Abstract: The invention relates to a method for etching a structure (1) including at least one material (4) to be etched, said method consisting in: selecting at least one chemical species that can react with the material (4) to be etched; selecting at least one soluble compound that can release this chemical species; producing a solution (11) containing the compound and a powder of particles or solid grains (13) in suspension; placing the material to be etched in the presence of the solution; and producing high-frequency ultrasounds in the solution, at at least one frequency, capable of generating active cavitation bubbles such that the chemical species is generated and reacts with the material to be etched, thereby producing a soluble compound or a precipitate.
Type:
Grant
Filed:
May 12, 2010
Date of Patent:
September 9, 2014
Assignees:
Institut Polytechnique de Grenoble, Universite Joseph Fourier
Abstract: The present invention relates to an adhesion substrate for at least one animal or human cell on the surface of which is generated an adhesion pattern for at least one animal or human cell, said pattern including at least two areas adhering to said cell, which are spaced apart by an area not adhering to said cell on which a polymer not adhering to said cell is immobilized, characterized in that the polymer is selected so as to have a conformation which may be modified by varying a parameter of the environment in which the substrate is found, to a method for preparing such a substrate and to the cell analysis methods using such a substrate.
Type:
Application
Filed:
July 24, 2012
Publication date:
August 21, 2014
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE JOSEPH FOURIER
Inventors:
Martial Balland, Kalpana Mandal, Lionel Bureau
Abstract: The invention relates to small cell penetrating peptides (CPP) derived from the scorpion toxin maurocalcine and to their use as vectors for the intracellular delivery of various drugs and agents.
Type:
Application
Filed:
June 20, 2012
Publication date:
August 21, 2014
Applicants:
Commissariat A L'Energie Atomique Et Aux Energies Alternatives, Universite Joseph Fourier, Institut National De La Sante Et De La Recherche Medicale (INSERM)
Abstract: The invention concerns a device for heating an object (6) in an intense magnetic field, comprising:—a light source (1), an optic fibre (2) for transporting the light emitted by said light source (1) and emitting a beam of light in the direction of the object (6) to be heated, a converging optical system (3), a diaphragm (4) positioned at the focusing point of the optical system (3),—a reflector (5), whereof the inner wall is defined by the revolution of a semi-parabola around an axis perpendicular to the optical axis of the parabola and passing through the focal point of said parabola, the optical axis of said reflector (5) coinciding with the optical axis (A) of the optical system (3) and the focal point (F?) of said reflector coinciding with the focusing point of said optical system (3).
Type:
Application
Filed:
September 20, 2012
Publication date:
August 14, 2014
Applicant:
UNIVERSITE JOSEPH FOURIER - GRENOBLE 1
Inventors:
Pierre-Frederic Sibeud, Eric Beaugnon, Gilles Pont
Abstract: The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.
Type:
Application
Filed:
July 20, 2012
Publication date:
August 14, 2014
Applicant:
UNIVERSITE JOSEPH FOURIER
Inventors:
Jean-Noël Denis, Marcelle Claude Jolivalt, Louis Max Maurin, Nikolaevna Olga Burchak
Abstract: The instant disclosure describes an optical device for the interferometric analysis of the surface condition of an object, including: a light source; an optical fiber capable of receiving the incident light wave and transmitting said wave to the object; a detector capable of detecting a combination between a light wave reflected by the optical fiber and a light wave returned by the object; and in which the optical fiber has a free end in the shape of a cone, with a vertex angle of between 15 and 25 degrees, the tip of the cone having dimensions of less than 50×50 nm, and the tip of the cone being placed, while in use, at a distance of between 5 and 50 ?m from the surface of the object.
Type:
Grant
Filed:
December 29, 2009
Date of Patent:
July 29, 2014
Assignees:
Universite Joseph Fourier, Centre National de la Recherche Scientifique, Commissariat a l'Energie Atomique et aux Energies Alternatives
Abstract: The invention relates to the field of production in thin coatings of electronic devices and/or MEMS and relates to an improved method for forming a pattern in a thin SiARC anti-reflective coating, comprising the doping by deposition of such SiARC coating covered with a resist pattern through a protective coating of the resist pattern, then etching the doped zones of the SiARC coating (FIG. 3c).
Type:
Application
Filed:
December 27, 2013
Publication date:
July 3, 2014
Applicants:
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENE ALT, Universite Joseph Fourier, CNRS-Centre National de la Recherche Scientifique
Inventors:
Nicolas POSSEME, Olivier JOUBERT, Laurent VALLIER
Abstract: A disclosed method involves: receiving, by a processing device, a first plurality of photon count values indicating a number of photons detected by an optical system during a plurality of first time periods as a result of laser beam excitation of an observation volume of a sample during fluorescence fluctuation microscopy analysis; calculating, by the processing device based on the first plurality of photon count values, a first count rate per molecule indicating the average number of photons detected per molecule of the observation volume; and generating, by the processing device based on the first count rate per molecule, a control signal for configuring a phase modulation device of the optical system.
Type:
Application
Filed:
March 15, 2013
Publication date:
June 19, 2014
Applicant:
UNIVERSITE JOSEPH FOURIER
Inventors:
Antoine Delon, Charles-Edouard Leroux, Alexei Grichine
Abstract: Method for monitoring an electrochemical cell or a battery (1), in particular method for monitoring the first charging of an electrochemical cell or of a battery (1) of Li-ion type, comprising a step of acquiring data relating to acoustic emissions produced in the electrochemical cell or in the battery and, by using the data acquired, a step of detecting: the formation of a passivation film on an electrode of the electrochemical cell or of the battery; and/or the first storage of lithium in an electrode of the electrochemical cell or of the battery.
Type:
Application
Filed:
April 27, 2012
Publication date:
June 12, 2014
Applicants:
Commissariat a L'energie Atomique et aux Energies Alternatives, Institut Polytechnique de Grenoble, Universite Joseph Fourier - Grenoble
Inventors:
Sylvie Genies, David Brun-Buisson, Nina Kircheva, Pierre-Xavier Thivel
Abstract: Silicon sintering method, without applying an external force, comprising placement of a silicon sample in a furnace, then heat treatment of this sample at, at least one temperature and at least one partial pressure of oxidising species to control the thickness of a silicon oxide layer on its surface.
Type:
Application
Filed:
October 14, 2011
Publication date:
June 5, 2014
Applicants:
Commissariat A L'energie Atomique ET Aux Energies Alternatives, Universite Joseph Fourier
Abstract: This invention concerns compounds with the formula: in which: R1?OH or NH2; OR2, OR3, OR4 and OR5 are alcohol, ether, ester, carbonate, carbamate, sulphonate or sulphamate groups; and if R5?H if R2?R3?R4, then R2, R3 and R4?H; if R2?H, then R3?H and R4?H; if R3?H, then R2?H and R4?H; if R4?H, then R2?H and R3?H; if R5?H if R2=H, then R3?H and R4?H; if R3?H, then R2?H and R4?H; if R4?H, then R2?H and R3?H, their use as antibiotic agents and the process for synthesizing them.
Type:
Grant
Filed:
January 22, 2009
Date of Patent:
May 20, 2014
Assignee:
Universite Joseph Fourier
Inventors:
Jean-Luc Decout, Isabelle Baussanne, Jerome Desire, Jean-Marc Paris
Abstract: A method for making a crossbar array of crossed conductive or semi-conductive access lines on a substrate, the crossbar array including on a crossbar array insulator, in a plane parallel to the substrate, a first level of lines including a plurality of first lines parallel with each other made of a conductive or semi-conductive material; on the first level of lines, a second level of lines including a plurality of second lines parallel with each other made of a conductive or semi-conductive material, the second lines being substantially perpendicular to the first lines. The method includes forming, on the substrate, a first cavity of substantially rectangular shape; forming a second cavity of substantially rectangular shape superimposed to the first cavity, the first and second cavities intersecting each other perpendicularly so as to form a resultant cavity.
Type:
Grant
Filed:
June 7, 2011
Date of Patent:
April 1, 2014
Assignees:
Commissariat a l'Energie Atomique, Centre National de la Recherche Scientifique, Universite Joseph Fourier
Inventors:
Julien Buckley, Karim Aissou, Thierry Baron, Gabriel Molas
Abstract: The present invention relates to a system for positioning with respect to a patient's body an observation and/or intervention device having a portion penetrating into the patient's body comprising a base disposed over the patient's body; a means for supporting the device formed of a first portion movably assembled on the base according to a connection with one degree of freedom, and of a second portion movably assembled on the first portion according to a connection with one degree of freedom and connected to the device; and means for actuating the first portion with respect to the base, and the second portion with respect to the first portion, in which the base surrounds at a distance at least partially the device, said device being detachably connected to the second portion to enable removal of the positioning system while leaving in place the device.
Type:
Application
Filed:
November 22, 2013
Publication date:
March 20, 2014
Applicant:
UNIVERSITE JOSEPH FOURIER
Inventors:
Peter Berkelman, Philippe Cinquin, Alain Jacquet, Jean Amault
Abstract: The invention relates to an image processing method for estimating a risk of atheroma plaque breakage, that includes the step of receiving (40) a so-called elastogram image representing the inner deformation resulting from the compression of an analyzed blood vessel tissue based on blood pressure, the step of pre-segmenting (50) the elastogram in order to obtain a pre-segmented image including a plurality of areas, and the step of calculating an elasticity image (60) representing the elasticity of at least one region of the elastogram, the region corresponding to an area selected among the plurality of areas of the pre-segmented image, and the elasticity image enabling the user to estimate the risk of atheroma plaque breakage, wherein said method is characterized in that: the pre-segmentation is carried out while considering the tissue as being a non-compressible elastic solid in order to determine the Young modulus gradient as equal to the sum of the Lagrange multiplier gradient and of a space depending vect
Type:
Grant
Filed:
November 23, 2009
Date of Patent:
February 25, 2014
Assignees:
Universite Joseph Fourier, Centre National de la Recherche Scientifique (CNRS)
Inventors:
Jacques Ohayon, Simon Le Floc'H, Gerard Finet, Philippe Tracqui
Abstract: The present patent application relates to a method for diagnosing angioedema with a gain-of-function mutation of kinin formation, and for determining the amount of BK or des-Arg9 -BK antagonist required for halting the effects of angioedema, from a plasma sample of a patient. The invention also relates to a kit for said determination.
Type:
Application
Filed:
April 12, 2012
Publication date:
February 20, 2014
Applicants:
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE, UNIVERSITE JOSEPH FOURIER (GRENOBLE 1)
Inventors:
Christian Drouet, Samuel Luyasu, Arije Ghannam
Abstract: The present invention relates to a pharmaceutical composition including a modified factor Xa (GDXa), said modified GDXa being nonthrombogenic, able to bind to TFPI but not able to bind to phospholipids, for preventing or treating a hemorrhagic accident in a patient with hemophilia A or B with or without inhibitor.
Type:
Application
Filed:
February 29, 2012
Publication date:
February 20, 2014
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE JOSEPH FOURIER (GRENOBLE 1)
Abstract: The present invention relates to compounds of formula (I), where R1 and R2, identical or different, are each independently a hydrogen atom or a non-substituted or substituted (C1-C12) alkyl group; R3 is a hydrogen atom or a non-substituted or substituted (C1-C6) alkyl group; R4 is a non-substituted or substituted (C1-C12) alkyl group or an aryl or heteroaryl group, said aryl and heteroaryl groups being non-substituted or substituted; and R5 is a non-substituted or substituted (C1-C12) alkyl group; or R4 and R5 are bonded to one another by a saturated hydrocarbon chain having 3 or 4 carbon atoms, optionally in hydrated form or in the form of a salt that is acceptable for being administered to animals or plants, for the use thereof as a potentiator of the effect of an antimicrobial agent or for the use thereof as an antimicrobial agent.
Type:
Application
Filed:
January 27, 2012
Publication date:
February 6, 2014
Applicants:
UNIVERSITE CLAUDE BERNARD LYON 1, UNIVERSITE JOSEPH FOURIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, HOSPICES CIVIL DE LYON
Inventors:
Anne Doleans-Jordheim, Jean Freney, Charles Dumontet, Ahcene Boumend Jel, Jean-Baptiste Veron, Yung-Sing Wong
Abstract: An in vitro diagnostic method for diagnosing a brain tumour belonging to the group formed by two types of tumours: ODGs and GBMs, and for identifying the type of tumour, the method includes the measurement of at least two ratios of the expression levels of miRNA pairs extracted from a biological sample originating from a patient suspected of presenting one of the above-mentioned brain tumours.
Type:
Application
Filed:
December 8, 2011
Publication date:
December 12, 2013
Applicants:
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE, UNIVERSITE JOSEPH FOURIER
Inventors:
Jean-Paul Issartel, François Berger, Elodie Lages, Audrey Guttin, Michèle El Atifi-Borel, Hélène Ipas
Abstract: The present invention relates to a system for positioning with respect to a patient's body an observation and/or intervention device having a portion penetrating into the patient's body comprising a base laid on the patient's body; a means for supporting the device formed of a first portion movably assembled on the base according to a connection with one degree of freedom, and of a second portion movably assembled on the first portion according to a connection with one degree of freedom and connected to the device; and means for actuating the first portion with respect to the base, and the second portion with respect to the first portion, in which the base surrounds at a distance at least partially the device, said device being detachably connected to the second portion to enable removal of the positioning system while leaving in place the device.
Type:
Grant
Filed:
June 29, 2011
Date of Patent:
November 26, 2013
Assignee:
Universite Joseph Fourier
Inventors:
Peter Berkelman, Philippe Cinquin, Alain Jacquet, Jean Arnault