xiao
Abstract: A nanostructured cross-wire memory architecture is provided that can interface with conventional semiconductor technologies and be electrically accessed and read. The architecture links lower and upper sets of generally parallel nanowires oriented crosswise, with a memory element that has a characteristic conductance. Each nanowire end is attached to an electrode. Conductance of the linkages in the gap between the wires encodes the information. The nanowires may be highly-conductive, self-assembled, nucleic acid-based nanowires enhanced with dopants including metal ions, carbon, metal nanoparticles and intercalators. Conductance of the memory elements can be controlled by sequence, length, conformation, doping, and number of pathways between nanowires. A diode can also be connected in series with each of the memory elements. Linkers may also be redox or electroactive switching molecules or nanoparticles where the charge state changes the resistance of the memory element.
Type:
Grant
Filed:
July 11, 2019
Date of Patent:
March 26, 2024
Assignees:
The Regents of the University of California, University of Washington, Emory University
Inventors:
Joshua Hihath, Manjeri P. Anantram, Yonggang Ke
Abstract: Chemically induced dimerizers (AbCIDs) have emerged as one of the most powerful tools to artificially regulate signaling pathways in cells; however, no facile method to identify or design these systems currently exists. The present invention provides a methodology to rapidly generate antibody-based chemically induced dimerizers (AbCIDs) from known small-molecule-protein complexes by selecting for synthetic antibodies that recognize the chemical epitope created by the bound small molecule. Success of this strategy is demonstrated by generating ten chemically-inducible antibodies against the BCL-xL/ABT-737 complex. Three of the antibodies are highly selective for the BCL-xL/ABT-737 complex over BCL-xL alone. Two exemplary important cellular applications of AbCIDs are demonstrated by applying them intracellularly to induce CRISPRa-mediated gene expression and extracellularly to regulate CAR T-cell activation with the small molecule, ABT-737.
Type:
Grant
Filed:
May 21, 2018
Date of Patent:
March 26, 2024
Assignee:
The Regents of the University of California
Inventors:
James A Wells, Zachary B. Hill, Alexander J. Martinko
Abstract: Alternating magnetic field (AMF) systems and devices and methods for producing nanobubbles said methods and devices. The AMF systems and devices of the present invention may feature sets of magnets configured to expose a flowing liquid to an alternating magnetic field. The alternating magnetic field destabilizes dissolved gas molecules to produce nanobubbles. The methods, systems, and devices of the present invention may be used to treat solution, for reducing fouling or corrosion in a tube system or pipe system, methods for increasing water porosity of soil, methods for treating thromboembolic disease, etc.
Type:
Grant
Filed:
February 11, 2021
Date of Patent:
March 26, 2024
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors:
James C. Earthman, Chuck Wagner, Ruqian Wu