Patents Assigned to Unigen, Inc.
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Patent number: 8729136Abstract: The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto.Type: GrantFiled: December 6, 2012Date of Patent: May 20, 2014Assignee: Unigen, Inc.Inventors: Qi Jia, Ji-Fu Zhao
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Publication number: 20140088183Abstract: The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also includes methods for isolating and purifying from an Acacia genus of plants a composition of flavans having dual specificity for cyclooxygenase (COX-2) and 5-lipoxygenase (5-LO) enzymes.Type: ApplicationFiled: August 20, 2013Publication date: March 27, 2014Applicant: Unigen, Inc.Inventors: Qi Jia, Timothy C. Nichols, Eric E. Rhoden, Scott Waite
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Publication number: 20140080774Abstract: The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.Type: ApplicationFiled: August 19, 2013Publication date: March 20, 2014Applicant: Unigen, Inc.Inventors: Qi Jia, Timothy C. Nichols, Eric E. Rhoden, Scott Waite
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Patent number: 8658838Abstract: The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.Type: GrantFiled: December 20, 2012Date of Patent: February 25, 2014Assignee: Unigen, Inc.Inventors: Sandip K. Nandy, Jiyun Liu, Alexandre Mikhailovitch Nesterov, Carmen Hertel, Abeysinghe A. Padmapriya
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Patent number: 8652535Abstract: The present invention provides a novel method for preventing and treating memory and cognitive impairment resulting from oxidative stress, inflammation and the process of aging, as well as, neurodegenerative conditions. The method is comprised of administering a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants to a host in need thereof. The present also includes a novel method for simultaneously inhibiting expression of pro-inflammatory cytokines, preventing ROS generation and augmenting anti-oxidant defenses. The activity of this composition is conducive to ultimately preserving cognitive function and providing a level of neuroprotection.Type: GrantFiled: August 25, 2011Date of Patent: February 18, 2014Assignee: Unigen, Inc.Inventors: Qi Jia, Bruce Burnett, Yuan Zhao
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Publication number: 20140004215Abstract: The present disclosure provides Diels-Alder adducts of chalcone and prenylphenyl moieties capable of modulating the activity of cannabinoid receptors, and to oligomers of flavan-3-ol capable of modulating fat absorption and storage. Such Diels-Alder adducts of chalcone and prenylphenyl moieties or oligomers of flavan-3-ol can optionally be used in combination with other weight management agents, such as anorectic agents, a lipase inhibitors, other cannabinoid receptor modulators, psychotropic agents, insulin sensitizers, stimulants, or satiety agents, as well as to methods of use thereof such as treating or preventing weight gain or obesity, promoting weight loss, appetite suppression, modifying satiety, or the like.Type: ApplicationFiled: May 29, 2013Publication date: January 2, 2014Applicants: Unigen, Inc., UNIGEN, INC.Inventors: Lidia Alfaro BROWNELL, Byong-Il CHOI, Brandon CORNELIUSEN, Mei-Feng HONG, Eu-Jin HYUN, Qi JIA, Ping JIAO, Hyun-Jin KIM, Mi-Ran KIM, Tae-Woo KIM, Bo-Su LEE, Young-Chul LEE, Jeong-Bum NAM, Mesfin YIMAN, Ji-Hye Hwang, Mi-Sun OH
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Patent number: 8592488Abstract: Diarylalkanes having the following structure: wherein Ar1, Ar2, R6, R7 and n are as defined herein are provided. The disclosed compounds find utility as inhibitors of binuclear enzymes. Methods for inhibiting binuclear enzymes as well as methods and compositions for preventing and treating diseases and conditions associated with binuclear enzymes are also provided.Type: GrantFiled: June 11, 2010Date of Patent: November 26, 2013Assignee: Unigen, Inc.Inventors: Qi Jia, Ji-Fu Zhao
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Patent number: 8586799Abstract: Compounds of structure (I): including stereoisomers, tautomers and salts thereof, wherein R1, R2, R3, R4, R5, R6, X, Y and Z are as defined herein. Such compounds are useful for the preparation of diarylpropane compounds. Methods for the preparation of compounds of structure (I) are also disclosed, as are methods employing compounds of structure (I) for the preparation of diarylpropanes.Type: GrantFiled: March 21, 2012Date of Patent: November 19, 2013Assignee: Unigen, Inc.Inventors: Sandip K. Nandy, Abeysinghe Arrachchigae Padmapriya
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Patent number: 8568799Abstract: The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also includes methods for isolating and purifying from an Acacia genus of plants a composition of flavans having dual specificity for cyclooxygenase (COX-2) and 5-lipoxygenase (5-LO) enzymes.Type: GrantFiled: January 20, 2012Date of Patent: October 29, 2013Assignee: Unigen, Inc.Inventors: Qi Jia, Timothy C. Nichols, Eric E. Rhoden, Scott Waite
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Patent number: 8535735Abstract: The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.Type: GrantFiled: June 11, 2012Date of Patent: September 17, 2013Assignee: Unigen, Inc.Inventors: Qi Jia, Timothy C. Nichols, Eric E. Rhoden, Scott Waite
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Publication number: 20130224135Abstract: The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto.Type: ApplicationFiled: December 6, 2012Publication date: August 29, 2013Applicant: UNIGEN, INC.Inventor: Unigen, Inc.
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Publication number: 20130209383Abstract: The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.Type: ApplicationFiled: December 20, 2012Publication date: August 15, 2013Applicant: UNIGEN, INC.Inventor: UNIGEN, INC.
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Publication number: 20130064910Abstract: The present invention relates to a composition comprising of plant extract as an active component, specifically, Bamboo extract and Scutellaria extract, for the treatment and prevention of atopic dermatitis. The present invention is a natural ingredient obtained from a plant. The present invention can control immune responses by inhibiting the release of histamine and leukotrien, and thus, has effect in the treatment or prevention of allergic diseases, inflammatory diseases and skin diseases, specifically atopic dermatitis. The present invention has been proven safe and beneficial effecting the treatment of atopic dermatitis through clinical trials, and thus, can be used for the treatment and prevention of atopic dermatitis.Type: ApplicationFiled: August 15, 2012Publication date: March 14, 2013Applicant: Unigen, Inc.Inventors: Sung Sick Woo, Dong Seon Kim, Young Chul Lee, Eun Jung Son
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Patent number: 8362305Abstract: The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.Type: GrantFiled: July 21, 2009Date of Patent: January 29, 2013Assignee: Unigen, Inc.Inventors: Sandip K. Nandy, Jiyun Liu, Alexandre Mikhailovitch Nesterov, Carmen Hertel, Abeysinghe A. Padmapriya
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Publication number: 20130012458Abstract: The present disclosure describes the identification and purification of 7-hydroxychromes that exhibit potent antioxidant activity. The present disclosure also includes methods for preventing and treating ROS mediated diseases and conditions and diseases and conditions associated with other oxidative processes. Included in this disclosure is an improved method to isolate and purify 7-hydroxychromones from plant sources.Type: ApplicationFiled: February 3, 2012Publication date: January 10, 2013Applicant: UNIGEN, INC.Inventors: Qi Jia, Thomas M. Farrow
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Publication number: 20130012463Abstract: The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.Type: ApplicationFiled: June 11, 2012Publication date: January 10, 2013Applicant: Unigen, Inc.Inventors: Qi Jia, Timothy C. Nichols, Eric E. Rhoden, Scott Waite
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Publication number: 20120329863Abstract: The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also includes methods for isolating and purifying from an Acacia genus of plants a composition of flavans having dual specificity for cyclooxygenase (COX-2) and 5-lipoxygenase (5-LO) enzymes.Type: ApplicationFiled: January 20, 2012Publication date: December 27, 2012Applicant: Unigen, Inc.Inventors: Qi Jia, Timothy C. Nichols, Eric E. Rhoden, Scott Waite
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Publication number: 20120245393Abstract: Compounds of structure (I): including stereoisomers, tautomers and salts thereof, wherein R1, R2, R3, R4, R5, R6, X, Y and Z are as defined herein. Such compounds are useful for the preparation of diarylpropane compounds. Methods for the preparation of compounds of structure (I) are also disclosed, as are methods employing compounds of structure (I) for the preparation of diarylpropanes.Type: ApplicationFiled: March 21, 2012Publication date: September 27, 2012Applicant: Unigen, Inc.Inventors: Sandip K. Nandy, Abeysinghe Arrachchigae Padmapriya
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Patent number: 8247007Abstract: The present invention relates to a composition comprising of plant extract as an active component, specifically, Bamboo extract and Scutellaria extract, for the treatment and prevention of atopic dermatitis. The present invention is a natural ingredient obtained from a plant. The present invention can control immune responses by inhibiting the release of histamine and leukotrien, and thus, has effect in the treatment or prevention of allergic diseases, inflammatory diseases and skin diseases, specifically atopic dermatitis. The present invention has been proven safe and beneficial effecting the treatment of atopic dermatitis through clinical trials, and thus, can be used for the treatment and prevention of atopic dermatitis.Type: GrantFiled: October 12, 2007Date of Patent: August 21, 2012Assignee: Unigen, Inc.Inventors: Sung Sick Woo, Dong Seon Kim, Young Chul Lee, Eun Jung Son
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Publication number: 20120201769Abstract: Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.Type: ApplicationFiled: February 2, 2012Publication date: August 9, 2012Applicant: Unigen, Inc.Inventors: Mei Feng Hong, Qi Jia, Lidia Alfaro Brownell