Abstract: Electrodes for a solid-state lithium-ion battery are provided. The electrodes have an active material layer containing or coated with electrolytes of lithium phosphate derivative compounds which contain an anionic framework capable of conducting lithium ions. Materials of specific formulae are provided and methods to alter the composite materials with inclusion of aliovalent ions shown. Lithium batteries containing the electrodes are also provided.

Abstract: The present invention provides for recombinant Endo-S2 mutants (named Endo-S2 glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent.

Abstract: Seroprotection analysis systems, kits, and techniques are described for testing oral fluid for the presence of protective levels of antibodies of interest. In one aspect, the presence of protective levels of target antibodies indicates a test subject has achieved a target seroprotection level, such as but not limited to a target seroprotection level following vaccination. A collection kit can include a swab that enables collection of oral fluid containing antibodies from both dentulous and edentulous individuals, a container that can be pre-filled with an extraction solution, and a nozzle that can be coupled to the container to form a fluid-tight device. A user can use the nozzle to seal the swab in the container and to compress the swab within the container.

Abstract: The present invention relates to compositions and methods for identifying and treating signature MP-associated diseases and conditions in subjects. In particular, treatment methods of the invention include administering a gelsolin agent to produce a therapeutic effect against a signature MP-associated disease or condition in a subject.

Abstract: The invention relates to compositions and methods as part of a pharmacotherapeutic strategy that targets the endochondral ossification process in a pharmacologically selective and site-specific manner. A variety of orthopedic pathologies are caused by or associated with generalized or local dysregulation of endochondral ossification, for example trauma to the bone growth plate or diaphysis can cause a serious imbalance in bone growth, leading to progressive deformity that today can only be treated surgically. Dysregulated endochondral ossification is also behind heterotopic ossification, which arises in soft tissues and causes pain, decrease in mobility and other clinical problems. The invention therefore provides RARy agonist and antagonist nanoparticle compositions for treating abnormal endochondral ossification and bone growth that can deliver robust local therapeutic control over a particular long bone's growth with a long-lasting effect.

Abstract: Systems, methods, apparatuses, and computer program products for providing multimodal emotion recognition. The method may include receiving raw input from an input source. The method may also include extracting one or more feature vectors from the raw input. The method may further include determining an effectiveness of the one or more feature vectors. Further, the method may include performing, based on the determination, multiplicative fusion processing on the one or more feature vectors. The method may also include predicting, based on results of the multiplicative fusion processing, one or more emotions of the input source.

Abstract: A process of simply, cheaply, and reproducibly creating complex tissue models using screen printing and the tissue model prepared using the screen printing process. These models are amenable to high throughput screening. They will allow the study of components of disease progression and can be used for screening therapies.

Abstract: A method of determining a pattern in a sequence of bits using a quantum computing system includes setting a first register of a quantum processor in a superposition of a plurality of string index states, encoding a bit string in a second register of the quantum processor, encoding a bit pattern in a third register of the quantum processor, circularly shifting qubits of the second register conditioned on the first register, amplifying an amplitude of a state combined with the first register in which the circularly shifted qubits of the second register matches qubits of the third register, measuring an amplitude of the first register and determining a string index state of the plurality of string index states associated with the amplified state, and outputting, by use of a classical computer, a string index associated with the first register in the measured state.

Abstract: Systems and methods are provided herein that implement and utilize temporal state machines and other temporal computational/memory circuits. For example, a temporal state machine is provided that comprises a temporal computational unit comprising at least one circuit to perform a time-domain operation, and a temporal memory unit. Both the temporal computational unit and temporal memory unit can operate using solely, or partially, time-encoded wavefronts. The computation unit accesses time-encoded wavefronts from the memory and can output and write time-encoded wavefronts back to the memory.

Abstract: In various embodiments, a solid oxide fuel cell features a functional layer for reducing interfacial resistance between the cathode and the solid electrolyte.

Abstract: An integrated circuit device for reservoir computing can include a weighted input layer, an unweighted, asynchronous, internal recurrent neural network made up of nodes having binary weighting, and a weighted output layer. Weighting of output signals can be performed using predetermined weighted sums stored in memory. Application specific integrated circuit (ASIC) embodiments may include programmable nodes. Characteristics of the reservoir of the device can be tunable to perform rapid processing and pattern recognition of signals at relatively large rates.

Abstract: A modular quantum computer architecture is developed with a hierarchy of interactions that can scale to very large numbers of qubits. Local entangling quantum gates between qubit memories within a single modular register are accomplished using natural interactions between the qubits, and entanglement between separate modular registers is completed via a probabilistic photonic interface between qubits in different registers, even over large distances. This architecture is suitable for the implementation of complex quantum circuits utilizing the flexible connectivity provided by a reconfigurable photonic interconnect network. The subject architecture is made fault-tolerant which is a prerequisite for scalability.

Abstract: A cooling system employs at least one composite elastocaloric device. Each composite device has a first member with a first material and a second member with an elastocaloric material. The first material increases in size in response to an applied electric or magnetic field and returns to its prior size upon removal of the applied electric or magnetic field. The first and second members are mechanically coupled together such that the increase in size of the first material applies a stress to the elastocaloric material and the return of the first material to its prior size releases said stress, thereby causing the elastocaloric material to absorb heat.

Abstract: Disclosed herein are methane conversion devices that achieve autothermal conditions and related methods using the methane conversion devices.

Abstract: The present invention relates to, in part, artificial antigen presenting cells that are useful in treating disease (including cancers) and have uses, for example, directly in vivo and/or in the expansion of a patients cells for re-introduction ex vivo.

Abstract: Disclosed herein are systems and methods for synthesizing a diamond using a diamond synthesis machine. A processor receives a plurality of images of a diamond during synthesis within a diamond synthesis machine, each of the plurality of images captured within a time period. The processor executes a diamond state prediction machine learning model using the plurality of images to obtain a predicted data object, the predicted data object indicating a predicted state of the diamond within the diamond synthesis machine at a time subsequent to the time period. The processor detects a predicted defect, a number of defects, defect types, and/or sub-features of such defects and/or other characteristics (e.g., a predicted shape, size, and/or other properties of predicted contours for the diamond and/or pocket holder) of the predicted state of the diamond. The processor adjusts operation of the diamond synthesis machine.

Abstract: An axial field rotary energy device can include a housing and a rotor rotatably coupled to the housing. The rotor can have an axis of rotation and magnets. A stator assembly can be coupled to the housing coaxial with and adjacent to the rotor. The stator assembly can include a printed circuit board (PCB) having electrically conductive coils and an internal air duct for cooling the stator assembly.

Abstract: The present invention provides for the use of recombinant Endo-S2 mutants (named Endo-S2 glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent.

Abstract: A gesture recognizing system for recognizing gestures includes a wearable band configured to wrap around an appendage of a user and a printed circuit board (PCB). The wearable band includes a first dielectric layer and a plurality of electrodes affixed on an outer surface of the first dielectric layer. When the first dielectric layer of the wearable band wraps around the appendage, each electrode is configured to form a capacitive sensor with skin of the user. The PCB includes a processor and a data collection hardware configured to collect data from capacitive sensors. The processor is configured to process the collected data and to recognize a gesture of the appendage of the user based on the processed data.

Abstract: Antibody-based binding agents derived from human and camelid immunoglobulins are described, as well as strains of yeast engineered to secrete the binding agents, and methods of treating and preventing Clostridium difficile infections using the engineered strains of yeast. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. The binding agents include camelid VHH peptide monomers, linked groups of VHH peptide monomers, VHH peptide monomers joined to antibody Fc domains, and VHH peptide monomers joined to IgG antibodies.