Abstract: This disclosure is directed to therapeutic compositions, and more particularly to microparticle compositions for the controlled delivery of telmisartan and actinomycin D.

Abstract: The present disclosure relates to biomarkers and methods for determining or predicting survival of patients with low grade glioma (LGG) or pediatric neuroblastoma. Further disclosed are methods of diagnosing and treating patients with low grade glioma (LGG) or pediatric neuroblastoma.

Abstract: A composition, workout/exercise supplement, treatment method for conditions associated with vasoconstriction, and method of extracting galloylated procyanidins. The composition includes galloylated procyanidins having a preponderance of (?)-epicatechins. The treatment methods include administering a therapeutically effective amount of galloylated procyanidins having a preponderance of (?)-epicatechins. The extraction methods include isolating galloylated procyanidins having a preponderance of (?)-epicatechins from a sample that contains polyphenols, catechins, epicatechins, and galloylated epicatechins.

Abstract: The present technology provides compounds according to Formula I or Formula III as well as compositions including such compounds useful for the treatment of metastatic cancer and/or glaucoma.

Abstract: Disclosed herein are compounds and methods for inhibiting Aha1 for the treatment of tauopathies and neurodegenerative diseases. The Aha1 inhibitor may reduce the interaction between Aha1 and Hsp90. The Aha1 inhibitor may reduce aggregation of tau protein. The Aha1 inhibitor may include a compound selected from KU-177, KU-174, and KU-308.

Abstract: A system and method of adjusting a field of view in an imaging system includes transmitting light across a transmission optical path and defining a field of view encompassing both uniform and spatially tenuous target objects within the transmitted light. A sensor within a return optical path of reflected light from at least a portion of one of the target objects allows a data processing computer to compile an image from a series of data outputs from the sensor. The image is analyzed to determine a region of interest within the image and by dynamically adjusting the light source, the computer is configured to change the field of view of the light source such that the image includes a higher resolution and/or signal intensity for the region of interest. The region of interest may include at least one spatially tenuous target object.

Abstract: This invention provides for a RSV-targeted nanoparticle PMN (RTPMN), combining HR2D anti-fusion peptide, and plasmid encoded siRNA against RSV-NS1 and/or RSV-P gene as a safe, effective and inexpensive anti-RSV prophylaxis and/or therapy.

Abstract: The present invention provides a system and method for measuring an impedance of one or more target cells before and after an electroporation protocol has been applied to the one or more target cells. The result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize the electrical treatment for a particular target cell or cellular tissue.

Abstract: As disclosed herein, ?-arrestin1 and ?-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both ?-arrestin1 and ?-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when ?-arrestin2 is overexpressed, tau levels become elevated. The data indicate that ?-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of ?-arrestin2. Therefore, disclosed herein are ?-arrestin oligomerization inhibitors that can be used to prevent ?-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a ?-arrestin oligomerization inhibitor disclosed herein.

Abstract: The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase 3 (Flt3) ligand, interleukin-6 (IL-6), macrophage migration inhibitory factor (MIF), interleukin-1 (IL-1), interleukin-3 (IL-3), erythropoietin (EPO), vascular endothelial growth factor A (VEGF-A), hypoxia-inducible transcription factor (HIF-1alpha), insulin like growth factor-1 (IGF-1), tumor necrosis factor (TNF), granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), Stem Cell Factor (SCF), Darbepoetin (ARANESP), and metalloproteinases, to an animal or person in need of treatment.

Abstract: Various examples are provided for systems and methods for geodesy in shallow water. In one example, a method includes obtaining, from a sensor module, a position of a superstructure of a moored device. At least one measurement corresponding to a heading, a pitch, or a roll of the superstructure can be obtained from the sensor module. An estimated position of an anchor, ballast, or other seafloor marker of the moored device can be determined based on the position of the superstructure and at least one corrected heading associated with the at least one measurement. The at least one corrected heading can be determined by applying a magnetic declination correction to the at least one measurement.

Abstract: A modular system for waste treatment, water recycling, and resource recovery includes a buffer tank to receive and pre-treat raw organic waste, at least one reactor tank configured as an anaerobic bioreactor that receives and digests pre-treated waste from the buffer tank, a membrane module having a membrane configured to filter waste from the digested waste from the at least one reactor tank to produce a permeate, a permeate collection tank configured to collect and store the permeate generated by the membrane module, a pump system having a plurality of pumps, and a control system configured to monitor the flow of waste and to control the pump system to control the flow of waste between the buffer tank, the at least one reactor tank, the membrane module, and the permeate collection tank.

Abstract: A method for motion recognition and embedding is disclosed. The method may include receiving a plurality of frames of an input video for extracting a feature vector of a motion in the plurality of frames, generating a plurality of sets of one or more motion component bits based on the feature vector and a plurality of classifiers, the plurality of sets corresponding to the plurality of classifiers, each set of one or more motion component bits representing a physical or mechanical attribute of the motion; and generating a motion code for a machine to execute the motion by combining the plurality of sets of one or more motion component bits. Other aspects, embodiments, and features are also claimed and described.

Abstract: A 4D-perfused tumoroid-on-a-chip platform used in personalized cancer treatment. The platform includes a plate with a plurality of bottomless wells that resides atop a microfluidic channel layer, which in turn resides atop a surface acoustic wave (SAW) based sensor layer that is capable of measuring potential pH values of fluids disposed within the platform. The microfluidic channel layer includes a plurality of bioreactors, with each bioreactor including an inlet well, a culture well, and an outlet well. The inlet well, culture well, and outlet well form a closed system via fluid conduits spanning from the inlet well to the culture well, as well as from the culture well to the outlet well. Due to the fluid flow from the plate to the chip, and from the inlet well to the outlet well on the chip through the culture well, target cell (tumoroid) growth is promoted within the culture well.

Abstract: A method of modulating neural activity using a combination of electrical and optical stimulation transmitted via a gold nanoparticle covered nanoelectrode is presented. The combination of short-duration green visible light optical pulses with the complementary sub-threshold level electric current pulses are capable of producing action potentials in neurons. Cells were found to have a greater than a 5× survival rate using this hybrid stimulation method as compared to pure plasmonic/optical stimulation. The cell stimulation success rate was 3× greater with hybrid stimulation.

Abstract: Provided herein are formulations effective for and methods of treating or preventing a neurodegenerative disorder in a subject in need thereof that can include administering an amount of an aPKC inhibitor to a subject in need thereof.

Abstract: Provided herein are novel VEGF mimics, pharmaceutical compositions thereof, and methods of their use in increasing or reducing angiogenesis.

Abstract: The present disclosure presents various systems and methods for implementing a physical unclonable function device. One such method comprises providing an integrated circuit having a plurality of set/reset flip flop logic circuits, wherein each of the set/reset flip flop logic circuits enters a metastable state for a particular input sequence. The method includes varying circuit parameters for each of the plurality of set/reset flip flop logic circuits to account for manufacturing variations in the set/reset flip flop logic circuits and enable generating a stable but random output in response to the particular input sequence. Thus, by applying the particular input sequence to the integrated circuit, a unique identifier for the integrated circuit can be derived from an output response of the plurality of set/reset flip flop logic circuits.

Abstract: A method for achieving a target joint preload includes identifying a thread pitch of a first fastener element used to secure two components together. The first fastener element is passed through the two components and a second fastener element is threaded onto the first fastener element. A tightening torque is applied to the second fastener element, which is measured as the trial tightening torque. A loosening torque is applied to the second fastener element, which is measured as the trial removal torque. A required tightening torque that is required to be applied to the second fastener element to achieve the target joint preload is calculated using only the thread pitch, the trial tightening torque, the trial removal torque, and the target joint preload.

Abstract: Described herein are cell-selective mRNA constructs that can contain a RNA of interest and one or more miRNA targets. The cell-selective mRNA constructs described herein can be used to express an RNA of interest to a cell in a cell-selective manner.