Abstract: Provided is a crystal of a novel pyrido[3, 4-d]pyrimidine derivative having excellent CDK 4/6 inhibitory activity. A crystal of a compound represented by formula (I). In the formula, R1 represents a hydrogen atom or a C1-3 alkyl group; R2 represents a hydrogen atom or an oxo group; L represents a single bond or a C1-3 alkylene group; and X represents CH or N.

Abstract: An object of the present invention is to provide a chair-type phototherapy device that enables a patient to perform light irradiation accurately targeted at a treatment site in a seated position on a chair and consequently achieves effective phototherapy even when the treatment site is in the back region that the patient is unable to see, for example, as in light irradiation for dysuria patients and patients with pain, and the patient performs light irradiation by himself/herself at home. The present invention provides a chair-type phototherapy device having a seat on which a patient is seated. The chair-type phototherapy device includes a radiation module configured to emit radiation light toward a living body, a drive module positioned behind the patient for moving the radiation module, and a fixing module fixing the drive module to the seat.

Abstract: The purpose of the present invention is to provide a compound that has excellent CDK4/6 inhibitory activity. The present invention is a compound represented by formula (I) or a pharmaceutically acceptable salt of the compound.

Abstract: A training device suppresses unintended operation of an operation rod when executing an operation mode in which operation of the operation rod is controlled based on a force applied to the operation rod. The training device includes the operation rod, a motor, a force detector, a rotation information output sensor, a first command calculator, and a force corrector. The operation rod moves a limb. The motor operates the operation rod in a direction of degree of freedom. The force detector detects a force component and outputs a force component signal. The rotation information output sensor detects an operation position of the operation rod in a corresponding direction of degree of freedom. The force corrector calculates a corrected force component value based on operation positions of the operation rod and force component signal. The first command calculator calculates a first motor control command based on the corrected force component value.

Abstract: Provided is an oxygen concentrator provided with a control means for recovering an oxygen concentration to a level suitable for treatment in an extremely short period of time by selecting an optimum purge time corresponding to the deterioration state of an adsorbent, wherein judgment of moisture-absorption deterioration is performed when the detected value of the oxygen concentration sensor is equal to or less than a control value of the oxygen concentration in the oxygen-enriched gas and the detected value of the pressure sensor is equal to or more than an adsorption pressure at which the oxygen concentration increases significantly before and after the control to reduce the purge time, and control of reducing a time for the purge step shorter than a preset time is performed.

Abstract: The present invention is an endoscope hemostatic material comprising a sheet-like nonwoven fabric that is formed from a hydrophobic material that has a bulk density of 40 to 110 mg/cm3 and a film thickness of 400 to 1400 ?m, and also an endoscope hemostatic material comprising a sheet-like nonwoven fabric that is formed from a hydrophobic material and that has an area density of 5.0 to 11.0 mg/cm3 and an average fiber diameter of 0.5 to 0.8 ?m, either of which is suitable for treatment of bleeding through an endoscope.

Abstract: The purpose of the present invention is to provide an antibody that can be expected to have a therapeutic effect in autoimmune diseases and anticancer treatment by inhibiting S1P transport by SPNS2 to thereby inhibit lymphocyte migration. The present invention is an SPNS2 neutralizing antibody or a fragment thereof, or a derivative thereof, that specifically binds to vertebrate SPNS2 and has lymphocyte migration inhibitory activity through SW transport inhibition.

Abstract: A phototherapy device including: an irradiation probe for radiating irradiation light toward a living body; a probe fixing unit into which the irradiation probe is inserted and at the same time fixed on a living body; an observation module placed on the probe fixing unit and provided with an observation means for observing an irradiation site irradiated with irradiation light which is radiated to the living body; and a moving means capable of moving the observation module to a space where the irradiation probe is to be placed in the probe fixing unit during observation of the irradiation site.

Abstract: The oxygen therapy system receives data for an elapsed time such as a flow rate value of the oxygen gas, and a blood oxygen level or a level of carbon dioxide partial pressure in arterial blood (PaCO2) of a user, from the oxygen supply device which controls a flow rate of the oxygen gas for inhalation based on the blood oxygen level or the carbon dioxide partial pressure in arterial blood (PaCO2) of the user so that the blood oxygen level or level of carbon dioxide partial pressure in arterial blood (PaCO2) is in a prescribed range.

Abstract: The invention provides methods for using and compositions of humanized antibodies that bind tau protein that is phosphorylated at the serine at position 413.

Abstract: A server 20 for monitoring of the state of use of an oxygen concentrator 10 that concentrates oxygen in air and supplies it to a user, comprises a communication unit 25, and a processing unit 21 that uses the communication unit 25 to receive operation data indicating the state of operation of the oxygen concentrator 10 and usage data for the state of use by the user using the oxygen concentrator 10, measured by a measuring apparatus 11, 12, while also generating message information when either or both the usage data and operation data fail to satisfy the monitoring conditions, and sending the message information together with the usage data and operation data, using the communication unit 25.

Abstract: The purpose of the present invention is to provide a miniaturized excitation coil with increased safety as an excitation coil used in magnetic stimulation therapy. The present invention provides an excitation coil having a spiral conductive wire part that generates a magnetic field, characterized by the conductive wire end faces of the spiral conductive wire part being parallel with respect to the central axis of the excitation coil.

Abstract: The present invention is intended to provide a nose drop having high absorption of peptide hormone oxytocin or an acid addition salt thereof, or a derivative thereof through nasal mucosa and little safety concern. The present invention is a pharmaceutical composition for administration to nasal mucosa containing oxytocin or an acid addition salt thereof, or a derivative thereof and a carboxyvinyl polymer, characterized by having an osmotic pressure ratio less than 1.

Abstract: A nozzle device for spinning comprising a nozzle, a polymer solution supply means that supplies a polymer solution to the nozzle and ejects the polymer solution from the nozzle tip, and a solvent vapor supply means that supplies a gas containing vapor of the same solvent as the solvent of the polymer solution at least to the vicinity of the polymer solution just ejected, and a spinning method using the nozzle device for spinning. Solidification of a spinning solution is prevented at the nozzle tip from which the spinning solution is ejected.

Abstract: The invention provides methods for using and compositions of humanized antibodies that bind tau protein that is phosphorylated at the serine at position 413.

Abstract: A compound, represented by the following formula or a medically acceptable salt thereof, having an effect of regulating the activity of an androgen receptor. In the formula, X represents S, O; Z represents (Ra)n-A-(CR13R14)0-1—(CR11R12)0-1; A represents aryl, heteroaryl; R1 represents alkyl, cycloalkyl, alkenyl, alkynyl, alkoxyalkyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl; R2 represents hydrogen, halogen, alkyl, cycloalkyl, phenyl; R3 represents hydrogen, halogen, alkyl, cycloalkyl, alkoxyalkyl, alkenyl, alkynyl, cycloalkenyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl, acyl, cycloalkylcarbonyl, benzoyl, spiroalkyl, adamantyl, silyl, R31R32NCO—; R4 and R5 represent hydrogen, halogen, alkyl, phenyl, and cycloalkyl.

Abstract: Provided is a training device capable of executing a plurality of operation modes, in which an operation rod is appropriately operated according to an operation mode. The training device includes the operation rod, a plurality of motors, a plurality of force detection units, and a plurality of first command calculation units. The operation rod allows a limb to move. The plurality of motors operate the operation rod in the direction of degree of freedom in which the operation rod can move. Each of the force detection units detects a corresponding force component and outputs a force component signal. The first command calculation units are connected to the corresponding force detection units. Each of the first command calculation units calculates a first motor control command on the basis of the corresponding force component signal.

Abstract: An operation teaching device used in operation teaching during movement and/or rotation operation of an object (2h) to adjust the object to a predetermined position and direction, including: a TOF type depth image camera (40) for obtaining three-dimensional shape information about the object; extraction means for extracting a feature region from the three-dimensional shape information acquired by the TOF type depth image camera (40) using a luminance image of the object obtained from information about light receiving intensity of the projection light, the projection light being reflected from the object and received with light receiving means; and generation means for generating information for the operation teaching by calculating a deviation between the three-dimensional shape information including the feature region of the object in the predetermined position and direction and the three-dimensional shape information including the feature region of the object in a current position and direction.

Abstract: [PURPOSE] The invention provides a novel therapeutic agent or prophylactic agent for cognitive disorders. [SOLUTION MEANS] The invention provides an antibody that participates in antigen-antibody reaction specifically with tau protein that has been phosphorylated in the vicinity of Ser413 of SEQ ID NO: 1, and a therapeutic agent or prophylactic agent for cognitive disorders comprising as an active ingredient a peptide that has been phosphorylated in the vicinity of Ser413.

Abstract: Provided is an exacerbation prediction device equipped with a respiration sensing means of continuously sensing respiration data of a patient, a calculation means of calculating stable respiration data that are respiration data during a condition in which a respiratory rate is lowered and stable for a certain period of time from the sensed continuous respiration data of the patient, and a prediction means of predicting occurrence of an acute exacerbation in the patient in accordance with the stable respiration data calculated during a certain period of time.