Patents Assigned to Ribozyme Pharmaceuticals, Inc.
  • Synthesis, deprotection, analysis & purification of RNA & ribozymes
    Publication number: 20030088087
    Abstract: Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
    Type: Application
    Filed: August 30, 2002
    Publication date: May 8, 2003
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, David Sweedler, Leonid Beigelman, Lech W. Dudycz, Susan Grimm, Anthony DiRenzo, Danuta Tracz
  • Non-nucleotide containing enzymatic nucleic acid
    Patent number: 6555668
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: April 29, 2003
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • Novel compositions for the delivery of negatively charged molecules
    Publication number: 20030073640
    Abstract: This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAs, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.
    Type: Application
    Filed: December 21, 2001
    Publication date: April 17, 2003
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Leonid Beigelman, Jasenka Matulic-Adamic, Alexander Karpeisky, Peter Haeberli, David Sweedler, Mark Reynolds, Nilabh Chaudhary, John Min
  • Method for screening nucleic acid catalysts
    Patent number: 6548657
    Abstract: Nucleic acid catalysts, method of screening for variants of nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences are described.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: April 15, 2003
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Alex Burgin, Leonid Beigelman, Laurent Bellon
  • Method and reagent for treatment of diseases by expression of the c-Myc gene
    Patent number: 6544755
    Abstract: An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of Burkitt's lymphoma or acute lymphocytic leukemia.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: April 8, 2003
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: James D. Thompson, Kenneth G. Draper
  • Base-modified enzymatic nucleic acid
    Patent number: 6528639
    Abstract: Method to produce a more active ribozyme by introducing a modified base into a substrate binding arm of the ribozyme or its catalytic core.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: March 4, 2003
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Leonid Beigelman, James McSwiggen, Alex Karpeisky
  • Nucleoside triphosphates and their incorporation into oligonucleotides
    Patent number: 6509460
    Abstract: Novel nucleoside triphosphates, methods of synthesis and process of incorporating these nucleoside triphosphates into oligonucleotides are disclosed.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: January 21, 2003
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Leonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler
  • Compositions and method for modulation of gene expression in plants
    Publication number: 20030014775
    Abstract: An enzymatic nucleic acid molecule with RNA cleaving activity, wherein said nucleic acid molecule modulates the expression of an gene in a plant. A transgenic plant comprising nucleic acids encoding for an enzymatic nucleic acid molecule with RNA cleaving activity, wherein said nucleic acid molecule modulates the expression of a gene in said plant.
    Type: Application
    Filed: September 21, 2001
    Publication date: January 16, 2003
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Michael G. Zwick, Brent V. Edington, James A. McSwiggen, Patricia Ann Owens Merlo, Lining Guo, Thomas A. Skokut, Scott A. Young, Otto Folkerts, Donald J. Merlo
  • 2?-O-amino-containing nucleoside analogs and polynucleotides
    Patent number: 6506888
    Abstract: Novel nucleoside or nucleotide analogs comprising 2′-O-amino residues, processes for their synthesis and incorporation into polynucleotides.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: January 14, 2003
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Alexander Karpeisky, Leonid Beigelman
  • Ribozyme treatment of diseases or conditions related to levels of NF-kappaB
    Publication number: 20030003469
    Abstract: Enzymatic RNA molecules which cleave rel A mRNA.
    Type: Application
    Filed: January 23, 2002
    Publication date: January 2, 2003
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Dan T. Stinchcomb, Kenneth G. Draper, James McSwiggen
  • 2'-deoxy-2'-alkylnucleotide containing nucleic acid
    Publication number: 20020197684
    Abstract: 2′-deoxy-2′-alkylnucleotides useful for stabilizing enzymatic nucleic acid molecules and antisense molecules.
    Type: Application
    Filed: March 21, 2002
    Publication date: December 26, 2002
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Alexander Karpeisky, Leonid Beigelman, Anil Modak
  • Method for target site selection and discovery
    Publication number: 20020192685
    Abstract: Nucleic acid catalysts, method of screening/selection for nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences involved in a biological process are described.
    Type: Application
    Filed: March 21, 2002
    Publication date: December 19, 2002
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventor: James D. Thompson
  • Non-nucleotide containing enzymatic nucleic acid
    Publication number: 20020193579
    Abstract: Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.
    Type: Application
    Filed: January 8, 2002
    Publication date: December 19, 2002
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, Jasenka Matulic-Adamic, Leonid Beigelman, Alex Karpeisky
  • Method and reagent for treatment of lung cancer and other malignancies caused by the deregulation of L-MYC gene expression
    Patent number: 6492512
    Abstract: An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of lung cancer.
    Type: Grant
    Filed: August 26, 1992
    Date of Patent: December 10, 2002
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: James D. Thompson, Kenneth G. Draper
  • Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides
    Patent number: 6489465
    Abstract: Novel xylo nucleoside or xylo nucleotide analogs, polynucleotides comprising xylo nucleotide substitution, processes for their synthesis and incorporation into polynucleotides.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: December 3, 2002
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Jasenka Matulic-Adamic, Leonid Beigelman
  • Compositions inducing cleavage of RNA motifs
    Publication number: 20020161209
    Abstract: Disclosed are compositions inducing cleavage of an RNA substrate, as well as their use for inducing cleavage of RNA substrates in vitro and in vivo. The compositions contain part of an active center, with the other part of the active center provided by the RNA substrate. The subunits of the active center region of the compositions are nucleotides and/or nucleotide analogues. The disclosed compositions also have flanking regions contributing to the formation of a specific hybridization with an RNA substrate. Preferred compositions form, in combination with an RNA substrate, a structure resembling a hammerhead structure. The active center of the disclosed compositions is characterized by the presence of I15.1 which allows cleavage of RNA substrates having C16.1.
    Type: Application
    Filed: October 2, 2001
    Publication date: October 31, 2002
    Applicant: Ribozyme Pharmaceuticals, Inc.
    Inventors: Janos Ludwig, Brian S. Sproat
  • Method for target site selection and discovery
    Patent number: 6448009
    Abstract: Nucleic acid catalysts, method of screening/selection for nucleic acid catalysts, synthesis of ribozyme libraries and discovery of gene sequences involved in a biological process are described.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: September 10, 2002
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventor: James D. Thompson
  • Method and reagent for inhibiting herpes simplex virus replication
    Patent number: 6440719
    Abstract: An enzymatic RNA molecule which specifically cleaves a herpes simplex virus mRNA molecule.
    Type: Grant
    Filed: August 8, 2000
    Date of Patent: August 27, 2002
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventor: Kenneth G. Draper
  • Ribozyme treatment of diseases or conditions related to levels of intercellular adhesion molecule-1 (CAM-1)
    Patent number: 6436644
    Abstract: The present invention relates to enzymatic RNA molecules which cleave ICAM-1 mRNA.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: August 20, 2002
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Susan Grimm, Dan T. Stinchcomb, James McSwiggen, Sean Sullivan, Kenneth G. Draper
  • Synthesis, deprotection, analysis and purification for RNA and ribozymes
    Patent number: 6437117
    Abstract: Method for purification and synthesis of RNA molecules and enzymatic RNA molecules in enzymatically active form.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: August 20, 2002
    Assignee: Ribozyme Pharmaceuticals, Inc.
    Inventors: Nassim Usman, Francine Wincott, David Sweedler, Leonid Beigelman, Lech W. Dudycz, Susan Grimm, Anthony DiRenzo, Danuta Tracz