Patents Assigned to Trustees of Princeton University
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Patent number: 11803974Abstract: Disclosed are a system and method for quantifying changes in animal posture from video recordings of multiple interacting animals. Also disclosed are a system and method for training a posture identification algorithm efficiently with minimal human effort and evaluating the posture of millions of animal images. The disclosed process employs video recordings of behaving animals to produce a full set of geometrical coordinates for each body part over time. Inter alia, the disclosed system should be useful for organizations interested in doing large small-molecule screens to find drugs that affect the behavior of animals, and for those investigating new behavioral diagnostics for human patients. The disclosed system allows one to record video of animals and then automatically calculate the position of each body part over time. The output of this calculation can be used for simple analysis of the amount of movement for specific body parts, or part of a more complex scheme for measuring behaviors.Type: GrantFiled: October 4, 2019Date of Patent: October 31, 2023Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Joshua W. Shaevitz, Mala Murthy, Talmo D. Pereira, Diego E. Aldarondo
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Patent number: 11795431Abstract: A method is disclosed for coating and patterning hydrogels in order to modify surface properties. The method exploits the water content of the hydrogel and the hydrophobicity of the reaction solvent to create a thin oxide adhesion layer on the hydrogel surface. This oxide adhesion layer enables rapid transformation of the hydrophilic, cell non-adhesive hydrogel into either a highly hydrophobic or a cell-adhesive hydrogel by reaction with an alkylphosphonic acid or an ?,?-diphosphonoalkane, respectively. Also disclosed are coated, patterned hydrogels and constructs comprising the coated, patterned hydrogels.Type: GrantFiled: August 17, 2018Date of Patent: October 24, 2023Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Jeffrey Schwartz, Jeffrey Chen, Kelly Lim
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Patent number: 11794180Abstract: In one aspect, phosphine compounds comprising three adamantyl moieties (PAd3) and associated synthetic routes are described herein. Each adamantyl moiety may be the same or different. For example, each adamantyl moiety (Ad) attached to the phosphorus atom can be independently selected from the group consisting of adamantane, diamantane, triamantane and derivatives thereof. Transition metal complexes comprising PAd3 ligands are also provided for catalytic synthesis including catalytic cross-coupling reactions.Type: GrantFiled: January 23, 2023Date of Patent: October 24, 2023Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Brad P. Carrow, Liye Chen
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Publication number: 20230332042Abstract: Biomineralization—the synthesis of inorganic materials using proteins—has recently gained interest as a low cost, green route for the production of metal chalcogenide semiconductor nanocrystals. Typical biomineralization approaches rely on proteins or biomolecules identified from organisms which possess a native biomineralization response. Disclosed herein is an alternative biomineralization approach for synthesizing metal chalcogenide nanocrystals which uses an artificially designed de novo protein. De novo proteins are non-natural proteins, allowing for facile modification of the protein through the tuning of amino acids within the sequence. This de novo protein was employed to produce size-controlled populations of semiconductor nanocrystals, with properties consistent with those produced using traditional routes.Type: ApplicationFiled: March 7, 2023Publication date: October 19, 2023Applicant: The Trustees of Princeton UniversityInventors: Michael Hecht, Sarangan Chari, Leah Spangler
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Publication number: 20230324816Abstract: Disclosed is a method of debris mitigation in laser produced plasma EUV light sources. The method describes a class of magnetic field configurations which exhausts debris away from sensitive components of the EUV device. This class contains a large range of configurations that may be suited and tuned to specific application requirements with a high degree of flexibility and can be generated by coils that are located away from the light collection cone.Type: ApplicationFiled: April 6, 2023Publication date: October 12, 2023Applicant: The Trustees of Princeton UniversityInventors: Ahmed Diallo, Christopher Berg Smiet, Ben Israeli, Marien Simeni Simeni
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Publication number: 20230322861Abstract: A synthetic peptide may be provided for use in dissolving tau inclusions. The peptide may include a first sequence consisting of M serine residues, where M is at least 30, and may be, e.g., 36-48. The synthetic peptide may include a second sequence fused to the C— or N-terminus of the first sequence. The second sequence may include 4-7 amino acids, the 4-7 amino acids including a kinase docking site. The kinase docking site may be configured such that the kinase phosphorylates an adjacent serine residue and starts a cascade such that all serine residues in the first sequence become phosphorylated. In some embodiments, the 4-7 amino acids may include a glutamic acid residue and/or an aspartic acid residue. In some embodiments, the glutamic acid residue and/or an aspartic acid residue is adjacent to a serine residue. Introduction of these peptides to cells allows for the dissolution of tau aggregates.Type: ApplicationFiled: March 21, 2023Publication date: October 12, 2023Applicant: The Trustees of Princeton UniversityInventors: Clifford P. Brangwynne, David W. Sanders
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Publication number: 20230328094Abstract: According to various embodiments, a system for detecting security vulnerabilities in at least one of cyber-physical systems (CPSs) and Internet of Things (IoT) devices is disclosed. The system includes one or more processors configured to construct an attack directed acyclic graph (DAG) unique to each CPS or IoT device of the devices. The processors are further configured to generate an aggregate attack DAG from a classification of each device and a location of each device in network topology specified by a system administrator. The processors are also configured to calculate a vulnerability score and exploit risk score for each node in the aggregate attack DAG. The processors are further configured to optimize placement of defenses to reduce an adversary score of the aggregate attack DAG.Type: ApplicationFiled: September 20, 2021Publication date: October 12, 2023Applicant: The Trustees of Princeton UniversityInventors: Jacob BROWN, Tanujay SAHA, Niraj K. JHA
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Patent number: 11784348Abstract: Disclosed is a class of organic salts and electrolytes, generally for use with electrochemical devices. Some of these salts enable the transport of magnesium ions without the presence of any additives, such as halide ions. Precursors are generated using simple fluorinated alcohols as well as abundant reagents. These precursors, often dissolved in ethereal solvents, may be combined with an appropriate Lewis acid to result in solutions that are able to conduct ions and allow for reversible electrodeposition.Type: GrantFiled: November 13, 2019Date of Patent: October 10, 2023Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Jake Herb, Craig Arnold, Carl Nist-Lund
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Patent number: 11783060Abstract: Devices and methods for processing detected signals at a detector using a processor are provided. The system involves (i) a data compressor that implements an algorithm for converting a set of data into a compressed set of data, (ii) a machine learning (ML) module coupled to the data compressor, the ML module transforming the compressed set of data into a vector and filtering the vector, (iii) a data encryptor coupled to the ML module that encrypts the filtered vector, and (iv) an integrity protection module coupled to the ML module, wherein the integrity protection module protects the integrity of the filtered vector.Type: GrantFiled: January 24, 2018Date of Patent: October 10, 2023Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventor: Niraj K. Jha
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Publication number: 20230319972Abstract: A fabric dielectric barrier discharge (DBD) device, a textile material comprising interconnected insulated conductive fibers can be used to generate a cold homogenous plasma by forming a discharge path from a conductive core of a first fiber, to a dielectric layer surrounding the conductive core, through an air gap towards, e.g., a second fiber or human skin. When the plasma that lights in and around the air gap comes into contact with a contaminated surface (containing, e.g., bacteria and/or viruses), it induces reactive species to form on the contaminated surface, and the reactive species are then allowed to kill the bacteria and/or viruses.Type: ApplicationFiled: June 2, 2021Publication date: October 5, 2023Applicant: The Trustees of Princeton UniversityInventors: Sophia GERSHMAN, Yevgeny RAITSES, Shurik YATOM,, Phillip EFTHIMION
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Publication number: 20230294363Abstract: Methods and devices for additive production of multi-materials are provided. Various devices may include a plurality of toolheads, each toolhead operably coupled to a different composition and having a kinematic coupling mechanism. The compositions may include a first composition comprising a cement paste or mortar, and a second composition comprising a thermoplastic polymer and/or an elastomeric polymer. The devices may include a moveable tool mount configured to be removably coupled to the kinematic coupling mechanism of each toolhead. A processor may be included that is configured to cause the deposition of the first composition and cause the deposition of the second composition simultaneous with the first composition and/or deposit the second composition after the first composition is deposited. Systems and techniques for toolpath creation may also be provided. In-situ structures may be provided that may include cement paste in contact with a thermoplastic polymer or an elastomeric polymer.Type: ApplicationFiled: March 16, 2023Publication date: September 21, 2023Applicant: The Trustees of Princeton UniversityInventors: Reza Moini, William Makinen
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Publication number: 20230295638Abstract: Provided herein are programmable condensate protein systems and nucleic acid constructs encoding the same. The protein system enables modular targeting of proteins of interest. Protein-peptide interaction domains (PPIDs) are incorporated to functionalize engineered condensates with the attributes of the recruited protein, resulting in a modular system that allows for diverse facile and reprogrammable applications, including in enzyme clustering of metabolic pathways. Colocalizing specific metabolic enzymes in these condensates results in functionalized organelles with which can be used to manipulate the output of engineered metabolic pathways for the production of a pharmaceutical precursor.Type: ApplicationFiled: May 27, 2021Publication date: September 21, 2023Applicant: The Trustees of Princeton UniversityInventors: Clifford BRANGWYNNE, José L. AVALOS, Mackenzie Thomas WALLS
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Publication number: 20230298825Abstract: Compositions of matter and devices using those compositions are provided, which can, e.g., impede or restrict the migration of halides from a halide perovskite active layer. The composite material may include n layers of semiconductors, wherein n ? 2. Each layer of semiconductors may contain (i) one or more organic semiconductor layers and one or more inorganic semiconductor layer in contact with the one or more organic semiconductor layers, (ii) one or more composite semiconductor layers, each composite semiconductor layer containing an organic material and inorganic material, or (iii) a combination thereof.Type: ApplicationFiled: January 12, 2023Publication date: September 21, 2023Applicant: The Trustees of Princeton UniversityInventors: Barry P. Rand, Ross A. Kerner, James C. Loy
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Patent number: 11759453Abstract: The disclosure provides compounds. In certain embodiments, compounds of the disclosure are capable of inhibiting a mammalian SHMT, such as human SMHT1 and/or SHMT2. Compounds of the disclosure have numerous uses.Type: GrantFiled: April 7, 2020Date of Patent: September 19, 2023Assignee: The Trustees of Princeton UniversityInventors: Joshua D. Rabinowitz, Hahn Kim, Gregory S. Ducker, Jonathan M. Ghergurovich
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Patent number: 11764669Abstract: Subject matter disclosed herein may relate to power converters, and may more particularly relate to multi-stage hybrid power converters, for example.Type: GrantFiled: December 22, 2020Date of Patent: September 19, 2023Assignees: The Trustees of Princeton University, pSemi CorporationInventors: Minjie Chen, Yenan Chen, David Giuliano
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Publication number: 20230289473Abstract: According to various embodiments, a method for encrypting image data for a neural network are disclosed. The method includes mixing the image data with other datapoints to form mixed data; and applying a pixel-wise random mask to the mixed data to form encrypted data. According to various embodiments, a method for encrypting text data for a neural network for natural language processing is disclosed. The method includes encoding each text datapoint via a pretrained text encoder to form encoded datapoints; mixing the encoded datapoints with other encoded datapoints to form mixed data; applying a random mask to the mixed data to form encrypted data; and incorporating the encrypted data into training a classifier of the neural network and fine-tuning the text encoder.Type: ApplicationFiled: June 17, 2021Publication date: September 14, 2023Applicant: The Trustees of Princeton UniversityInventors: Sanjeev ARORA, Kai LI, Yangsibo HUANG, Zhao SONG, Danqi CHEN
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Publication number: 20230284629Abstract: Disclosed are methods of forming an antimicrobial and/or antiviral metal coating on a substrate comprising surface groups that bond to a metal alkoxide to form a 3-dimensional metal oxide/alkoxide adhesion layer. The methods include A) soaking or spraying a substrate comprising a 3-dimensional metal oxide/alkoxide layer with a solution of a transition metal salt, and reduction of the transition metal salt to form a continuous network of transition metal within the 3-D layer, or B) soaking or spraying a substrate comprising a 3-dimensional metal oxide/alkoxide layer with a solution of a post-transition metal salt, sintering at high temperature to form a continuous post-transition metal network within the 3-D layer, and electrolyzing to replace post-transition metal with a transition metal.Type: ApplicationFiled: September 28, 2021Publication date: September 14, 2023Applicants: THE TRUSTEES OF PRINCETON UNIVERSITY, ORTHOBOND CORPORATIONInventors: Jeffrey Schwartz, Carlos E. Caicedo-Carvajal, Gregorg E. Lutz, Siyang Yang
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Publication number: 20230285352Abstract: Compositions including dihydromyricetin (DHM) and methods for forming them through hot melt extrusion.Type: ApplicationFiled: September 13, 2022Publication date: September 14, 2023Applicants: The Trustees of Princeton University, Cheers Health, Inc.Inventors: Robert K. PRUD'HOMME, Brooks POWELL, Vikram PANSARE, Nicholas CAGGIANO
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Patent number: 11753744Abstract: Compositions and methods are provided for DNA barcoding of designer mononucleosome and polynucleosome (chromatin array) libraries for use, for example, for the profiling of chromatin readers, writers, erasers, and modulators thereof.Type: GrantFiled: August 24, 2018Date of Patent: September 12, 2023Assignee: The Trustees of Princeton UniversityInventors: Tom W. Muir, Uyen T. T. Nguyen, Manuel M. Mueller
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Patent number: 11746131Abstract: Provided herein is an isolated fusion protein comprising a light-responsive domain and a heterologous peptide component. Exposure of the fusion protein to light induces a conformational change in the fusion protein that alters an activity of the fusion protein and the activity is a binding activity selected from an in vitro binding activity, an in vivo extracellular binding activity and an in vivo intracellular binding activity. Also provided are methods of using and identifying the fusion proteins.Type: GrantFiled: June 1, 2020Date of Patent: September 5, 2023Assignee: The Trustees of Princeton UniversityInventors: Jared Toettcher, Jose Avalos, Maxwell Wilson, Alexander Goglia, Evan M. Zhao, Agnieszka Gil, Cesar Carrasco-Lopez