Patents Assigned to The Queen's University of Belfast
  • Patent number: 10344167
    Abstract: This invention relates to polymer particles, a process for their preparation, the use of these particles for the preparation of an electrophoretic device, electrophoretic displays comprising such particle, and new polymerizable dyes.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: July 9, 2019
    Assignees: Merck Patent GmbH, The Queen's University of Belfast
    Inventors: Jonathan Henry Wilson, Louise Diane Farrand, Anthony Lawrence, Sarah Youngs
  • Patent number: 10316268
    Abstract: The present invention is directed to a basic ionic liquid treatment for removing chloropropanol and/or glycidol, or their fatty acid esters, from glyceride oil, as well as a process for refining glyceride oil which includes the basic ionic liquid treatment. The present invention also relates to uses of the basic ionic liquid and glyceride oil compositions obtained from the ionic liquid treatment.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: June 11, 2019
    Assignees: THE QUEEN'S UNIVERSITY OF BELFAST, EVONIK DEGUSSA GMBH
    Inventors: Peter Goodrich, Eoghain O'Hara, Martin Atkins, Christopher K. Hamer, Daniel Witthaut, Gabriela Fedor, Ulrich Boes
  • Patent number: 10308744
    Abstract: This invention relates to polymer particles, a process for their preparation, electrophoretic fluids comprising such particles, and electrophoretic display devices comprising such fluids.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: June 4, 2019
    Assignees: Merck Patent GmbH, The Queen's University of Belfast
    Inventors: Louise D. Farrand, Nils Greinert, Jonathan H. Wilson, Thomas Bauer, Claire Topping, Sarah Norman
  • Patent number: 10280190
    Abstract: Derivatives of nicotinic acid riboside (NAR), nicotinamide riboside (NR), and reduced NAR and NR, including 1-(2?,3?,5?-triacetyl-beta-D-ribofuranosyl)-1,4-dihydronicotinic acid (4a), and compositions containing the same and/or reduced derivative forms of nicotinamide riboside including 1-(2?,3?,5?-triacetyl-beta-D-ribofuranosyl)-1,4-nicotinamide (2), are provided for use in the care of treatment of skin and skin conditions. In some embodiments, the invention relates to pharmaceutical compositions and cosmetic compositions containing one or more NR, NAR, NRH, or NARH derivatives, or prodrugs or salts thereof. In further embodiments, the invention relates to methods of using one or more NR, NAR, NRH, or NARH derivatives, or prodrugs, solvates, or salts thereof, to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival and overall cell and tissue health.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: May 7, 2019
    Assignees: ChromaDex, Inc., The Queen's University of Belfast
    Inventors: Ryan Dellinger, Marie Eugenie Migaud, Philip Redpath, Troy Rhonemus, Richard Cunningham
  • Patent number: 10267807
    Abstract: The present invention relates to a method for diagnosing and/or prognosing renal dysfunction. The method comprises the steps of: —(a) determining the level of an anti-inflammatory cytokine present in a urine sample from a subject prior to physical trauma, prior to a hypotensive event, prior to sepsis, and/or prior to septic shock syndrome; (b) determining the level of the anti-inflammatory cytokine present in a urine sample from the subject following physical trauma, following or during a hypotensive event, following or during sepsis, and/or following or during septic shock syndrome; (c) calculating the difference between the level of the anti-inflammatory cytokine determined in step a) from the level of the anti-inflammatory cytokine determined in step b), and (d) providing a diagnosis and/or prognosis on the basis of a comparison between the difference calculated in step c) and the difference calculated in step c) when steps a) and b) are practiced on a control group.
    Type: Grant
    Filed: April 21, 2009
    Date of Patent: April 23, 2019
    Assignees: BELFAST HEALTH AND SOCIAL CARE TRUST, THE QUEEN'S UNIVERSITY OF BELFAST
    Inventors: William Thomas McBride, Marilyn Armstrong
  • Patent number: 10188744
    Abstract: The present invention is directed to an amphipathic peptide and methods of using the amphipathic peptide for delivering small molecule agents to a cell. Ideally, the amphipathic cell penetrating peptide comprises less than approximately 50 amino acid residues with at least 6 arginine residues, at least 12 Alanine Residues, at least 6 leucine residues, optionally at least one cysteine residue, and at least two but no greater than three glutamic acids wherein the arginine residues are evenly distributed along the length of the peptide; and the peptide has a defined ratio of arginine to negatively charged amino acid residues and a defined ratio of hydrophilic amino acid residues to hydrophobic amino acid residues. The present invention is also directed to a nanoparticle and cell delivery system comprising the amphipathic cell penetrating peptide of the invention. The peptide, nanoparticle or cell delivery system of the invention may be used in therapy.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: January 29, 2019
    Assignee: The Queen's University of Belfast
    Inventors: Helen McCarthy, Aleksey Zholobenko, Ashley Davison, Tracy Robson
  • Patent number: 10138432
    Abstract: Mercury is removed from a mercury-containing hydrocarbon fluid feed by utilizing ionic liquids. The mercury-containing hydrocarbon fluid feed is contacted with a metallate salt immobilized on a solid support material. A hydrocarbon fluid product having a reduced mercury content compared to the mercury-containing fluid feed is separated from the ionic liquid.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: November 27, 2018
    Assignee: THE QUEEN'S UNIVERSITY OF BELFAST
    Inventors: Mahpuzah Abai, Martin P. Atkins, Kuah Y. Cheun, John Holbrey, Peter Nockemann, Kenneth R. Seddon, Geetha Srinivasan, Yiran Zou
  • Patent number: 10106686
    Abstract: This invention relates to particles comprising a pigment core particle encapsulated by a polymer, a process for their preparation, electrophoretic fluids comprising such particles, and electrophoretic display devices comprising such fluids.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: October 23, 2018
    Assignees: Merck Patent GmbH, The Queen's University of Belfast
    Inventors: Louise D. Farrand, Claire Topping, Sarah Norman
  • Patent number: 10094839
    Abstract: The present invention relates to a method for a method for predicting the development of renal dysfunction in a subject following physical trauma, hypotension, sepsis and/or septic shock syndrome, wherein the method comprises the steps of: —a. determining the level of an anti-inflammatory cytokine present in a sample taken from the subject after physical trauma, after a hypotensive event, after sepsis, and/or after septic shock syndrome; b. predicting the development in the subject of renal dysfunction on the basis of the level of an anti-inflammatory cytokine determined in step a).
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: October 9, 2018
    Assignees: THE QUEEN'S UNIVERSITY OF BELFAST, BELFAST HEALTH AND SOCIAL CARE TRUST
    Inventors: William Thomas McBride, Marilyn Armstrong
  • Publication number: 20180258127
    Abstract: The present disclosure provides nicotinate/nicotinamide riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, and synthetic processes for the preparation thereof.
    Type: Application
    Filed: May 11, 2018
    Publication date: September 13, 2018
    Applicants: ChromaDex Inc., The Queen's University of Belfast
    Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Ryan Dellinger, Troy Rhonemus, Sylesh Venkataraman, Brian Nettles
  • Publication number: 20180244927
    Abstract: The present invention provides a polymerizable coating composition comprising: (i) 1-vinyl-2-pyrrolidinone (NVP) and 2-hydroxyethylmethacrylate (2-HEMA) for forming a copolymer; (ii) a poly(vinyl pyrrolidone) (PVP) polymer having a molecular weight of at least 500,000 g·mol?1; (iii) a co-polymerizable crosslinker for crosslinking the 1-vinyl-2-pyrrolidinone (NVP) and the 2-hydroxyethylmethacrylate (2-HEMA); (iv) a co-polymerizable initiator for initiating co-polymerisation of the 1-vinyl-2-pyrrolidinone (NVP) and 2-hydroxyethylmethacrylate (2-HEMA); (v) a surfactant selected from non-ionic triblock copolymers of ethylene oxide/propylene oxide, nonionic triblock copolymers of poly(propylene oxide) (PPO) and poly(ethylene oxide) (PEO), tetrablock copolymers of PPO and PEO; Triton X-100 and derivatives thereof, polyethylene glycols and derivatives thereof, PEO derivatives of sorbitan monolaurate, and combinations of any two or more thereof; (vi) a solvent, wherein a vinyl component is 1-vinyl-2-pyrrolidinone for
    Type: Application
    Filed: March 4, 2016
    Publication date: August 30, 2018
    Applicant: The Queen's University of Belfast
    Inventors: Colin McCoy, Sean Gorman, David Jones, Daniel Corbett, Nicola Irwin
  • Patent number: 10000520
    Abstract: The present disclosure provides nicotinate/nicotinamide riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, and synthetic processes for the preparation thereof.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: June 19, 2018
    Assignees: ChromaDex Inc., The Queen's University of Belfast
    Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Ryan Dellinger, Troy Rhonemus, Sylesh Venkataraman, Brian Nettles
  • Patent number: 10000519
    Abstract: The invention relates to methods of preparing nicotinamide riboside and derivatives thereof.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: June 19, 2018
    Assignee: THE QUEEN'S UNIVERSITY OF BELFAST
    Inventors: Marie Migaud, Philip Redpath, Kerri Crossey, Mark Doherty
  • Patent number: 9975915
    Abstract: The present disclosure provides novel crystalline forms of nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, modified derivatives thereof, and phosphorylated analogs thereof, or salts, solvates, or prodrugs thereof; and methods of preparation thereof.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: May 22, 2018
    Assignees: The Queen's University of Belfast, ChromaDex Inc.
    Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
  • Publication number: 20180134742
    Abstract: The present disclosure provides novel crystalline forms of nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, modified derivatives thereof, and phosphorylated analogs thereof, or salts, solvates, or prodrugs thereof, and methods of preparation thereof.
    Type: Application
    Filed: November 10, 2017
    Publication date: May 17, 2018
    Applicants: The Queen's University of Belfast, ChromaDex Inc.
    Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
  • Publication number: 20180134743
    Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof; and novel crystalline forms thereof.
    Type: Application
    Filed: November 10, 2017
    Publication date: May 17, 2018
    Applicants: The Queen's University of Belfast, ChromaDex Inc.
    Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
  • Patent number: 9856422
    Abstract: The present invention relates to a process for the removal of naphthenic acids from crude oils and crude oil distillates by use of supported basic ionic liquids.
    Type: Grant
    Filed: November 23, 2011
    Date of Patent: January 2, 2018
    Assignee: The Queen's University of Belfast
    Inventors: Christopher Hardacre, Peter Goodrich, Azlan Hussain, David Rooney
  • Patent number: 9823256
    Abstract: There is provided a molecular marker CXCR1 for predicting response and survival in subjects afflicted with cancer who would benefit from treatment with and Epidermal Growth Factor Receptor (EGFR) targeted therapeutic.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: November 21, 2017
    Assignee: The Queen's University of Belfast
    Inventors: David John James Waugh, Richard Wilson, Olabode Oladipo
  • Patent number: 9822232
    Abstract: This invention relates to a process for the preparation of a dispersion comprising black polymer particles, such black polymer particles prepared by the process, the use of the dispersion and the black polymer particles in electrophoretic fluids, and electrophoretic display devices comprising such fluids.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: November 21, 2017
    Assignees: Merck Patent GmbH, The Queen's University of Belfast
    Inventors: Louise D. Farrand, Sarah Norman
  • Patent number: 9815222
    Abstract: A process for the preparation of a metal-organic compound, said metal-organic compound comprising at least one metal ion and at least one organic ligand, wherein said organic ligand is capable of associating with said metal ion, comprising at least the steps of; providing a first reactant comprising at least one metal in ionic form; providing a second reactant comprising at least one organic ligand capable of associating with said metal in ionic form; and admixing said first and second reactants under conditions of prolonged and sustained pressure and shear sufficient to synthesize said metal-organic compound.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: November 14, 2017
    Assignee: The Queen's University of Belfast
    Inventors: Stuart James, Tony McNally, Robert Haydon