Patents Assigned to The Trustees of Boston University
  • Retractable endoscopic suction tube
    Patent number: 11337586
    Abstract: Disclosed herein is an aspiration assembly for attaching to an endoscope. The aspiration assembly comprises an extendable suction tube for aspirating an object (e.g., smoke, blood, blood clot, bone debris, or tissue debris) at or near a surgical site during an endoscopic surgery. The aspiration assembly can further comprise an irrigation tube for directing a fluid to the surgical site for cleaning the endoscope lens. By integrating an extendable suction tube with the endoscope, the technology described herein obviate the need for instrument switching and/or multiple surgeons during the surgery.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: May 24, 2022
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, BOSTON MEDICAL CENTER CORPORATION, FRAUNHOFER USA, INC.
    Inventors: Anand Devaiah, Andre Sharon, Alexis Sauer-Budge, Holger Wirz, Yuzhang Yang, Stephanus Johannes Marcellis Van Der Kemp, Daniel Echeverria
  • Enzyme-based electrochemical nicotine biosensor
    Patent number: 11331020
    Abstract: Described herein is an amperometric biosensor, e.g., chronoamperometric biosensor for the measurement of the concentration of nicotine. Also disclosed herein is a wearable nicotine biosensor device and a biosensor that detects nicotine in smoke. The biosensor disclosed herein comprises a nicotine-catalyzing enzyme, such as NicA2 or mutant NicA2 enzymes. Also described herein are systems comprising said amperometric biosensor, e.g., chronoamperometric biosensor and methods of using said chronoamperometric biosensor.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: May 17, 2022
    Assignee: Trustees of Boston University
    Inventors: James Galagan, Mark W. Grinstaff, Uros Kuzmanovic, Mingfu Chen, Margarita Alexandrovna Tararina, Karen Nazaretian Allen
  • Infusion system and components thereof
    Patent number: 11331463
    Abstract: Certain embodiments provide multi-medicament infusion systems for preventing the cross-channeling of medicaments. The system may include one or more of an infusion pump, medicament reservoirs, collars, a multi-channel fluid conduit, and an infusion set. The medicament reservoirs and/or collars may be sized and shaped differently such that the medicament reservoirs can only be inserted into the system selected configurations.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: May 17, 2022
    Assignee: Trustees of Boston University
    Inventors: Edward R. Damiano, Firas H. El-Khatib, Rajendranath Selagamsetty, Kirk D. Ramey
  • ANTIBODY THERAPIES AND METHODS FOR TREATING CORONAVIRUS INFECTION
    Publication number: 20220144939
    Abstract: Described herein are methods of treating COVID19 from a coronavirus infection, methods of treating a subject having a coronavirus infection, methods of improving a survival rate of a subject having a coronavirus infection, methods of determining prognosis of a subject having a coronavirus infection, methods of preventing or treating organ-dysfunction or multi-organ dysfunction or failure associated with a coronavirus infection, methods of combinational therapy for a subject having a coronavirus infection, methods of reducing microthrombi formation or low flow organ-ischemia associated with a coronavirus infection by administering a DEspR inhibitor.
    Type: Application
    Filed: October 14, 2021
    Publication date: May 12, 2022
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Nelson RUIZ-OPAZO, Victoria HERRERA
  • Assistive flexible suits, flexible suit systems, and methods for making and control thereof to assist human mobility
    Patent number: 11324655
    Abstract: In at least some aspects, the present concepts include a method for configuring an assistive flexible suit including the acts of outfitting a person with an assistive flexible suit, monitoring an output of at least one sensor of the assistive flexible suit as the person moves in a first controlled movement environment, identifying at least one predefined gait event using the output of the at least one sensor, adjusting an actuation profile of the at least one actuator and continuing to perform the acts of monitoring, identifying and adjusting until an actuation profile of the at least one actuator generates a beneficial moment about the at least one joint to promote an improvement in gait. The at least one controller is then set to implement the actuation profile.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: May 10, 2022
    Assignees: Trustees of Boston University, President and Fellows of Harvard College
    Inventors: Stefano Marco Maria De Rossi, Kathleen Elizabeth O'Donnell, Jaehyun Bae, Alan Thomas Asbeck, Kenneth G. Holt, Conor J. Walsh
  • Hsp90 inhibitors and uses thereof
    Patent number: 11312722
    Abstract: Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related diseases.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: April 26, 2022
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, The Governing Council of the University of Toronto
    Inventors: Lauren Elaine Brown, David S Huang, Leah E. Cowen, Luke Whitesell, Paul Marcyk
  • HETEROCYCLIC LSF INHIBITORS AND THEIR USES
    Publication number: 20220112206
    Abstract: The present invention is directed to heterocyclic SV40 Factor (LSF) inhibitors and their uses. In some implementations, the present invention discloses small-molecule compounds of Formula (I). In some implementations, the compounds of Formula (I) are used in methods for inhibiting LSF in a subject. In some implementations, the compounds of Formula (I) are used in methods for treating cancer in a subject.
    Type: Application
    Filed: December 22, 2021
    Publication date: April 14, 2022
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Scott E. SCHAUS, Ulla HANSEN, John A. KAVOURIS, Emily A. YORK, Niranjana POKHAREL
  • Microelectromechanical shutters for organic vapor jet printing
    Patent number: 11292245
    Abstract: A device includes a nozzle including a discharge end for discharging a fluid, a shutter plate including an aperture, the shutter plate positioned at the discharge end of the nozzle, a plurality of tethers coupled to the shutter plate, and a plurality of electrostatic actuators. Each of the plurality of electrostatic actuators are coupled to one or more of the plurality of tethers. The plurality of electrostatic actuators are configured to move the shutter plate between an open position and a closed position relative the discharge end of the nozzle. In the open position, the aperture is in fluid communication with the discharge end of the nozzle to permit fluid from the discharge end of the nozzle to flow through the aperture. In the closed position, at least a portion of the shutter plate inhibits fluid from the discharge end of the nozzle from flowing through the aperture.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: April 5, 2022
    Assignees: Trustees of Boston University, The Regents of the University of Michigan
    Inventors: David J. Bishop, Lawrence Barrett, Stephen Forrest
  • Aperiodic nano-optical array for angular shaping of incoherent emissions
    Patent number: 11294195
    Abstract: Disclosed herein are a number of dielectric pillars, arranged to form a close-packed aperiodic array, such as a Vogel spiral, where the geometries of the aperiodic array produce azimuthally isotropic scattering of luminescence within a restricted angular cone of extraction. The aperiodic array can be formed, attached or placed on a converting material, such as, phosphor, to restrict emission to within the angular cone of extraction. The phosphor could be part of a converting illumination device, such as a phosphor coated light emitting diode, or a laser activated remote phosphor converting device.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: April 5, 2022
    Assignees: OSRAM Opto Semiconductors GmbH, Trustees of Boston University
    Inventors: Luca Dal Negro, Alan Lenef, Madis Raukas, Sean Gorsky, Ran Zhang
  • CHIMERIC ANTIGEN RECEPTOR (CAR) MODULATION
    Publication number: 20220098246
    Abstract: The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.
    Type: Application
    Filed: June 9, 2021
    Publication date: March 31, 2022
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: John NGO, Wilson WONG, Meng Lai Nicole WONG, Huishan LI, Elliot P. TAGUE
  • Amidino- and amino-rocaglates as novel translation inhibitors and anticancer agents
    Patent number: 11279708
    Abstract: Herein are described the preparation of a series of synthetic rocaglates, amidino- and amino-rocaglates, which display inhibition of protein translation and tumor cell proliferation (in vitro and in vivo). The methods described herein allow the preparation of libraries of modified rocaglates. This chemical modification of the rocaglate scaffold changes the C8b-hydroxyl of the natural product series to a more optimal hydrogen bond donor/acceptor.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: March 22, 2022
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: John A. Porco, Jr., Wenhan Zhang, Gerard Pelletier, Jennifer Chu
  • PAPER-BASED SYNTHETIC GENE NETWORKS
    Publication number: 20220081729
    Abstract: Disclosed herein are shelf-stable compositions based on synthetic gene networks and/or cell-free systems that are lyophilized on a solid support. The compositions can be easily transported and stored for a period of time, and activation can be done by simply adding water. Methods of use are also disclosed herein, including, but are not limited to, sensing and a variety of logic functions. The invention permits straightforward, sterile and abiotic distribution of synthetic biology-based technology to clinical settings, food processing and industry, the military and consumer products.
    Type: Application
    Filed: September 28, 2021
    Publication date: March 17, 2022
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Keith PARDEE, James J. COLLINS
  • Structured substrates for optical surface profiling
    Patent number: 11275030
    Abstract: This disclosure provides methods and devices for the label-free detection of target molecules of interest. The principles of the disclosure are particularly applicable to the detection of biological molecules (e.g., DNA, RNA, and protein) using standard SiO2-based microarray technology.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: March 15, 2022
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: M. Selim Unlu, David A. Bergstein, Michael F. Ruane, Bennett B. Goldberg
  • FLUORESCENCE-CODED MID-INFRARED PHOTOTHERMAL MICROSCOPE
    Publication number: 20220074861
    Abstract: Microscopic analysis of a sample includes a fluorescent dye disposed within the sample. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. An optical source generates a probe beam directed to impinge on the sample. A detector detects fluorescent emissions from the sample when the probe beam impinges on the sample. A data acquisition and processing system acquires and processes the detected fluorescent emissions from the sample to: (i) generate a signal indicative of infrared absorption by the sample, (ii) generate a signal indicative of temperature in the sample based on the signal indicative of infrared absorption by the sample, (iii) generate an image of the sample using the signal indicative of temperature in the sample.
    Type: Application
    Filed: September 3, 2021
    Publication date: March 10, 2022
    Applicant: Trustees of Boston University
    Inventors: Ji-Xin Cheng, Yi Zhang, Cheng Zong
  • Situ expansion of engineered devices for regeneration
    Patent number: 11266766
    Abstract: Engineered human tissue seed constructs are provided that are suitable for implantation in subjects. Methods of making and using the engineered tissue seed constructs are provided.
    Type: Grant
    Filed: March 26, 2021
    Date of Patent: March 8, 2022
    Assignees: Massachusetts Institute of Technology, Trustees of Boston University
    Inventors: Sangeeta N. Bhatia, Kelly R. Stevens, Christopher S. Chen
  • Stretch release drug delivery materials
    Patent number: 11266768
    Abstract: The disclosure provides a drug delivery device that can release a drug or other molecule of interest in response to application of a mechanical force, such as tension, and methods of use thereof. The present disclosure provides a tension-responsive drug delivery device by exploiting a difference in mechanical properties between a drug-loaded core material and a supertiydrophobic barrier coating consisting of interconnected micro- and nano-sized particles formulated via the electrospraying of a mixture of biocompatible polymers.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: March 8, 2022
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Mark Grinstaff, Jonah Andrew Kaplan, Julia Wang
  • QUINOLIN-2(1H)-ONE INHIBITORS OF LATE SV40 FACTOR
    Publication number: 20220062272
    Abstract: The present invention is directed to compositions, methods and kits for treatment of cancer, e.g., hepatocellular carcinoma (HCC). In some embodiments, the present invention discloses the use of a small-molecule compounds of Formula (I) to inhibit tubulin acetylation, to inhibit cell migration, or to modulate cell compaction.
    Type: Application
    Filed: September 1, 2021
    Publication date: March 3, 2022
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Scott Edward SCHAUS, Ulla HANSEN, Emily Ann YORK, Niranjana POKHAREL
  • NOVEL FUNGAL MODULATORS
    Publication number: 20220064152
    Abstract: The present invention is directed to compounds, compositions, and methods for inhibiting drug-efflux pumps. The compounds, compositions, and methods can be used for enhancing the activity of therapeutic agents that are efflux pump substrates and for the treatment of drug-resistant diseases or disorders, such as microbial infections and cancers.
    Type: Application
    Filed: August 31, 2021
    Publication date: March 3, 2022
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Lauren E. BROWN, Kaddy CAMARA, Leah E. COWEN, John A. PORCO, JR.
  • NOVEL DRUG-CONTROLLED SYSTEMS AND USES THEREOF
    Publication number: 20220062234
    Abstract: The technology described herein is directed to polypeptide systems using drug-controlled peptide docking domains and cognate docking domain-binding peptides and their use to control cellular signaling, activity, and/or gene expression.
    Type: Application
    Filed: August 31, 2021
    Publication date: March 3, 2022
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: John T. NGO, Mary DUNLOP, Elliot Parker TAGUE, Nathan Michael TAGUE, Alexander Michael MARZILLI
  • ENGINEERED EXTRACELLULAR RECEPTOR CONSTRUCTS AND USES THEREOF
    Publication number: 20220064252
    Abstract: Described herein are methods and compositions related to modular engineered receptor polypeptide constructs and their use in modulating the activity of a cell.
    Type: Application
    Filed: August 27, 2021
    Publication date: March 3, 2022
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Elliot Parker TAGUE, John T. NGO, Jeffrey Blye MCMAHAN