Patents Assigned to The University of New Mexico
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Patent number: 6134295Abstract: An apparatus dedicated to taking diagnostic quality images to confirm the accuracy of radiotherapy treatments. The apparatus is sufficiently compact to be used in the existing treatment heads of linear accelerators capable of delivering both electron and x-ray radiation. A compact electron drift tube is made long enough to penetrate the substantial shielding of a linear accelerator, thereby obviating the need to locate the entire generating device within the head of the machine. The diameter of the drift tube of the present invention is made small enough to penetrate the shielding without causing undue leakage of radiation.Type: GrantFiled: October 29, 1998Date of Patent: October 17, 2000Assignee: University of New MexicoInventors: Thomas H. Kirby, Donna Siergiej, Edl Schamiloglu
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Patent number: 6132977Abstract: SNAP-25 (synaptosomal associated protein) is purified from cerebrospinal or amniotic fluid for immunoassay and quantitation. Quantitation of these proteins is useful in the diagnosis and monitoring of brain disorders and diseases such as schizophrenia and Alzheimer's.Type: GrantFiled: March 13, 1998Date of Patent: October 17, 2000Assignee: University of New MexicoInventors: Peter M. Thompson, Nora Perrone-Bizzozero
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Patent number: 6124498Abstract: In one embodiment, the present invention provides a compound comprising: ##STR1## wherein A=H or OHX=OH, a halogen, OR, NHR, NR'R" where R, R', and R"=H, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, or C.sub.2-8 alkynyl, cycloalkyl, cycloalkenyl, aryl, aralkyl or heterocyclic, substituted or unsubstituted; andR.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 =H, C.sub.1-8 alkyl, C.sub.2-8 alkenyl, or C.sub.2-8 alkynyl, cycloalkyl, cyloalkenyl, aryl or heterocyclic, substituted or unsubstituted, wherein R.sub.1 includes at least one methylene spacer through which R.sub.1 is attached to said compound. The present invention also provides methods for making hydroxynaphthoic acids.Type: GrantFiled: April 28, 1998Date of Patent: September 26, 2000Assignee: University Of New MexicoInventors: David L. Vander Jagt, Lorraine M. Deck, Robert E. Royer
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Patent number: 6122109Abstract: In one embodiment, the present invention provides a microlens having very small focal length. The present invention also provides a non-planar microstructure having a covering layer which is slowly oxidizing or substantially free of oxygen. The present invention also provides methods for forming such microlenses and microstructures. In addition, the present invention provides a VCSEL which includes one or more non-planar microstructures of the present invention.Type: GrantFiled: April 15, 1999Date of Patent: September 19, 2000Assignee: The University of New MexicoInventors: Gregory M. Peake, Stephen D. Hersee
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Patent number: 6117146Abstract: The present invention provides an adjustable vasculopath device for holding a blood vessel prior to the insertion of medical devices such as needles or intravenous tubes into the blood vessel. The vasculopath device includes a pair of probes which may be inserted intradermally to hold the blood vessel. The present invention also provides a method for holding a blood vessel using two probes inserted intradermally.Type: GrantFiled: June 14, 1999Date of Patent: September 12, 2000Assignee: The University of New MexicoInventor: Samuel H. Slishman
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Patent number: 6114545Abstract: The present invention provides novel haloenol lactones that are effective as active site inhibitors of cholesterol esterase. By inhibiting cholesterol esterase the inhibitors of the present invention provide a new approach to the treatment of hypercholesterolemia through limiting the bioavailability of dietary cholesterol.Type: GrantFiled: December 16, 1999Date of Patent: September 5, 2000Assignee: University of New MexicoInventors: Lorraine Deck, David L. Vander Jagt
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Patent number: 6109852Abstract: A chemical (coating and reduction)/mechanical/electrical treatment of ion-exchange materials (preferably ion-exchange membranes) to convert them to artificial muscles. The figure is a perspective view of an actuator of the invention showing the treated membrane actuator (A) with electrodes (25 and 26) placed at one end of the membrane, the electrodes being further attached to a power source (35). Artificial muscles created by the inventive method are capable of undergoing electrically-controllable large deformations resembling the behavior of biological muscles. A typical flap muscle of 0.2-0.4 mm thickness, 2-5 mm width and 20 mm length manufactured by the inventive process can achieve a completely reversible maximum deflection of 12-15 mm under a maximum voltage of 2.0-2.5 volts.Type: GrantFiled: February 5, 1999Date of Patent: August 29, 2000Assignee: University of New MexicoInventors: Mohsen Shahinpoor, Mehran Mojarrad
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Patent number: 6106804Abstract: Radioactive arsenic (.sup.72 As) labelled tissue specific ligands are prepared and used in the medical imaging of malignant breast or prostate tumors.Type: GrantFiled: June 13, 1997Date of Patent: August 22, 2000Assignee: The University of New MexicoInventors: Robert B. Palmer, Jerry L. Born
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Patent number: 6108085Abstract: Interferometric auto-correlation is obtained using third-order (.chi..sup.(3)) nonlinearities. The nonlinear signal is separated from the linear interferometric response in order to extract information about the amplitude and the chirp of the ultrashort pulses. In one technique, cross-polarized beams are provided to eliminate the linear response. In another technique, electronic filtering is used. Electronic filtering provides substantial reduction of cost, size and complexity over conventional second harmonic generator crystals.Type: GrantFiled: November 19, 1996Date of Patent: August 22, 2000Assignee: University of New MexicoInventor: Mansoor Sheik-Bahae
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Patent number: 6102921Abstract: A medical anastomosis sling for use in the repair or regeneration of nerves. Nerve ends are placed in a breathable semiporous membrane having sets of elongate and wide tabs which are secured and sealed around the ends via circumferential fasteners and surgical clips for securing and sealing the sling in position without the necessity of suturing the device for optimal anastomosis.Type: GrantFiled: December 21, 1990Date of Patent: August 15, 2000Assignee: University of New MexicoInventors: Yong Hua Zhu, Wolff M. Kirsch, Robert B. Cushman
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Patent number: 6096536Abstract: Compounds termed "vitaletheine modulators" which include beta-alanyl-taurine and carbobenzoxy beta-alanyl-taurine are synthesized and added to culture media for in vitro culture of cells such as mammalian or plant cells. The compounds support cell vitality, and provide increased cellular life span, increased cellular bioproductivity, improved cellular function, and adaption of resistant cells to culturing. Carbobenzoxy beta-alanyl-taurine is produced by coupling .beta.-alanine, which has it's terminal amine protected with a carbobenzoxy (CBZ) group, to N-hydroxysuccinimide to produce an active ester of .beta.-alanine, coupling two of the active esters to cystamine to produce a CBZ-protected .beta.-alethine having an internal disulfide bond, isolating and purifying the CBZ-protected .beta.-alethine, and reacting the CBZ-protected .beta.-alethine with iodine to oxidize the disulfide bond to obtain carbobenzoxy beta-alanyl-taurine.Type: GrantFiled: June 5, 1995Date of Patent: August 1, 2000Assignee: University of New MexicoInventors: Galen D. Knight, Terence J. Scallen
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Patent number: 6097867Abstract: A low-cost fabrication technique, readily extensible to volume manufacturing is presented for an electro-optically active fiber segment (31) that can be simply integrated into optoelectronic devices. The fabrication technique offers a dielectric isolation structure (16, 17) surrounding the fiber (10) to allow high field poling, a pair of electrodes (37, 38) used both for poling and for inducing an electro-optic effect, and ends of the fiber (18, 19) unaffected by the fabrication and available for splicing with additional fiber sections. The technique is readily adaptable to specialized electrode structures including striplines and/or microstrip lines for high frequency applications and segmented electrodes (52) for quasi-phasematched three-wave mixing applications. By combining the electro-optically active fiber segment (31) with other fibers in an integrated fiber modulator, high frequency modulation of an optical signal may be achieved with applications in telecommunications.Type: GrantFiled: August 3, 1998Date of Patent: August 1, 2000Assignee: The University of New MexicoInventors: Steven R. J. Brueck, Xiang-Cun Long
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Patent number: 6066716Abstract: A method for purifying heat shock protein complexes is provided which comprises the steps of adding a solution containing heat shock protein complexes, in which heat shock proteins are associated with peptides, polypeptides, denatured proteins or antigens, to a column containing an ADP matrix to bind the heat shock proteins complexes to the ADP matrix and adding a buffer containing ADP to the column to remove the heat shock protein complexes in an elution product. Additionally a method for synthesizing heat shock protein complexes and purifying the complexes so produced is provided which comprises the steps of adding heat shock proteins to an ADP matrix column to bind them to the matrix, adding a solution of peptides, polypeptides, denatured proteins or antigens to the column to bind them to the heat shock proteins as heat shock protein complexes and adding a buffer containing ADP to the column to remove the complexes in an elution product.Type: GrantFiled: September 19, 1997Date of Patent: May 23, 2000Assignee: University of New MexicoInventors: Erik S. Wallen, Jan Roigas, Pope L. Moseley
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Patent number: 6046241Abstract: .beta.-alethine is identified as an anti-tumor agent.Type: GrantFiled: June 6, 1995Date of Patent: April 4, 2000Assignee: University of New MexicoInventors: Galen D. Knight, Paul L. Mann, Terrance J. Scallen
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Patent number: 6042998Abstract: The present invention extends the available spatial frequency content of an image through the use of a method and apparatus for combining nonlinear functions of intensity to form three dimensional patterns with spatial frequencies that are not present in either of the individual exposures and that are beyond 2/.lambda. in all three spatial directions. The resulting pattern has spatial frequency content beyond the limits set by optical propagation of spatial frequencies limited to 2/.lambda. (e.g. pitch reduction from .about..lambda./2 to at least .about..lambda./4). The extension of spatial frequencies preferably extends the use of currently existing photolithography capabilities, thereby resulting in a significant economic impact. Multiplying the spatial frequency of lithographically defined structures suitably allows for substantial improvements in, inter alia, crystal growth, quantum structure growth and fabrication, flux pinning sites for high-T.sub.Type: GrantFiled: September 17, 1997Date of Patent: March 28, 2000Assignee: The University of New MexicoInventors: Steven R. J. Brueck, Saleem H. Zaidi
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Patent number: 6034255Abstract: The present invention provides novel haloenol lactones that are effective as active site inhibitors of cholesterol esterase. By inhibiting cholesterol esterase the inhibitors of the present invention provide a new approach to the treatment of hypercholesterolemia through limiting the bioavailability of dietary cholesterol.Type: GrantFiled: April 15, 1999Date of Patent: March 7, 2000Assignee: University of New MexicoInventors: Lorraine Deck, David L. Vander Jagt
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Patent number: 6033644Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.Type: GrantFiled: November 5, 1998Date of Patent: March 7, 2000Assignee: University of New MexicoInventors: Jerry L. Born, Dennis Eshima, Paul L. Mann, Nicholas A. Matwiyoff
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Patent number: 6031011Abstract: A set of tropodegradable bromine-containing hydrocarbon foam-blowing agents to (1) decrease the flammability of closed-cell foams and (2) to decrease flammability safety problems that may occur during foam production is disclosed. The agents are characterized by high flammability reduction efficiency and short atmospheric lifetimes. The latter property is essential and results in a low ozone depletion potential (ODP) and a low global warming potential (GWP). The agents are bromine-containing alkenes, bromine-containing ethers, bromine-containing amines, bromine-containing carbonyl compounds, bromine-containing aromatics, bromine-containing alcohols, and/or bromine-containing non-fluorinated alkanes.Type: GrantFiled: June 25, 1998Date of Patent: February 29, 2000Assignee: University of New MexicoInventor: Robert E. Tapscott
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Patent number: 6025911Abstract: A measuring device completely determines the characteristics of light pulses in a beam of ultrashort light pulses using optoelectronic detectors instead of second harmonic generating crystals. An optical system provides a spatial dispersion of an ultrashort pulse in at least one dimension. A two slit filter intercepts the dispersed beam whereby the transmitted spectra combine to provide a beat frequency within selected limits. An optoelectronic detector detects the beat frequency and outputs a signal functionally related to the beat frequency that contains spectral phase information that is sufficient to characterize the pulse. In another embodiment, a beam splitter splits the beam into first and second beams, wherein one of the beams is time delayed and the other beam is spectrally dispersed. The two beam are recombined to provide information about the spectral phase of the ultrashort pulse. The pulse is completely characterized when the spectral phase information is combined with amplitude information.Type: GrantFiled: November 14, 1995Date of Patent: February 15, 2000Assignee: University of New MexicoInventors: Scott A. Diddams, Jean-Claude M. Diels, Prien Steffen
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Patent number: 6022689Abstract: A method of preparing flourescent in situ hybridization slides, comprising: providing a slide with a raised ring thereon; providing to the slide a DNA probe; providing to the slide cells and target DNA; providing to the slide a formamide-free mixture of 10%.+-.2% by weight dextran sulfate and 15%-25% glycerol and 0.9% by weight salt or a solution of 10%.+-.2% by weight dextran sulfate, 10-30% by volume formamide and 0.9% by weight salt; placing a coverglass on the ring; denaturing and hybridizing the slide; and performing a post-hybridization wash of the slide.Type: GrantFiled: October 9, 1996Date of Patent: February 8, 2000Assignee: University of New MexicoInventors: Gloria E. Sarto, Donald M. Thompson