Patents Assigned to Teikoku Pharma USA, Inc.
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Transdermal Systems for the Delivery of Therapeutic Agents Including Granisetron Using Iontophoresis
Publication number: 20130245537Abstract: A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.Type: ApplicationFiled: May 13, 2013Publication date: September 19, 2013Applicant: Teikoku Pharma USA, Inc.Inventors: Carter R. Anderson, Walter L. Sembrowich, Russell L. Morris, Robert Cohen -
Patent number: 8535711Abstract: The potential for environmental release of unused and expired medications is reduced by the provision of a system and method for combining the unused or expired medication with an amount of activated carbon as part of a disposal procedure.Type: GrantFiled: March 26, 2009Date of Patent: September 17, 2013Assignee: Teikoku Pharma USA, Inc.Inventors: Carter R. Anderson, Russell L. Morris
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Patent number: 8535692Abstract: Local anesthetic emulsion compositions are provided. The local anesthetic emulsion compositions may include: an oily phase comprising a eutectic mixture of a local anesthetic and an acyclic amide; a surfactant; and an aqueous phase. Also provided are methods of making and using the emulsions.Type: GrantFiled: October 4, 2010Date of Patent: September 17, 2013Assignee: Teikoku Pharma USA, Inc.Inventors: Adchara Pongpeerapat, Toru Hibi
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Publication number: 20130233748Abstract: The potential for substance abuse involving residual amounts of abusable substances remaining in used skin-worn patches is reduced by the provision of a system and method for combining the abusable substance with a separate anti-abuse substance agent as part of a removal or disposal procedure.Type: ApplicationFiled: April 22, 2013Publication date: September 12, 2013Applicant: TEIKOKU PHARMA USA, INC.Inventors: Carter R. Anderson, Russell L. Morris
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Patent number: 8475836Abstract: Topical patch preparations that contain an odorless physiological cooling agent, and methods for using the same are provided. The subject topical patch preparations are made up of an adhesive gel composition that is present on a support, where the adhesive gel composition includes the odorless physiological cooling agent, a water-soluble polymer gel, water and a water holding agent. In using the subject topical patch preparations, the topical patch preparations are applied to a skin surface of a subject and maintained at the site of application for a period of time sufficient for an effective amount of the an odorless physiological cooling agent to be administered to the subject. The subject invention finds use in a variety of applications.Type: GrantFiled: December 6, 2011Date of Patent: July 2, 2013Assignee: Teikoku Pharma USA, Inc.Inventor: Jutaro Shudo
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Patent number: 8475837Abstract: The potential for substance abuse involving residual amounts of abusable substances remaining in used skin-worn patches is reduced by the provision of a system and method for combining the abusable substance with a separate anti-abuse substance agent as part of a removal or disposal procedure.Type: GrantFiled: November 23, 2010Date of Patent: July 2, 2013Assignee: Teikoku Pharma USA, Inc.Inventors: Carter R. Anderson, Russell L. Morris
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Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis
Patent number: 8463373Abstract: A disposable skin-worn device for the transdermal delivery at least one dose of charged therapeutic substances, including granisetron, by iontophoresis, the device comprising a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, a counter reservoir, a source of electric power connected in a circuit between the donor reservoir and the counter reservoir and a control system for controlling current flow in the circuit to enable at least one dose of the therapeutic substance to be delivered transdermally by iontophoresis and wherein the control system includes a control element selected from the group consisting of a sensor activated by an external signal and a switch.Type: GrantFiled: November 29, 2010Date of Patent: June 11, 2013Assignee: Teikoku Pharma USA, Inc.Inventors: Carter R. Anderson, Walter L. Sembrowich, Russell L. Morris, Robert Cohen -
Patent number: 8449913Abstract: Methods for administering a dermatological agent to a subject are provided. In the subject methods an effective amount of a topical formulation of the dermatological agent is topically applied to a host. The topically applied formulation of dermatological agent is then occluded with a hydrogel patch, where a feature of the hydrogel patch is that it lacks a pharmaceutically active agent. Also provided are methods of treating a subject for a disease condition by administering a dermatological agent to the subject. Also provided are kits for use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications.Type: GrantFiled: April 26, 2010Date of Patent: May 28, 2013Assignees: Teikoku Pharma USA, Inc., Teikoku Seiyaku Kabushiki KaishaInventors: John Koo, Jutaro Shudo, Sadanobu Shirai
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Patent number: 8445010Abstract: The potential for substance abuse involving residual amounts of abusable substances remaining in used skin-worn patches is reduced by the provision of a system and method for combining the abusable substance with a separate anti-abuse substance agent as part of a removal or disposal procedure.Type: GrantFiled: December 22, 2010Date of Patent: May 21, 2013Assignee: Teikoku Pharma USA, Inc.Inventors: Carter R. Anderson, Russell L. Morris
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Publication number: 20130115268Abstract: Methods for administering a dermatological agent to a subject are provided. In the subject methods an effective amount of a topical formulation of the dermatological agent is topically applied to a host. The topically applied formulation of dermatological agent is then occluded with a hydrogel patch, where a feature of the hydrogel patch is that it lacks a pharmaceutically active agent. Also provided are methods of treating a subject for a disease condition by administering a dermatological agent to the subject. Also provided are kits for use in practicing the subject methods. The subject methods and compositions find use in a variety of different applications.Type: ApplicationFiled: December 27, 2012Publication date: May 9, 2013Applicants: TEIKIKOKU SEIYAKU KABUSHIKI KAISHA, TEIKOKU PHARMA USA, INC.Inventors: Teikoku Pharma USA, INC., Teikikoku Seiyaku Kabushiki Kaisha
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Publication number: 20130085313Abstract: General medication disposal systems are provided. Aspects of the systems include devices having a sealable container dimensioned to accommodate a pharmaceutical composition; and an amount of an inactivating substance, e.g., granulated or pelletized activated carbon, present inside of the of sealable container. Aspects of the invention further include methods of making and using the systems, as well as kits comprises the devices of the system.Type: ApplicationFiled: September 27, 2012Publication date: April 4, 2013Applicant: TEIKOKU PHARMA USA, INC.Inventor: TEIKOKU PHARMA USA, INC.
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Publication number: 20130085312Abstract: Devices for use in the disposal of pharmaceutical compositions are provided. Aspects of the devices include: a support having a surface; an activated carbon layer present on the surface; and an adhesive for stably associating a pharmaceutical composition with the activated carbon layer upon application of the pharmaceutical composition to the activated carbon layer. Also provided are methods of using the devices and kits containing the devices.Type: ApplicationFiled: September 27, 2012Publication date: April 4, 2013Applicant: Teikoku Pharma USA, Inc.Inventor: Teikoku Pharma USA, Inc.
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Publication number: 20130052241Abstract: Non-aqueous taxane pro-emulsion formulations are provided. Pro-emulsion formulations of embodiments of the invention include a taxane, an oil component, a surfactant component and, optionally, a non-aqueous solvent component. Also provided are methods of making and using the pro-emulsion formulations, as well as kits that include the pro-emulsion formulations.Type: ApplicationFiled: October 24, 2012Publication date: February 28, 2013Applicant: TEIKOKU PHARMA USA, INC.Inventor: TEIKOKU PHARMA USA, INC.
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Publication number: 20130018298Abstract: The present invention relates generally to iontophoretic drug delivery systems for transdermal delivery of therapeutic agents and, more particularly, to packaging such systems for long shelf life and easy assembly for use. The system package includes an iontophoretic skin worn patch component that accommodates a power source, electronics, electrodes and a drug pack component that carries a therapeutic agent which is contained as a separate sealed component. The packaged system further provides for ease of assembly at the time of use.Type: ApplicationFiled: September 20, 2012Publication date: January 17, 2013Applicant: TEIKOKU PHARMA USA, INC.Inventor: Teikoku Pharma USA, Inc.
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Patent number: 8329212Abstract: The potential for substance abuse involving residual amounts of abusable substances remaining in used skin-worn patches is reduced by the provision of a system and method for combining the abusable substance with a separate anti-abuse substance agent as part of a removal or disposal procedure.Type: GrantFiled: November 19, 2009Date of Patent: December 11, 2012Assignee: Teikoku Pharma USA, Inc.Inventors: Carter R. Anderson, Russell L. Morris
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Patent number: 8295923Abstract: A wearable iontophoresis device for the prolonged delivery of a positively charged pharmaceutical species from a salt formulation is disclosed that includes a readily oxidizable metal-based sacrificial anode in the form of a generally planar layer having a connecting area that has a width that is sufficient to insure complete consumption of the oxidizable metal wherein the anode is configured to have a minimum operating life of at least 6 hours under skin-safe conditions, and a drug delivery gel pad in electrical contact with said anode for accommodating a gel containing a positively charged pharmaceutical species in salt form formulated for transdermal delivery.Type: GrantFiled: August 31, 2009Date of Patent: October 23, 2012Assignee: Teikoku Pharma USA, Inc.Inventors: Kathleen A. Eischen, Carter R. Anderson, Russell L. Morris
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Patent number: 8295924Abstract: A transdermal system for the delivery of an anesthetic or other active therapeutic agent directly to a selected site of injured skin tissue by iontophoresis is disclosed, which utilizes a transdermal skin-worn patch including a donor electrode chamber containing a donor electrode and an amount of an active agent in a form suitable for transdermal delivery in electrical communication with the donor electrode and a return electrode. The patch also contains a source of electric current connected in a circuit with the donor and return electrode, a current regulating device is optionally provided in the circuit for controlling the electrical output of the patch and at least the donor electrode chamber includes a provision for absorbing a quantity of fluid associated with weepage from adjacent injured skin tissue.Type: GrantFiled: January 20, 2011Date of Patent: October 23, 2012Assignee: Teikoku Pharma USA, Inc.Inventors: Carter R. Anderson, Russell L. Morris, Robert Cohen
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Patent number: 8239018Abstract: An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species has a base layer of including a linking conductive base material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the linking conductive base material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, connected by a narrow exposed linking area of the base layer material remaining exposed therebetween.Type: GrantFiled: August 25, 2010Date of Patent: August 7, 2012Assignee: Teikoku Pharma USA, Inc.Inventors: Carter R. Anderson, Russell L. Morris
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Patent number: 8168670Abstract: Pyrazolone derivative emulsion formulations are provided. The emulsion formulations include a pyrazolone derivative active agent, e.g., Edaravone, oil, water and an emulsifier. Also provided are methods of making and using the subject emulsion formulations.Type: GrantFiled: November 7, 2008Date of Patent: May 1, 2012Assignees: Teikoku Pharma USA, Inc., Techno Guard Co., Ltd.Inventor: Kiichiro Nabeta
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Patent number: 8105624Abstract: Topical patch preparations that contain an odorless physiological cooling agent, and methods for using the same are provided. The subject topical patch preparations are made up of an adhesive gel composition that is present on a support, where the adhesive gel composition includes the odorless physiological cooling agent, a water-soluble polymer gel, water and a water holding agent. In using the subject topical patch preparations, the topical patch preparations are applied to a skin surface of a subject and maintained at the site of application for a period of time sufficient for an effective amount of the an odorless physiological cooling agent to be administered to the subject. The subject invention finds use in a variety of applications.Type: GrantFiled: December 16, 2005Date of Patent: January 31, 2012Assignee: Teikoku Pharma USA, Inc.Inventor: Jutaro Shudo