Abstract: Nucleic acid molecules from Cannabis sativa (cannabis, hemp, marijuana) have been isolated and characterized, and encode polypeptides having aromatic prenyltransferase activity. Specifically, the enzyme, CsPT1, is a geranylpyrophosphate olivetolate geranyltransferase, active in the cannabinoid biosynthesis step of prenylation of olivetolic acid to form cannabigerolic acid (CBGA). Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
Type:
Grant
Filed:
August 4, 2010
Date of Patent:
November 11, 2014
Assignees:
National Research Council of Canada, University of Saskatchewan
Abstract: The present application relates to functionalized nanodiamonds, to complexes comprising a functionalized nanodiamond reversibly bound to a nucleic acid and to compositions comprising such functionalized nanodiamonds and complexes. In particular, the functionalized nanodiamonds comprise at least one naturally occurring basic amino acid, or analogs or derivatives thereof, covalently linked to a nanodiamond. The present application also includes methods and uses of the complexes and compositions, for example for delivering a nucleic acid to a cell.
Type:
Application
Filed:
April 17, 2014
Publication date:
October 23, 2014
Applicant:
University of Saskatchewan
Inventors:
Ildiko Badea, Ronald Verrall, Jackson M. Chitanda, Randeep Kaur, Saniya Alwani
Abstract: The present disclosure relates to functionalized nanodiamonds comprising at least one MALDI matrix covalently bonded to a nanodiamond and compositions comprising the same. The present disclosure also relates to methods of performing matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS), for example on small molecules, using matrices comprising at least one MALDI matrix covalently bonded to a nanodiamond.
Abstract: Methods for recovery of recyclable water and/or fermentation co-products from thin stillage process streams. Microbial metabolites plant derivatives and/or plant extractives are removed from thin stillage after which water is recovered and recycled. Thin stillage is commingled with polar organic solvents or with oil to react microbial metabolites, plant derivatives and/or plant extractives. The reacted organic solvents are then separated from the processed thin stillage. Thin stillage may be commingled with an oil to re act with certain organic compounds, after which, the reacted oil is separated from the processed thin stillage is further extracted with one or more polar organic solvents. Alternatively, thin stillage may be first processed with one or more polar organic solvents, and then processed with an oil. Useful organic compounds may be recovered from the reacted oil and reacted organic solvents.
Type:
Grant
Filed:
June 2, 2009
Date of Patent:
September 16, 2014
Assignee:
University of Saskatchewan
Inventors:
Martin J. Reaney, Yunhua Jia, Jianheng Shen, Komsulee Ratanapariyanuch
Abstract: Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.
Type:
Application
Filed:
February 15, 2013
Publication date:
September 4, 2014
Applicants:
University of Saskatchewan, International Vaccine Institute, Dalhousie University, The University of British Columbia
Inventors:
University of Saskatchewan, The University of British Columbia, Dalhousie University, International Vaccine Institute
Abstract: Methods of selectively detecting the presence of at least one compound in a gaseous medium. A silicon substrate can be exposed to the gaseous medium under conditions to adsorb the at least one compound to the silicon substrate to form a modified silicon substrate. The modified silicon substrate can be analyzed to determine if the at least one compound was present in the gaseous medium. The step of analyzing can include using X-ray spectroscopy.
Type:
Application
Filed:
January 29, 2013
Publication date:
July 31, 2014
Applicant:
University of Saskatchewan
Inventors:
Alexander Moewes, John Anderson McLeod, Ernst Zagidovich Kurmaev, Igor Anatolievich Levitsky, Petr Sushko, Teak Dagan Boyko
Abstract: The present invention relates to primers for the universal amplification and detection of Archaea, which primers are designed based on a multiple sequence alignment of Archaea Type II chaperonin (thermo-some) genes. For detection of Archaea having templates with a GC content of below 60%, primers are designed so that inosine residues are found at degenerate positions. For amplification of higher GC content templates, degenerate positions are replaced with specific nucleotide bases found in the high GC organism. The primers are useful for detecting, identifying and quantifying Archaea in a sample and for determining a phylogenetic relationship of a test Archaea organism.
Type:
Grant
Filed:
March 8, 2011
Date of Patent:
June 24, 2014
Assignee:
University of Saskatchewan
Inventors:
Janet Elizabeth Hill, Bonnie Laura Chaban
Abstract: Compositions and methods for stimulating an immune response against Shiga toxin-producing Escherichia coli (STEC) antigens are disclosed. The compositions include a multiple epitope fusion protein comprising more than one epitope of an immunogenic STEC protein from more than one STEC serotype. Additional compositions include at least two purified STEC proteins, wherein the STEC proteins are selected from a full-length STEC protein, an immunogenic fragment or variant thereof, wherein at least one of the STEC proteins generates antibodies that react with STEC O157 and at least one other STEC serotype.
Type:
Grant
Filed:
April 6, 2010
Date of Patent:
May 27, 2014
Assignee:
University of Saskatchewan
Inventors:
Andrew Potter, David Asper, Dragan Rogan
Abstract: Polypeptides having alkanoyl-CoA activity have been identified and characterized, as have nucleic acids encoding these polypeptides. Expression or over-expression of the nucleic acids alters levels of cannabinoid compounds in organisms. The polypeptides may be used in vivo or in vitro to produce cannabinoid compounds.
Type:
Application
Filed:
July 13, 2012
Publication date:
May 22, 2014
Applicants:
UNIVERSITY OF SASKATCHEWAN, NATIONAL RESEARCH COUNCIL OF CANADA
Abstract: Systems and methods of controlling user interaction with an application. The systems and methods include executing an application, providing a graphical overlay coupled to the application where the graphical overlay is configured to display a visualization or a visual effect, measuring at least one engagement characteristic to provide a measured condition and providing the visualization based on the measured condition. Examples of engagement characteristic include user physiological condition, type of the application selected, duration of time spent interacting with the application, duration of time spent interacting with one or more input receiving devices, pressure exerted over one or more input receiving devices and noise level of the user.
Type:
Application
Filed:
October 25, 2012
Publication date:
May 1, 2014
Applicant:
UNIVERSITY OF SASKATCHEWAN
Inventors:
Regan Mandryk, Shane Dielschneider, Michael Kalyn, Andre Doucette
Abstract: This disclosure relates to cyclodextrin-based drug delivery agents that comprise a cyclodextrin moiety covalently linked to a moiety of a gemini surfactant. Pharmaceutical compositions comprising the drug delivery agent and a therapeutic agent are also disclosed.
Type:
Application
Filed:
May 18, 2012
Publication date:
April 24, 2014
Applicant:
University of Saskatchewan
Inventors:
Ildiko Badea, Ronald Verrall, Peng Yang, Marianna Foldvari, Jackson Chitanda, Deborah Michel
Abstract: Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.
Type:
Application
Filed:
November 12, 2013
Publication date:
March 6, 2014
Applicants:
University of Saskatchewan, The University of British Columbia
Abstract: The present invention is directed to wheat plants having increased resistance to an imidazolinone herbicide. More particularly, the present invention includes wheat plants containing one or more IMI nucleic acids such as a Teal IMI cultivar. The nucleic acids are preferably located on or derived from different genomes. The present invention also includes seeds produced by these wheat plants and methods of controlling weeds in the vicinity of these wheat plants.
Abstract: A novel strain of Trichoderma harzianum called TSTh20-1 is described. TSTh20-1 is useful in promoting plant growth, increasing water use efficiency of plants and in remediation of soil or water.
Type:
Grant
Filed:
September 16, 2010
Date of Patent:
December 3, 2013
Assignees:
University of Washington, University of Saskatchewan
Inventors:
Susan Gail Willets Kaminskyj, James Frederick Basinger, Xiaohui Bao, Russell John Rodriguez, Regina Soon Redman
Abstract: The present application includes a process and a microorganism of the genus Lactobacillus that converts glycerol to 1,3-propanediol. The conversion is accomplished by a proprietary microorganism that is easily cultured in glycerol rich waste products of ethanol production, such as thin stillage.
Type:
Application
Filed:
October 7, 2011
Publication date:
November 28, 2013
Applicant:
University of Saskatchewan
Inventors:
Martin J.T. Reaney, Monique Haakensen, Darren Korber, Takuji Tanaka, Kornsulee Ratanapariyanuch
Abstract: Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.
Type:
Grant
Filed:
October 22, 2007
Date of Patent:
November 19, 2013
Assignees:
The University of British Columbia, University of Saskatchewan
Abstract: A Coleus plant particularly distinguished by unique elongated, bronze and orange-colored secondary leaflets resembling a lobster claw and attached to the main leaf by single narrow veins, is disclosed.
Abstract: A Coleus plant particularly distinguished by triangular leaves with many deep lobes and yellow-green leaves with purple margins, is disclosed.
Abstract: A Coleus plant particularly distinguished by unique elongated, bronze and orange-colored secondary leaflets resembling a lobster claw and attached to the main leaf by single narrow veins, is disclosed.
Abstract: A Coleus plant particularly distinguished by triangular leaves with many deep lobes and yellow-green leaves with purple margins, is disclosed.
Type:
Grant
Filed:
May 10, 2012
Date of Patent:
December 9, 2014
Assignee:
University of Saskatchewan Department of Plant Sciences