Abstract: The present invention provides an anti-IGF-I receptor antibody that binds specifically to an IGF-I receptor of a vertebrate and has the proliferation-inducing activity of a vertebrate-derived cell, or a fragment thereof, or derivatives of these.

Abstract: The oxygen supply device supplying a user with an oxygen gas for inhalation comprises: a first sensor unit acquiring information on percutaneous arterial oxygen saturation (SpO2) of the user, a second sensor unit acquiring information on respiratory frequency per minute (BPM), and a control unit. Under the condition where the SpO2 level acquired by the first sensor unit is equal to or larger than the predetermined first threshold and the BPM value acquired by second sensor unit is equal to or larger than the predetermined second threshold, the control unit regards the condition as a possible sign of CO2 narcosis that exhibits an increase in PaCO2 level, and thus judges the condition as an abnormal sign. Then the control unit executes controls such as stopping supply of the oxygen gas to the user, and the like.

Abstract: A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.

Abstract: The invention provides methods for using and compositions of humanized antibodies that bind tau protein that is phosphorylated at the serine at position 413.

Abstract: A respiratory information acquisition device used for a PSA type oxygen concentration device that switches and uses multiple adsorption cylinders includes a respiratory information acquisition means of measuring a first pressure of a periodic pressure fluctuation in an oxygen supply path when oxygen is supplied to a patient from the PSA type oxygen concentration device and a second pressure of a periodic pressure fluctuation in the oxygen supply path when oxygen is not supplied to the patient from the PSA type oxygen concentration device, a phase confirmation means of matching phases of the first pressure and the second pressure, and a subtraction processing means of calculating a difference between the first pressure and the second pressure in the condition where the phases are matched.

Abstract: The device of the invention is equipped with a pressure sensor and a control unit, and the control unit judges a point at which a pressure gradient calculated from a signal of the pressure sensor becomes larger than a pressure gradient threshold as an inspiration sensing point and starts respiratory gas supply. In addition, the device judges from a frequency of the inspiration sensing point during predetermined time whether a pressure gradient threshold used as a criterion for the inspiration sensing point corresponds to an activity state of the user, and when the pressure gradient threshold does not correspond to the activity state, switches the pressure gradient threshold to another threshold and thus fits the pressure gradient threshold to the activity state.

Abstract: The present invention pertains to a therapeutic drug or prophylactic drug for diabetic nephropathy, said drug comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract: The purpose of the present invention is to provide a compound that has excellent CDK4/6 inhibitory activity. The present invention is a compound represented by formula (I) or a pharmaceutically acceptable salt of the compound.

Abstract: The present inventors generated modified antibodies in which several Fc domains are linked in tandem to the C terminus of the heavy chain, and modified antibodies in which Fc domains are linked in tandem via spacers, and measured the affinity for Fc receptors, CDC activity, and ADCC activity. A previous report indicated that CDC activity is not enhanced by linking multiple Fcs. However, the modified antibodies of the preset invention exhibited enhanced ADCC activity. The methods of the present invention enable provision of antibody pharmaceuticals having a marked therapeutic effect.

Abstract: A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.

Abstract: A magnetic stimulation device includes an excitation coil, a coil driving power supply configured to supply a current having a specific current waveform pattern to the excitation coil, and a coil type detection device configured to distinguish a type of the excitation coil connected to the coil driving power supply, among a plurality of excitations coils. The coil driving power supply includes a control unit configured to control the coil driving power supply to select the specific current waveform pattern among a plurality of current waveform patterns predetermined for each of the plurality of excitation coils, based on the type of the excitation coil distinguished by the coil type detection device and supply the current with the specific current waveform pattern to the excitation coil.

Abstract: A rehabilitation assistance device (1), provided with: an arm part (30) having a holding part (20) for holding a part of the upper limb or the lower limb of a user, the arm part (30) movably supporting the holding part (20); a memory unit (80) for storing training information, the memory unit (80) storing first training information defined in advance; a motion information acquisition unit (61) for acquiring motion information associated with the movement of the holding part (20), the motion information acquisition unit (61) acquiring first motion information for the holding part (20) moved on the basis of the first training information; a motion evaluation unit (72) for generating evaluation information in which the motion information is evaluated, the motion evaluation unit (72) evaluating the first motion information and generating first evaluation information; and a display (40) for displaying at least one of the training information, the motion information, and the evaluation information.

Abstract: The purpose of the invention is to provide a transcranial magnetic stimulation system capable of guiding a patient into an optimum posture for treatment. The system 1 of the invention includes an optical device 502 for projecting a light spot 805 to a head of a patient and detecting a reflection light of the light spot; a memory means 71 for memorizing information included in the reflection light detected by the optical device as a reference information when the projected light spot on the patient overlaps a marking (800) provided on the patient; a calculation means 72 for using the reference information memorized in the memory means and a comparison information included in the reflection light of the light spot to calculate an overlap ratio between the marking and the light spot corresponding to the comparison information; and a display means 504 for displaying the overlap ratio.

Abstract: A rehabilitation assistance device (1), provided with: an arm part (30) having a holding part (20) for holding a part of the upper limb or the lower limb of a user, the arm part (30) movably supporting the holding part (20); a memory unit (80) for storing training information, the memory unit (80) storing first training information defined in advance; a motion information acquisition unit (61) for acquiring motion information associated with the movement of the holding part (20), the motion information acquisition unit (61) acquiring first motion information for the holding part (20) moved on the basis of the first training information; a motion evaluation unit (72) for generating evaluation information in which the motion information is evaluated, the motion evaluation unit (72) evaluating the first motion information and generating first evaluation information; and a display (40) for displaying at least one of the training information, the motion information, and the evaluation information.

Abstract: Provided is a magnetic stimulation device, which does not feel hot to the user. The magnetic stimulation device (1) comprises: a contact plate (2) to be disposed near the user's head; an exciting coil (3) to be held above the contact plate (2); a casing (4), which covers at least the upper side of the exciting coil (3), in which openings (17, 18) are provided above the center of the exciting coil (3) winding, and in which a gap that is open on the outside of the exciting coil (3) is formed between the casing and the contact plate (2); and a suction fan (5) for drawing out air between the contact plate (2) and the casing (4) from the openings (17, 18) of the casing (4).

Abstract: Provided is a therapeutic electromagnetic stimulation device applying a magnetic field to an object person. The device includes a magnetic field generating means, a magnetic field detecting means, and a data generating means configured to generate custom data pairs for an individual object person. The data generating means is configured to generate the custom data pairs using: a result of detection of intensities in a state in which the magnetic field generating means are disposed respectively at a plurality of sampling spots near a specific site of the object person, and a plurality of parent data pairs each including (a) at least information of a three-dimensional position of the magnetic field generating means pairing with (b) information of the intensities of the corresponding components of the magnetic field at a position having at least the information of the three-dimensional position, and the information (a) and (b) is previously recorded.

Abstract: The present invention provides an intraorally rapidly disintegrating tablet that can be formed using an ordinary apparatus, that has hardness with no practical problem and that disintegrates rapidly with good feeling in the oral cavity. The present invention is intraorally rapidly disintegrating tablet produced by compression molding of a granule coated with a disintegrant, in which the granule contains a disintegrant also inside thereof and a drug except ambroxol hydrochloride inside and/or outside thereof.

Abstract: The present invention is directed to rapid positioning assistance for a mechanical section of a transcranial magnetic stimulation system. This transcranial magnetic stimulation system comprises a coil section 11 that is in contact with or in the vicinity of the head of the subject, and a mechanical section 30 that supports the coil section 11. The mechanical section 30 includes a plurality of adjustment mechanisms that adjust position of a plurality of movable members, and determines position and attitude of the coil section 11 by adjustment using the plurality of adjustment mechanisms. Receiving means receives desired change for at least one of position and attitude of the coil section 11. Guidance means provides guidance of an adjustment procedure for at least one of the plurality of adjustment mechanisms so as to realize adjustment corresponding to the desired change that has been received.

Abstract: Provided is a configuration capable of executing a detection test for a comfort level including the quality of sleep, which is measurable at home without requiring the measurement of brain waves or electrocardiogram. The respiratory waveform of a subject during sleep is continuously measured and recorded from the respiratory gas flow, etc., and is window-Fourier transformed at each measurement time to generate a frequency spectrum, and a bandwidth including a respiratory frequency is extracted. The index indicating the regularity of the respiratory period of the subject is also calculated at each time point during the sleep, and the time-dependency of this index during the sleep is represented as a graph. A medical device includes a sleep evaluation system equipped with a control means for performing control so that a sleep cycle repeated at a cycle of about 90 minutes is clearly observed if the comfort level including the quality of sleep of the subject is favorable.

Abstract: Provided is a configuration capable of executing a detection test for a comfort level including the quality of sleep, which is measurable at home without requiring the measurement of brain waves or electrocardiogram. The respiratory waveform of a subject during sleep is continuously measured and recorded from the respiratory gas flow, etc., and is window-Fourier transformed at each measurement time to generate a frequency spectrum, and a bandwidth including a respiratory frequency is extracted. The index indicating the regularity of the respiratory period of the subject is also calculated at each time point during the sleep, and the time-dependency of this index during the sleep is represented as a graph. A medical device includes a sleep evaluation system equipped with a control means for performing control so that a sleep cycle repeated at a cycle of about 90 minutes is clearly observed if the comfort level including the quality of sleep of the subject is favorable.