Abstract: The invention provides a method for preparing an actinide metal peroxide from a corresponding actinide metal oxide under solid reaction conditions.
Abstract: An isolated recombinant parvovirus vector comprising a synthetic enhancer comprising plurality of enhancer sequences operably linked to a promoter, and methods of using the vector, are provided.
Abstract: In certain embodiments, the present invention provides a modified transfer RNA (tRNA) comprising a T-arm, a D-arm, and anticodon-arm and an acceptor arm, wherein the T-arm comprises nucleotides that interact with the elongation factor 1 alpha protein, and methods of use thereof.
Abstract: The methods and systems provided can automatically determine an Arteriolar-to-Venular diameter Ratio, AVR, in blood vessels, such as retinal blood vessels and other blood vessels in vertebrates. The AVR is an important predictor of increases in the risk for stroke, cerebral atrophy, cognitive decline, and myocardial infarct.
Type:
Grant
Filed:
March 26, 2018
Date of Patent:
May 2, 2023
Assignees:
University of Iowa Research Foundation, United States Government as Represented by the Department of Veterans Affairs
Inventors:
Michael D. Abramoff, Meindert Niemeijer, Xiayu Xu, Milan Sonka, Joseph M. Reinhardt
Abstract: Certain embodiments of the invention provide a method for improving maternal and/or offspring health, comprising administering an effective amount of a nicotinamide adenine dinucleotide (NAD) precursor to a female mammal (e.g., pregnant or lactating female mammal).
Type:
Grant
Filed:
November 29, 2017
Date of Patent:
April 25, 2023
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Charles M. Brenner, Po Hien Ear, Ankita Chadda, Marie E. Migaud, Hanna Stevens
Abstract: In certain embodiments, the present invention provides a musclin peptide and methods of increasing muscle growth, performance, resistance to injury and/or preventing or reducing muscle atrophy and improving overall skeletal muscle, metabolic and cardiac health in an animal in need thereof by administering a musclin peptide.
Abstract: The present invention relates to a process of removing free-unlabeled radionuclides from a radiopharmaceutical prior to administering the radiopharmaceutical to the patient using size-exclusion or ion-exchange mechanisms.
Type:
Application
Filed:
November 10, 2022
Publication date:
April 6, 2023
Applicant:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Michael K. Schultz, Somya Kapoor, Douglas R. Spitz
Abstract: The present invention provides in certain embodiments a carcinoma-targeting conjugate comprising Formula I wherein T is a SST2R targeting ligand, L is a linker, and X is a chelator, for the therapeutic treatment of cancer, and methods of use thereof.
Type:
Application
Filed:
January 28, 2021
Publication date:
April 6, 2023
Applicant:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Dongyoul Lee, Michael K. Schultz, Mengshi Li, Nicholas Baumhover, F. Christoper Pigge
Abstract: The present disclosure provides methods for treating or preventing Huntington's disease (HD) in a subject in need thereof, comprising administering a therapeutic agent that activates mTORC 1 function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment, and methods for modulating mHTT-associated metabolic phenotypes and/or reversal of striatal atrophy by administering a therapeutic agent that activates mTORC1 function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment.
Abstract: A machine implemented method includes acquiring at a processor a first image of a patent by performing a computed tomography (CT) scan of a patient and applying at the processor a generative neural network model to the first image of the patient to generate a second image of the patient. The method may further include performing, at the processor, an analysis using the first image and the second image. The first image may be a first pulmonary image and the second image may be a second pulmonary image. The first pulmonary image may show lungs at a first volume and the second pulmonary image may show the lungs at a second volume, the first volume different from the second volume. The first pulmonary image may be a scan of the lungs at expiration and the second pulmonary image may be an inspiratory image of the lungs.
Type:
Application
Filed:
August 19, 2022
Publication date:
March 9, 2023
Applicant:
University of Iowa Research Foundation
Inventors:
Muhammad F. A. Chaudhary, Joseph M. Reinhardt, Sarah E. Gerard, Eric A. Hoffman
Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with a GSH synthesis inhibitor and an anti-cancer composition.
Type:
Grant
Filed:
July 31, 2020
Date of Patent:
March 7, 2023
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Michael K. Schultz, Somya Kapoor, Douglas R. Spitz
Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or more components of a SIN CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing SIN CRISPR complex formation in eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity and to edit or modify a target site in a genomic locus of interest to alter or improve the status of a disease or a condition.
Type:
Grant
Filed:
January 30, 2019
Date of Patent:
February 28, 2023
Assignees:
THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, UNIVERSITY OF IOWA RESEARCH FOUNDATION
Abstract: The invention provides compositions, kits and methods to treat a hyperproliferative disorder with an agent that increases expression of MCR1 and an MCR1 ligand. The invention also provides a method of treating drug-resistant melanoma, comprising administering an MCR1 ligand to a patient in need thereof. The present invention also provides in certain embodiments a melanoma-targeting conjugate comprising Formula I: T-L-X wherein T is a MCR1 ligand, L is a linker, and X an anti-cancer composition, for the therapeutic treatment of a hyperproliferative disorder. The present invention also provides methods, kits and uses of the conjugate of Formula I.
Type:
Grant
Filed:
October 21, 2021
Date of Patent:
February 14, 2023
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Michael K. Schultz, Frances L. Johnson, Somya Kapoor, Dongyoul Lee, Mengshi Li, Molly Martin
Abstract: This disclosure describes the use of a phosphodiesterase-5 (PDE5) inhibitor to reduce an individual's desire to smoke and/or frequency of smoking. In some embodiments, the PDE5 inhibitor is sildenafil (e.g., Viagra).
Type:
Application
Filed:
November 13, 2020
Publication date:
February 9, 2023
Applicants:
BEHAVIORAL DIAGNOSTICS, LLC, UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Eric A. HOFFMAN, Albert Tao-man LEUNG, Alejandro Comellas, Alicia GERKE, Robert PHILIBERT
Abstract: Compositions comprising a reverse-temperature sensitive hydrogel comprising a biopolymer such as a polysaccharide and a synthetic polymer, and a compound in an amount that reversibly inhibits respiratory enzyme complex I, and methods of using the composition, are provided.
Type:
Grant
Filed:
May 12, 2020
Date of Patent:
January 31, 2023
Assignee:
University of Iowa Research Foundation
Inventors:
Todd O. McKinley, James A. Martin, Mitchell Coleman, Tae-Hong Lim, Marc Brouillette
Abstract: The various embodiments disclosed here relate to systems, methods, and devices for monitoring bladder health. Certain implementations are directed to patients who require daily catheterization. The various embodiments have at least one tube coupled to a catheter, a pressure sensor, a pump, and a processor. Certain embodiments include a digital device with a software application capable of displaying the monitored readings.
Type:
Grant
Filed:
November 26, 2019
Date of Patent:
January 17, 2023
Assignee:
University of Iowa Research Foundation
Inventors:
Christopher Cooper, Ryan Steinberg, Lewis Thomas, Eric Pahl, Sanam Zarei, Kayla Jones
Abstract: Methods and systems are described for a rotating shield brachytherapy device. As disclosed herein, the rotating shield brachytherapy (RSBT) apparatus may comprise a radiation source, a drive assembly, a catheter, and an applicator. The applicator can have an outer surface and opposed proximal and distal end portions and a longitudinal axis extending along a length of the catheter. The distal end portion of the catheter can comprise one or more radiation shields and is configured to receive the radiation source. The drive assembly can be configured to engage the proximal end portion of the catheter to selectively rotate the catheter about the longitudinal axis.
Type:
Grant
Filed:
September 25, 2019
Date of Patent:
January 3, 2023
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Ryan T. Flynn, Yusung Kim, Xiaodong Wu, Karolyn M. Hopfensperger, Quentin E. Adams
Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with a GSH synthesis inhibitor and an anti-cancer composition.
Type:
Grant
Filed:
July 31, 2020
Date of Patent:
December 20, 2022
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Michael K. Schultz, Somya Kapoor, Douglas R. Spitz
Abstract: Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activated radicals at the surface of the substrate, simultaneously forming the crosslinked zwitterionic coating and anchoring it to the surface of the substrate. Photomasking techniques can be used to micropattern the zwitterionic coatings. The zwitterionic coatings can be applied to a variety of substrates, including medical devices and systems.
Type:
Grant
Filed:
June 24, 2017
Date of Patent:
December 13, 2022
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventors:
Elise Lin Cheng, C. Allan Guymon, Marian R. Hansen, Braden Leigh