Abstract: There is provided a system and method for managing a case database that can enhance the quality of information to be registered. Once a user performs an operation to request registration of a case, it is first searched whether or not a case that can be determined to be similar to the case has already been registered in a case database. A result of the search is then reported, while executable processing options determined based on the result of the search are also reported. If the case that can be determined to be similar has already been registered, the executable processing options include processing of registering as a new case, processing of registering by adding into an existing case, and processing of cancelling registration. If the case that can be determined to be similar has not been registered, the executable processing options include processing of registering as a new case and processing of cancelling registration.

Abstract: Described herein is a method for simulating indoor illuminance which includes preparing an intrinsic optical property function of a bidirectional transmittance function and a bidirectional reflectivity function based on values actually measured for each plate-shaped optical member; for a skylight constructed by combining a plurality of those optical members, creating an optical physical model based on the intrinsic optical property function and the construction mode of each optical member constituting the skylight; calculating the skylight light distribution data for daylight, which is introduced through the skylight, by using the optical physical model; and simulating the indoor illuminance, which would be provided by actually installing the skylight, on the basis of the light distribution data. The simulation is performed on a computer system which has stored the intrinsic optical property function of each optical member in a database.

Abstract: The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and R1 to R8 and R34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like), or a pharmacologically acceptable salt thereof.

Abstract: Disclosed are an antitumor preparation comprising a combination of (1) a combination drug of tegafur/gimeracil/oteracil potassium, (2) at least one ingredient selected from the group consisting of folinic acid and pharmacologically acceptable salts thereof, and (3) cis-oxalate(1R,2R-diaminocyclohexane)platinum(II); a kit comprising a combination of pharmaceutical compositions for treating cancer in a mammal, comprising: (a) a combination drug of tegafur/gimeracil/oteracil potassium in a therapeutically effective amount; (b) a composition containing at least one ingredient selected from the group consisting of folinic acid and pharmacologically acceptable salts thereof in an amount effective for enhancing antitumor effects, and (c) a composition containing cis-oxalate(1R,2R-diaminocyclohexane)platinum(II) in an amount effective for enhancing antitumor effects; and a method for treating cancer.

Abstract: A case image search apparatus according to the presently disclosed subject matter includes: an input unit for inputting a diagnostic object image group from an imaging apparatus; an estimation unit for estimating attributes of a diagnostic object image included in the diagnostic object image group on the basis of the diagnostic object image; a calculation unit for calculating a first feature amount which is a feature amount of the diagnostic object image corresponding to the attribute estimated by the estimation unit; and a search unit for searching a database for a similar case image group similar to the diagnostic object image group by comparing the first feature amount with a second feature amount which is a feature amount of a case image included in the case image group stored in the database corresponding to the attribute estimated by the estimation unit.

Abstract: Provided are a sulfated C-glycoside which is a novel compound serving as a precursor of chafuroside and chafuroside analogs; a method for efficiently producing the sulfated C-glycoside; and a method for efficiently producing chafuroside and chafuroside analogs using said sulfated C-glycoside. A sulfated C-glycoside represented by general formula (A1) or (B1) [wherein R1, R2 and R3 independently represent each a hydrogen atom or an OH group] is obtained by extracting tea leaves or tea tannins with water, a lower alcohol solvent having 1 to 3 carbon atoms or a liquid mixture comprising the same. Alternatively, the sulfated C-glycoside is produced by reacting a flavone C-glycoside such as isovitexin or vitexin with a sulfate group-introducing agent to thereby sulfate the flavone C-glycoside. By heating the sulfated C-glycoside thus obtained, chafuroside and chafuroside analogs are efficiently produced.

Abstract: Provided is a 1,3,4-oxadiazole-2-carboxamide compound which has STAT3 inhibitory activity and is useful as an anticancer agent. Provided is a 1,3,4-oxadiazole-2-carboxamide compound represented by formula (I) or a pharmacologically acceptable salt thereof (in the formula, Ar represents a furyl group or the like; R1 represents a hydrogen atom or the like; and —X—Y represents a diaryl group such as a biphenyl group).

Abstract: An agent having antiallergic effects is provided, which is easily produced and ingested. A solvent extract of green soybean is used as an antiallergic agent. A solvent extract of green soybean having the effect of suppressing IgE production and the effect of shifting the Th1-Th2 balance to the Th1 side is useful as an antiallergic agent.

Abstract: Case images are registered so as not to cause bias (or partiality or imbalance) in amounts of feature of the case images included in a database of a similar image search system for image diagnosis. Since registration of the case images to the database is controlled according to degrees of similarity of the amounts of feature, it is possible to prevent a lot of similar case images from being included in the search result. Thus, it is possible to reduce possibility of representing a similar search result which may interfere with an accurate diagnosis by a diagnostician.

Abstract: This invention provides a laser marking method that can form a very minute mark of a predetermined shape, such as a letter or pattern, with clarity and high solidity, on the surface of a substrate. The laser marking method of the invention comprises the steps of (1) depositing a coloring material on the surface of a substrate of thermoplastic material to form a thin film of the coloring material, and (2) applying a laser beam to the thin film of the coloring material in conformity with a predetermined marking shape to cause the portions of the substrate irradiated with the laser beam to soften and to cause the thus softened portions to mix with the coloring material, thereby developing the predetermined marking shape on the surface of the substrate.

Abstract: Rice grains are soaked in water to give a rice-grain soaked liquid to allow the rice grains to absorb water and the entire rice-grain soaked liquid is then charged into a mill to mill the rice grains to prepare finely-divided rice grains containing water absorbed therein and the finely-divided rice grains form a rice paste containing free water present therebetween; the finely-divided rice grains in the rice paste can be fine; and, in addition, since free water is involved upon milling, deterioration of components by heat can be avoided. In addition, the finely-divided rice grains can remain in a water-absorbed state, and damage of finely-divided rice grains (starch simple grains) by drying can be avoided. In addition, since free water increases affinity between a kneaded product of a different kind of cereal flour or other ingredients and the rice paste, mixing thereof can be rapidly carried out.

Abstract: This invention provides a reagent for protein electrophoresis, an electrophoresis gel or buffer composition containing the reagent, and a protein separation method and an electrophoresis kit using the reagent and the composition.

Abstract: The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and R1 to R8 and R34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like.), or a pharmacologically acceptable salt thereof.

Abstract: Disclosed are an antitumor preparation comprising a combination of (1) a combination drug of tegafur/gimeracil/oteracil potassium, (2) at least one ingredient selected from the group consisting of folinic acid and pharmacologically acceptable salts thereof, and (3) cis-oxalate(1R,2R-diaminocyclohexane)platinum(II); a kit comprising a combination of pharmaceutical compositions for treating cancer in a mammal, comprising: (a) a combination drug of tegafur/gimeracil/oteracil potassium in a therapeutically effective amount; (b) a composition containing at least one ingredient selected from the group consisting of folinic acid and pharmacologically acceptable salts thereof in an amount effective for enhancing antitumor effects, and (c) a composition containing cis-oxalate(1R,2R-diaminocyclohexane)platinum(II) in an amount effective for enhancing antitumor effects; and a method for treating cancer.

Abstract: Disclosed are: a method for identifying/analyzing a gene for an antibody in one cell derived from a human; a technique for producing an antibody derived from an identified one B cell; and others. A gene for an antibody specific to a melanoma antigen is analyzed/identified at a one-cell level by using an immortalized B cell produced from peripheral blood monocytes from a melanoma patient or a primary B cell included in the peripheral blood monocytes. It is found that B cells capable of producing a specific antibody can be separated on one cell by one cell basis by staining the B cells with a GST-labeled melanoma-specific cancer antigen MAGE1, an Alexa-labeled anti-GST antibody and a PE-labeled anti-human IgG antibody and carrying out the single cell sorting of the stained B cells. Further, a practical technique for extracting total RNA from the separated one B cell and cloning a gene for a specific antibody into the total RNA efficiently can be established.

Abstract: A case image search apparatus according to the presently disclosed subject matter includes: an input unit for inputting a diagnostic object image group from an imaging apparatus; an estimation unit for estimating attributes of a diagnostic object image included in the diagnostic object image group on the basis of the diagnostic object image; a calculation unit for calculating a first feature amount which is a feature amount of the diagnostic object image corresponding to the attribute estimated by the estimation unit; and a search unit for searching a database for a similar case image group similar to the diagnostic object image group by comparing the first feature amount with a second feature amount which is a feature amount of a case image included in the case image group stored in the database corresponding to the attribute estimated by the estimation unit.

Abstract: Case images are registered so as not to cause bias (or partiality or imbalance) in amounts of feature of the case images included in a database of a similar image search system for image diagnosis. Since registration of the case images to the database is controlled according to degrees of similarity of the amounts of feature, it is possible to prevent a lot of similar case images from being included in the search result. Thus, it is possible to reduce possibility of representing a similar search result which may interfere with an accurate diagnosis by a diagnostician.

Abstract: An inexpensive scanning irradiation device of a particle beam is obtained without using a rotating gantry. A first scanning electromagnet and a second scanning electromagnet, whose deflection surfaces of the particle beam are the same, and which bend the particle beam having an incident beam axis angle of approximately 45 degrees relative to a horizontal direction in reverse directions to each other; an electromagnet rotation driving mechanism which integrates the first and the second scanning electromagnets and rotates these scanning electromagnets around the incident beam axis; and a treatment bed are provided. The particle beam deflected by the first and the second scanning electromagnets can be obtained at a range of ?45 degrees to +45 degrees in deflection angle from an incident beam axis direction.

Abstract: A method of rearing, cultivating or stocking crustacea, and crustacea reared, cultivated or stocked by the method. The method improves the survival rate and survival period of the crustacea. In the method, the crustacea are reared, cultivated or stocked within a deep sea water drawn from the sea at a depth of above 100 meters. The crustacea may be deep sea crustacea living in the sea at a depth of above 100 meters. The crustacea do not include crustacea living in the Sea of Japan at a depth of above 250 meters. The deep sea water may have a temperature of below 20° C.

Abstract: A method of rearing, cultivating or stocking crustacea, and crustacea reared, cultivated or stocked by the method. The method improves the survival rate and survival period of the crustacea. In the method, the crustacea are reared, cultivated or stocked within a deep sea water drawn from the sea at a depth of above 100 meters. The crustacea may be deep sea crustacea living in the sea at a depth of above 100 meters. The crustacea do not include crustacea living in the Sea of Japan at a depth of above 250 meters. The deep sea water may have a temperature of below 20° C.