Abstract: An infrared spectrometer system with automated tablet sampling includes an infrared spectrometer providing a modulated output beam to a sample position, and reflected and transmitted light detectors. A tablet holding wheel is mounted to advance multiple tablets one at a time to the sample position. The tablet holding wheel includes a tablet wheel base having a plurality of transmission openings therein in a circular pattern around a central axis of the base, grippers adjacent to each of the transmission openings that are movable inwardly and outwardly, and a cam ring mounted to and rotatable with respect to the tablet wheel base, the cam ring being operatively engaged with the grippers to move the grippers outwardly and inwardly to engage and hold tablets over the transmission openings.