Patents Assigned to Theranos, Inc.
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Patent number: 9619627Abstract: Systems and methods are provided for collecting, preparing, and/or analyzing a biological sample. A sample collection site may be utilized with one or more sample processing device. The sample processing device may be configured to accept a sample from a subject. The sample processing device may perform one or more sample preparation step and/or chemical reaction involving the sample. Data related to the sample may be sent from the device to a laboratory. The laboratory may be a certified laboratory that may generate a report that is transmitted to a health care professional. The health care professional may rely on the report for diagnosing, treating, and/or preventing a disease in the subject.Type: GrantFiled: February 18, 2013Date of Patent: April 11, 2017Assignee: Theranos, Inc.Inventor: Elizabeth A. Holmes
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Patent number: 9596156Abstract: Methods and systems are provided for connecting an electronic device to a network. In some situations, the electronic device connects to a first network provider and pings a first server having a static internet protocol address and a second server having a dedicated uniform resource locator. If the electronic device receives a response from the first and second server, the electronic device maintains its connection to the first network provider. Otherwise, the electronic device connects to a second network provider and pings the first and second servers.Type: GrantFiled: March 4, 2013Date of Patent: March 14, 2017Assignee: Theranos, Inc.Inventor: Sunny Balwani
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Patent number: 9592508Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: July 1, 2013Date of Patent: March 14, 2017Assignee: Theranos, Inc.Inventors: Elizabeth Holmes, Joy Roy, John Kent Frankovich
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Patent number: 9588109Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.Type: GrantFiled: January 27, 2016Date of Patent: March 7, 2017Assignee: Theranos, Inc.Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
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Patent number: 9581588Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.Type: GrantFiled: August 20, 2015Date of Patent: February 28, 2017Assignee: Theranos, Inc.Inventors: Tammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
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Patent number: 9575058Abstract: The present invention provides fluidic devices and systems that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.Type: GrantFiled: November 5, 2014Date of Patent: February 21, 2017Assignee: Theranos, Inc.Inventors: Shaunak Roy, Malissa Takahashi, Ian Gibbons, Edmond Ku, Thanh Dang, Tammy Burd, Adam Vollmer, Elizabeth A. Holmes
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Patent number: 9572550Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.Type: GrantFiled: May 20, 2016Date of Patent: February 21, 2017Assignee: Theranos, Inc.Inventor: Gayle Lee
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Patent number: 9562860Abstract: Methods and devices for cytometric analysis are provided. A cytometry apparatus is provided which may be used with a stationary sample cuvette for analysis of a stationary sample or with a flow sample cuvette for analysis of a flowing sample. The methods and devices provided herein may be used to perform cytometric analysis of samples under a wide range of experimental and environmental conditions.Type: GrantFiled: June 19, 2014Date of Patent: February 7, 2017Assignee: Theranos, Inc.Inventors: Chinmay Pangarkar, Karan Mohan
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Patent number: 9551027Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases and primers.Type: GrantFiled: November 18, 2014Date of Patent: January 24, 2017Assignee: Theranos, Inc.Inventors: Kamila Belhocine, Josephine Lee, Pranav Patel, Aaron Richardson, Scott Tabakman
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Patent number: 9546394Abstract: Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed.Type: GrantFiled: January 23, 2015Date of Patent: January 17, 2017Assignee: Theranos, Inc.Inventors: Douglas Matje, Ian Gibbons, Paul Patel, Elizabeth A. Holmes
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Patent number: 9538992Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.Type: GrantFiled: March 14, 2014Date of Patent: January 10, 2017Assignee: Theranos, Inc.Inventor: Gayle Lee
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Patent number: 9529976Abstract: Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may be determined by the condition or past history of a subject. Test results may be obtained within a short amount of time after sample placement in a testing device, or within a short amount of time after being obtained from the subject. A prescription for treatment of a detected disorder may be provided, and may be filled, at the POS location. A bill may be automatically generated for the testing, or for the prescription, may be automatically sent to an insurance provider, and payment may be automatically obtained.Type: GrantFiled: September 5, 2014Date of Patent: December 27, 2016Assignee: Theranos, Inc.Inventors: Clarissa Lui, Elizabeth A. Holmes
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Patent number: 9515618Abstract: In one embodiment, a femtowatt sensitivity optical detector is provided using one or more photodiodes, intended as a replacement for the photomultiplier based photon counting unit.Type: GrantFiled: September 9, 2015Date of Patent: December 6, 2016Assignee: Theranos, Inc.Inventors: Karan Mohan, Marcelo Martinez
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Patent number: 9513224Abstract: Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples.Type: GrantFiled: January 22, 2014Date of Patent: December 6, 2016Assignee: Theranos, Inc.Inventors: Karan Mohan, Chinmay Pangarkar, James Wasson
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Patent number: 9513197Abstract: Improved methods, devices, and systems for mixing fluids, including small volumes of fluid, are provided. Pressing a pipette tip against an inner surface of a mixing vessel allows pressure to be applied within the tip. Greater pressure may be built-up than would be possible without engaging the tip with the mixing vessel. Disengaging the tip allows fluid flow through the tip, providing improved fluid mixing as compared to methods lacking engagement of a pipette tip with an inner surface of a mixing vessel while applying pressure within the pipette tip. Mixing vessels having features on an inner surface that are configured to engage a pipette tip, and to occlude an orifice of a pipette tip, are provided. Sample analysis devices and systems including pipette tips and mixing vessels configured to engage each other for pressure application within the tip are provided.Type: GrantFiled: March 14, 2016Date of Patent: December 6, 2016Assignee: Theranos, inc.Inventor: Matthew Black
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Patent number: 9500639Abstract: Compositions and methods for measuring coagulation parameters using very small volumes of blood are provided. Advantageously, the methods described herein can be performed from a single drop of blood (about 20 ?L) while generally leaving enough sample to perform other measurements, optionally in a multiplexed format. The methods and devices do not require a skilled operator and can be performed at the point of service, which can be an important feature for managing blood coagulation disorders and treatments thereof.Type: GrantFiled: July 17, 2013Date of Patent: November 22, 2016Assignee: Theranos, Inc.Inventors: Mark Dayel, Samartha Anekal, Paul Patel, Ian Gibbons, Elizabeth Holmes
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Patent number: 9494521Abstract: Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples.Type: GrantFiled: July 25, 2013Date of Patent: November 15, 2016Assignee: Theranos, Inc.Inventors: Elizabeth A. Holmes, Chinmay Pangarkar, Timothy Smith, Karan Mohan, Samartha Anekal, Daniel L. Young, James R. Wasson
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Patent number: 9464981Abstract: The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.Type: GrantFiled: December 5, 2014Date of Patent: October 11, 2016Assignee: Theranos, Inc.Inventors: Ian Gibbons, Anthony J. Nugent, Anthony Delacruz, Daniel L. Young, Elizabeth A. Holmes, Andrew Drake, Timothy Michael Kemp, Sunny Balwani, Chinmay Pangarkar
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Patent number: D775428Type: GrantFiled: November 11, 2015Date of Patent: December 27, 2016Assignee: Theranos, Inc.Inventor: Pey-Jiun Ko
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Patent number: D779081Type: GrantFiled: January 11, 2016Date of Patent: February 14, 2017Assignee: Theranos, Inc.Inventor: Patricia McHale