Abstract: The present invention relates to 2?-Fluoro-6?-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses, especially HBV.

Abstract: The invention provides a new convergent approach for the synthesis of 2?-fluoro-6?-methylene-carbocyclic adenosine (FMCA) and 2?-fluoro-6?-methylene-carbocyclic guanosine (FMCG) from a readily available starting material in eight steps. An efficient and practical methodology for stereospecific preparation of a versatile carbocyclic key intermediate, (1S,3R,4R)-3-tert-butoxy-4-(tert-butoxymethyl)-2-fluoro-5-methylenecyclopentanol (compound 8 of scheme 1A or a) in only six (6) steps is also provided. Prodrugs of these compounds are also prepared.

Abstract: Provided herein are plant/plant pathogen volatile compound electrochemical sensors, plant/plant pathogen volatile detection systems, and methods for detecting stress-induced plant volatile compounds and/or a plant-pathogen emitted volatile compounds.

Abstract: The present invention relates to the production of avian induced pluripotent stem cells from non-pluripotent somatic cells, including embryonic fibroblasts and adult somatic cells. In this method, avian (including quail or chicken) somatic cells are reprogrammed into a state closely resembling embryonic stem cells including the expression of key stem cell markers alkaline phosphatase, etc. by transfecting/transducing the non-stem cells with genes (preferably using a non-integrating vector as otherwise described herein or alternatively an integrating vector, such a lentiviral vector, retroviral vector or inducible lentiviral vector, among others) which express at least nanog, Lin28 and cMyc. In preferred aspects of the invention, the transfected/transduced vectors express nanog, Lig28, cMyc, Oct 4 (POU5F1 or PouV), SOX2 and KLF4. The induced stem cells which are produced contribute to all 3 germ layers, the trophectoderm and in certain aspects, the gonad in chimeric offspring.

Abstract: Biodegradable composite membranes with antimicrobial properties consisting of nanocellulose fibrils, chitosan, and S-Nitroso-N-acetylpenicillamine (SNAP) were developed and tested for food packaging applications. Nitric oxide donor, SNAP was encapsulated into completely dispersed chitosan in 100 mL, 0.1N acetic acid and was thoroughly mixed with nanocellulose fibrils (CNF) to produce a composite membrane. The fabricated membranes had a uniform dispersion of chitosan and SNAP within the nanocellulose fibrils, which was confirmed through Scanning Electron Microscopy (SEM) micrographs and chemiluminescence nitric oxide analyzer. The membranes prepared without SNAP showed lower water vapor permeability than that of the membranes with SNAP. The addition of SNAP resulted in a decrease in the Young's modulus for both 2-layer and 3-layer membrane configurations.

Abstract: The present application provides solvent-free methods for decarboxylation of amino acids via imine formation with a ketone, enone, enal, aldehyde co-reagent or combination thereof, under heated conditions, with optional recovery of the co-reagent and/or co-reagent byproduct.

Abstract: Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.

Abstract: Disclosed herein are prodrugs of platinum containing anticancer agents such as cisplatin that contain an alkylating moiety. Upon administration, the prodrugs release the platinum containing anticancer agent and the alkylating agent, which can form an adduct with DNA or can protect the platinum containing agent from removal. The disclosed prodrugs can be used to treat various cancers, including cisplatin resistant cancers.

Abstract: Various examples are provided for jamming avoidance response (JAR), and photonic implementations thereof. In one example, a method includes generating optical pulses that correspond to raising envelope of a beat signal associated with an interference signal and a reference signal; generating optical spikes that correspond to positive zero crossing points of the reference signal; and providing a phase output that indicates whether the beat signal is leading or lagging the reference signal, the phase output based at least in part upon the optical spikes. An adjustment to a reference frequency can be determined based at least in part upon the optical pulses and the phase output. In another example, a JAR system includes photonic circuitry to generate the optical pulses; photonic circuitry to generate the optical spikes; and photonic circuitry to provide the phase output. A logic unit can determine the adjustment to the reference frequency.

Abstract: Nanoparticles include a core, a hydrophilic layer around the core, and one or more mitochondrial targeting moieties, and may optionally include one or more contrast agents or one or more therapeutic agents. For effective mitochondrial targeting the nanoparticles have a diameter of about 200 nm or less or have a zeta potential of about 0 mV or more.

Abstract: A new variety of Pennisetum alopecuroides plant named ‘Tift PA17’ produces a reduced number of seeds, making it less invasive.

Abstract: A new variety of Pennisetum alopecuroides plant named ‘Tift PA19’ produces a reduced number of seeds, making it less invasive.

Abstract: A new variety of Pennisetum alopecuroides plant named ‘Tift PA5’ produces a reduced number of seeds, making it less invasive.

Abstract: A new variety of Pennisetum alopecuroides plant named ‘Tift PA18’ produces a reduced number of seeds, making it less invasive.

Abstract: A mitochondria targeted gold nanoparticle (T-3-BP-AuNP) decorated with 3-bromopyruvate (3-BP) and delocalized lipophilic triphenylphosphonium (TPP) cations to target the mitochondrial membrane potential (??m) was developed for delivery of 3-BP to cancer cell mitochondria by taking advantage of higher ??m in cancer cell compared to normal cells. This construct showed remarkable anticancer activity in prostate cancer cells compared to non-targeted construct NT-3-BP-AuNP and free 3-BP. Anticancer activity of T-3-BP-AuNP was further enhanced upon laser irradiation by exciting the surface plasmon resonance band of AuNP and thereby utilizing a combination of 3-BP chemotherapeutic and AuNP photothermal effects. T-3-BP-AuNPs showed markedly enhanced ability to alter cancer cell metabolism by inhibiting glycolysis and demolishing mitochondrial oxidative phosphorylation in prostate cancer cells.

Abstract: A new variety of Pennisetum alopecuroides plant named ‘Tift PA5’ produces a reduced number of seeds, making it less invasive.

Abstract: A new variety of Pennisetum alopecuroides plant named ‘Tift PA17’ produces a reduced number of seeds, making it less invasive.

Abstract: A new variety of Pennisetum alopecuroides plant named ‘Tift PA18’ produces a reduced number of seeds, making it less invasive.

Abstract: A new variety of Pennisetum alopecuroides plant named ‘Tift PA19’ produces a reduced number of seeds, making it less invasive.

Abstract: The new variety ‘TH-1321’ ripens around mid-April in southeastern Georgia. The fruit of the new variety ‘TH-1321’ are very large, firm, have good flavor and scar. The new variety ‘TH-1321’ is vigorous with an estimated chilling requirement of about 50 to 100 hours at or below approximately 7° C. The asexually reproduced variety is reliably propagated vegetatively.