Abstract: A system may include a first device and a second device. The second device may be configured to execute an application and validate that the application is able to cause the second device to (i) communicate with the first device and (ii) communicate with a user of the second device. The second device may be configured to (a) check one or more settings of the second device and/or (b) convey a request for data to the first device and determine whether the second device receives the requested data. The second device may be configured to cause the second device to display a message requesting confirmation that the second device displayed the message and determine whether the second device receives the requested confirmation that the second device displayed the message.

Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds having metal chelating moieties that reduce degradation of the analyte indicator.

Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds having dithio-, thio- or mercapto-containing moieties that reduce degradation of the analyte indicator.

Abstract: In one aspect, a tunneling tool for creating a subcutaneous pocket below a skin surface is provided. The tunneling tool may include a handle, a rod, a first prong, and a second prong. The rod and the first and second prongs may extend from a first end of the handle. The rod may extend farther from the first end of the handle than the first and second prongs and be configured to create the subcutaneous pocket. The first and second prongs may be configured to limit the depth at which the rod is capable of creating the subcutaneous pocket. The first and second prong may comprise first and second length indicators, respectively, configured to indicate a length of the subcutaneous pocket formed by the rod. In another aspect, a method of creating a subcutaneous pocket using the tunneling tool is provided.

Abstract: A sensor, system, and method for detecting and correcting for changes to an analyte indicator of an analyte sensor. The analyte indicator may be configured to exhibit a first detectable property that varies in accordance with an analyte concentration and an extent to which the analyte indicator has degraded. The analyte sensor may also include a degradation indicator configured to exhibit a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded. The analyte sensor may generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) a degradation measurement based on the second detectable property exhibited by the degradation indicator. The analyte sensor may be part of a system that also includes a transceiver. The transceiver may use the analyte and degradation measurements to calculate an analyte level.

Abstract: An insertion tool for creating a subcutaneous pocket and implanting a device in the pocket. The tool may include a cannula extending from a handle, a dissector tip disposed at a distal end of the cannula, and a rod. The cannula and dissector tip may create the pocket. The cannula may include a passage and an opening into the passage, and the cannula may be disposed in the passage and move along the passage between a retracted position and an extended position. The rod and the cannula may be configured such that, when the rod is at the retracted position, the cannula holds the device in the passage, and as the cannula moves from the extended position to the retracted position, the rod forces the device through the opening at the distal end of the cannula, at least partially out of the cannula, and at least partially into the pocket.

Abstract: A computing device receives analyte data produced by an analyte monitoring sensor over a communications link from at least one first device. Health data, comprising at least part of the analyte data, may be communicated over a communications link to at least one second device in response to a request. The first device may be positioned over the analyte monitoring sensor using signal strength and location information. External analyte data may be employed to calibrate the analyte monitoring sensor.

Abstract: An analyte monitoring system may include an analyte sensor and a transmitter. The analyte sensor may include an indicator element that exhibits one or more detectable properties based on an amount or concentration of an analyte in proximity to the indicator element. The analyte sensor may be configured to generate one or more raw signals indicative of one or more analyte amounts or concentrations. The transmitter may be configured to receive from the analyte sensor one or more raw signals indicative of analyte concentration. The transmitter may be configured to denoise the raw signal using a real-time filtering technique with one or more time-varying parameters. The transmitter may be configured to predict ahead of time an analyte concentration based on one or more of the received one or more raw signals using one or more prediction models.

Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds containing boronate or boronic acid moieties that reduce degradation of the analyte indicator.

Abstract: A first communication device may communicate wirelessly with a second communication device. The first communication device may include a wireless communication integrated circuit (IC) configured to (i) receive application data from an application controller, (ii) encapsulate the application data in data packets, and (iii) use an antenna to transmit the data packets. In some embodiments, the first and second communication devices may agree on a length of connection intervals, and the first communication device may transmit two or more of the data packets to the second communication device during each of one or more of the connection intervals. In some embodiments, during periods when there is no application data to encapsulate and transmit to the second communication device, the first communication device may transmit a message to the second communication device, and transmitting the message may keep a wireless link between the first and second communication devices active.

Abstract: A multisite sensing system including two or more analyte sensors, an interface device, and a shared bus. The interface device may be configured to receive a power signal and generate power for powering the analyte sensors and to convey data signals generated by the analyte sensors. The shared bus connected to the interface device and each of the analyte sensors and configured to provide the power generated by the interface device to the analyte sensors and to provide the data signals generated by the analyte sensors to the interface device. The interface device may be an inductive element. The shared bus may be a two wire, multiplexed bus. The analyte sensors may be spatially separated for analyte sensing at least two different locations. The analyte sensors may generate data signals indicative of the presence and/or amount of the same analyte or of one or more different analytes.

Abstract: A system, transceiver, and method for calculating and correcting levels (e.g., analyte levels) in a first medium (e.g., blood) using measurements from a second medium (e.g., interstitial fluid). In some embodiments, a transceiver may calculate an initial second medium level. The transceiver may calculate an initial second medium level rate of change (“ROC”) using at least the initial second medium level and past second medium level(s). The transceiver may calculate a first medium level using at least the initial second medium level and the initial second medium level ROC. The transceiver may calculate a subsequent second medium level. The transceiver may calculate an updated second medium level ROC using at least the initial second medium level, the subsequent second medium level, and past second medium level(s). The transceiver may calculate a corrected first medium level using at least the initial second medium level and the updated second medium level ROC.

Abstract: Systems, methods, and apparatuses that provide alerts based on analyte data and acceleration data. An analyte sensor may generate the analyte data. An accelerometer may generate the acceleration data. A transceiver may convert the analyte data into analyte concentration values. The transceiver may convert the acceleration data into activity information. The transceiver may generate an alert based on the analyte concentration values and activity information. The alert may be communicated to a user by a mobile medical application executed on the transceiver and/or a display device (e.g., smartphone) in communication with the transceiver. The mobile medical application may display (e.g., on a display of the display device) a plot or graph of the analyte concentration values and activity information with respect to time.

Abstract: An analyte monitoring system includes an analyte sensor, a transceiver, and a display device. The analyte sensor may include an analyte indicator that exhibits one or more detectable properties based on an amount or concentration of an analyte in proximity to the analyte indicator. The transceiver may receive first sensor data directly from the analyte sensor and may calculate first analyte information using at least the received first sensor data. The display device may receive second sensor data directly from the analyte sensor and calculates second analyte information using at least the received second sensor data. The transceiver may convey the first analyte information, and the display device may receive the first analyte information conveyed by the transceiver and display the first and second analyte information.

Abstract: An analyte monitoring system may include an analyte sensor, a transceiver, and a display device. The transceiver may be configured to operate in two or more modes of operation. The display device may be configured to communicate with the transceiver. The two or more modes of operation may include a clinical mode in which the transceiver receives first sensor data from the analyte sensor and calculates one or more first analyte levels using at least the received first sensor data but does not convey the one or more first analyte levels to the display device. The two or more modes of operation may include an unblinded mode in which the transceiver receives second sensor data from the analyte sensor, calculates one or more second analyte levels using at least the received second sensor data, and conveys the one or more second analyte levels to the display device.

Abstract: A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and a multiple metal protective system including multiple metals incorporated in and/or in close proximity to a surface of the analyte indicator that reduce deterioration of the analyte indicator.

Abstract: Analyte monitoring systems and methods may include calculating an analyte level and an analyte level rate of change using at least measurement information conveyed by an analyte sensor, displaying the analyte level, determining whether the analyte level is lower than a first lower analyte level threshold, determining whether the analyte level is lower than a second lower analyte level threshold, comparing the analyte level rate of change to an analyte level rate of change threshold, and displaying one or more of a low analyte level alert and a rate of change alert. The low analyte level alert may be displayed if the analyte level is lower than the first lower analyte threshold, and the rate of change alert may be displayed if the analyte level is lower than the second lower analyte level threshold and the analyte level is changing faster than the analyte level rate of change threshold.

Abstract: An analyte monitoring system and method. The analyte monitoring system may include an analyte sensor and a transceiver. The analyte sensor may include an analyte indicator that exhibits one or more detectable properties based on an amount or concentration of an analyte in proximity to the indicator. The transceiver may be configured to receive one or more measurements from the sensor. The transceiver may be configured to assess in real time a performance of the sensor based on at least the one or more measurements. The transceiver may be configured to determine whether the performance of the sensor is deficient based at least on the assessed performance of the sensor. The transceiver may be configured to calculate an analyte level based on at least the one or more sensor measurements. The transceiver may be configured to determine whether the calculated analyte level is a spike.

Abstract: An analyte monitoring system and method. The analyte monitoring system may include an analyte sensor and a transceiver. The analyte sensor may include an indicator element that exhibits one or more detectable properties based on a concentration of an analyte in proximity to the indicator element. The transceiver may be configured to (i) receive measurement information from the analyte sensor, (ii) calculate the concentration of the analyte in proximity to the indicator element based on at least the received measurement information, and (iii) calculate a blood analyte concentration based on the calculated concentration of the analyte in proximity to the indicator element by (1) incorporating the calculated concentration of the analyte in proximity to the indicator element into a governing equation that models analyte transport over an interval, and (2) solving the governing equation. In some embodiments, the governing equation includes no more than two discrete boundary conditions.

Abstract: An implantable device with in vivo functionality, where the functionality of the device is negatively affected by ROS typically associated with inflammation reaction as well as chronic foreign body response as a result of tissue injury, is at least partially surrounded by a protective material, structure, and/or a coating that prevents damage to the device from any inflammation reactions. The protective material, structure, and/or coating is a biocompatible metal, preferably silver, platinum, palladium, gold, manganese, or alloys or oxides thereof that decomposes reactive oxygen species (ROS), such as hydrogen peroxide, and prevents ROS from oxidizing molecules on the surface of or within the device. The protective material, structure, and/or coating thereby prevents ROS from degrading the in vivo functionality of the implantable device.