Patents Assigned to University of Georgia Research Foundation, Inc.
  • Genetically engineered microbes and methods for producing citramalate
    Patent number: 10731185
    Abstract: Provided herein is a genetically engineered microbe which accumulates citramalate. In one embodiment, the microbe includes an exogenous polynucleotide encoding a citramalate synthase which catalyzes the condensation of acetyl CoA and pyruvic acid. Optionally, the microbe also includes a second exogenous polynucleotide encoding a citrate synthase which catalyzes the condensation of acetyl CoA and oxaloacetate, and the citrate synthase activity in the microbe is reduced compared to a control microbe. In one embodiment, the citrate synthase includes at least one amino acid substitution in the acetyl-CoA binding pocket, the mobile loop, the NADH binding site, and the oxaloacetate binding site, or a combination thereof. Also provided herein are methods for using the genetically engineered microbe, including a method for producing citramalate. The method can further include isolating the citramalate.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: August 4, 2020
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Xianghao Wu, Mark Eiteman
  • TREATMENT AND DETECTION OF INFECTION AND DISEASE ASSOCIATED WITH DIFFERENT FUNGAL PATHOGENS
    Publication number: 20200222517
    Abstract: The invention generally provides methods of treating or preventing infection and/or disease associated with different fungal pathogens in a subject in need, using an isolated antiserum generated against an immunogenic peptide of one fungal pathogen that contains antibodies that cross-protect the subject from infection and/or disease associated with one or more different fungal pathogens. The antiserum may be generated against a Kexin peptide derived from one of a Pneumocystis, Aspergillus, Candida, or Cryptococcus fungal pathogen. The resulting cross-protective, isolated antiserum may be used as a therapeutic for treating or protecting a subject who receives the antiserum against infection and/or disease associated with multiple fungal pathogens, in addition to the pathogen against which the antiserum is generated.
    Type: Application
    Filed: September 26, 2018
    Publication date: July 16, 2020
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: Karen A. Norris, Whitney Rabacal
  • 2'-Fluoro-6'-Methylene Carbocyclic Nucleosides and Methods of Treating Viral Infections
    Publication number: 20200220830
    Abstract: The present invention relates to 2?-Fluoro-b?-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses, especially HBV.
    Type: Application
    Filed: November 26, 2019
    Publication date: July 9, 2020
    Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Chung K. Chu, Jianing Wang
  • Devices and methods for separating particles
    Patent number: 10676719
    Abstract: Devices for non-invasive, label-free separation of particles in liquid, including circulating tumors cells in blood, are provided. Embodiments of the disclosure provide for devices employing magnetic fluids and magnets for separation of circulating tumor cells from blood. Methods for separation of particles including circulating tumor cells are also provided.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: June 9, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Leidong Mao, Carsten Schroeder, Wujun Zhao
  • Induced photodynamic therapy using nanoparticle scintillators as transducers
    Patent number: 10646570
    Abstract: Photodynamic therapy systems comprising a nanoparticle that emits electromagnetic radiation having a first wavelength when irradiated with electromagnetic radiation, a photosensitizer which absorbs electromagnetic radiation of said first wavelength and a biocompatible mesoporous material are disclosed herein. In some examples, the photodynamic therapy system comprises a core comprising the nanoparticle, a first shell comprising the biocompatible mesoporous material, and a photosensitizer embedded in the first shell. Upon irradiation by, for example, X-rays, the nanoparticle can function as a transducer, converting X-ray photons to visible photons, and in turn, activating the photosensitizers. Methods of using the photodynamic therapy system are also disclosed.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: May 12, 2020
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Jin Xie, Hongmin Chen, Geoffrey D. Wang
  • Calcium sensing receptors, ligands, compositions, and methods of use
    Patent number: 10639299
    Abstract: Described herein are compounds that can bind CaSR and/or a CaSR extracellular domain and formulations thereof. Also described herein are methods of inhibiting CaSR and/or treating a disease or disorder associated with a mutation in CaSR by administering a compound or formulation thereof described herein. Also described herein are assays that can be used to identify compounds that can bind an extracellular domain of CaSR.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: May 5, 2020
    Assignees: Georgia State University Research Foundation, Inc., University of Georgia Research Foundation, Inc., Board of Trustees of Michigan State University
    Inventors: Jenny Jie Yang, Jian Hu, Edward Brown, Kelley Moremen
  • Gene for induction of parthenogenesis, a component of apomictic reproduction
    Patent number: 10633672
    Abstract: Methods and compositions disclosed herein generally relate to genes involved in plant reproduction and methods of using the same.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: April 28, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Peggy Ozias-Akins, Joann A. Conner
  • Production of viruses in cell culture
    Patent number: 10626379
    Abstract: The present invention relates to methods of replicating viruses in vitro. In particular, the invention relates to a genetically modified population of cells, and/or a population of cells treated with an exogenous compound, wherein the cells are capable of producing more virus than cells lacking the genetic modification and/or lacking treatment with the exogenous compound. The invention also relates to methods of producing populations of such cells, as well as the use of the viruses obtained to prepare vaccine compositions.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: April 21, 2020
    Assignees: Commonwealth Scientific and Industrial Research Organisation, University of Georgia Research Foundation, Inc.
    Inventors: Andrew Bean, John William Lowenthal, Luis Fernando Malaver-Ortega, Ralph A. Tripp
  • Avian reovirus vaccines
    Patent number: 10588958
    Abstract: The present invention relates to novel strains of avian reovirus that were isolated from clinical cases of viral arthritis/tenosynovitis in chickens in the southeast United States. The invention is directed to these novel group 1 and group 2 avian reoviruses, diagnostic assays using antibodies and/or nucleotide- or amino acid-specific components of such viruses, such as the S1 gene encoding the sigma C protein, and to vaccines that protect chickens from disease caused by such viruses.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: March 17, 2020
    Assignee: University of Georgia Research Foundations, Inc.
    Inventor: Holly S. Sellers
  • Ultra high-speed photonics based radio frequency switching
    Patent number: 10587938
    Abstract: Various examples are provided for radio frequency (RF) switching. In one example, a RF switch includes a dual-drive Mach-Zehnder modulator (DDMZM) that can generate a single-sideband (SSB) signal by modulating an input RF signal onto an optical carrier; a tunable phase modulator incorporated loop mirror filter (PM-LMF) that can optically notch filter the SSB signal in response to a control signal; and a photodetector (PD) that can generate a RF output signal based upon the SSB signal. In another example, a method includes modulating an input RF signal onto an optical carrier to generate a SSB signal; notch filtering the SSB signal by a tunable PM-LMF in response to a control signal; and generating a RF output signal based upon the SSB signal.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: March 10, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Mable P. Fok, Jia Ge
  • PIV5-based amplifying virus-like particles
    Patent number: 10563178
    Abstract: Compositions, methods of use and methods of manufacture are provided for PIV5-based amplifying VLP (AVLP) that can deliver an expressible heterologous nucleotide sequence in target cells without producing progeny, and which demonstrate useful safety and therapeutic efficacy in multiple animal and human health applications, such as vaccination, gene therapy and cancer therapy.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: February 18, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Biao He
  • Metal-encapsulated carbonaceous dots
    Patent number: 10548993
    Abstract: Nanoparticles described as metal-encapsulated carbonaceous dots or M@C-dots are disclosed. Also disclosed are specific M@C-dots with gadolinium, so called Gd@C-dots. These nanoparticles are biologically inert and preclude the release of metal in biological environments. In addition, despite a dimension exceeding the commonly recognized threshold for renal clearance, the disclosed nanoparticles can be efficiently cleared via urine after systematic injection. Methods of making and using such nanoparticles are also disclosed.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: February 4, 2020
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Jin Xie, Hongmin Chen, Geoffrey D. Wang
  • Systems and methods for measuring mitochondrial capacity
    Patent number: 10542932
    Abstract: In one embodiment, measuring mitochondrial capacity includes performing arterial occlusions on a patient, measuring oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin within the patient's body during the occlusions, calculating a blood volume correction factor that accounts for a change in blood volume that occurs during the arterial occlusions, and applying the correction factor to the measured oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements to obtain correct oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: January 28, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Kevin K. McCully, Terence E. Ryan
  • Photonics based tunable multiband microwave filter
    Patent number: 10547280
    Abstract: Various examples are provided for tunable radio frequency (RF) filtering. In one example, a RF multiband filter includes a Lyot filter including a tunable birefringence loop including a circulator and a polarization controller (PC) and a phase modulator (PM). The Lyot filter can generate an optical comb based at least in part upon a received optical signal and a polarization rotation angle of the polarization controller. The phase modulator (PM) can generate a modulated tap signal by modulating the optical comb by a RF input signal.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: January 28, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Mable P. Fok, Jia Ge
  • Continuously tunable and highly reconfigurable multiband RF filter
    Patent number: 10541661
    Abstract: Various examples are provided for highly reconfigurable multiband radio frequency (RF) filters. The multiband RF filters can be continuously tunable. In one example, a multiband RF filter includes a Lyot loop filter that can generate an optical comb using an input optical signal from a tunable Mach-Zehnder interferometer (MZI), a birefringent device, and a polarization rotation angle of a polarization controller. The tunable MZI can include a tunable delay line that can adjust comb spacing of the optical comb. In another example, a multiband RF filter includes a second MZI in series with a first MZI. The second MZI can generate a second tunable output signal from a first tunable output signal from the first MZI. In another example, the multiband RF filter can include a third MZI in series with the second MZI. The third MZI can generate a third tunable output signal from the second tunable output signal.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: January 21, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Mable P. Fok, Jia Ge
  • Crapemyrtle plant named ‘DJ 05-14’
    Patent number: PP31586
    Abstract: A new crapemyrtle plant has deep, uniform purple foliage and stems; a light lavender to white flower color; an intermediate upright growth habit; and powdery mildew and Cercospera resistance.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: March 24, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Matthew A. Dirr, Donglin Zhang
  • Southern highbush blueberry plant named ‘TH-1876’
    Patent number: PP31684
    Abstract: The new variety ‘TH-1876’ ripens around early May in southern Georgia. The fruit of the new variety ‘TH-1876’ are large, firm and have good flavor and scar. The new variety ‘TH-1876’ is vigorous with an estimated chilling requirement of about 300 to 350 hours at or below approximately 7° C. The asexually reproduced variety is reliably propagated vegetatively.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: April 21, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith
  • Crapemyrtle plant named ‘DJ 01-14’
    Patent number: PP31691
    Abstract: A new crapemyrtle plant has deep, uniform purple foliage and stems; a true pink flower color; an intermediate upright growth habit; and powdery mildew and Cercospera resistance.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: April 21, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Matthew A. Dirr, Donglin Zhang
  • Southern highbush blueberry plant named ‘TH-1125’
    Patent number: PP31863
    Abstract: The new variety ‘TH-1125’ ripens around early May in south Georgia. The fruit of the new variety ‘TH-1125’ are large, firm and have good flavor. The new variety ‘TH-1125’ is vigorous with an estimated chilling requirement of about 250 to 300 hours at or below approximately 7° C. The asexually reproduced variety is reliably propagated vegetatively.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: June 16, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith
  • Crapemyrtle plant named ‘DJ 06-14’
    Patent number: PP31558
    Abstract: A new crapemyrtle plant has deep, uniform purple foliage and stems; a deep raspberry pink/red flower color; an intermediate upright growth habit; and powdery mildew and Cercospera resistance.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: March 17, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Matthew A. Dirr, Donglin Zhang