Patents Assigned to The Ohio State University Research Foundation
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Patent number: 8658647Abstract: A number of compounds and use of the compounds in a method for treating or preventing cancer in a subject by administering to the subject a pharmaceutical composition including a compound of formula I or a pharmaceutically acceptable salt thereof are described. The compounds can also be used to inhibit integrin-linked kinase in a cell, which has an effect on the Akt signaling pathway.Type: GrantFiled: November 21, 2011Date of Patent: February 25, 2014Assignee: The Ohio State University Research FoundationInventors: Ching-Shih Chen, Su-Lin Lee, Samuel K. Kulp
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Patent number: 8652564Abstract: Protein binding onto a polymeric surface is enhanced by treating the surface with an amine-bearing polymer like poly(ethylene imine). When used in ELISA, the treated surface improves the performance of the assay.Type: GrantFiled: May 7, 2007Date of Patent: February 18, 2014Assignee: The Ohio State University Research FoundationInventors: Shang-Tian Yang, Yunling Bai
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Publication number: 20140034405Abstract: A powertrain is adapted to drive ground-engaging elements disposed along longitudinally-opposing sides of a vehicle. The powertrain includes at least one engine, a first electric machine, a second electric machine, a third electric machine, a first differential mechanism and a second differential mechanism. The engine and first electric machine are operatively connected to the first and second differential mechanisms. The second electric machine is operatively connected to the first differential mechanism and the third electric machine is operatively connected to the second differential mechanism. The first and second differential mechanisms are each operatively connected to drivably engage one or more ground-engaging elements disposed on a different one of the longitudinally-opposing sides of the associated vehicle. A vehicle including such a powertrain as well as methods of using the same are also included.Type: ApplicationFiled: October 2, 2013Publication date: February 6, 2014Applicant: The Ohio State University Research FoundationInventors: Codrin-Gruie Cantemir, Gabriel G. Ursescu, Georgio Rizzoni
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Patent number: 8633161Abstract: The invention provides for methods of treating a mammal who has a BCR/ABL-mediated leukemia, including chronic myelogenous leukemia (CML), particularly the blast crisis stage of CML, Philadelphia-positive acute lymphoblastic leukemia (Ph?-ALL), and refractory leukemias. The invention also provides for compounds for the treatment of these leukemias and methods of identifying anti-leukemic agents.Type: GrantFiled: March 24, 2006Date of Patent: January 21, 2014Assignee: The Ohio State University Research FoundationInventors: Danilo Perrotti, Paolo Neviani, Ramasamy Santhanam, John C. Byrd, Guido Marcucci, Natarajan Muthusamy, Ching-Shih Chen
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Patent number: 8632510Abstract: A capsule configured for in vivo refilling of a thereapeutic agent. In certain embodiments, the capsule may contain methotrexate.Type: GrantFiled: April 13, 2010Date of Patent: January 21, 2014Assignees: The Board of Regents of the University of Texas System, The Ohio State University Research FoundationInventors: Mauro Ferrari, Xuewu Liu, Alessandro Grattoni, Randy Goodall, Lee Hudson
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Publication number: 20140017272Abstract: Delivery systems and methods are provided for delivering a biologically active protein to a host animal. The systems and methods provided include obtaining an algal cell transformed by an expression vector, the expression vector comprising a nucleotide sequence coding for the biologically active protein, operably linked to a promoter. In one illustrated embodiment, the biologically active protein is an antigenic epitope and upon administration to the animal the algal cell induces an immune response in the host animal.Type: ApplicationFiled: January 2, 2013Publication date: January 16, 2014Applicants: The Ohio State University Research Foundation, ALGAEOMICS LLCInventor: Richard T. Sayre
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Publication number: 20140018409Abstract: Described herein are methods of determining an HCC subtype in a subject which includes a) obtaining a sample from the subject, b) assaying the sample to detect the expression of 1 or more biomarkers, and c) correlating the expression of the biomarkers with an HCC subtype in a subject. Also described are methods of detecting HCC stem cells in a sample, and methods and compositions for treating subjects with HCC that take advantage of the biomarkers associated with HCC stem cells.Type: ApplicationFiled: June 12, 2013Publication date: January 16, 2014Applicants: The Government of the United States of America, as represented by the Secretary of the Department of, The Ohio State University Research FoundationInventors: Xin Wei Wang, Junfang Ji, Taro Yamashita, Carlo M. Croce
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Publication number: 20140010831Abstract: Compositions, methods, and vaccines that may stimulate the immune system and that may be used for treating malignancies associated with overexpression of the HER-2 protein are provided. Such compositions include epitopes of the HER-2 proteins.Type: ApplicationFiled: May 30, 2013Publication date: January 9, 2014Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventor: Pravin Kaumaya
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Publication number: 20130327122Abstract: An NO sensing system includes an inlet for receiving an original sample, a humidifier, fluidly communicating with the inlet, and a first sensor. The original sample is fluidly transmitted through the humidifier and exits the humidifier as a humidified sample having a humidity above a predetermined level. The first sensor generates a potential difference in response to presence of NO in the humidified sample. The potential difference is indicative of a level of NO within the original sample.Type: ApplicationFiled: June 11, 2012Publication date: December 12, 2013Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Prabir K. Dutta, Suvra P. Mondal
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Publication number: 20130316447Abstract: Malignant tumors that are intrinsically resistant to conventional therapies are significant therapeutic challenges. An embodiment of the present invention provides an oncolytic virus capable of killing target cells, such as a tumor cells. In various embodiments presented herein, the oncolytic virus is armed or encodes a therapeutic polypeptide. In at least one embodiment, a recombinant oncolytic virus has been generated that can specifically replicate in cancer cells leading to their destruction and at the same time secrete robust amounts of a therapeutic polypeptide. Compositions and methods disclosed herein have broad therapeutic applicability.Type: ApplicationFiled: May 28, 2013Publication date: November 28, 2013Applicant: The Ohio State University Research FoundationInventor: The Ohio State University Research Foundation
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Patent number: 8592465Abstract: Compounds according to formula (I) are disclosed where Q is S, N, or O; X is optional, and can be O?, S?, ?N—NH2, ?N—OH, or —OH; Y is optional and can be —N(H)—, O, or C1 to C20 hydrocarbon; and R1 and R2 are each independently substituted or unsubstituted single-, fused- or multiple-ring aryl or (hetero)cyclic ring systems. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.Type: GrantFiled: June 16, 2009Date of Patent: November 26, 2013Assignees: University of Tennessee Research Foundation, The Ohio State University Research FoundationInventors: Duane D. Miller, Wei Li, Zhao Wang, Yan Lu, Jianjun Chen, James T. Dalton, Chien-Ming Li
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Patent number: 8591533Abstract: An apparatus and method for non-surgically creating a restriction in a tissue is provided where a binding mechanism (36) is inserted into the issue. This invention also relates to an apparatus for creating a stoma of variable and reproducible size in a hollow organ.Type: GrantFiled: February 6, 2008Date of Patent: November 26, 2013Assignee: The Ohio State University Research FoundationInventors: Bradley J. Needleman, Jeffrey W. Hazey, Richard Peters
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Patent number: 8580827Abstract: A series of celecoxib derivatives defined by Formula I: were prepared and evaluated for their ability to inhibit the gram-negative bacteria Francisella tularensis. Pharmaceutical compositions including celecoxib derivatives and their use in methods for treating or preventing infection by Francisella tularensis in a subject are described.Type: GrantFiled: September 12, 2012Date of Patent: November 12, 2013Assignee: The Ohio State University Research FoundationInventors: Ching-Shih Chen, Hao-Chieh Chiu, Samuel Kulp, John S. Gunn, Larry S. Schlesinger
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Publication number: 20130296249Abstract: Methods for blocking autoreactive T cell-initiated destruction of tissues in a mammal are provided. In one embodiment, the method comprises administering a purified CD24 polypeptide, a fusion protein comprising such polypeptide, or a biologically active fragment of such polypeptide to a mammalian subject who is suspected of having or predisposed to having an autoimmune disease. In another embodiment, anti-CD24 antibody or anti-CD24 Fab fragments are administered to the subject. In another embodiment, the method comprises administering a CD24 antisense molecule, an expression vector encoding a CD24 antisense molecule, CD24 dsRNAi, or an expression vector encoding CD24 dsRNAi to the subject. The present invention also relates to isolated and purified CD24 fusion proteins employed in the present methods and to transgenic mice that express the human CD24 protein on their T cells and/or their vascular endothelial cells but do not express murine heat shock antigen on any cells.Type: ApplicationFiled: May 2, 2013Publication date: November 7, 2013Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Yang Liu, Pan Zheng, Xue-Feng Bai
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Patent number: 8575334Abstract: Disclosed is a method for separating anthocyanins depleted in phenolic mixture content from fruits or vegetables feedstock containing anthocyanins and phenolic mixtures. The first step is to contact the feedstock with a cation-exchange resin at low pH for a time period effective for the resin to selectively bind with the anthocyanins. Next, the non-bound phenolic mixture is separated from the resin for recovery. The bound resin is subjected to solvent wash to release the anthocyanins for recovery.Type: GrantFiled: July 30, 2010Date of Patent: November 5, 2013Assignee: The Ohio State University Research FoundationInventors: Maria Monica Giusti, Jian He
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Patent number: 8573348Abstract: A powertrain is adapted to drive ground-engaging elements disposed along longitudinally-opposing sides of a vehicle. The powertrain includes at least one engine, a first electric machine, a second electric machine, a third electric machine, a first differential mechanism and a second differential mechanism. The engine and first electric machine are operatively connected to the first and second differential mechanisms. The second electric machine is operatively connected to the first differential mechanism and the third electric machine is operatively connected to the second differential mechanism. The first and second differential mechanisms are each operatively connected to drivably engage one or more ground-engaging elements disposed on a different one of the longitudinally-opposing sides of the associated vehicle. A vehicle including such a powertrain as well as methods of using the same are also included.Type: GrantFiled: October 12, 2007Date of Patent: November 5, 2013Assignee: The Ohio State University Research FoundationInventors: Codrin-Gruie Cantemir, Gabriel G. Ursescu, Giorgio Rizzoni
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Publication number: 20130289004Abstract: A method of treating infection by Staphylococcus in a subject by administering a pharmaceutical composition including a celecoxib derivative of formula I or a pharmaceutically acceptable salt thereof is described. The preparation of numerous celecoxib derivatives for testing as potential anti-staphylococcal agents is also described.Type: ApplicationFiled: October 31, 2011Publication date: October 31, 2013Applicant: The Ohio State University Research FoundationInventors: Ching-Shih Chen, Hao-Chieh Chiu, Dasheng Wang, Samuel K. Kulp
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Patent number: 8569482Abstract: A new class of micro- and nano-particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.Type: GrantFiled: November 29, 2011Date of Patent: October 29, 2013Assignee: The Ohio State University Research FoundationInventors: Periannan Kuppusamy, Vijay Kutala, Jay L. Zweier, Pawel Kwiatkowski
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Patent number: 8568694Abstract: A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.Type: GrantFiled: January 15, 2010Date of Patent: October 29, 2013Assignee: The Ohio State University Research FoundationInventors: Periannan Kuppusamy, Ramasamy P. Pandian, Narasimham L. Parinandi, Jay L. Zweier
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Patent number: 8568587Abstract: A supported nanofiber medium useful for segregating chemical species is provided by selecting a polymer, selecting a substrate; and electrospinning the polymer to form a nanofiber medium on the supporting substrate. When the substrate is a planar surface, the nanofiber medium will be a mat suitable for conducting chromatographic separation. When the substrate is a filament, the nanofiber medium is an annular mat suitable for solid phase microextraction. The nanofiber media formed may be selectively cross-linked and at least partially carbonized to carbon nanofibers. The nanofiber medium is supported on the substrate without the use of binder material.Type: GrantFiled: March 11, 2011Date of Patent: October 29, 2013Assignee: The Ohio State University Research FoundationInventors: Susan V. Olesik, Jonathan E. Clark, Jeremy K. Steach, Joseph W. Zewe