Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, an anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.

Abstract: The invention provides a method for increasing the growth of a plant or the harvest yield of a plant comprising, contacting the plant with a trisulfide or a tetrasulfide. The methods of the invention may conveniently be employed in indoor growth facilities or in conjunction with a hydroponic growth system.

Abstract: The present invention relates to methods and compositions for treating leishmaniasis in mammals. The invention more particularly relates to immunotherapeutic treatment of Leishmania in infected mammals, and is suitable for treating animals (e.g., dogs) and humans. The invention may be used alone or in combination with conventional chemotherapeutic agents.

Abstract: Provided is a method of using a nanowire diode with an array of more than 100 nanowires functionalized with binding agents that bind to one or more specific biomarkers, the nanowires being non-horizontally aligned on a substrate, and the nanowires being electrically connected to each other, to measure the presence or absence of the one or more specific biomarkers. The method comprises exposing the nanowires to a solution of interest, shining light with a wavelength between 350 nm and 700 nm on the nanowire diode, measuring electrical current that is optically induced in the nanowire diode by the light, and comparing the optically induced electrical current with and without the solution of interest present to deduce a concentration of the one or more specific biomarkers in the solution of interest.

Abstract: A method for estimating stream flow data of a channel includes steps of acquiring direct measurement of an index velocity of the channel, acquiring stage measurements for the channel for use in determining slope of a free surface, and applying a data-driven model combining the index velocity and a continuous slope-area method which uses the slope of the free surface to estimate stream flow data of the channel without using conventional rating curves. The direct measurement of the index velocity and the stage measurements may be received at a computing device executing instructions for applying the data-driven model.

Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a SIN CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing SIN CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.

Abstract: Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.

Abstract: The invention provides a method and kits for inhibiting integrin ?9?1 activity comprising contacting integrin ?9?1 or a binding partner of integrin ?9?1 with an isolated anti-integrin ?9 inhibitor, wherein the integrin ?9?1 activity is inhibited. In certain aspects, the present invention provides a novel intervention by targeting integrin ?9?1 with a functional blocking inhibitor (e.g., peptides or antibodies) to limit brain damage following reperfusion after ischemic stroke.

Abstract: The disclosure relates to a composite comprising a metal film having a first major surface and opposed second major surface, at least a portion of the metal film having a sheet resistance of at least 15 ?/sq, an optical transmittance of at least 60% within the visible spectrum, and tunable bandpass filtering effect in the THz frequency range; a dielectric substrate comprising a first major surface and opposed second major surface; the metal film first major surface located on at least a portion of the dielectric substrate first major surface. The disclosure also relates to methods of making such composites and articles comprising such composites.

Abstract: Embodiments of the present systems and methods may provide techniques that may provide the capability to autonomously and automatically identify cases of suspected abuse, which may then be subject to follow up review and action. For example, in an embodiment, a system for identifying potential physical abuse in a location may comprise at least one video camera provided at the location and a computer system comprising a processor, memory accessible by the processor, and computer program instructions stored in the memory and executable by the processor to cause the computer system to perform: receiving video data from the at least one video camera, identifying potential physical abuse from the video data, the identification being to within a predetermined confidence level, and transmitting information indicating that a potential human threat has been identified.

Abstract: A metal alloy is provided which includes by weight percentage of the metal alloy, 28 to 55 percent copper, 45 to 63 percent nickel, and 4 to 10 percent iron. The metal alloy may be weight percentage 28 percent copper, 62 percent nickel, and 10 percent iron. The metal alloy may be formed into a foil which may have a thickness of 100 ?m or less or 50 ?m or less. A magnetic field instrument may include a magnetometer core body formed from one or more layers of the foil. The magnetometer core body may be a ring core or a racetrack core. The magnetic field instrument may further include a sense winding and may further include a drive winding. The magnetic field instrument may be a fluxgate magnetometer.

Abstract: An eyelid flipper tool is used to flip a patient's eyelid to gain access to the patient's meibomian gland lands and gland openings. The eyelid flipper tool has a concave end and a convex end connected by a center section. The concave end has a concave edge with a concave end width, a concave radius, and a curvature. The convex end of the eyelid flipper tool has a convex edge with a convex end up with, a convex end radius, and a curvature. The radii of the concave end and the convex end and the curvature of the ends are dimensioned to conform to the curvature of the eyelids or the globe of a patient's eye.

Abstract: A prevention and safety management system utilizes a non-intrusive imaging sensor (e.g. surveillance cameras, smartphone cameras) and a computer vision system to record videos of workers not wearing sensors. The videos are analyzed using a deep machine learning algorithm to detect kinematic activities (set of predetermined body joint positions and angles) of the workers and recognizing various physical activities (walk/posture, lift, push, pull, reach, force, repetition, duration etc.). The measured kinematic variables are then parsed into metrics relevant to workplace ergonomics, such as number of repetitions, total distance travelled, range of motion, and the proportion of time in different posture categories. The information gathered by this system is fed into an ergonomic assessment system and is used to automatically populate exposure assessment tools and create risk assessments.

Abstract: The various embodiments disclosed here relate to systems, methods, and devices for monitoring bladder health via pressure. Certain implementations are directed to patients who require daily catheterization. The various embodiments have at least one tube coupled to a catheter, a pressure sensor and a processor. Further implementations feature an optional pump and measure volume. Certain embodiments include a digital device with a software application capable of displaying the monitored readings.

Abstract: A data-driven method for streamflow forecasting is provided. The method includes steps of measuring index velocity at an index velocity gaging station associated with a stream to provide index velocity data, simultaneously with measuring the index velocity, measuring water stage at the index velocity gaging station to provide stage data, and applying a data-driven model implemented using a computing device to the index velocity data and the stage data, the data-driven model further using historical index velocity data and historical stage data collected at the station to forecast at least one of magnitude and timing of a flood crest arrival during occurrence of a hydrological event. The index-velocity data and the stage data may be concurrently collected using a Horizontal Acoustic Doppler Current Profiler (HADCP). The method may further include generating using the computing device an alert in advance of flood crest.

Abstract: A method for needle position optimization for prostate brachytherapy for use with a radiation delivery device configured to use a plurality of needles inserted into a prostate of a patient includes obtaining imagery of the prostate of the patient, generating a needle pool for prostate brachytherapy treatment of the patient based on the imagery of the prostate of the patient, and determining at a computing device an optimum prostate brachytherapy treatment plan for the patient by iteratively removing needles from the needle pool by forming and computationally solving a convex optimization problem wherein the convex optimization problem uses a quadratic dosimetric penalty function, dwell time regularization by total variation, and block sparsity regularization term.

Abstract: The invention provides a compound of formula (I): wherein X, Y Z, R1, R2, and X+ have any of the values described in the specification. The compounds are useful to increase plant growth and/or to increase harvest yield.

Abstract: A method of vaccinating a subject is provided, where a cancer protective response is produced. A first vaccine comprises an adenovirus vector comprising at least one nucleic acid molecule that produces a cancer protective response is administered, followed by one or more second vaccines comprising an alphavirus replicon particle comprising RNA comprising or produced from the nucleic acid molecule. In an embodiment the cancer is prostate cancer.

Abstract: The invention includes systems having a cover attached to a frame, and a transmission unit with a rotational device connected to or part of the frame. The cover is mechanically connected to the at least one rotational device. A vibration dampening unit mechanically connected to the transmission unit such that translational movement (e.g. vertical movements) of the cover causes rotational movement of the rotational device. The rotational movement is, in turn, transmitted to the vibration dampening unit via the transmission unit. Preferably, the vibration dampening unit is a passive unit and also a resistance force modulated vibration dampening unit.

Abstract: The invention provides a compound of formula I: wherein X, Y, Z, R?, R2, and X+ have any of the values described in the specification. The compounds are useful to increase plant growth and/or to increase harvest yield.