Abstract: An analyte monitoring system and methods for extending the life of a sensor in an analyte monitoring system. The analyte sensor may include an analyte sensor and a transceiver. The analyte sensor may include an indicator, a detector, and an amplifier. The indicator may be configured to exhibit one or more detectable properties based on an amount or concentration of an analyte in proximity to the indicator. The detector may be configured to detect one or more of the detectable properties and output an analyte signal indicative of the amount or concentration of the analyte in proximity to the indicator. The amplifier may be configured to amplify the analyte signal. The transceiver may be configured to adjust a gain of the amplifier. The transceiver may be configured to additionally or alternatively adjust a drive current of a light source of the analyte sensor.

Abstract: Systems, methods, and apparatuses for reducing error between calculated analyte levels and impractical analyte measurements using practical analyte measurements as reference measurements for calibration. Reducing the error may include converting a practical reference analyte measurement into an estimated impractical analyte level, updating a conversion function using the estimated impractical analyte level, and using the updated conversion function to calculate an analyte level. In some embodiments, the practical reference analyte measurement may be a capillary blood analyte measurement, and the estimated impractical analyte level may be an estimated venous blood analyte level. In some embodiments, the updated conversion function may minimize the error between analyte levels calculated using the updated conversion function and estimated venous blood analyte levels.

Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor substrate, electrode or housing, an analyte indicator covering at least a portion of the sensor, and one or more compounds that reduce degradation of the analyte indicator.

Abstract: Analyte monitoring methods and systems for interferent detection. The methods may include using one or more analyte detectors of an analyte sensor to generate one or more analyte measurements indicative of an analyte level in a first medium. The methods may include using one or more interferent detectors of the analyte sensor and/or one or more interferent sensors of a transceiver to generate one or more interferent measurements indicative of an interferent level in the first medium. The methods may include using a transceiver interface of the analyte sensor to convey the one or more analyte measurements and using a sensor interface of the transceiver to receive the one or more analyte measurements from the analyte sensor. The methods may include using the transceiver to calculate an analyte level in a second medium using at least the one or more analyte measurements and the one or more interferent measurements.

Abstract: Systems, methods, and devices for determining the condition of a skin surface covered by an adhesive patch. An external device may be configured to be attached to the skin surface via the adhesive patch. A light source of the external device may emit light through the adhesive patch. A photodetector of the device may output a signal indicative of an amount of the light received by the photodetector after passing through the adhesive patch. A controller of the device may determine, based on the signal, a condition of the skin surface covered by the adhesive patch. In some alternative embodiments, the photodetector may instead by in an implantable device, which may convey the signal to the external device. In some other alternative embodiments, the light source may instead be in an implantable device.

Abstract: Systems and methods for determining an amount of time that a subject spends within a target analyte range by time-of-day. The systems and methods may determine a first time-in-target value indicating a percentage of time within a first time-of-day range that a subject's analyte level was less than a first threshold and greater than a second threshold using at least data points from first and second days. The systems and methods may determine a second time-in-target value indicating a percentage of time within a second time-of-day range that the subject's analyte level was less than the first threshold and greater than the second threshold using at least data points from the first and second days. The systems and methods may display the first time-in-target value and the second time-in-target value.

Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor substrate, electrode or housing, an analyte indicator covering at least a portion of the sensor, and one or more probes that identify degradative species in an environment of the sensor.

Abstract: A sensing system including analyte sensing devices, an interface device, and shared communication device. The interface device may be configured to receive a power signal and generate power for powering the sensing devices and to convey data signals generated by the sensing devices. The sensing system may be configured to receive addressed and unaddressed commands. The sensing devices may be configured to perform activities (e.g., measurement sequences) in parallel in response to the unaddressed commands (e.g., unaddressed measurement commands). The sensing devices may be configured to only perform activities (e.g., conveying measurement data) in response to addressed commands (e.g., addressed read measurement data commands) if the sensing devices determine that the addressed commands are addressed to them.

Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor substrate, electrode or housing, an analyte indicator covering at least a portion of the sensor, and one or more optical signal stabilizing additives in an environment of the sensor.

Abstract: A first communication device may communicate wirelessly with a second communication device. The first communication device may include a wireless communication integrated circuit (IC) configured to (i) receive application data from an application controller, (ii) encapsulate the application data in data packets, and (iii) use an antenna to transmit the data packets. In some embodiments, the first and second communication devices may agree on a length of connection intervals, and the first communication device may transmit two or more of the data packets to the second communication device during each of one or more of the connection intervals. In some embodiments, during periods when there is no application data to encapsulate and transmit to the second communication device, the first communication device may transmit a message to the second communication device, and transmitting the message may keep a wireless link between the first and second communication devices active.

Abstract: An analyte monitoring system may include one or more sensors, one or more transceivers, one or more primary display devices, a remote computing device, and one or more secondary display devices. Each sensor may be in communication with a respective transceiver, and each transceiver may be in communication with a respective primary display device. A patient application may be stored as computer readable instructions in a storage medium of a primary display device, and an observer application is stored as computer readable instructions in a storage medium of a secondary display device. The patient application may be configured to allow a user of the primary display device to share analyte information with a secondary display device. The observer application may be configured to allow a user of the secondary display device to receive and display the shared analyte information.

Abstract: Apparatuses and methods for improving the accuracy of an analyte sensor are disclosed. The sensor may include a photodetector and a low angle sensitive (LAS) optical filter. The photodetector may be configured to convert received light into current indicative of the intensity of the received light. The LAS optical filter may be configured to prevent light having a wavelength outside a band pass region from reaching the photodetector and to pass light having a wavelength within the band pass region to the photodetector. The percentage of light passing through the LAS optical filter may decrease as the angle of incidence of the light increases.

Abstract: A sensor, system, and method for detecting and correcting for changes to an analyte indicator of an analyte sensor. The analyte indicator may be configured to exhibit a first detectable property that varies in accordance with an analyte concentration and an extent to which the analyte indicator has degraded. The analyte sensor may also include a degradation indicator configured to exhibit a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded. The analyte sensor may generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) a degradation measurement based on the second detectable property exhibited by the degradation indicator. The analyte sensor may be part of a system that also includes a transceiver. The transceiver may use the analyte and degradation measurements to calculate an analyte level.

Abstract: A system including a sensor and a transceiver and configured to determine a concentration of an analyte in a medium of a living animal. The sensor may include first and second signal photodetectors and first and second reference photodetectors, which may each be covered by an associate filter. The first photodetector may receive light emitted from first and second grafts, respectively. The grafts may receive excitation light from one or more light sources. The transceiver may receive signals from the photodetectors of the sensor and may determine the analyte concentration based on the received signals.

Abstract: Systems and methods for automatically triggering wireless power and data exchange between an external reader and an implanted sensor. The implanted sensor may measure the strength of an electrodynamic field received wirelessly from the reader and convey field strength data based on the measured strength of the received electrodynamic field to the reader. If the field strength data indicates that the strength of an electrodynamic field received by the sensor is sufficient for the implanted sensor to perform an analyte measurement, the reader may convey an analyte measurement command to the sensor, which may execute the analyte measurement command and convey measurement information back to the reader. The systems and methods may trigger the analyte measurement as the reader transiently passes within sufficient range/proximity to the implant (or vice versa).

Abstract: A removal tool uses magnetic attraction to guide the removal tool toward an implantable device subcutaneously implanted in subcutaneous tissue of a host and to remove the implantable device from the host. The removal tool may include first and second lever members that are pivotably connected together, and the first and second lever members include a pair of jaw members configured to move between open and closed positions to grasp the implantable device. The first jaw member may include a magnet to magnetically attract and couple to an implantable device implanted subcutaneously below a skin surface of a host.

Abstract: A system and method for measuring an amount of blood and/or clotting in a pocket around an implantable device. The system may include a first light source configured to emit light over a first wavelength range. The system may include a first photodetector configured to output a first signal indicative of an amount of the first light received by the first photodetector. The system may include the implantable device and an external device. The implantable device may include one of the first light source and the first photodetector, and the external device may include the other of the first light source and the first photodetector. In some embodiments, the external device may include a controller configured to calculate the amount of blood/or clotting in the pocket around the implantable device using at least a measurement of the first signal.

Abstract: An analyte monitoring system and method. The analyte monitoring system may include an analyte sensor and a transmitter. The analyte sensor may include an indicator element that exhibits one or more detectable properties based on an amount or concentration of an analyte in proximity to the indicator element. The transmitter may be configured to receive measurement information from the analyte sensor. The transmitter may be configured to assess in real time a performance of the analyte sensor based on at least the measurement information. The transmitter may be configured to determine whether the performance of the analyte sensor is deficient based at least on the assessed performance of the analyte sensor. The transmitter may be configured to predict an amount of time remaining before the performance of the analyte sensor becomes deficient based on at least the assessed performance of the analyte sensor.

Abstract: A sensing system including analyte sensing devices, an interface device, and shared communication device. The interface device may be configured to receive a power signal and generate power for powering the sensing devices and to convey data signals generated by the sensing devices. The sensing system may be configured to receive addressed and unaddressed commands. The sensing devices may be configured to perform activities (e.g., measurement sequences) in parallel in response to the unaddressed commands (e.g., unaddressed measurement commands). The sensing devices may be configured to only perform activities (e.g., conveying measurement data) in response to addressed commands (e.g., addressed read measurement data commands) if the sensing devices determine that the addressed commands are addressed to them.

Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and a drug eluting material having tailored elution properties that contains a drug that reduces deterioration of the analyte indicator, wherein the drug eluting material is incorporated in and/or in close proximity to the analyte indicator, and the drug eluting material is configured to release the drug according to a tailored elution profile.