Abstract: A prophylactic and/or therapeutic agent for idiopathic pulmonary fibrosis is disclosed. The prophylactic and/or therapeutic agent for idiopathic interstitial pneumonia (IPF or the like) contains a compound having an LPA3 agonistic activity or a salt thereof.

Abstract: A dinitrogen pentoxide generating device and a method for generating dinitrogen pentoxide. An NOx generating unit is able to use, as a raw material gas, a gas containing nitrogen and oxygen and produce a plasma to generate a nitrogen oxide. An ozone generating unit is able to use, as a raw material gas, the gas containing nitrogen and oxygen or a gas obtained after the plasma has been produced by the NOx generating unit and produce a plasma to generate ozone. A mixing unit is able to hold the nitrogen oxide generated by the NOx generating unit and the ozone generated by the ozone generating unit in the same space for a predetermined time to generate dinitrogen pentoxide.

Abstract: A force sensor module includes: a force sensor configured to detect an external force according to the amount of deflection of a strain element that deflects in response to the external force; a housing that accommodates the force sensor; and a force transferring section configured to transfer the external force to the strain element, the force transferring section being accommodated in the housing so as to be in contact with the strain element and having a part that includes an end of the force transferring section and that protrudes outside the housing through a surface of the housing, the amount of protrusion of the part of the force transferring section measured from the surface of the housing being set such that the force sensor is not damaged even in a case where the end lies in the same plane as the surface of the housing.

Abstract: Provided are a magnetoresistance effect element and a magnetic memory having a shape magnetic anisotropy and using a recording layer having an anti-parallel coupling. A first magnetic layer (3) and a second magnetic layer (5) of the magnetoresistance effect element include a ferromagnetic substance, have a magnetization direction variable to the direction perpendicular to a film surface and are magnetically coupled in an anti-parallel direction, and a junction size D (nm), which is a length of the longest straight line on an end face perpendicular to the thickness direction of the first magnetic layer (3) and the second magnetic layer (5), a film thickness t1 (nm) of the first magnetic layer (3), and a film thickness t2 (nm) of the second magnetic layer (5) satisfy relationships D<t1 and D?t1 or D?t1 and D<t2.

Abstract: A magnetoresistance effect element with a small element size can be provided which achieves both an increase in a thermal stability factor ? and a reduction in a writing current IC0 and which improves a performance index ?/IC0(?A?1) obtained by dividing the thermal stability factor ? by the writing current IC0. The magnetoresistance effect element includes a first reference layer (B1), a first junction layer (11), a first magnetic layer (21), a first non-magnetic coupling layer (31), a second magnetic layer (22), and a second junction layer (12), and a film thickness of the first non-magnetic coupling layer (31) is 0.1 nm or more and 0.3 nm or less.

Abstract: There are provided a viscometer that can accurately measure a bulk viscosity of a small amount of a liquid sample such as 100 ?L or less, and a method for measuring viscosity. A viscometer (1) comprises a fixing member (31), an upper unit (10), a lower unit (11), and an information processing unit (50). A method for measuring viscosity comprises measuring a viscosity of the sample by measuring a response voltage during resonance from a detecting means (19) that detects displacement of a leaf spring (17) in one direction due to vibration of the upper unit (10) through applying an AC voltage to a piezoelectric element (15) while changing a frequency by the information processing unit (50).

Abstract: An object of the present invention is to provide a novel method for producing, without using an organic iron compound as a production raw material, water in which permanganate ions exist stably over a long period of time. As a means for resolution, the method comprises dissolving a divalent inorganic iron compound and a divalent manganese compound in water with a pH of less than 3.5, and then feeding ozone microbubbles into the water.

Abstract: An object of the invention is to provide titanium dioxide coloring particles capable of developing colors other than red and yellow while maintaining non-toxicity of titanium dioxide and a titanium dioxide particle mixture containing the titanium dioxide coloring particles, and to provide a method capable of producing the titanium dioxide coloring particles exhibiting the excellent properties by a simple process with a small environmental load. The invention relates to titanium dioxide coloring particles having a brookite type or rutile type crystal structure and co-doped with at least nitrogen and boron, a titanium dioxide particle mixture containing the titanium dioxide coloring particles, and a method for producing the titanium dioxide coloring particles in which a hydrothermal reaction of titanium diboride is caused in presence of an acid or urea, and then a nitriding treatment is performed in an ammonia gas atmosphere or by mixing with urea or carbon nitride.

Abstract: Provided are a mutant cis-prenyltransferase (CPT) family protein and a method for producing a polyisoprenoid, which enable the production of a high molecular weight polyisoprenoid. Included is a mutant cis-prenyltransferase (CPT) family protein obtained by mutating the amino acid sequence of a C-terminal region of a cis-prenyltransferase (CPT) family protein not found on rubber particles to be identical or similar to the amino acid sequence of a C-terminal region of a cis-prenyltransferase (CPT) family protein found on rubber particles.

Abstract: Provided are a mutant cis-prenyltransferase (CPT) family protein and a method for producing a polyisoprenoid, which enable the production of a high molecular weight polyisoprenoid. Included is a mutant cis-prenyltransferase (CPT) family protein obtained by mutating the amino acid sequence of a N-terminal region of a cis-prenyltransferase (CPT) family protein not found on rubber particles to be identical or similar to the amino acid sequence of a N-terminal region of a cis-prenyltransferase (CPT) family protein found on rubber particles.

Abstract: Provided are a mutant cis-prenyltransferase (CPT) family protein and a method for producing a polyisoprenoid, which enable the production of a high molecular weight polyisoprenoid. Included is a mutant cis-prenyltransferase (CET) family protein obtained by mutating the amino acid sequence of a N-terminal region of a cis-prenyltransferase (CPT) family protein not found on rubber particles to be identical or similar to the amino acid sequence of a N-terminal region of a cis-prenyltransferase (CPT) family protein found on rubber particles, and mutating the amino acid sequence of a C-terminal region of the cis-prenyltransferase (CPT) family protein not found on rubber particles to be identical or similar to the amino acid sequence of a C-terminal region of a cis-prenyltransferase (CPT) family protein found on rubber particles.

Abstract: A pressure container for crystal production having excellent corrosion-resistance is provided. This pressure container produces crystals within the container using a seed crystal, a mineralizer, a raw material, and ammonia in a supercritical state or a subcritical state as a solvent. The pressure container has Ag present over the entire surface of at least the inner surface thereof in contact with the solvent. The Ag can be disposed by one or a combination of two or more among, for instance, Ag lining, Ag welding, and Ag plating. The mineralizer is preferably a fluorine mineralizer containing no halogen atoms other than fluorine.

Abstract: In order to enable the measurement of thermal property information about a subject, this thermal diffusion coefficient measuring device, which is used by contacting the surface of a living body, is provided with: a biological information sensor comprising a temperature sensor and a heat flux sensor; and a heating/cooling control means. The temperature sensor is provided at a position contacting the surface of the living body, and operates so as to detect skin temperature. The heat flux sensor is provided at a position contacting the surface of the living body, while being adjacent to the temperature sensor, and operates so as to detect heat flux on the surface of the living body. The heating/cooling control means enables the measurement of the temperature diffusion coefficient of a thermal resistance component that is present between the biological information sensor and a deep inner portion of the living body.

Abstract: Amyotrophic lateral sclerosis (ALS) is a life-threatening neurodegenerative disease characterized by the progressive loss of motor neurons. Muse cells are endogenous reparative pluripotent-like stem cells distributed to various tissues. Once intravenously injected, such cells, upon sensing sphingosine-1-phosphate produced by damaged cells, settle selectively on damaged sites, and after homing, can exhibit multiphase effects including natural differentiation into tissue-protecting and tissue-reconstructing cells. In the present invention, with G93A-Tg mice serving as an ALS model, human Muse cells injected intravenously successfully homed into the lumbar cord, mainly at the pia mater and the lower white matter, and expressed glial-like forms and GFAP. Meanwhile, no such homing or differentiation was observed in the case of human mesenchymal stem cells (MSCs), and, rather, MSCs were found distributed to the lungs.

Abstract: An electrostatic acoustic wave generating device and an electrostatic speaker making entries of dust, water, moisture, etc. into the device and the speaker, allowing reduction in power. A plate-like fixed electrode has a through hole penetrating the thickness of the fixed electrode. A vibrating body and a vibrating electrode each having a plate-like shape are arranged closer to one surface and closer to the other surface of the fixed electrode respectively, and are movable in the respective thickness directions thereof. A connection member connects the vibrating body and the vibrating electrode to each other through the through hole of the fixed electrode to cause the vibrating body and the vibrating electrode to move toward the same direction. Voice signal input is capable of applying a voltage to the fixed electrode, the vibrating body, and the vibrating electrode to move the vibrating body between the fixed electrode and the vibrating body.

Abstract: A force sensor is provided, the force sensor including: a first substrate; a metasurface pattern provided on a principal surface; a protective layer covering the metasurface pattern; a second substrate provided so as to face the first substrate; a reflective layer provided on a second principal surface; and a spacer defining a spacing between the first substrate and the second substrate, so that the force sensor is capable of offering desired response characteristics specified at the time of design.

Abstract: An ophthalmic information processing apparatus includes an acquisition unit and a disease estimation unit. The acquisition unit is configured to acquire a plurality of images with different cross-sectional orientations from each other of a subject’s eye. The disease estimation unit is configured to output estimation information for estimating whether or not the subject’s eye is a glaucoma eye from the images, using a plurality of learned models obtained by performing machine learning for each type of the images.

Abstract: Provided is a method for manufacturing a force sensor including: preparing a first substrate which is made of a material that transmits electromagnetic waves and includes on its surface a metal array arranged in a periodic pattern and a second substrate which includes on its surface a metal layer that reflects electromagnetic waves; forming a spacer member on the surface of the first substrate; forming a first metal layer around the spacer member on the surface of the first substrate; forming a second metal layer in a region corresponding to the first metal layer on the second substrate; and fusing the first metal layer and the second metal layer together to fix the first substrate and the second substrate in a state in which the spacer member formed on the surface of the first substrate abuts the surface of the second substrate.

Abstract: An ophthalmic information processing apparatus includes a determiner and a detector. The determiner is configured to determine a presence or absence of a disc hemorrhage for a front image of a fundus of a subject's eye, using a disc hemorrhage determination model obtained by performing machine learning using a plurality of fundus images labeled with labels indicating the presence or absence of a disc hemorrhage as first teaching data. The detector is configured to detect a disc hemorrhage region depicted in the front image that is determined to have the disc hemorrhage, using a disc hemorrhage region detection model obtained by performing machine learning using a plurality of pairs of image groups as second teaching data, each pair having a front image of a fundus and a disc hemorrhage region image representing a disc hemorrhage region depicted in the front image.

Abstract: Provided is a force sensor including: a first substrate that is made of a material that transmits electromagnetic waves and includes a metal array arranged in a periodic pattern on its surface; a second substrate that is disposed to face the first substrate with a gap therebetween and includes a metal layer that reflects the electromagnetic waves transmitted through the first substrate on its surface; a connecting member configured to connect the first substrate to the second substrate and define an internal space that houses the metal array and the metal layer; and an inert substance that fills the internal space.