Patents Assigned to Unigen, Inc.
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Publication number: 20170014461Abstract: Compositions and methods for treatment of and maintaining the health of the liver are disclosed that include a mixture of plant extracts, wherein the plant extracts comprise at least one Artemisia extract, at least one Aloe gel powder, and at least one Schizandra extract. Compositions and methods for treatment of and maintaining the health of the liver are disclosed that include a mixture of plant extracts, wherein the plant extracts comprise at least one Artemisia extract enriched for at least one polymer or biopolymer, at least one Aloe gel powder enriched for at least one chromone, and at least one Schizandra extract enriched for at least one lignan and organic acid.Type: ApplicationFiled: July 12, 2016Publication date: January 19, 2017Applicant: Unigen, Inc.Inventors: Qi Jia, Mesfin Yimam, Ping Jiao, Mei Feng Hong, Breanna Moore
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Publication number: 20160263013Abstract: The present disclosure provides a mixture of sugar apple and rosemary extracts, optionally in combination with prickly ash extract, for use as skin care compositions.Type: ApplicationFiled: October 30, 2014Publication date: September 15, 2016Applicants: Unigen, Inc., Unigen, Inc.Inventors: Lidia Alfaro Brownell, Min Chu, Brandon Corneliusen, Mei-Feng Hong, Ji-Hye Hwang, Eu-Jin Hyun, Qi Jia, Ping Jiao, Mi-Ran Kim, Bo-Su Lee, Young-Chul Lee, Jeong-Bum Nam, Mi-Sun Oh, Mesfin Yimam
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Patent number: 9370544Abstract: The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier.Type: GrantFiled: November 12, 2013Date of Patent: June 21, 2016Assignee: Unigen, Inc.Inventor: Qi Jia
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Publication number: 20160083322Abstract: The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.Type: ApplicationFiled: June 25, 2015Publication date: March 24, 2016Applicant: Unigen, Inc.Inventors: Sandip K. Nandy, Jiyun Liu, Alexandre Mikhailovitch Nesterov, Carmen Hertel, Abeysinghe Arrachchigae Papmapiya
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Publication number: 20160067296Abstract: The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.Type: ApplicationFiled: September 14, 2015Publication date: March 10, 2016Applicant: UNIGEN, INC.Inventors: Lidia Alfaro Brownell, Min Chu, Mei-Feng Hong, Eu-Jin Hyun, Qi Jia, Ping Jiao, Young-Chul Lee, Mesfin Yimam
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Patent number: 9168242Abstract: The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also includes methods for isolating and purifying from an Acacia genus of plants a composition of flavans having dual specificity for cyclooxygenase (COX-2) and 5-lipoxygenase (5-LO) enzymes.Type: GrantFiled: August 20, 2013Date of Patent: October 27, 2015Assignee: Unigen, Inc.Inventors: Qi Jia, Timothy C. Nichols, Eric E. Rhoden, Scott Waite
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Patent number: 9126913Abstract: The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto.Type: GrantFiled: March 13, 2014Date of Patent: September 8, 2015Assignee: Unigen, Inc.Inventors: Qi Jia, Ji-Fu Zhao
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Patent number: 9096507Abstract: The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.Type: GrantFiled: January 13, 2014Date of Patent: August 4, 2015Assignee: Unigen, Inc.Inventors: Sandip K. Nandy, Jiyun Liu, Alexandre Mikhailovitch Nesterov, Carmen Hertel, Abeysinghe A. Padmapriya
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Patent number: 9078891Abstract: The present disclosure describes the identification and purification of 7-hydroxychromes that exhibit potent antioxidant activity. The present disclosure also includes methods for preventing and treating ROS mediated diseases and conditions and diseases and conditions associated with other oxidative processes. Included in this disclosure is an improved method to isolate and purify 7-hydroxychromones from plant sources.Type: GrantFiled: February 3, 2012Date of Patent: July 14, 2015Assignee: Unigen, Inc.Inventors: Qi Jia, Thomas M. Farrow
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Patent number: 9061039Abstract: The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.Type: GrantFiled: August 19, 2013Date of Patent: June 23, 2015Assignee: Unigen, Inc.Inventors: Qi Jia, Timothy C. Nichols, Eric E. Rhoden, Scott Waite
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Patent number: 9045405Abstract: Compounds of structure (I): including stereoisomers, tautomers and salts thereof, wherein R1, R2, R3, R4, R5, R6, X, Y and Z are as defined herein. Such compounds are useful for the preparation of diarylpropane compounds. Methods for the preparation of compounds of structure (I) are also disclosed, as are methods employing compounds of structure (I) for the preparation of diarylpropanes.Type: GrantFiled: October 16, 2013Date of Patent: June 2, 2015Assignee: Unigen, Inc.Inventors: Sandip K. Nandy, Abeysinghe Arrachchigae Padmapriya
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Patent number: 8945518Abstract: The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-Ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions associated with mouth, gums and teeth. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity and reduces cytokine production at the mRNA level in normal, aged and damaged periodontal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the mouth, gums and teeth.Type: GrantFiled: October 19, 2005Date of Patent: February 3, 2015Assignee: Unigen, Inc.Inventors: Qi Jia, Yuan Zhao
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Publication number: 20140370128Abstract: The present invention relates to a composition comprised of a plant extract as an active component, specifically, Bamboo extract and Scutellaria extract, for the treatment and prevention of atopic dermatitis. The present invention is a natural ingredient can be obtained from a plant. The present invention can control immune responses by inhibiting the release of histamine and leukotrien, and thus, has effect in the treatment or prevention of allergic diseases, inflammatory diseases and skin diseases, specifically atopic dermatitis. The present invention has been proven safe and beneficial effecting the treatment of atopic dermatitis through clinical trials, and thus, can be used for the treatment and prevention of atopic dermatitis.Type: ApplicationFiled: May 27, 2014Publication date: December 18, 2014Applicant: Unigen, Inc.Inventors: Sung-Sick Woo, Dong-Seon Kim, Young-Chul Lee, EunJung Son
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Publication number: 20140371491Abstract: The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto.Type: ApplicationFiled: March 13, 2014Publication date: December 18, 2014Applicant: Unigen, Inc.Inventors: Qi Jia, Ji-Fu Zhao
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Publication number: 20140363388Abstract: The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.Type: ApplicationFiled: January 13, 2014Publication date: December 11, 2014Applicant: UNIGEN, INC.Inventors: Sandip K. Nandy, Jiyun Liu, Alexandre Mikhailovitch Nesterov, Carmen Hertel, Abeysinghe A. Padmapriya
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Patent number: 8852657Abstract: The identification and isolation of chromones and novel chromone compositions from plant sources that exhibit up-regulation of adiponectin production by adipocytes and the normalization of virtually hundreds of genes related to glucose and fatty acid metabolic and signaling pathways. The chromone compositions are effective in enhancing adiponectin production by adipocytes and regulating genes involved in fatty acid biosynthesis, mitochondrial ?-oxidation of fatty acids, steroid biosynthesis, gluconeogenesis, fat transport, PPAR?/RXR? liver signaling and xenobiotic metabolism. The chromone compositions can be used to increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals. Included are methods for the prevention and treatment of a variety of diseases and conditions including, but not limited to insulin resistance, glucose intolerance, hyperglycemia, metabolic syndromes, dyslipidemia, and hypertriglyceridemia.Type: GrantFiled: January 9, 2008Date of Patent: October 7, 2014Assignee: Unigen, Inc.Inventors: Ji-Fu Zhao, Julie Tseng-Crank, Mesfin Yimam, Qi Jia
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Publication number: 20140235899Abstract: Compounds of structure (I): including stereoisomers, tautomers and salts thereof, wherein R1, R2, R3, R4, R5, R6, X, Y and Z are as defined herein. Such compounds are useful for the preparation of diarylpropane compounds. Methods for the preparation of compounds of structure (I) are also disclosed, as are methods employing compounds of structure (I) for the preparation of diarylpropanes.Type: ApplicationFiled: October 16, 2013Publication date: August 21, 2014Applicant: Unigen, Inc.Inventors: Sandip K. Nandy, Abeysinghe Arrachchigae Padmapriya
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Patent number: 8790724Abstract: The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-Ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions associated with the skin. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity in normal, aged and damaged dermal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the skin mediated by cyclooxygenase (COX) and lipoxygenase (LOX).Type: GrantFiled: February 16, 2011Date of Patent: July 29, 2014Assignee: Unigen, Inc.Inventor: Qi Jia
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Patent number: 8771761Abstract: The present invention relates to a composition comprising of plant extract as an active component, specifically, Bamboo extract and Scutellaria extract, for the treatment and prevention of atopic dermatitis. The present invention is a natural ingredient obtained from a plant. The present invention can control immune responses by inhibiting the release of histamine and leukotriene, and thus, has effect in the treatment or prevention of allergic diseases, inflammatory diseases and skin diseases, specifically atopic dermatitis. The present invention has been proven safe and beneficial effecting the treatment of atopic dermatitis through clinical trials, and thus, can be used for the treatment and prevention of atopic dermatitis.Type: GrantFiled: August 15, 2012Date of Patent: July 8, 2014Assignee: Unigen, Inc.Inventors: Sung Sick Woo, Dong Seon Kim, Young Chul Lee, Eun Jung Son
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Publication number: 20140178509Abstract: The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier.Type: ApplicationFiled: November 12, 2013Publication date: June 26, 2014Applicant: Unigen, Inc.Inventor: Qi Jia