Patents Assigned to Theranos, Inc.
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Patent number: 9858660Abstract: Systems and methods are provided for collecting, preparing, and/or analyzing a biological sample. A sample collection site may be utilized with one or more sample processing device. The sample processing device may be configured to accept a sample from a subject. The sample processing device may perform one or more sample preparation step and/or chemical reaction involving the sample. Data related to the sample may be sent from the device to a laboratory. The laboratory may be a certified laboratory that may generate a report that is transmitted to a health care professional. The health care professional may rely on the report for diagnosing, treating, and/or preventing a disease in the subject.Type: GrantFiled: February 15, 2013Date of Patent: January 2, 2018Assignee: Theranos, Inc.Inventor: Elizabeth A. Holmes
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Patent number: 9835548Abstract: The devices and systems disclosed herein provide multiple optical capabilities in a single device or system. Methods for using these devices and systems are provided. These devices and systems are configurable for operation in each of a spectroscopy mode, a fluorescence mode, and a luminescence mode, and are capable of performing spectroscopic, fluorescence, and luminescence observations, measurements, and analyzes when operated in the corresponding spectroscopy mode, fluorescence mode, or luminescence mode. These devices and systems include mirror dispersion elements having multiple faces including an optical dispersion element on one face (e.g., a diffraction grating or a prism) and a reflective element on another face (e.g., a mirror). These multiple capabilities eliminate the need to move or load a sample in multiple devices when subjecting a sample to multiple analyzes, and thus provide greater accuracy, precision, and speed while reducing complexity and cost of sample analysis.Type: GrantFiled: May 20, 2016Date of Patent: December 5, 2017Assignee: Theranos, Inc.Inventors: Karan Mohan, Samartha Anekal
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Patent number: 9810704Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: February 18, 2014Date of Patent: November 7, 2017Assignee: Theranos, Inc.Inventors: Elizabeth A. Holmes, Sunny Balwani, Michael Chen, John K. Frankovich, Gary Frenzel, Samartha Anekal, Adrit Lath, Alexander Loo, Chinmay Pangarkar, Joy Roy, Timothy Smith, Daniel Young
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Patent number: 9795929Abstract: In one embodiment described herein, a bodily fluid separation material is provided comprising a formed component capture region and a bodily fluid pass-through region. The pass-through region has structures with a reduced liquid leaching quality relative to than the capture region, wherein during separation material use, bodily fluid enters the capture region prior to entering the pass-through region. Optionally, a bodily fluid pass-through region has a reduced amount of liquid leaching material relative to than the capture region.Type: GrantFiled: March 15, 2014Date of Patent: October 24, 2017Assignee: Theranos, Inc.Inventors: Samartha Anekal, Deborah Sloan
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Patent number: 9784670Abstract: The devices and systems disclosed herein provide multiple optical capabilities in a single device or system. Methods for using these devices and systems are provided. These devices and systems are configurable for operation in each of a spectroscopy mode, a fluorescence mode, and a luminescence mode, and are capable of performing spectroscopic, fluorescence, and luminescence observations, measurements, and analyses when operated in the corresponding spectroscopy mode, fluorescence mode, or luminescence mode. These devices and systems include mirror dispersion elements having multiple faces including an optical dispersion element on one face (e.g., a diffraction grating or a prism) and a reflective element on another face (e.g., a mirror). These multiple capabilities eliminate the need to move or load a sample in multiple devices when subjecting a sample to multiple analyses, and thus provide greater accuracy, precision, and speed while reducing complexity and cost of sample analysis.Type: GrantFiled: January 21, 2015Date of Patent: October 10, 2017Assignee: Theranos, Inc.Inventors: Karan Mohan, Samartha Anekal
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Patent number: 9772291Abstract: This invention is in the field of medical devices. Specifically, the present invention provides fluidic systems having a plurality of reaction sites surrounded by optical barriers to reduce the amount of optical cross-talk between signals detected from various reaction sites. The invention also provides a method of manufacturing fluidic systems and methods of using the systems.Type: GrantFiled: June 1, 2015Date of Patent: September 26, 2017Assignee: Theranos, Inc.Inventors: Timothy Michael Kemp, Chris Todd, Ron Oral, Shulin Zeng, John Howard, Jeff Fenton
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Patent number: 9725760Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such nucleic acid polymerases and primers.Type: GrantFiled: March 15, 2014Date of Patent: August 8, 2017Assignee: Theranos, Inc.Inventors: Kamila Belhocine, Josephine Lee, Pranav Patel, Aaron Richardson, Scott Tabakman
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Patent number: 9719081Abstract: Fusion proteins having thermostable blunt-end ligase activity are provided. Blunt-end ligases are useful for DNA amplification, sequencing, production of recombinant DNA and recombinant fusion proteins, and other purposes. These thermostable blunt-end DNA ligases are useful in ligation schemes which include, e.g., an incubation at about 60-65° C. or higher, or as high as about 94° C., or at other temperatures. The ligases disclosed herein may enable high temperature blunt-end ligation without need for molecular crowding agents, and so may be useful for many nucleic acid ligation-amplification schemes, e.g., ones which operate at a uniform temperature (e.g., at about 60° C. or higher), including ones which require temperature cycling, e.g., from about 94° C. to about 60° C. (or higher) for one, two, three, or more cycles.Type: GrantFiled: January 20, 2016Date of Patent: August 1, 2017Assignee: Theranos, Inc.Inventor: Frederick Christians
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Patent number: 9719990Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: September 18, 2015Date of Patent: August 1, 2017Assignee: Theranos, Inc.Inventors: Elizabeth A. Holmes, Ian Gibbons, Paul Patel, Samartha Anekal
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Patent number: 9677993Abstract: The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.Type: GrantFiled: July 1, 2015Date of Patent: June 13, 2017Assignee: Theranos, Inc.Inventors: Anthony Nugent, Daniel Young, Elizabeth A. Holmes, Michael Siegel, Ryan Wistort
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Patent number: 9664702Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: September 26, 2011Date of Patent: May 30, 2017Assignee: Theranos, Inc.Inventors: Elizabeth Holmes, Joy Roy
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Patent number: 9645143Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: October 1, 2015Date of Patent: May 9, 2017Assignee: Theranos, Inc.Inventors: Elizabeth A. Holmes, James Wasson, Pey-Jiun Ko
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Patent number: 9636062Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.Type: GrantFiled: March 15, 2014Date of Patent: May 2, 2017Assignee: Theranos, Inc.Inventors: Elizabeth A. Holmes, Michael Chen, Pey-Jiun Ko, Tammy Burd, Adrit Lath, Patricia McHale
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Patent number: 9632102Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: September 26, 2011Date of Patent: April 25, 2017Assignee: Theranos, Inc.Inventors: Elizabeth Holmes, Sunny Balwani
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Patent number: 9623411Abstract: In one embodiment described herein, a cartridge is provided comprising a cartridge frame; a plurality of diluents each in an expandable container; a plurality of reagents each in an expandable container; and a plurality of mixing vessels comprising empty expandable containers.Type: GrantFiled: June 19, 2014Date of Patent: April 18, 2017Assignee: Theranos, Inc.Inventors: Gary Frenzel, Samartha Anekal, Daniel Young
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Patent number: D784517Type: GrantFiled: November 2, 2015Date of Patent: April 18, 2017Assignee: Theranos, Inc.Inventor: Patricia McHale
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Patent number: D785782Type: GrantFiled: November 24, 2015Date of Patent: May 2, 2017Assignee: Theranos, Inc.Inventor: Michael Chen
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Patent number: D785783Type: GrantFiled: December 1, 2015Date of Patent: May 2, 2017Assignee: Theranos, Inc.Inventors: Michael Chen, Patricia McHale
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Patent number: D791964Type: GrantFiled: June 21, 2016Date of Patent: July 11, 2017Assignee: Theranos, Inc.Inventor: Clarissa Lui
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Patent number: D797919Type: GrantFiled: June 15, 2016Date of Patent: September 19, 2017Assignee: Theranos, Inc.Inventor: Pey-Jiun Ko