Patents Assigned to Seoul National University Hospital
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Publication number: 20210395214Abstract: The present invention relates to a novel Usnic acid derivative exhibiting an inhibitory effect on TSLP secretion or pharmaceutically acceptable salts thereof, and a use thereof.Type: ApplicationFiled: October 10, 2019Publication date: December 23, 2021Applicant: SEOUL NATIONAL UNIVERSITY HOSPITALInventors: Chan Yeong HEO, So Min KANG, Da som JEON
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Patent number: 11123409Abstract: Provided are a method of preventing and/or treating an eye disease, using a Cas9 protein and a guide RNA targeting VEGF-A, and a ribonucleoprotein including a Cas9 protein and a guide RNA targeting VEGF-A.Type: GrantFiled: July 27, 2017Date of Patent: September 21, 2021Assignees: INSTITUTE FOR BASIC SCIENCE, SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, SEOUL NATIONAL UNIVERSITY HOSPITALInventors: Jin-Soo Kim, Jeong Hun Kim, Sung Wook Park, Kyoungmi Kim
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Polypeptide derived from CAP1 and pharmaceutical composition comprising same as effective ingredient
Patent number: 11091515Abstract: The present invention relates to a polypeptide derived from CAP1 and a pharmaceutical composition comprising the same as an effective ingredient and, more particularly, to a peptide including the amino acid sequence of SEQ ID NO: 1, any 0 to 20 amino acid residues added to the N terminus thereof, and any 0 to 75 amino acid residues added to the C terminus thereof, and a pharmaceutical composition comprising the peptide as an effective ingredient for the prevention and alleviation of inflammatory diseases, the inhibition of cancer and cancer metastasis, the prevention and alleviation of diabetes, the prevention and alleviation of arteriosclerosis or cardiovascular diseases, and the prevention and alleviation of heart failure.Type: GrantFiled: January 31, 2018Date of Patent: August 17, 2021Assignee: SEOUL NATIONAL UNIVERSITY HOSPITALInventors: Hyo Soo Kim, Hyun Duk Jang, Sang Eun Lee -
Publication number: 20210214667Abstract: The bioenvironmental simulation device according to an embodiment of the present invention includes at least one mounting unit on which cells to be measured are placed, a rotational force application unit configured to rotate the mounting unit so as to apply a rotational force to the cells to be measured placed on the mounting unit, and a culture liquid flow device through which a culture liquid flows across the mounting unit, wherein the culture liquid flows by the culture liquid flow device so as to apply a shear force to the cells to be measured.Type: ApplicationFiled: December 10, 2019Publication date: July 15, 2021Applicants: Seoul National University R&DB Foundation, Seoul National University HospitalInventors: Seung Hee YANG, Yon Su KIM, Dong Ki KIM, Sa Ram LEE, Yong Chul KIM, Mi Yeon YU, Ji Eun KIM
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Patent number: 10947241Abstract: The present invention relates to a compound represented by Chemical Formula 1, or a pharmaceutically acceptable salt thereof. The compound according to the present invention can be usefully used for the prevention or treatment of cardiovascular diseases.Type: GrantFiled: October 27, 2017Date of Patent: March 16, 2021Assignee: Seoul National University HospitalInventors: Ja Kyung Yoo, Nora Lee, Chun Ho Lee, Myunggi Jung, Hyo-Soo Kim
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Publication number: 20210045916Abstract: A liquid medicine administration identifying device according to an embodiment of the present invention comprises: a body including a receiving space for receiving an administration container, through which a liquid medicine can be administrated; a sensing unit installed at the body to sense that the administration container is compressed or overturned; and a transmission unit for transmitting a sensing result of the sensing unit to the outside.Type: ApplicationFiled: February 1, 2019Publication date: February 18, 2021Applicants: SEOUL NATIONAL UNIVERSITY HOSPITAL, RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITYInventors: Tae Woo KIM, Tai Myoung CHUNG
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Patent number: 10881319Abstract: An apparatus for treating dizziness comprises an input unit configured to input a type of dizziness suffered by a patient, a storage unit configured to store different treatment methods respectively corresponding to different types of dizziness, an operation unit configured to search for a treatment method corresponding to the diagnosed type of dizziness among the treatment methods stored in the storage unit based on the diagnosed type of dizziness, and an output unit configured to output the searched treatment method for the inputted type of dizziness to the patient.Type: GrantFiled: June 15, 2015Date of Patent: January 5, 2021Assignee: Seoul National University HospitalInventors: Myung-Whan Suh, Jun Ho Lee, Seung Ha Oh, Chiheon Kwon, Joong Woo Ahn, Yunseo Ku, Hee Chan Kim
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Patent number: 10864383Abstract: The present disclosure relates to a respiratory gating system for inducing respiration of a patient during radiation therapy. A respiratory gating system according to one embodiment of the present disclosure comprises: an image management unit for acquiring an MRI image of a patient and processing the acquired image; and a projection unit for displaying the MRI image acquired and processed by the image management unit to the patient in real time, wherein the projection unit may be configured to project an image of a treatment area of the patient in real time using, as a screen, a bore of a radiotherapy equipment which is formed to surround the patient in order to acquire the MRI image.Type: GrantFiled: October 29, 2018Date of Patent: December 15, 2020Assignees: SEOUL NATIONAL UNIVERSITY HOSPITAL, PAPRICA Lab. Co., Ltd.Inventors: Hong Gyun Wu, Jong Min Park, Chang Heon Choi, Jung In Kim
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Publication number: 20200375449Abstract: A system for monitoring a volume of a bladder during a surgical procedure. The system includes one or more processors; and a memory that is communicatively coupled to the one or more processors and stores one or more sequences of instructions, which when executed by one or more processors causes steps to be performed comprising: receiving information of a maximum volume of the bladder before the surgical procedure; receiving one or more ultrasound images from an ultrasonic scanner; based on the one or more ultrasound images, determining a volume of the bladder; comparing a maximum volume of the bladder to the determined volume of the bladder; and responsive to a difference between the maximum volume and determine volume of the bladder exceeding a threshold, issuing a warning associated with the difference.Type: ApplicationFiled: August 19, 2020Publication date: December 3, 2020Applicant: SEOUL NATIONAL UNIVERSITY HOSPITALInventors: Seung-June OH, Hyoun-Joong KONG
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Patent number: 10786147Abstract: A system for controlling a pressure inside a bladder through an endoscope, where the distal end portion of the endoscope is located inside the bladder and the endoscope has an inlet port through which fluid to enter the bladder and an outlet port through which fluid in the bladder to exit the bladder. The system includes one or more processors that receive a first signal from a first pressure sensor installed in a first fluid passageway that is in fluid communication with the inlet port; receives a second signal from a second pressure sensor installed in a second fluid passageway that is in fluid communication with the outlet port; and based on at least one of the first and second signals, actuates a valve installed in the first fluid passageway of fluid so as to adjust the flow rate into the bladder through the inlet port.Type: GrantFiled: June 17, 2018Date of Patent: September 29, 2020Assignee: SEOUL NATIONAL UNIVERSITY HOSPITALInventors: Seung-June Oh, Hyoun-Joong Kong
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Publication number: 20200292553Abstract: The present invention relates to a composition for predicting or diagnosing a liver disease, and a liver disease prediction or diagnosis method using same, and more specifically, to a marker for predicting or diagnosing liver fibrosis in non-alcoholic fatty liver disease (NAFLD), and a prediction or diagnosis method using same. By using the composition for predicting or diagnosing a liver disease, according to the present invention, the level of the GDF15 protein, having a positive correlation with liver fibrosis in NAFLD, may be checked, and thus an effect is achieved whereby same may be effectively used for predicting and diagnosing liver fibrosis in NAFLD.Type: ApplicationFiled: August 20, 2018Publication date: September 17, 2020Applicant: Seoul National University HospitalInventor: Won KIM
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COMPOSITION FOR SURFACE MODIFICATION OF MEDICAL IMPLANT AND MEDICAL IMPLANT SURFACE-MODIFIED THEREBY
Publication number: 20200268937Abstract: Disclosed are a composition for surface modification of a medical implant and a medical implant surface-modified thereby, and according to a medical implant according to one embodiment, itaconic acid may be bound to the surface of the medical implant with high binding stability, and fibrosis inhibition and inflammatory response inhibition effects at an implantation site are exhibited.Type: ApplicationFiled: July 18, 2018Publication date: August 27, 2020Applicant: SEOUL NATIONAL UNIVERSITY HOSPITALInventors: Chan Yeong Heo, Han Soo Park, Byung Hwi Kim, Byung Ho Shin, Jung Hee Shim, Mallinath S Birajdar, Hyun Joo Cho, Chanutchamon Sutthiwanjampa -
Publication number: 20200268302Abstract: A non-transitory tangible computer-readable medium or media include one or more sequences of instructions which, when executed by one or more processors, causes steps to be performed, where the steps include receiving data obtained from baseline clinical evaluation and a urodynamic test for a patient, the diagnostic engine having been trained to associate a data obtained from a urodynamic test with one or more lower urinary tract dysfunction; extracting one or more features from the received data; identifying one or more urodynamic parameters of the patient's lower urinary tract dysfunction, based on the one or more extracted features; and generating an output that includes information of one or more lower urinary tract dysfunction associated with the one or more identified urodynamic parameters.Type: ApplicationFiled: September 10, 2019Publication date: August 27, 2020Applicant: SEOUL NATIONAL UNIVERSITY HOSPITALInventor: Seung-June Oh
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Patent number: 10722202Abstract: The present invention comprises: a first X-ray irradiation apparatus and a second X-ray irradiation apparatus for irradiating a subject with X-rays; an X-ray generation unit supporting so that first and second X-rays irradiated onto the subject are detected by a set detector when the subject is irradiated with the first and second X-rays from the first and second X-ray irradiation apparatuses, respectively; and a mode selection unit for allowing selection of any one mode from among a 2D imaging mode and 3D imaging mode, wherein the angles with respect to the subject of the first and second X-ray irradiation apparatuses are determined on the basis of said any one mode selected by means of the mode selection unit from among the 2D imaging mode and 3D imaging mode. According to the present invention, the mode can be easily selected according to need from among the 2D imaging mode and 3D imaging mode.Type: GrantFiled: April 26, 2017Date of Patent: July 28, 2020Assignee: Seoul National University HospitalInventors: Chang Hwan Yoon, Dong Hoon Han
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Patent number: 10682054Abstract: The present disclosure relates to an apparatus for angiographic optical coherence tomography in the retina or the choroid, and a method for diagnosing diseases by using the same and, more specifically, to: an apparatus for angiographic optical coherence tomography in the retina and the choroid, capable of diagnosing, at an early stage, shock states or diseases such as those of sepsis by quickly and objectively recognizing the low perfusion of tissue; and a diagnostic method using the same.Type: GrantFiled: July 31, 2018Date of Patent: June 16, 2020Assignees: SEOUL NATIONAL UNIVERSITY HOSPITAL, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Wangyuhl Oh, Jang Ryul Park, Kyuseok Kim
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Patent number: 10674924Abstract: Systems and methods for mapping a cavernous nerve near an organ. The system includes: one or more processors; and a memory that is communicatively coupled to the one or more processors and stores one or more sequences of instructions, which when executed by one or more processors causes steps to be performed comprising: applying an excitation signal to an electrode at a tip of an laparoscope, the tip being configured to contact a point on a tissue near an organ; responsive to the excitation signal, measuring a change in a signal from a pair of electrodes configured to be installed on the penis, the change in the signal being associated with an erectile function of the penis; and based on the change in the signal from the pair of electrodes, determining a distance between the point on the tissue and a cavernous nerve near the organ.Type: GrantFiled: February 22, 2018Date of Patent: June 9, 2020Assignee: SEOUL NATIONAL UNIVERSITY HOSPITALInventors: Chang Wook Jeong, Keewon Kim
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Publication number: 20200126665Abstract: Provided are a device, a method, and a computer program for self-diagnosis and treatment of benign paroxysmal positional vertigo, which is for, when a patient with benign paroxysmal positional vertigo develops or appeals symptoms, immediately, easily and accurately diagnosing the symptoms by patients themselves using a sequential and efficient self-diagnosis algorithm associated with an optimized self-diagnosis questionnaire data without temporal or spatial constraints, and presenting an optimal treatment method, so as to allow the patients to receive appropriate on-site treatments. The present disclosure is effective in not only immediate treatment of benign paroxysmal positional vertigo, but also reducing medical expenses and additional social costs incurred for treatments of dizziness.Type: ApplicationFiled: October 25, 2019Publication date: April 23, 2020Applicant: SEOUL NATIONAL UNIVERSITY HOSPITALInventors: Ji-Soo Kim, Hyo-Jung Kim
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Patent number: 10611720Abstract: Provided are a compound represented by the following Formula I, or a solvate, stereoisomer, or pharmaceutically acceptable salt thereof, and a composition for preventing or treating hair loss, the compound including the compound as an active ingredient:Type: GrantFiled: January 31, 2018Date of Patent: April 7, 2020Assignees: UNIST (ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY), Seoul National University HospitalInventors: Mi Hee Lim, Sang Tae Kim, Ho Seong Han
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Patent number: 10597362Abstract: The present invention relates to a compound represented by Chemical Formula 1, or a pharmaceutically acceptable salt thereof. The compound according to the present invention can be usefully used for the prevention or treatment of cardiovascular diseases.Type: GrantFiled: October 27, 2017Date of Patent: March 24, 2020Assignee: Seoul National University HospitalInventors: Ja Kyung Yoo, Nora Lee, Chun Ho Lee, Hyo-Soo Kim
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Patent number: 10588906Abstract: Provided herein is a method of preventing hair loss or promoting hair growth, the method including administering an effective amount of a PDE 3 inhibitor. More particularly, when the method of the present disclosure is used, an excellent hair loss prevention or hair growth promotion effect is obtained by inhibiting the activity of PDE 3.Type: GrantFiled: July 25, 2018Date of Patent: March 17, 2020Assignee: SEOUL NATIONAL UNIVERSITY HOSPITALInventors: Ohsang Kwon, Hye-In Choi, Seong Jin Jo, Kyu Han Kim