Abstract: The present disclosure is a combination of a cylinder and a piston ring, the combination including a cylinder of an internal combustion engine and a piston ring sliding on an inner peripheral surface of the cylinder. The piston ring has an outer peripheral surface sliding on the inner peripheral surface of the cylinder, and the outer peripheral surface is formed of a substantially hydrogen-free amorphous carbon coating. The Vickers hardness Hd of the amorphous carbon coating and the Vickers hardness Hb of the inner peripheral surface of the cylinder satisfy Hd+Hb?2500 HV. The ratio ID/IG of the peak intensity of the D band to the peak intensity of the G band in a Raman spectrum obtained by measuring the amorphous carbon coating by Raman spectroscopy is 0.60 or more and 1.33 or less.

Abstract: To provide a pharmaceutical composition capable of enhancing the effect of an immune checkpoint inhibitor against tumor or cancer in a subject. Provided is a pharmaceutical composition that comprises bacterial cells, a culture supernatant, a metabolite, and/or a bacterial cell extract of Ruminococcaceae enterobacterium, and is administered in combination with an immune checkpoint inhibitor.

Abstract: A method for detecting a target substance in a sample includes a step of introducing the sample and a reagent that generates a fluorescent substance in a presence of the target substance into each well of a well array; a step of sealing each well of the well array with a sealing liquid such that each well forms an independent reaction space; a step of replacing the sealing liquid with a water-absorbing organic solvent, thereby dehydrating the content of the well, reducing the volume, and generating the fluorescent substance in a case where the target substance is present in the content; and a step of emitting excitation light to the fluorescent substance to detect fluorescent light generated in each well of the well array, in which detection of the fluorescent light in the well indicates the presence of the target substance in the well.

Abstract: A three-dimensional shaped object can achieve both of a property in the case of a high dense degree and a property in the case of a low dense degree, and have a high strength. The three-dimensional shaped object includes a dense portion formed on one side so as to be dense, and a porous portion formed on an opposite side so as to be porous. The dense portion and the porous portion are formed by a reaction product of a ceramic material with a chelating agent.

Abstract: To provide an agent that increases expression of genes contributing to hair growth in dermal papilla cells, a scalp care agent, and a hair growth agent which are topical agents that exhibit effect in terms of causing increase in hair shaft diameter, and improving maximum hair shaft length, and improving hair shaft elongation rate, and new hair growth and increasing expression of genes contributing to hair growth in dermal papilla cells, and promoting hair shaft growth at head hair, beard, eyelashes, and/or eyebrows, such agents are made to contain an active ingredient in the form of palmitoyl dipeptide-5 diaminohydroxybutyrate.

Abstract: An antibody against spike protein of SARS-CoV-2 is provided, the antibody having a specific heavy chain variable region and a specific light chain variable region, or a fragment of the antibody, the antibody or fragment thereof inhibiting the binding between the spike protein of SARS-CoV-2 and ACE2, the antibody or fragment thereof inhibiting SARS-CoV-2 infection; and a pharmaceutical composition including the antibody or fragment thereof and a pharmaceutically acceptable carrier, the pharmaceutical composition including two or more kinds of the antibody or fragment thereof.

Abstract: In order to realize a light absorber wherein the wavelengths absorbed can be adjusted, an embodiment of the present invention provides a light absorber 100 provided with a group of dielectric protrusions 102, a conductive thin film 104, and a conductive thick film 108. The group of dielectric protrusions has each dielectric protrusion protruding at a random position on a dielectric surface. A dielectric thin film is disposed on or above at least part of the surface of the dielectric protrusions and on or above at least part of the dielectric surface where the dielectric protrusions are not present; and the dielectric thick film spreads out along the dielectric surface and being kept separate from the dielectric thin film. The group of dielectric protrusions can be provided by disposition of dielectric particles in an in-plane random arrangement on the surface.

Abstract: An optical system that obtains characteristics of a transmission path in atmosphere, when laser light propagates through this transmission path, at a place separated from this transmission path and before the propagation, and corrects wavefront of the laser light based on the obtained characteristics, is provided. The optical system is provided with an irradiation device and an atmospheric characteristics obtaining system. The irradiation device irradiates an external target with light via a first optical path. The atmospheric characteristics obtaining system is arranged in a second optical path separated from the first optical path and obtains characteristics of atmospheric environment in the first optical path with respect to the irradiated light. The irradiation device is provided with wavefront correction optics. The wavefront correction optics correct wavefront of the irradiated light based on the obtained characteristics.

Abstract: A magneto-optical trap apparatus includes a vacuum vessel for encapsulating an atom to be trapped, an anti-Helmholtz coil for applying a magnetic field to an inside of the vacuum vessel, a laser device for generating a laser beam, and an irradiation device for irradiating the generated laser beam from a plurality of directions. The laser beam includes a first laser beam detuned from a first resonance frequency when the atom transits from a total angular momentum quantum number F in a ground state to a total angular momentum quantum number F?=F+1 in an excited state, and a second laser beam detuned from a second resonance frequency when the atom transits from the total angular momentum quantum number F in the ground state to a total angular momentum quantum number F?=F?1 in the excited state, among transitions from J=0 in a ground state to J?=1 in an excited state.

Abstract: An object of the present invention is to provide clinically applicable aAVC-NY-ESO-1 cells stably expressing NY-ESO-1 in order to use aAVC-NY-ESO-1 cells in treating patients having a NY-ESO-1-expressing cancer. The present invention provides, for example, a human-derived cell comprising a polynucleotide encoding CD1d and a polynucleotide encoding NY-ESO-1 or a fragment thereof, wherein the polynucleotide encoding NY-ESO-1 or a fragment thereof is operably linked to an inducible promoter.

Abstract: The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.

Abstract: Disclosed herein are a system for identifying cells on a microscopic image. According to some embodiments, the system comprises a non-transitory processor-readable medium, and a processor communicably configured to receive the microscopic image, and process the received microscopic image with a convolutional neural network (CNN) model having a modified U-Net architecture. Also disclosed herein are methods for identifying a spatial pattern of human induced pluripotent stem cells (hiPSCs) by using the present system.

Abstract: The method for evaluating the body temperature regulating function includes: acquiring an autonomic index of a target; acquiring a perspiration index of the target; and evaluating the body temperature regulating function of the target by using the autonomic index of the target and the perspiration index of the target. In one preferred embodiment, the autonomic index includes at least one of a heart rate variability index or a pulse rate variability index, and the perspiration index includes at least one of a skin conductance change or an amount of perspiration.

Abstract: An object of the present invention is to provide a vehicle and a composition for transplantation comprising retinal tissue and the vehicle, which are for the treatment of retinal degenerative diseases such as retinitis pigmentosa (RP) and are suitable for the subretinal transplantation of retinal tissue. The vehicle for transplantation of the present invention is a vehicle for transplantation for subretinally transplanting retinal tissue, the vehicle having a viscosity of 5 to 500 mPa·s at a shear rate of 2 (1/s) at 25° C., and comprising hyaluronic acid and a pharmaceutically acceptable aqueous liquid. The composition for transplantation of the present invention comprises transplant retinal tissue and the vehicle for transplantation of the present invention.

Abstract: An object of the present invention is to provide a complex containing two or more neural retina-containing cell aggregates, and a method for manufacturing the same. The complex of the present invention is a complex comprising: two or more cell aggregates each containing a neural retina derived from a pluripotent stem cell; and a matrix, the two or more cell aggregates being arranged in the matrix. The method for manufacturing the complex of the present invention is a method for manufacturing a complex in which two or more neural retina-containing cell aggregates are arranged in a matrix, comprising: (1) a first step of preparing two or more cell aggregates of neural retinas from a pluripotent stem cell; and (2) a second step of contacting the two or more cell aggregates in a predetermined arrangement with the matrix or a precursor of the matrix, followed by the gelation of the matrix.

Abstract: Provided is a connection body of high-temperature superconducting wire materials including a first oxide high-temperature superconducting wire material and a second oxide high-temperature superconducting wire material, characterized in that a first superconducting layer of the first oxide high-temperature superconducting wire material and a second superconducting layer of the second oxide high-temperature superconducting wire material are bonded together via a junction including M-Cu—O (wherein M is a single metal element or a plurality of metal elements included in the first superconducting layer or the second superconducting layer). The connection body may be, for example, a connection body of Bi2223 wire materials, and the junction may include CaCuO2.

Abstract: This disclosure relates to a peptide inducing immunity to SARS-CoV-2. Also, the disclosure relates to a composition containing the peptide and inducing immunity to SARS-CoV-2.

Abstract: An object of the present invention is to provide a ventral hindgut organoid for producing a bladder organoid that comprises a layer structure of bladder epithelial cell types like the urinary bladder. An aspect of the present invention is to provide a method for producing a ventral hindgut organoid, comprising culturing a pluripotent stem cell with an inducer medium A containing activin A and GSK3? inhibitor to induce differentiation into definitive endoderm cells and culturing the definitive endoderm cells with an inducer medium B containing fibroblast growth factor, GSK3? inhibitor, and optionally further containing bone morphogenetic protein, and then culturing them in the presence of extracellular matrix with an inducer medium B containing fibroblast growth factor, GSK3? inhibitor, and optionally further containing bone morphogenetic protein to form a ventral hindgut organoid.

Abstract: A control method of controlling a computer to analyze, at a second facility, nucleic acid sequence data obtained, at a first facility, by a sequencer that reads a nucleic acid sequence, for a gene panel test, comprising receiving, from the first facility via a network, a sequence data set comprising a plurality of nucleic acid sequence data obtained by the sequencer corresponding to each of a plurality of library samples comprising a first library sample and a second library sample, which are prepared from a specimen of a subject, and link information indicating that the first library sample and the second library sample are prepared from the specimen of the same subject; analyzing a first sequence data and a second sequence data corresponding to each of the first library sample and the second library sample linked by the link information; and outputting analysis information based on an analysis result of the first sequence data and an analysis result of the second sequence data, is disclosed.

Abstract: An inspection device includes: a light source for outputting pulsed excitation light with a time width of 10 picoseconds to 10 nanoseconds; a nonlinear optical crystal for generating a terahertz wave by optical wavelength conversion of the excitation light; and a detector for detecting a reflected wave of the terahertz wave reflected by an inspection target.