Abstract: There is provided a method of providing information about prognosis after cardiac arrest. The method includes the steps of: calculating biological information based on a signal relating to a hemoglobin concentration measured from a cerebral region of a subject to be measured; and providing the information about the prognosis after cardiac arrest of the subject with reference to the calculated biological information and a biomarker relating to the prognosis after cardiac arrest measured from a blood of the subject.
Type:
Application
Filed:
March 5, 2021
Publication date:
April 20, 2023
Applicants:
SEOUL NATIONAL UNIVERSITY HOSPITAL, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, OBE LAB., INC.
Inventors:
Sang Bae KO, Tae Jung KIM, Hyeon Min BAE, Jong Kwan CHOI, Jae Myoung KIM
Abstract: The present disclosure relates to a novel compound or a salt thereof, a composition for detecting cysteine, a fluorescent probe, and a composition for diagnosing cancer, which contain the same, a method for detecting cysteine, a method for providing information for diagnosing cancer, and a method for producing the novel compound. According to the present disclosure, there may be provided a method of synthesizing and purifying a fluorescent probe for cysteine detection and applying the same to diagnose cervical cancer by detecting cysteine in human urine.
Type:
Application
Filed:
October 28, 2021
Publication date:
April 6, 2023
Applicants:
Industry-Academic Cooperation Group of Kyung Hee University, SEOUL NATIONAL UNIVERSITY HOSPITAL
Inventors:
Do Kyoung Kim, Chang Wook Jeong, Jong Min An
Abstract: Disclosed are an artificial prosthesis and a method for manufacturing same. The artificial prosthesis includes a surface having a pattern formed thereon, the pattern comprising straight line shapes aligned in parallel with each other, and has the effect of reducing inflammation in a region implanted with the prosthesis, and effectively reducing capsular contracture side effects.
Abstract: Some embodiments of the present disclosure provide a pneumothorax detection method performed by a computing device. The method may comprise obtaining predicted pneumothorax information, predicted tube information, and a predicted spinal baseline with respect to an input image from a trained pneumothorax prediction model; determining at least one pneumothorax representative position for the predicted pneumothorax information and at least one tube representative position for the predicted tube information, in a prediction image in which the predicted pneumothorax information and the predicted tube information are displayed; dividing the prediction image into a first region and a second region by the predicted spinal baseline; and determining a region in which the at least one pneumothorax representative position and the at least one tube representative position exist among the first region and the second region.
Type:
Grant
Filed:
November 12, 2019
Date of Patent:
January 31, 2023
Assignees:
LUNIT INC., SEOUL NATIONAL UNIVERSITY HOSPITAL
Inventors:
Min Chul Kim, Chang Min Park, Eui Jin Hwang
Abstract: Provided is a method of operating an apparatus for prostate cancer analysis operated by at least one processor, the method including: receiving digital slide images prepared from serial sections of a prostatectomy specimen, and a gross image of the serial sections; acquiring prostate cancer-related histological information of each received digital slide image using an artificial neural network model trained to infer histological information from the digital slide images; generating digital pathology images by displaying the prostate cancer-related histological information inferred from the artificial neural network model on each digital slide image; and providing a histological mapping image in which a tumor region extracted from each digital pathology image is mapped to a gross image of the corresponding section.
Type:
Grant
Filed:
July 5, 2022
Date of Patent:
January 31, 2023
Assignees:
SEOUL NATIONAL UNIVERSITY HOSPITAL, KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, PLANIT HEALTHCARE INC.
Inventors:
Jinwook Choi, Kyoungbun Lee, Gyeong Hoon Kang, Kyung Chul Moon, Gheeyoung Choe, Kyu Sang Lee, Jeong Hwan Park, Won-Ki Jeong, Se Young Chun, Youngkwan Kim
Abstract: The bioenvironmental simulation device according to an embodiment of the present invention includes at least one mounting unit on which cells to be measured are placed, a rotational force application unit configured to rotate the mounting unit so as to apply a rotational force to the cells to be measured placed on the mounting unit, and a culture liquid flow device through which a culture liquid flows across the mounting unit, wherein the culture liquid flows by the culture liquid flow device so as to apply a shear force to the cells to be measured.
Type:
Grant
Filed:
December 10, 2019
Date of Patent:
December 20, 2022
Assignees:
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, SEOUL NATIONAL UNIVERSITY HOSPITAL
Inventors:
Seung Hee Yang, Yon Su Kim, Dong Ki Kim, Sa Ram Lee, Yong Chul Kim, Mi Yeon Yu, Ji Eun Kim
Abstract: An intervertebral fusion cage is disclosed. An intervertebral fusion cage according to an embodiment of the present invention comprises: a body including a receiving part of which upper and lower portions are open, an upper guide part, and a lower guide part; a moving member disposed in the receiving part; a screw which is screw-coupled to the body and moves forwards or backwards relative to the body integrally with the moving member when rotating; an upper plate which has a guided part guided by the upper guide part and is disposed above the body while being engaged with the moving member; and a lower plate which has a guided part guided by the lower guide part and is disposed under the body while being engaged with the moving member.
Type:
Application
Filed:
September 29, 2020
Publication date:
December 15, 2022
Applicants:
CG BIO CO., LTD., SEOUL NATIONAL UNIVERSITY HOSPITAL
Abstract: A DNA analysis method and a DNA analyzing device using terahertz wave capable of accurately determining a type of cancer from DNA using terahertz wave are disclosed. The DNA analysis method according to the present invention comprises: (a) irradiating terahertz wave onto methylated DNA; (b) detecting the terahertz wave reflected from the methylated DNA; (c) detecting a peak of a waveform of the terahertz wave detected in the step (b); and (d) determining type of cancer from the peak detected in the step (c).
Type:
Grant
Filed:
November 16, 2017
Date of Patent:
December 6, 2022
Assignees:
UNIVERSITY OF SEOUL INDUSTRY COOPERATION FOUNDATION, SEOUL NATIONAL UNIVERSITY HOSPITAL
Inventors:
Joohiuk Son, Hwayeong Cheon, Heejin Yang
Abstract: The present invention relates to a biomarker composition for diagnosing and predicting prognosis of prostate cancer, and that the detection rate and expression level of gene combination composed with AR (Androgen receptor), AR-V7 (Androgen receptor variant 7), EpCAM (Epithelial cell adhesion molecule) in blood tumor cells (CTC) isolated from patients, Epithelial cell adhesion molecule), KRT-19 (Cytokeratin 19), PSA (Prostate specific antigen), and PSMA (Prostate specific membrane antigen) in circulating tumor cells (CTCs) isolated from patients is related to the level of malignancy in prostate cancer is confirmed and thus the gene combination provides as a biomarker for prostate cancer diagnosis and a biomarker for prognosis prediction of prostate cancer.
Type:
Application
Filed:
April 28, 2021
Publication date:
July 7, 2022
Applicants:
INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, SEOUL NATIONAL UNIVERSITY HOSPITAL
Abstract: A Cyclo (his-pro) (CHP) is useful for preventing, ameliorating, or treating fibrosis. A pharmaceutical composition containing CHP may be used for preventing or treating fibrosis. A health functional food composition containing CHP may be used for preventing or ameliorating fibrosis. An antifibrotic composition, a method of preventing, ameliorating, or treating fibrosis by using CHP, and/or a use of CHP in the manufacture of the pharmaceutical composition for preventing or treating fibrosis are disclosed.
Type:
Application
Filed:
March 30, 2020
Publication date:
June 30, 2022
Applicants:
NOVMETAPHARMA CO., LTD., SEOUL NATIONAL UNIVERSITY HOSPITAL, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Inventors:
Hoe Yune JUNG, Heon Jong LEE, Jong Su JEON, Do Hyun LEE, Yon Su KIM, Seung Hee YANG, Yong Chul KIM, Jong Joo MOON, Ji Eun KIM
Abstract: Provided is a medical implant including: an implant base having a surface made of a silicon material; a linker having one end attached onto the surface of the implant base; and a cytokine bound to another end of the linker. By inducing the secretion of anti-inflammatory cytokines, a capsular contracture, which is one of the complications that may occur after transplantation of the patient's breast implant, may occur less.
Type:
Application
Filed:
December 11, 2019
Publication date:
June 30, 2022
Applicants:
SEOUL NATIONAL UNIVERSITY HOSPITAL, SOOKMYUNG WOMEN'S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
Inventors:
Chan Yeong HEO, Sun Young NAM, Mi Ji LEE, Byung Ho SHIN, Dong Sik SHIN, Seong Soo KIM
Abstract: A cyclo(His-Pro)(CHP) is useful for preventing, alleviating or treating peritoneal fibrosis. A pharmaceutical composition for preventing or treating peritoneal fibrosis, a dietary supplement composition for preventing or alleviating peritoneal fibrosis, and a peritoneal dialysis solution, which all contain CHP is disclosed. Also disclosed are a method for preventing or treating peritoneal fibrosis by using CHP, a peritoneal dialysis method using CHP, a use of CHP during the preparation of a pharmaceutical composition for preventing or treating peritoneal fibrosis, and/or a use of CHP in the preparation of a peritoneal dialysis solution.
Type:
Application
Filed:
March 30, 2020
Publication date:
June 23, 2022
Applicants:
NOVMETAPHARMA CO., LTD., SEOUL NATIONAL UNIVERSITY HOSPITAL, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
Inventors:
Hoe Yune JUNG, Do Hyun LEE, Heon Jong LEE, Yon Su KIM, Seung Hee YANG
Abstract: The present disclosure discloses a biomarker capable of predicting the therapeutic response to anticancer agents and prognosis of triple-negative breast cancer patients, and the use thereof. A biomarker according to the present disclosure allows the provision of optimized personal therapeutic methods through correct personalized treatment, contributing to the quality and prolongation of life of patients.
Type:
Grant
Filed:
March 8, 2018
Date of Patent:
May 24, 2022
Assignees:
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, INDUSTRY-ACADEMIC COOPERATION FOUNDATION OF SUNCHON NATIONAL UNIVERSITY, SEOUL NATIONAL UNIVERSITY HOSPITAL
Inventors:
Wonshik Han, Dong-Young Noh, Han-Byoel Lee, Eun-Kyu Kim, Ae-Kyung Park, Hyeong-Gon Moon
Abstract: Provided is a pulmonary edema monitoring apparatus, which is always attached to the body and is capable of continuously monitoring whether a pulmonary edema occurs, for a patient with advanced disease or a shock patient. This pulmonary edema monitoring apparatus includes: an ultrasound frequency module which is attached to the chest of a patient, generates an ultrasound, and receives a reflection wave reflected from the inside of a human body; and a control module which measures the intensity (this is referred to as “ultrasound radio frequency data”) of the reflection wave, determines whether a pulmonary edema occurs on the basis of an increasing rate of the ultrasound radio frequency data according to a degree of multiple reflection, and provides an alarm.
Type:
Grant
Filed:
December 21, 2018
Date of Patent:
February 15, 2022
Assignee:
SEOUL NATIONAL UNIVERSITY HOSPITAL
Inventors:
You Hwan Jo, Jae Hyuk Lee, Hyuk Sool Kwon
Abstract: Disclosed are a method for preparing induced pluripotent stem cells from endocardium-derived adult stem cells isolated from peripheral blood and a method for differentiating induced pluripotent stem cells into cardiovascular cells. The endocardium-derived adult stem cells are primary culture cells for preparing induced pluripotent stem cells, can be readily isolated and cultured only with a small amount of peripheral blood, have a high proliferation property so as to be storable without generic variation, and can rapidly ensure a cell number so as to be usable in cell therapy. The endocardium-derived adult stem cells have sternness, thereby having high preparation efficiency, and are derived from the endocardium so as to have the epigenetic memory of cardiovascular cells, thereby having an advantage of being able to be differentiated, after preparing induced pluripotent stem cells, into cardiovascular cells such as endothelial cells, smooth muscle cells and cardiomyocytes with a high efficiency.
Type:
Grant
Filed:
November 18, 2015
Date of Patent:
February 1, 2022
Assignee:
SEOUL NATIONAL UNIVERSITY HOSPITAL
Inventors:
Hyo-Soo Kim, Han-Mo Yang, Ju-Young Kim, Joo-Eun Lee