Patents Assigned to The Trustees of Boston University
  • DNA recombinase circuits for logical control of gene expression
    Patent number: 11030531
    Abstract: The invention provides, inter alia, recombinase-based systems that provide for integrated logic and memory in living cells such as mammalian cells. The nucleic acid cassettes, switches, and systems described herein allow for control of gene expression or gene regulation. The invention also provides nucleic acid-based switches for adopted T-cell therapy.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: June 8, 2021
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Wilson W. Wong, Benjamin Harris Weinberg
  • ONE-STEP FLOW-MEDIATED SYNTHESIS OF CANNABIDIOL (CBD) AND DERIVATIVES
    Publication number: 20210163387
    Abstract: Herein are described apparatus and processes for the preparation of cannabinoids, such as cannabidiol (CBD) and derivatives thereof. The apparatus and processes described can be used for the one-step, flow-mediated synthesis of cannabidiol and derivatives with improved overall yield, material throughput, and product purity relative to batch processes.
    Type: Application
    Filed: January 14, 2021
    Publication date: June 3, 2021
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: John A. PORCO, JR., Aaron B. BEELER, Lauren E. BROWN, Richard V. TRILLES
  • ANTI-DEspR INHIBITORS AS THERAPEUTICS FOR INHIBITION OF PATHOLOGICAL ANGIOGENESIS AND TUMOR CELL INVASIVENESS AND FOR MOLECULAR IMAGING AND TARGETED DELIVERY
    Publication number: 20210155700
    Abstract: Provided herein are novel compositions comprising anti-DEspR antibodies and fragments thereof, including fully human, composite engineered human, humanized, monoclonal, and polyclonal anto-DEspR antibodies and fragments thereof, and methods of their use in a variety of therapeutic applications. The compositions comprising the anti-DEspR antibodies and fragments thereof described herein are useful in diagnostic and imaging methods, such as DEspR-targeted molecular imaging of angiogenesis, and for companion diagnostic and/or in vivo-non invasive imaging and/or assessments.
    Type: Application
    Filed: January 26, 2021
    Publication date: May 27, 2021
    Applicant: Trustees of Boston University
    Inventors: Nelson Ruiz-Opazo, Victoria L.M. Herrera
  • Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
    Patent number: 11002724
    Abstract: Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. A new class of chemically modified nanopore sensors are provided with two approaches for monolayer coating of nanopores by: (1) self-assembly from solution, in which nanopores ?10 nm diameter can be reproductibly coated, and (2) self-assembly under voltage-driven electrolyte flow, in which 5 nm nanopores may be coated. Applications of chemically modified nanopore are provided including: the detection of biopolymers such as DNA and RNA; immobilizing enzymes or other proteins for detection or for generating chemical gradients; and localized pH sensing.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: May 11, 2021
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Amit Meller, Meni Wanunu
  • GM3 FUNCTIONALIZED NANOPARTICLES
    Publication number: 20210128489
    Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.
    Type: Application
    Filed: April 9, 2020
    Publication date: May 6, 2021
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Bjoern Markus Reinhard, Suryaram Gummuluru
  • Diffractive axilenses and uses thereof
    Patent number: 10996383
    Abstract: An optical element includes a substrate and a pattern. The substrate has a top surface and a bottom surface. The pattern is provided on the top surface. The pattern includes multiple levels such that a thickness of the pattern is less than a design wavelength. The pattern is configured to focus an incident radiation, received at one of the top surface or the bottom surface of the substrate, at one or more prescribed focal locations on a detection plane. The one or more prescribed focal locations on the detection plane changes in proportion to a wavelength of the incident radiation. The detection plane is an achromatic focal plane when the incident radiation includes multiple wavelengths.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: May 4, 2021
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Luca Dal Negro, Yuyao Chen, Wesley Britton
  • Ceramides for evaluating risk of cardiovascular disease
    Patent number: 10996231
    Abstract: The present disclosure provides the use of two very long chain ceramides for determining the risk of cardiovascular disease.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: May 4, 2021
    Assignees: Washington University, Trustees of Boston University
    Inventors: Jean E. Schaffer, Daniel S. Ory, Linda Peterson, Vasan S. Ramachandran, Vanessa Xanthakis
  • METHODS FOR TREATING NETOSIS AND NEUTROPHIL ACTIVATION
    Publication number: 20210121549
    Abstract: Described herein are methods and compositions relating to methods of inhibiting neutrophils, e.g., inhibiting NET release or NETosis, by means of a DEspR inhibitor, e.g., an anti-DEspR antibody reagent. In some embodiments, the methods can relate to the treatment of a disease, e.g., cancer or a disease wherein neutrophils; NETs; or NETosing or NETting neutrophils contribute to pathogenesis, chronicity, or worsening of disease. In some embodiments, the DEspR inhibitor can be a bi-specific reagent or an antibody-drug conjugate.
    Type: Application
    Filed: October 27, 2020
    Publication date: April 29, 2021
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Nelson RUIZ-OPAZO, Victoria L.M. HERRERA
  • TISSUE MARKERS
    Publication number: 20210121263
    Abstract: The inventions provided herein relate to tissue markers and uses thereof, e.g., to mark a target tissue site (e.g., a biopsy site in a breast tissue) or to produce a cell scaffold. The tissue markers described herein are designed to be resistant to fast migration (e.g., immediate migration after implantation through a needle track) and slow migration (e.g., over an extended period of time) upon implantation at a target tissue site (e.g., a biopsy site in a breast tissue), without using an adhesive. Additionally or alternatively, the tissue markers described herein can be readily detectable by at least one imaging modality, e.g., but not limited to magnetic resonance imaging, X-ray imaging, ultrasound imaging, or a combination thereof.
    Type: Application
    Filed: December 14, 2020
    Publication date: April 29, 2021
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, BOSTON MEDICAL CENTER CORPORATION
    Inventors: Mark W. GRINSTAFF, Boris Nicolas BLOCH, Jonah KAPLAN
  • 2D ELECTROCHROMIC METAL-ORGANIC-FRAMEWORKS
    Publication number: 20210122775
    Abstract: Herein are described two-dimensional metal organic frameworks (2D MOFs). The 2D MOFs includes a plurality of multivalent metals or metal ions and a plurality of multidentate ligands arranged to form a crystalline structure having a lateral size of at least about 2.5 ?m and a thickness of less than about 5 nm. Herein are also described methods for preparing the 2D MOFs. The 2D MOFs can be used, for example, in electrochromic devices such as smart windows and flexible displays.
    Type: Application
    Filed: October 23, 2020
    Publication date: April 29, 2021
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Xi LING, Ran LI, Lu PING
  • Data storage and retrieval system using online supervised hashing
    Patent number: 10990626
    Abstract: A data storage and retrieval system employs online supervised hashing for indexing a data set and retrieving data items therefrom. A hash-based mapping is used to generate hash codes for indexing content items. Data items may be retrieved based on either/both a query label (using corresponding codewords) and the content item itself (using the hash codes). The hash-based mapping is updated using an objective function of distance between the hash codes and respective codewords for labels of labelled content items, preserving semantic similarities of content items. The codewords may be error-correcting codes. Techniques for efficiently updating the index include (1) cycle-based updating and ternary codewords, and (2) reservoir sample-based method of determining when to trigger an update.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: April 27, 2021
    Assignee: Trustees of Boston University
    Inventors: Stanley Sclaroff, Fatih Cakir, Kun He
  • Cantilever-free scanning probe microscopy
    Patent number: 10989736
    Abstract: A system includes a probe assembly, a camera, and a control system. The probe assembly includes a rigid substrate, a compliant layer provided on the rigid substrate, one or more rigid probes can be arranged on the compliant layer to cover at least a portion of the compliant layer, and a reflective layer can cover the one or more rigid probes and uncovered portions of the compliant layer. The camera is configured to generate image data from the probe assembly. The control system is configured to receive image data from the camera and develop a topographical image of a surface of a sample, based at least in part on the received image data.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: April 27, 2021
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Keith Andrew Brown, Wenhan Cao, Nourin Alsharif
  • Methods of producing aggregate-free monomeric diphtheria toxin fusion proteins and therapeutic uses
    Patent number: 10988512
    Abstract: The present invention is a DNA expression vector comprising: a toxP; a mutant toxO that blocks Fe-mediated regulation of gene expression; and a DNA sequence encoding a protein, wherein the toxP and the mutant toxO regulate expression of the DNA segment encoding the protein. It is preferred that DNA expression vectors of the present invention include DNA sequences encoding a signal peptide so that a protein expressed is attached to the signal peptide prior to processing. Novel proteins are produced off of the DNA expression vector of the present invention.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: April 27, 2021
    Assignees: The Johns Hopkins University, Trustees of Boston University
    Inventors: William R. Bishai, John R. Murphy, Laurene Cheung, Shashank Gupta, Cynthia K. Bullen
  • METHODS AND COMPOSITIONS RELATING TO LUNG FUNCTION
    Publication number: 20210113581
    Abstract: The technology described herein is directed to methods and compositions for prognosis and treatment of respiratory disease, e.g., COPD.
    Type: Application
    Filed: October 15, 2020
    Publication date: April 22, 2021
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Elizabeth Jeanne BECKER, Katrina STEILING, Avrum E. SPIRA, Marc E. LENBURG
  • CAL-T CONSTRUCTS AND USES THEREOF
    Publication number: 20210113653
    Abstract: The technology described herein is directed to compositions comprising components of multi-component CALs or CARs, e.g., a TCR recognition domain; and one or both of: (a) an intracellular signaling domain; and (b) a first-type protein interaction domain. Further provided herein are methods for treating or preventing an autoimmune disease, a transplant rejection, or graft versus host disease.
    Type: Application
    Filed: October 16, 2020
    Publication date: April 22, 2021
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, THE GENERAL HOSPITAL CORPORATION
    Inventors: Mohammadreza PAKYARI, Wilson WONG, Atsushi OKUMA, Curtis CETRULO
  • One-step flow-mediated synthesis of cannabidiol (CBD) and derivatives
    Patent number: 10981850
    Abstract: Herein are described apparatus and processes for the preparation of cannabinoids, such as cannabidiol (CBD) and derivatives thereof. The apparatus and processes described can be used for the one-step, flow-mediated synthesis of cannabidiol and derivatives with improved overall yield, material throughput, and product purity relative to batch processes.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: April 20, 2021
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: John A. Porco, Aaron B. Beeler, Lauren E. Brown, Richard V. Trilles
  • Efficiently querying databases while providing differential privacy
    Patent number: 10984130
    Abstract: Technologies are provided for efficiently querying a database using a plurality of oblivious random-access memories (ORAMs) while providing differential privacy. Subsets of a set of database records can be stored in a plurality of ORAMs. The subsets of database records in the separate ORAMs can be concurrently accessed (for example, by a database query server). When a database query is received, a number of database records that match the query can be identified for each of the ORAMs. A differential privacy constraint can be used to determine an additional number of database records to be retrieved from each ORAM. The differential privacy constraint can specify an upper bound on the number of records to be retrieved from each ORAM to prevent (or reduce the risk of) information leakage. Once all of the identified records are retrieved from the plurality of ORAMs, the additional records can be discarded.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: April 20, 2021
    Assignees: Georgetown University, Trustees of Boston University, Bornio, Inc.
    Inventors: Yaacov Nissim Kobliner, Georgios Kellaris, George Kollios
  • Methods and compositions related to differentiated lung cells
    Patent number: 10975357
    Abstract: Described herein are methods and compositions related to induced alveolar epithelial type 2 cells (iAEC2s), e.g., artificially-produced epithelial type 2 cells.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: April 13, 2021
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Darrell N. Kotton, Anjali Jacob
  • Functionalization of endogenous bacteria
    Patent number: 10968454
    Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: April 6, 2021
    Assignees: Massachusetts Institute of Technology, Trustees of Boston University
    Inventors: Timothy Kuan-Ta Lu, Robert James Citorik, James Collins, Russell-John Krom
  • Polypeptide compositions and methods for site-specific targeting of therapeutic agents
    Patent number: 10953107
    Abstract: Described herein are methods and compositions related to compositions comprising combinations of V/K-type and V/E-type docking peptides and uses thereof, e.g., to deliver therapeutic agents to treat certain conditions such as cancer, infection, or trauma.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: March 23, 2021
    Assignee: Trustees of Boston University
    Inventors: Mark W. Grinstaff, Christopher Gromisch, Victoria Herrera, Nelson Ruiz-Opazo