Patents Assigned to The Ohio State University Research Foundation
  • Particles for cell targeting
    Patent number: 8563022
    Abstract: Provided is a composition that includes oblate spheroidal particles comprising an active agent, such as a therapeutic or imaging agent, and a method for treating or monitoring a physiological condition, such as a disease, by administering the composition to a subject in need thereof. Also provided are methods for making particles that have a volume that can enhance the particles' adhesion to a target site in a subject's body for a pre-selected shape of the particles and methods for making particles that have a shape that can enhance particles' adhesion to a target site in a subject's body for a pre-selected volume of the particles.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: October 22, 2013
    Assignees: Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Paolo Decuzzi, Mauro Ferrari
  • PDK-1/AKT signaling inhibitors
    Patent number: 8546441
    Abstract: A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I: wherein X is selected from the group consisting of alkyl and haloalkyl; Ar is an aryl radical selected from the group consisting of phenyl, biphenyl, naphthyl, anthryl, phenanthryl, and fluorenyl; and wherein Ar is optionally substituted with one or more radicals selected from the group consisting of halo, C1-C4 alkyl, C1-C4 haloalkyl, azido, C1-C4 azidoalkyl, aryl, alkylaryl, haloaryl, haloalkylaryl, and combinations thereof; and R is selected from the group consisting of nitrile, acetonitrile, ethylnitrile, propylnitrile, carboxamide, amidine, tetrazole, oxime, hydrazone, acetamidine, aminoacetamide, guanidine, and urea. Also provided are methods of using the compounds for the treatment and prevention of cancer in humans.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: October 1, 2013
    Assignee: The Ohio State University Research Foundation
    Inventor: Ching-Shih Chen
  • DNA methylation inhibitors
    Patent number: 8546397
    Abstract: A number of DNA methylation inhibitors are described. The DNA methylation inhibitors were identified using a two-component enhanced green fluorescent protein reporter system to screen a compound library containing procainamide derivatives. The DNA methylation inhibitors can be used for cancer therapy and prevention.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: October 1, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Ching-Shih Chen, Arthur Y. Shaw, Yu-Wei Leu, Shu-Huei Hsiao
  • Apparatus for Treating Items with Gas
    Publication number: 20130251863
    Abstract: Apparatus for treating items with a treatment gas to decontaminate the items includes a chamber which receives the items. The chamber has a gas inlet in fluid communication with a distribution duct positioned within the chamber. The duct distributes the treatment gas throughout the chamber to prevent gas stratification. The chamber may also have a gas outlet for exhausting the chamber, a treatment gas source providing gas, such as ozone, carbon dioxide, or other treatment gas to the chamber. A vacuum pump is used to lower the pressure within the chamber and a purge pump is used to flush the treatment gas from the chamber upon completion of the treatment. A liquid reservoir is used to maintain a desired humidity within the chamber. A heat exchanger is used to maintain a desired temperature within the chamber, and a fan is used to circulate the treatment gas within the chamber.
    Type: Application
    Filed: March 20, 2012
    Publication date: September 26, 2013
    Applicant: The Ohio State University Research Foundation
    Inventors: Ahmed Yousef, Jennifer Perry, David Kasler, Sudhir Kartikeya Sastry
  • Method for Treating Shell Eggs with Gas
    Publication number: 20130251864
    Abstract: A method for treating shell eggs with a gas includes subjecting the eggs to lower than atmospheric pressure for a period of time, heat for a period of time, and a treatment gas for a period of time. The treatment gas may be ozone at about 8-12% concentration by weight, the treatment temperature may be between 55° C. and 60° C. for about 2-25 minutes, and the atmospheric pressure may be from about 60-81 kPa for about 33 minutes or less. Eggs treated using this method showed a reduction in the concentration of Salmonella Enteritidis of at least log 5.
    Type: Application
    Filed: August 24, 2012
    Publication date: September 26, 2013
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Jennifer Perry, Ahmed Yousef
  • NANOCHANNELED DEVICE AND RELATED METHODS
    Publication number: 20130240483
    Abstract: A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.
    Type: Application
    Filed: May 2, 2013
    Publication date: September 19, 2013
    Applicants: The Ohio State University Research Foundation, The Board of Regents of the University of Texas System
    Inventors: Mauro FERRARI, Xuewu LIU, Alessandro GRATTONI, Daniel FINE, Randy GOODALL, Sharath HOSALI, Ryan MEDEMA, Lee HUDSON
  • ANTI-INFECTIVE AGENTS AGAINST INTRACELLULAR PATHOGENS
    Publication number: 20130237575
    Abstract: A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I: wherein X wherein X is —CF3, Ar is selected from and R is selected from where R? is L-Lys, D-Lys, ?-Ala, L-Lue, L-Ile, Phe, SO2CH2CH2NH2, SO2NH2, Asn, Glu or Gyl, and R? is methyl, ethyl, allyl, CH2CH2OH, CH2CN, CH2CH2CN, CH2CONH2,
    Type: Application
    Filed: April 24, 2013
    Publication date: September 12, 2013
    Applicant: The Ohio State University Research Foundation
    Inventors: Ching-Shih Chen, Hao-Chieh Chiu, Dasheng Wang
  • MiR-29-based methods for the diagnosis and prognosis of acute myeloid leukemia (AML)
    Patent number: 8530159
    Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML). The invention also provides methods of identifying anti-AML agents.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: September 10, 2013
    Assignee: The Ohio State University Research Foundation
    Inventor: Carlo M. Croce
  • Methods for transfecting natural killer cells
    Patent number: 8530187
    Abstract: Methods for stably transfecting mammalian natural killer cells comprising: transfecting a packaging cell line with a retroviral expression vector; culturing the transfected packaging cell line in a cell culture medium; and culturing the mammalian natural killer cells with the cell culture medium. Natural killer cells transfected according to the disclosed methods are also provided.
    Type: Grant
    Filed: March 21, 2005
    Date of Patent: September 10, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Michael A. Caligiuri, Rossana Trotta, Jianhua Yu, Brian Becknell
  • Method of diagnosing poor survival prognosis colon cancer using miR-16b
    Patent number: 8518647
    Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: August 27, 2013
    Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology Transfer
    Inventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
  • Immunogenic Epitopes, Peptidomimetics, And Anti-Peptide Antibodies, And Methods of Their Use
    Publication number: 20130216564
    Abstract: Provided herein are compositions and methods for the treatment of cancers. The compositions comprise at least one VEGF peptide mimic, HER-2 epitope, immunogenic VEGF peptides, and HER-2 immunogenic epitopes. The peptides and epitopes may be linear, cyclized, retro-inverso, or a combination of such forms. Also provided herein are antibodies raised to VEGF peptide mimics, HER-2 epitopes, immunogenic VEGF peptides, and HER-2 immunogenic epitopes.
    Type: Application
    Filed: October 26, 2012
    Publication date: August 22, 2013
    Applicant: The Ohio State University Research Foundation
    Inventor: Kaumaya Pravin
  • Carbonation calcination reaction process for COcapture using a highly regenerable sorbent
    Patent number: 8512661
    Abstract: A process for the efficient capture of CO2 and sulfur from combustion flue gas streams and gasification based fuel gas mixtures using regenerable and recyclable calcium based sorbents. The regeneration of the calcium sorbent is accomplished by hydrating the sorbent at high temperatures of about 600° C. and a pressure higher than 6 bars to lower the parasitic energy consumption.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: August 20, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Liang-Shih Fan, Shwetha Ramkumar, William Wang, Robert Statnick
  • Calcium looping process for high purity hydrogen production integrated with capture of carbon dioxide, sulfur and halides
    Patent number: 8496909
    Abstract: A process for producing hydrogen comprising the steps of: (i) gasifying a fuel into a raw synthesis gas comprising CO, hydrogen, steam, sulfur and halide contaminants in the form of H2S, COS, and HX, wherein X is a halide; (ii) passing the raw synthesis gas through a water gas shift reactor (WGSR) into which CaO and steam are injected, the CaO reacting with the shifted gas to remove CO2, sulfur and halides in a solid-phase calcium-containing product comprising CaCO3, CaS and CaX2; (iii) separating the solid-phase calcium-containing product from an enriched gaseous hydrogen product; and (iv) regenerating the CaO by calcining the solid-phase calcium-containing product at a condition selected from the group consisting of: in the presence of steam, in the presence of CO2, in the presence of synthesis gas, in the presence of H2 and O2, under partial vacuum, and combinations thereof.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: July 30, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Shwetha Ramkumar, Liang-Shih Fan
  • MicroRNA fingerprints during human megakaryocytopoiesis
    Patent number: 8486912
    Abstract: Described herein is a method of decreasing expression of MAFB in a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a MAFB gene product where an effective amount of at least one miR-130a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the MAFB gene product in the subject.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: July 16, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Carlo M. Croce, Ramiro Garzon, George A. Calin
  • Compositions and methods for the diagnosis and therapy of BCL2-associated cancers
    Patent number: 8481505
    Abstract: The invention provides methods and compositions for the treatment of cancers associated with overexpression of a BCL2 gene and/or gene product in a subject, and methods and compositions for the improvement of anti-cancer therapy, such as chemotherapy and radiation therapy. The invention also encompasses methods for determining the efficacy of a cancer therapy in a subject and methods for inducing apoptosis of a cell.
    Type: Grant
    Filed: September 11, 2006
    Date of Patent: July 9, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Carlo M. Croce, George A. Calin
  • Nanochanneled device and related methods
    Patent number: 8480637
    Abstract: A nanochannel delivery device and method of manufacturing and use. The nanochannel delivery device comprises an inlet, an outlet, and a nanochannel. The nanochannel may be oriented parallel to the primary plane of the nanochannel delivery device. The inlet and outlet may be in direct fluid communication with the nanochannel.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: July 9, 2013
    Assignees: The Board of Regents of the University of Texas System, The Ohio State University Research Foundation
    Inventors: Mauro Ferrari, Xuewu Liu, Alessandro Grattoni, Daniel Fine, Randy Goodall, Sharath Hosali, Ryan Medema, Lee Hudson
  • Heteroaryl-containing isoflavones as aromatase inhibitors
    Patent number: 8476313
    Abstract: Compounds and methods useful for treating and prevention of cancer, particularly hormone-dependent breast cancer. Provided are compounds of formula I: wherein X is selected from O, N, S, SO, SO2, and S(CH2)n, wherein n=1-10; R1 and R2 may be the same or different and are selected from H, OH, OCH3, OCH2CH3, OCH2C6H5, NH2, NHCH3, N(CH3)2, CH3, CH2CH3, CH2CH2CH3, CH(CH3)2, C(CH3)3, NO2, F, Cl, Br, CF3, SH, SCH3, SCH2CH3, OCOCH3, OCOC(CH3)3, OCOCH2COOH, and CN; and R3 is a nitrogen-containing heterocyclic ring. Also provided are method for treating or preventing cancer in a subject by administering a therapeutically effective amount of a heteroaryl-containing isoflavone, or a pharmaceutically acceptable salt or prodrug thereof, to a subject in need of treatment.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: July 2, 2013
    Assignee: The Ohio State University Research Foundation
    Inventors: Robert W. Brueggemeier, Young-Woo Kim, John C. Hackett
  • Chimeric peptides comprising HER-2 B-cell epitopes and T-helper epitopes
    Patent number: 8470333
    Abstract: Compositions, methods, and vaccines that may stimulate the immune system and that may be used for treating malignancies associated with overexpression of the HER-2 protein are provided. Such compositions include epitopes of the HER-2 proteins.
    Type: Grant
    Filed: February 1, 2010
    Date of Patent: June 25, 2013
    Assignee: The Ohio State University Research Foundation
    Inventor: Pravin Kaumaya
  • NOVEL METHYLENEDIOXY PHENOLIC COMPOUNDS AND THEIR USE TO TREAT DISEASE
    Publication number: 20130157986
    Abstract: Pharmaceutical compounds and compositions are provided which are methylenedioxy phenolic compounds and their derivatives, along with methods of making them and methods of using them for therapeutic purposes. The compounds and compositions are advantageous in that they can be used to treat or prevent cardiovascular disease, vascular disease and/or inflammatory disease, as well as Type I and Type II Diabetes and Dyslipidemia patients at risk for hypertension, stroke, cardiovascular and renal disease.
    Type: Application
    Filed: June 12, 2012
    Publication date: June 20, 2013
    Applicants: INVASC THERAPEUTICS, INC., OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: SAMPATH PARTHASARATHY, SANJAY RAJAGOPALAN, DESIKAN RAJAGOPAL
  • Methods and compositions for inducing deregulation of EPHA7 and ERK phosphorylation in human acute leukemias
    Patent number: 8466119
    Abstract: Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (ALL) or a predisposition to ALL, uses and compositions are disclosed.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: June 18, 2013
    Assignee: The Ohio State University Research Foundation
    Inventor: Carlo M. Croce