Abstract: An optical correction is predictively performed based on a result of AI learning previously performed by use of learning data including measurement data. The optical compensation system is provided with wavefront correction optics, a sensor and a controller. The wavefront correction optics corrects a wavefront of light that passes through a given optical path. The sensor obtains environmental information in the optical path. The controller calculates, based on the environmental information, a predicted wavefront disturbance of the light that has passed through the optical path and controls the wavefront correction optics so as to cancel the predicted wavefront disturbance.

Abstract: A persistent current switch includes a superconducting wire including a substrate and a superconducting layer disposed on the substrate, and a heater. The superconducting wire includes a surface including a first portion and a second portion that are disposed apart from each other along a longitudinal direction of the superconducting wire. The first portion and the second portion face each other. The heater is sandwiched between the first portion and the second portion.

Abstract: The present inventors have found that by cultivating insect cells, into which the Cas3 gene has been introduced, at relatively low temperatures, it is possible to efficiently express recombinant Cas3 proteins with maintained activity, and by purifying the soluble fractions of these cells, it is possible to collect active forms of the recombinant Cas3 proteins in high purity and high yield.

Abstract: A gel dosimeter for radiation dosimetry includes a radically polymerizable monomer, a gelator, glucose, and glucose oxidase. Although a conventional polymer gel dosimeter contains a deoxygenating agent such as tetrakis(hydroxymethyl)phosphonium chloride, such a deoxygenating agent fails to exhibit sufficient effects. Thus, a more effective deoxygenation treatment technique has been required for a gel dosimeter.

Abstract: A superconducting magnet according to one embodiment includes: a coil including a superconducting layer having a first portion and a second portion, and a joining portion; and a cryostat in which the coil is stored. The first portion and the second portion are located in a termination portion. The superconducting layer forms a closed loop by superconducting joining of the first portion and the second portion at the joining portion. The superconducting layer is made of a high-temperature superconductor. A current flows through the joining portion in a superconducting state when a magnetic field equal to or greater than 1.0 tesla and equal to or less than 5.0 tesla is applied to the joining portion at 77 kelvin. The cryostat is configured such that a temperature inside the cryostat is equal to or greater than 2.0 kelvin and equal to or less than 77 kelvin.

Abstract: A radiation dosimetry gel, usable in a polymer gel dosimeter having an improved sensitivity and high safety, includes a gelator, and a compound of the following Formula (1): wherein R1 is a hydrogen atom or a methyl group, m and n are each an integer of 2 to 4, k is 0 or 1, and a plurality of R1s and ms are each the same as or different from one another. Also provided for is a radiation dosimeter including the radiation dosimetry gel as a material for radiation dosimetry.

Abstract: An optical device includes a first axicon lens to which collimated light is incident and which is configured to form diverging ring-shaped light; a lens to which the ring-shaped light formed by the first axicon lens is incident and which is configured to form ring-shaped collimated light; and a condensing mirror that is configured to condense the ring-shaped collimated light formed by the lens. A photoacoustic microscope includes the optical device described above and a detector that is configured to detect an acoustic wave caused by light condensed by the condensing mirror.

Abstract: It is included an internal gear (2), an external gear (3) having flexibility, and a wave generator (4) that forms a meshing part (P) with the internal gear (2) in the external gear (3) and moves the meshing part (P) in a circumferential direction of the internal gear (2). The wave generator (4) is configured such that the meshing part (P) is formed at three or more positions in a circumferential direction of the external gear (3). A value (DpF/ZF) obtained by dividing a working pitch diameter DpF of the external gear (3) by the number of teeth ZF is greater than a value (DpR/ZR) obtained by dividing a working pitch diameter DpR of the internal gear (2) by the number of teeth ZR.

Abstract: A novel technique is provided that analyzes the state of life using multivariate data relating to life. A state visualization device includes: a coarse-graining portion configured to perform coarse-graining on values corresponding to a plurality of items included in sample data; a model creation portion configured to obtain, using binarized values, a mathematical model for calculating energies each fitting a frequency of occurrence of a state represented by a combination of values corresponding to the items; a graph creation portion configured to create a graph in which the state is placed in two-dimensional space; and an interpolation processing portion configured to create a landscape image by smoothing and interpolating a discrete graph.

Abstract: A spheroidal graphite cast iron having a chemical composition of: C: 3.0% to 4.0%, Si: 2.0% to 2.4%, Cu: 0.20% to 0.50%, Mn: 0.15% to 0.35%, S: 0.005% to 0.030%, Mg: 0.03% to 0.06%, each by mass, and the balance being Fe and inevitable impurities, where Mn and Cu are contained at 0.45% to 0.75% in total; and a structure in which a ferrite layer encloses spheroidal graphite crystallized out in a matrix of pearlite. Part of the pearlite is extended from the matrix side to the spheroidal graphite side to divide the ferrite layer at one or more areas.

Abstract: To provide a hair growth agent and a scalp care agent which are topical agents that exhibit scalp care effect as well as effect in terms of causing increase in hair shaft diameter and effect in terms of improving maximum hair shaft length and improving hair shaft elongation rate and new hair growth and increasing expression of genes contributing to hair growth in dermal papilla cells and promoting hair shaft growth at head hair, beard, eyebrows, and/or eyelashes, these are made to contain an active ingredient in the form of phytosphingosine.

Abstract: A method for detecting a target nucleic acid fragment in a sample includes a step of contacting the sample with a gRNA complementary to the target nucleic acid fragment, a Cas protein, and a substrate nucleic acid fragment, in which the Cas protein is immobilized on a solid phase, a substrate nucleic acid fragment is labeled with a fluorescent substance and a quencher, in a case of being cleaved by nuclease activity of a three-part complex of the Cas protein, the gRNA, and the target nucleic acid fragment, fluorescent light is emitted, the contact is performed in a reaction space having a volume of 10 aL to 100 pL, thereby forming the three-part complex in a case where the target nucleic acid fragment is present in the sample, cleaving the substrate nucleic acid fragment, and separating the fluorescent substance from the quencher; and detecting the fluorescent light, in which the detection of the fluorescent light indicates the presence of the target nucleic acid fragment in the sample.

Abstract: To provide a long-life compression ring without an increase in the outer peripheral abrasion near the gap regardless of the ring material or the presence or absence of the outer peripheral hard coating, in an annular compression ring having a pair of gap faces opposed to each other to form a free gap and a nominal diameter d1 equal to an inner diameter of a cylinder to which the compression ring is attached to along with a piston, a self tangential force is 5N to 50N, and a radius of curvature R1 and the nominal diameter d1 satisfy a relationship: ?0.01?(2R1?d1)/d1<0.002 where the radius of curvature R1 is that of outer peripheral arcs of gap end portions in a free shape state before the compression ring is attached to the cylinder, and the gap end portions are defined in ranges between the gap faces and positions where a center angle from a midpoint of the free gap is 35°.

Abstract: It is included an internal gear (2), an external gear (3) having flexibility, and a wave generator (4) that forms a meshing part (P) with the internal gear (2) in the external gear (3) and moves the meshing part (P) in a circumferential direction of the internal gear (2). The wave generator (4) is configured such that the meshing part (P) is formed at three or more positions in a circumferential direction of the external gear (3). A value (DpF/ZF) obtained by dividing a working pitch diameter DpF of the external gear (3) by the number of teeth ZF is greater than a value (DpR/ZR) obtained by dividing a working pitch diameter DpR of the internal gear (2) by the number of teeth ZR.

Abstract: There is a need to maintain or enhance the magnetic field correction accuracy of a physics package while making the physics package more compact and portable. A triaxial magnetic field correction coil is provided inside a vacuum chamber surrounding a clock transition space having atoms disposed therein. The triaxial magnetic field correction coil is formed into a shape such that it is possible to correct, for magnetic field components of three axial directions passing through the clock transition space, a constant term, a first order spatial derivative term, a second order spatial derivative term, a third or higher order spatial derivative term, or some given combination of these terms. The triaxial magnetic field correction coil can be used in, for example, a physics package for an optical lattice clock.

Abstract: The present invention provides novel antisense oligonucleotide pharmaceutical compositions having higher RNA aggregate-removing activity than conventional pharmaceutical compositions. The pharmaceutical composition of the present invention contains an oligonucleotide having any base sequence of a repeated sequence in which cytosine-adenine-guanine trinucleotides are repeated 5 to 13 times, from the 5? end to the 3? end, and the oligonucleotide has a mixmer structure containing at least two types of RNase H inactive nucleotide analogs. The present invention provides the pharmaceutical composition of the present invention used for the treatment of some symptoms of myotonic dystrophy type 1 disease.

Abstract: A rotating movable body for a wire rope includes a rotating portion through the interior of which a wire rope passes, the wire rope being formed by twisting together eight strands, and rotary plates provided on the rotating portion so as to engage with parts of the outer shape of the wire rope, wherein the rotary plates are arranged at a predetermined interval in the extension direction of the wire rope, and in a state where each of the plurality of strands is in contact with one of the rotary plates, the rotating portion moves in the extension direction of the wire rope and rotates so as to follow the twist of the strands.

Abstract: The invention provides a method of differentiating human pluripotent stem cells to ectodermal cell by treating human pluripotent stem cells, which are dissociated single cells, and inducing differentiation to ectodermal cells under conditions where a ROCK(Rho-kinase) inhibitor is present in a culture medium in contact with the cells after dissociation of the human pluripotent stem cells.

Abstract: This invention provides, as a therapeutic method for eradication of neoplastic diseases of the blood with poor diagnosis, a cell co-expressing a chimeric antigen receptor (CAR) protein and a CXCL12 receptor protein on the cell membrane, and an agent and a pharmaceutical composition having anti-tumor activity, which comprises such cell.

Abstract: An optical lattice clock includes a clock transition space having disposed therein an atom group trapped in an optical lattice, and a triaxial magnetic field correction coil for correcting the magnetic field of the clock transition space. Additionally, in a correction space that includes the clock transition space and is larger than the clock transition space, a photoreceiver promotes the clock transition of the atom group trapped in the optical lattice and acquires a clock transition frequency distribution for the correction space. Further, a corrector corrects the magnetic field of the triaxial magnetic field correction coil on the basis of the frequency distribution measured by the photo receiver.