Patents Assigned to The Regents of the University of Colorado
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Patent number: 11974730Abstract: In some embodiment, the present invention is directed to a device for obtaining samples from a subject. In other embodiments, methods and devices of the present invention allow the evaluation of conditions of the gastrointestinal tract of a subject. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embodiment, the invention comprises a method for measuring esophageal inflammation comprising deploying a device into the esophagus of a subject, removing the device after a predetermined period of time, analyzing the device for a diagnostic indicator of esophageal inflammation and evaluating the diagnostic indicator to diagnose esophageal inflammation.Type: GrantFiled: May 11, 2020Date of Patent: May 7, 2024Assignees: The Regents of the University of Colorado, The Board of Trustees of the University of IllinoisInventors: Glenn T. Furuta, Steven J. Ackerman
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Patent number: 11976328Abstract: Disclosed are biomarkers, methods and assay systems for the identification of poor prognosis of interstitial pneumonia (pulmonary fibrosis) in an individual diagnosed with suspected of having interstitial pneumonia.Type: GrantFiled: July 14, 2020Date of Patent: May 7, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: David A. Schwartz, Tasha E. Fingerlin, Weiming Zhang
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Patent number: 11975314Abstract: Structures, catalysts, and reactors suitable for use for a variety of applications, including gas-to-liquid and coal-to-liquid processes and methods of forming the structures, catalysts, and reactors are disclosed. The catalyst material can be deposited onto an inner wall of a microtubular reactor and/or onto porous support structures using atomic layer deposition techniques.Type: GrantFiled: August 19, 2022Date of Patent: May 7, 2024Assignee: The Regents of the University of Colorado, a body corporateInventors: Staci A. Moulton, Alan W. Weimer
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Patent number: 11974748Abstract: A system and method for end-to-side anastomosis to an anatomical passageway is disclosed. The system and method are particularly useful in coupling an LVAD pump to an aorta. The system and method include using a tubular graft member having a skirt flange that engages the side of the aorta, a seating assembly and a flanged stent for securing the tubular graft to the side of the anatomical passageway. An assembly for creating an opening in the side of the anatomical passageway and an assembly for delivering the tubular graft is also disclosed.Type: GrantFiled: January 10, 2020Date of Patent: May 7, 2024Assignee: The Regents of the University of ColoradoInventor: Max Bannister Mitchell
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Patent number: 11971535Abstract: The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.Type: GrantFiled: April 20, 2020Date of Patent: April 30, 2024Assignee: The Regents of the University of Colorado, A Body CorporateInventors: Juliet T. Gopinath, Emily A. Gibson, Victor M. Bright, Richard Weir, Diego Restrepo, Baris Ozbay
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Patent number: 11974502Abstract: Soft motherboards having rigid plugin modules are described herein. In one aspect of the present disclosure, an electronic device can include a polymeric substrate having: a plurality of slots, each configured for receiving an electronic module; one or more electrical junctions including a stretchable conductive interconnect electronically coupling a slot to another slot of the plurality of slots; and at least one electronic module including: a film configured to: support other components of the electronic module; and be inserted, and be partially housed in, one of the plurality of slots of the polymeric substrate; and at least one electrode coupled to the film and positioned to be in contact with a corresponding electrical junction of the polymeric substrate when the film is partially housed in the polymeric substrate.Type: GrantFiled: February 10, 2022Date of Patent: April 30, 2024Assignee: The Regents of the University of ColoradoInventors: Jianliang Xiao, Yan Sun, Wei Ren
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Patent number: 11965831Abstract: Sub-diffraction limited fluorescent images using a fiber-based stimulated emission depletion (STED) microscope are reported. Both excitation and depletion beams are transported through polarization-maintaining fiber and a lateral resolution of 100 nm has been achieved.Type: GrantFiled: March 1, 2019Date of Patent: April 23, 2024Assignee: The Regents of the University of Colorado, a Body CorporateInventors: Juliet T. Gopinath, Brendan M. Heffernan, Robert Niederriter, Stephanie A. Meyer, Diego Restrepo, Emily A. Gibson, Mark E. Siemens
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Patent number: 11964985Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.Type: GrantFiled: May 12, 2020Date of Patent: April 23, 2024Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE., INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Dan Theodorescu, Michael Fitzpatrick Wempe, David Ross, Samy Meroueh, Martin A. Schwartz, Phillip Reigan
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Patent number: 11960247Abstract: According to some aspects of the present disclosure, an atomic clock and methods of forming and/or using an atomic clock are disclosed. In one embodiment, an atomic clock includes: a light source configured to illuminate a resonance vapor cell; a narrowband optical filter disposed between the light source and the resonance vapor cell and arranged such that light emitted from the light source passes through the narrowband optical filter and illuminates the resonance vapor cell. The resonance vapor cell is configured to emit a signal corresponding to a hyperfine transition frequency in response to illumination from the light source, and a filter cell is disposed between the light source and the resonance vapor cell and configured to generate optical pumping. An optical detector is configured to detect the emitted signal corresponding to the hyperfine transition frequency.Type: GrantFiled: May 15, 2023Date of Patent: April 16, 2024Assignee: The Regents of the University of Colorado, a body corporateInventors: Svenja Knappe, Sean Krzyzewski
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Publication number: 20240120091Abstract: Embodiments of the present technology include a wearable physiological monitoring device, related algorithms and software that are tied to a portable electronic device for readout. The wearable device can perform real-time measurement of a number of physiological and environmental parameters including heart rate, pulse oximetry, respiration, movement, environmental particulate matter, moisture, temperature (e.g., ambient air and body temperatures) and geospatial location. Some embodiments may establish a physiological baseline for a patient by measuring the above parameters during a healthy state. Collected data can be wirelessly transmitted to a portable electronic device or monitoring and feedback platform where software will analyze the data and make assessments of the device wearer's health based upon the wearer's baseline.Type: ApplicationFiled: December 4, 2023Publication date: April 11, 2024Applicant: The Regents of the University of Colorado, a body corporateInventors: Robin Deterding, Tam Vu
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Patent number: 11952576Abstract: A novel method of diluting the structures in the cell population, such that individual cells, dependent on the activity of the structures, become single measurement devices. This can be applied to all Bacterial Microcomparments (“BMCs”), organelles, and macromolecules, and could provide a universal method for the design of novel ones and understanding of the diverse structures. In one aspect the present invention provides A method of creating a bacterial strain with inducible and detectable carboxysomes. The method includes the steps of incorporating a labeled carbon-fixation enzyme into the genome of a bacterium; deleting all or a portion of the ccm operon from the bacterium; and reintroducing a ccm operon comprising an inducible promoter to create a ?ccm+ strain.Type: GrantFiled: November 16, 2020Date of Patent: April 9, 2024Assignee: The Regents of the University of Colorado, a body corporateInventors: Jeffrey Carlyle Cameron, Nicholas C. Hill, Jian Wei Tay, Sabina Altus, David Matthew Bortz, Kristin Ann Moore
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Patent number: 11952353Abstract: Compounds that inhibit the activity of Signal transducer and activator of transcription 3 (STAT3), or pharmaceutically acceptable salts or prodrugs thereof, and methods of using these compounds to treat cancer and other diseases.Type: GrantFiled: December 6, 2019Date of Patent: April 9, 2024Assignee: The Regents of the University of ColoradoInventors: Philip Reigan, Donald S. Backos, Christopher J. Matheson, Steffanie L. Furtek, Craig T. Jordan, Maria L. Amaya
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Patent number: 11944725Abstract: The present invention relates to a medical implant, and more particularly, to a vascular implant having a dual coating structure for preventing in-stent restenosis and thrombosis. In one embodiment, the invention contemplates a vascular stent with a coating comprising a hydrophobic, degradable core with a coaxial sheath comprising at least one polyethylene-glycol derivative. In one embodiment, the at least one polyethylene-glycol derivative comprises polyethylene-glycol dimethacrylate.Type: GrantFiled: June 28, 2019Date of Patent: April 2, 2024Assignee: The Regents of the University of Colorado, A Body CorporateInventors: Parnaz Boodagh, Wei Tan, Michael Floren
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Patent number: 11946598Abstract: Methods, systems, and devices for ultra or extreme-high vacuum are described. Such systems may comprise a vacuum chamber, a target within the vacuum chamber, two or more overlapping radiation shields arranged within an inner vacuum space of a vacuum chamber, and surrounding at least a portion of the target, a first and a second cooling element unit thermally coupled to a first and second radiation shield of the two or more overlapping radiation shields, wherein the first unit is configured to reduce the first radiation shield's temperature to at least <100K, and the second unit is configured to reduce the second radiation shield's temperature to at least <25K, and a third cooling element unit coupled to the target and isolated from the first and second radiation shield, wherein the third cooling element unit is configured to reduce the target's temperature to at least <4K.Type: GrantFiled: September 12, 2019Date of Patent: April 2, 2024Assignee: The Regents of of the University of Colorado, a body corporateInventors: Daniel Dessau, Justin Griffith
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Publication number: 20240092837Abstract: The present invention describes peptides, peptides carriers, peptide nanobodies, and peptide-drug covalent conjugates having efficient cell and tissue penetration. The peptides and associated configurations can be used in covalent attachments or as complexes or nanoparticles in conjunction with therapeutic agents to enhance their tissue, cellular, and intracellular delivery. Also, the peptides and associated configurations can enhance binding to negatively charged matrices in the body for improved localization or retention of therapeutic carriers and agents.Type: ApplicationFiled: July 26, 2023Publication date: March 21, 2024Applicant: The Regents of the University of Colorado, A Body CorporateInventors: Uday Kompella, Arun Upadhyay
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Patent number: 11932867Abstract: Methods of preventing or treating rheumatoid arthritis (RA) in a subject by introducing the DRB1*04:01K71E mutation that is resistant to RA. The resistant allele is introduced into the subject having or at risk of developing RA, using a HLA CRISPR/Cas9 vector that targets codon 71 in the HLA allele DRB1*04:01, introducing a single A to G point mutation in codon 71 by homology directed repair to alter the lysine at position 71 of the expressed protein to glutamic acid. This modified allele is affected in the subject's hematopoietic stem cells, which are then expanded and transplanted back into the patient. This microgene therapy confers RA-resistance via an autologous transplant. The invention includes isolated nucleic acids, vectors, recombinant viruses, cells, and pharmaceutical compositions to modify the HLA DRB1*04:01 allele.Type: GrantFiled: April 25, 2018Date of Patent: March 19, 2024Assignees: National Jewish Health, The Regents of the University of Colorado, a Body CorporateInventors: Brian Freed, Kirsten Anderson, Christina Roark, Jennifer Matsuda
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Patent number: 11933781Abstract: A method of screening a test compound, e.g., a fibrosis or IPF inhibitor, for induction of an unjammed-to-jammed transition (UJT) in fibrotic primary human bronchial epithelial cells (HBECs) isolated from a subject with a fibrotic lung disease includes culturing the fibrotic primary HBECs at an air-liquid interface for a time sufficient to provide a differentiated pseudostratified epithelium contacting the cultured cells with the test compound; and monitoring the motility of the cultured cells to identify the cultured cells as moving or stationary; wherein stationary cultured cells indicate that the test compound induces the UJT. Also included are methods of identifying lung fibrosis biomarkers.Type: GrantFiled: December 9, 2021Date of Patent: March 19, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADOInventors: David Schwartz, Ian Stancil
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Patent number: 11933973Abstract: The present disclosure relates generally to methods and systems useful in imaging applications, especially biological imaging applications, and applications in the metrology, atmospheric, scientific and medical fields. In one aspect, the disclosure provides a method of imaging an object, including illuminating the object with incident radiation through one or more adaptive optical elements; receiving transmitted radiation from the object at a photodetector to provide a base image; and performing the following steps one or more times: adjusting the one or more adaptive optical elements, the adjustment including modifying an optical transfer function of the one or more adaptive optical elements, and receiving transmitted radiation from the object at the photodetector to provide an adjusted image; wherein the adjustment and receiving steps are performed until the adjusted image has substantially reduced aberrations compared to the base image.Type: GrantFiled: October 3, 2018Date of Patent: March 19, 2024Assignee: The Regents of the University of ColoradoInventors: Juliet Gopinath, Mo Zohrabi, Victor M. Bright, Omkar Supekar, Robert H. Cormack, Emily Gibson, Connor McCullough
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Patent number: 11933899Abstract: Through discrimination of the scattered signal polarization state, a lidar system measures a distance through semi-transparent media by the reception of single or multiple scattered signals from a scattering medium. Combined and overlapped single or multiple scattered light signals from the medium can be separated by exploiting varying polarization characteristics. This removes the traditional laser and detector pulse width limitations that determine the system's operational bandwidth, translating relative depth measurements into the conditions of two surface timing measurements and achieving sub-pulse width resolution.Type: GrantFiled: January 24, 2022Date of Patent: March 19, 2024Assignees: The Regents of the University of Colorado, LiteWave Technologies, Inc.Inventors: Jeffrey P. Thayer, Geoffrey Crowley, Andrew W. Gisler, Steven Mitchell, Matthew Hayman
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Patent number: 11925798Abstract: A method for synchronously driving more than two or more rotational tissue screws and a method for simultaneously affixing a medical device to tissue employing the synchronous drive system. The method employs a synchronous drive system is particularly configured to affix an apical cuff to cardiac muscle tissue by simultaneously driving a plurality of rotational tissue screws through the apical cuff and into cardiac muscle tissue thereby affixing the apical cuff to the cardiac muscle tissue.Type: GrantFiled: May 24, 2022Date of Patent: March 12, 2024Assignee: The Regents of the University of ColoradoInventors: Max Bannister Mitchell, Jeremy H. Morgan