Abstract: A method and system provide the ability to autonomously operate an unmanned aerial system (UAS) over long durations of time. The UAS vehicle autonomously takes off from a take-off landing-charging station and autonomously executes a mission. The mission includes data acquisition instructions in a defined observation area. Upon mission completion, the UAS autonomously travels to a target landing-charging station and performs an autonomous precision landing on the target landing-charging station. The UAS autonomously re-charges via the target landing-charging station. Once re-charged, the UAS is ready to execute a next sortie. When landed, the UAS autonomously transmits mission data to the landing-charging station for in situ or cloud-based data processing.

Abstract: A photonic integrated circuit comprising one or more waveguides comprising a second order non-linearity configured to operate on optical pulses each having a pulse length shorter than 1000 optical cycles, as measured at their full width at half maximum. The circuit is configured to generate one or more quantum states carried by one or more of the optical pulses, manipulate one or more of the quantum states, and/or measure one or more of the quantum states.

Abstract: Harmonic drives are used widely in robotics as a method for achieving high gear reductions and for driving force transmissions. The harmonic drive is made a three components: a wave generator, a flexspline, and a circular spline. Embodiments described flexsplines for a metal strain wave gearing. The cup of the flexspline is free from sharp edges and with a rounded bottom with a curvature maximized based on the geometry of the flexspline. Compared to a steel flexspline, implementations of flexsplines will have the same outer diameter, the same number of teeth and profile, the same input shaft/base, the same wall thickness near the teeth, but comprise a rounded bottom where the input shaft/base transitions to the straight wall of the flexspline, providing improved performance of BMG flexsplines by reducing low cycle fatigue failures due to stress concentrations.

Abstract: Disclosed herein are engineered light-sensitive proteins, for example channelrhodopsins and variants thereof. Also disclosed are compositions for expressing the light-sensitive proteins in cells, tissues, organs and subjects, and methods for using the light-sensitive proteins to, for example, enable minimally-invasive neuronal circuit interrogation in living organism, and treat neuronal and ocular disorders.

Abstract: A method for etching a surface including obtaining a structure comprising a plurality of nanowires on or above a substrate and a dielectric layer on or above the nanowires, wherein the dielectric layer comprises protrusions formed by the underlying nanowires; reacting a surface of the dielectric layer with a reactant, comprising a gas or a plasma, to form a reactive layer on the dielectric layer, wherein the reactive layer comprises a chemical compound including the reactant and elements of the dielectric layer and the reactive layer comprises sidewalls defined by the protrusions; and selectively etching the reactive layer, wherein the etching etches the protrusions laterally through the sidewalls so as to planarize the surface and remove or shrink the protrusions.

Abstract: Among the various aspects of the present disclosure is the provision of systems and methods of phase-sensitive compressed ultrafast photography.

Abstract: A method of fabricating a photonic device includes in part, forming a multitude of metal and dielectric layers over a semiconductor substrate to form a structure. The metal layers form a continuous metal trace that characterize an etch channel. At least one of the metal layers extends towards an exterior surface of the structure such that when the structure is exposed to a metal etch, the metal etch removes the metal from the exterior surface of the structure and flows through the etch channel to fully etch the metal layers. The metal etch leaves behind a dielectric structure characterizing a photonic device. The photonic device may be a suspended rib waveguide, a suspended channel waveguide, a grating coupler, an interlayer coupler, a photodetector, a phase modulator, an edge coupler, and the like. A photonics system may include one or more of such devices.

Abstract: A quantum phased array comprising one or more arrays of emitter elements each emitting one or more particles having one or more quantum wavefunctions; one or more a phase shifting elements coupled to the emitter elements, each of the phase shifting elements comprising a source of a vector potential applying one or more phase shifts to the one or more quantum wavefunctions; and a control circuit coupled to the one or more phase shifting elements, the control circuit configuring the one or more vector potentials to control an interference of the quantum wavefunctions forming a distribution of the one or more particles at a target, and wherein the distribution is described by a wavefunction interference pattern resulting from the interference controlled by the vector potentials.

Abstract: Cascaded metasurfaces can control the phase, amplitude and polarization of an electromagnetic beam, shaping it in three dimensional configuration not achievable with other methods. Each cascaded metasurface has dielectric or metallic scatterers arranged in a period array. The shape of the scatterers determines the three dimensional configuration of the output beam and is determined with iterative calculations through computational simulations.

Abstract: Disclosed herein is a spectroscopy device incorporating a mid-infrared laser. In one particular embodiment a spectroscopy device is provided including: a substrate; a single mode laser positioned on the substrate; a single mode detector positioned opposite to the single mode laser on the substrate. A gap is formed between the single mode laser and the single mode detector and a substance is positioned in the gap. The single mode laser is configured to output a tunable narrow wavelength of radiation towards the detector and when the single mode laser outputs a wavelength of radiation overlapping one of the substance's rotational-vibrational energy levels, the substance at least partially absorbs the radiation. The single mode detector is configured to measure the amount of narrow wavelength radiation that is not absorbed by the substance between the single mode detector and the single mode laser.

Abstract: Disclosed herein are conditional siRNAs activatable by CBF?-MYH11 oncogenic gene and use thereof for treating conditions such as acute myeloid leukemia (AML). The conditional siRNAs target MCL-1 or HDAC8.

Abstract: A surgical method of cataract fragmentation and extraction via microbubble cavitation is described. In particular, gas-filled microbubbles are injected into a lens capsule of a subject's eye, and cavitation of the microbubbles is activated by applied ultrasound energy. The ultrasound energy can be applied from an external device. The cavitation fragments cataract tissues without damaging other tissue, such as the lens capsule. Fragmented lens material is then aspirated from the lens capsule. The method can be used alone or in conjunction with other methods, such as phacoemulsification.

Abstract: The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. For example, the present invention provides methods of treating immune and/or inflammatory disorders by administering a composition comprising a compound having the structure of Formula (I).

Abstract: Compositions and methods are provided for the identification of peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context.

Abstract: Methods for the fabrication of metal strain wave gear flexsplines using a specialized metal additive manufacturing technique are provided. The method allows the entire flexspline to be metal printed, including all the components: the output surface with mating features, the thin wall of the cup, and the teeth integral to the flexspline. The flexspline may be used directly upon removal from the building tray.

Abstract: Systems, methods and apparatuses are provided for the measurement of intraocular pressure. These systems, methods and apparatuses can include an imaging apparatus for capturing two- or three-dimensional images or video of a patient's eye. An image reconstruction based on the captured images or video can be performed, and measurements can be taken of blood vessel features, curvature metrics, or distances between point pairs. In some embodiments, blood pressure measurements can also be taken synchronously with the captured images or video. From these measurements, a relationship between certain medical condition (e.g., elevated intraocular pressure, heart arrhythmia) and the extracted metrics can be established.

Abstract: A system for performing spectroscopy, including a first frequency comb source outputting first electromagnetic radiation comprising a first frequency comb centered at a first wavelength and having a first repetition rate; a second frequency comb source outputting a second electromagnetic radiation comprising a second frequency comb centered at a second wavelength and having a second repetition rate; a nonlinear device positioned to receive the first frequency comb and the second frequency comb, wherein the nonlinear device interacts the first frequency comb and the second frequency comb through sum frequency generation or difference frequency generation so as to generate an output electromagnetic radiation; and a detection system outputting a signal in response to detecting an interference of the output electromagnetic radiation with a third electromagnetic radiation, the signal comprising information used for determining a spectrum of at least the first frequency comb or the second frequency comb.

Abstract: An RF signal generator wirelessly transferring power to a wireless device includes, in part, a multitude of generating elements generating a multitude of RF signals transmitted by a multitude of antennas, a wireless signal receiver, and a control unit controlling the phases and/or amplitudes of the RF signals in accordance with a signal received by the receiver. The signal received by the receiver includes, in part, information representative of the amount of RF power the first wireless device receives. The RF signal generator further includes, in part, a detector detecting an RF signal caused by scattering or reflection of the RF signal transmitted by the antennas. The control unit further controls the phase and/or amplitude of the RF signals in accordance with the signal detected by the detector.

Abstract: A superconducting composition of matter including overlapping first and second regions. The regions comprise unit cells of a solid, the first region comprises an electrical insulator or semiconductor, and the second region comprises a metallic electrical conductor. The second region extends through the solid and a subset of said second region comprise surface metal unit cells that are adjacent to at least one unit cell from the first region. The ratio of the number of said surface metal unit cells to the total number of unit cells in the second region being at least 20 percent.

Abstract: Provided are an optical modulating device and a system including the optical modulating device. The optical modulating device includes a substrate, and a phase modulator formed on the substrate and including a Fabry-Perot cavity. The Fabry-Perot cavity of the phase modulator includes a first reflective layer, a second reflective layer, and a tunable core formed between the first reflective layer and the second reflective layer, wherein the tunable core is formed of a semiconductor material and is configured to modulate a phase of light corresponding to modulation of a refractive index of the tunable core according to electrical control.