Abstract: The invention relates to an optical device for interferometric analysis of the condition of the internal surface of a tube (11). The device comprises an optical fibre (3), the free end of which is pointed and then bevelled at the single core thereof and the bevelled surface is metalised (10), such that only part of the surface of the fibre core participates in reflecting the incident beam perpendicularly to the axis of the fibre.

Abstract: A method is disclosed for continuously monitoring a blood pressure measurement using a sensor connected by a hydraulic link to an arterial catheter, the method includes determining the dynamic parameters of the link, analyzing the frequency content of the incident signal, detecting one of the following situations: (a) ability of the link to transmit the incident signal with a distortion below a threshold, (b) ability of the link to transmit the incident signal with a distortion above the threshold and possibility of correcting the measured signal, (c) inability of the link to transmit the incident signal with a distortion below the threshold and impossibility of correcting the measured signal, periodic application of a mechanical action to the tubing providing the hydraulic link.

Abstract: A biofuel cell intended to be immersed into a liquid medium containing a sugar and oxygen, wherein the anode includes an enzyme capable of catalyzing the oxidation of the sugar and a redox mediator of low redox potential capable of exchanging electrons with the anode enzyme and the cathode includes an enzyme capable of catalyzing the reduction of oxygen and a redox mediator of high redox potential capable of exchanging electrons with the cathode enzyme. Each of the anode and cathode electrodes is formed of a solid agglomerate of a conductive material mixed with the appropriate enzyme and redox mediator and is solid with an electrode wire.

Abstract: The instant disclosure describes a radiofrequency propagation line including a conducting strip connected to a conducting plane parallel to the plane of the conducting strip, wherein the conducting plane includes a network of nanowires made of an electrically conductive, non-magnetic material extending orthogonally to the plane of the conducting strip, in the direction of said conducting strip.

Abstract: A novel cell including first and second chambers containing a solvent and separated by a wall permeable to the solvent and impermeable to hydronium and/or hydroxyl ions; a first electrode in the first chamber; a second electrode in the second chamber; a first redox couple in the first chamber comprising a first oxidizer and a first reducer taking part in first oxidation-reduction reactions resulting in an electron exchange with the first electrode; a second redox couple in the second chamber comprising a second oxidizer and a second reducer taking part in second oxidation-reduction reactions resulting in an electron exchange with the second electrode, the wall being impermeable to the first and second redox couples; and first enzymes or first microorganisms placed in the first or second chamber and promoting a third oxidation-reduction reaction resulting transforming a first substance to a second substance comprising acid or alkaline species.

Abstract: The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.

Abstract: The present disclosure concerns a method for the identification of the presence or absence of cancer cells in a biological sample, more particularly a method for the identification of the susceptibility or resistance to a treatment with CD20 agonists of cancer cells in a biological sample, the methods including determining the level of expression of the gene Cyclon in the cells and comparing the level of expression to the level of expression in a non-cancer cell, wherein a level of expression higher than the level of expression in a non-cancer cell is an indication of the presence of a cancer cell, more particularly an indication of cancer cells with a resistance to treatment with antagonists. Kits for the determination of a level of expression of the Cyclon gene in a biological sample, a method for the identification of Cyclon expression antagonists, and methods for treating patients are provided.

Abstract: The tank is of the type including a container (4) for housing hydrogen, and metallic hydride placed inside the container. According to one aspect of the invention, it includes at least one solid body (6) formed of a compacted material including metallic hydride and a matrix. Application in particular for tanks for internal combustion engines or for fuel cells, in particular for motor vehicles, as well as for any stationary or mobile application using hydrogen.

Abstract: A process for obtaining an array of nanodots (212) for microelectronic devices, characterized in that it comprises the following steps: deposition of a silicon layer (210) on a substrate (100, 132), formation, above the silicon layer (210), of a layer (240) of a material capable of self-organizing, in which at least one polymer substantially forms cylinders (242) organized into an array within a matrix (244), formation of patterns (243) in the layer (240) of a material capable of self-organizing by elimination of the said cylinders (242), formation of a hard mask (312) by transfer of the said patterns (243), production of silicon dots (212) in the silicon layer (210) by engraving through the hard mask (312), silicidation of the silicon dots (212), comprising deposition of a metal layer (510).

Abstract: The invention relates to a method for producing a component comprising a conductive grid insulated from a semiconductor monocrystalline diamond substrate by an insulating region, comprising the following steps: a) oxygenating the surface of the substrate so as to replace the hydrogen surface terminations of the substrate with oxygen surface terminations; and b) forming the insulating region on the surface of the substrate by repeated monatomic layer deposition.

Abstract: A computerized bone motion tracking system according to one exemplary embodiment is configured to: provide a non-invasive means for accurate measurement and tracking of the motion of a bone using a volumetric ultrasound transducer and a three dimensional position measurement system; provide relative measurements of one bone relative to another bone of a joint; decompose relative joint motion into specific components; and measure joint instability and range of motion.

Abstract: A protein complex isolated from its natural medium and including the ZEBRA protein of sequence SEQ ID NO: 1, the isolated protein complex having the following properties: it is more stable than the ZEBRA protein, in particular it is more resistant to the action of the proteases than the ZEBRA protein, it is capable of specifically binding the AZ125 and AZ130 monoclonal antibodies, it is soluble in a body fluid, and in particular a body fluid selected from the group constituted by blood and serum, and to its detection process and the uses of this process for the prognosis or diagnosis of lymphoproliferative episodes associated with the EBV.

Abstract: A process for obtaining an adapted strain of Pseudomonas includes the following steps: deleting the genes ExoS, ExoT, aroA and IasI in an initial Pseudomonas strain cultivated in a LB medium; progressively cultivating this strain in a chemically defined medium based on a glucose minimal medium supplemented with magnesium and calcium; wherein the adapted strain presents the same toxicity and secretion capacities than the initial strain, and its doubling time when cultivated in the chemically defined medium is less than 60 minutes. An adapted strain is furthermore treated to become ‘killed but metabolically active’.

Abstract: The use of isoquinolones for preparing drugs, including novel isoquinolones as well as their synthesis method. In particular, isoquinolone derivatives used in the treatment of pathological angiogenesis, and more particularly of cancer.

Abstract: The present invention relates to a method for dosing the control capacity of plasma serpin (SERine Protease INhibitor) C1 inhibitor (C1Inh) on the basis of a patient blood sample. The invention also relates to a kit specially designed for said dosing.

Abstract: Novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.

Abstract: An actuator that includes an enclosure having a wall impermeable to a first solute and permeable to a solvent and containing, at least temporarily, a catalyst capable of promoting the transformation of at least one second solute into the first solute to vary the osmotic pressure in the enclosure; and a deformable chamber connected to the enclosure, the chamber being capable of increasing in volume under the action of the solvent moving from the enclosure into the chamber by osmosis or the enclosure being designed to be arranged in contact with the solvent, the chamber being capable of increasing in volume under the action of the solvent penetrating into the enclosure by osmosis.

Abstract: The invention relates to a method for functionalizing an electrically conductive substrate, which is not a substrate made of gold, via a layer of chemical compounds, said method comprising the following steps: a step in which the electrically conductive substrate is placed in contact with chemical compounds comprising at least a disulfide terminal group; a step in which the disulfide terminal group of said chemical compounds is electro-oxidized, causing said chemical compounds to form a layer at the surface of the electrically conductive substrate.

Abstract: The present invention relates to nanobodies specifically directed against VCAM-1 and to their use in medical imaging and in diagnostic, prognostic and treatment methods.

Abstract: The invention relates to a method for etching a structure (1) including at least one material (4) to be etched, said method consisting in: selecting at least one chemical species that can react with the material (4) to be etched; selecting at least one soluble compound that can release this chemical species; producing a solution (11) containing said compound; placing the structure (1) in a position such that the surface of the material to be etched is in the presence of the solution and additional bubbles of a gas; and producing high-frequency ultrasounds in the solution, at at least one frequency, capable of generating reactive cavitation bubbles such that the chemical species is generated in the presence of these additional bubbles and reacts with the material to be etched, thereby producing a soluble compound or a precipitate.