Abstract: Provided are novel bis-cyclic guanidine compounds, and the use thereof for treating bacterial infection.

Abstract: The present invention provides pharmaceutical compositions and methods for use and manufacture thereof. The pharmaceutical compositions comprise a therapeutically effective amount of a cannabinoid or a pharmaceutically acceptable salt or solvate thereof and an amphiphilic copolymer comprising at least one hydrophilic component and at least one hydrophobic component. The cannabinoid is encapsulated in the amphiphilic copolymer, and the composition is suitable for intranasal or inhalation delivery.

Abstract: An apparatus measures the transverse profile of vectorial optical field beams, including both the phase and the polarization spatial profile. The apparatus contains a polarization separation module, a weak perturbation module, and a detection module. Characterizing the transverse profile of vector fields provides an optical metrology tool for both fundamental studies of vectorial optical fields and a wide spectrum of applications, including microscopy, surveillance, imaging, communication, material processing, and laser trapping.

Abstract: Described herein are electrochemical cells that include composite gel positioned between the first electrode and second electrode, wherein the composite gel comprises an electrolyte, a polyaryl amine, and an oxidant. The composite gels described herein are easy to produce at a low-cost, which makes them suitable in a number of different applications electrochromic devices, supercapacitors, solar cells, and hybrid photoactive supercapacitors.

Abstract: Disclosed herein is a catalyst composite containing a perovskite-oxide and an oxide support, methods of preparing a catalyst composite containing a perovskite-oxide and an oxide support, and the use thereof for CO2 conversion by a reverse water gas shift chemical looping (RWGS-CL) process.

Abstract: An exemplary method of indicating a condition of grout within a post-tensioned tendon involves positioning a magnet and a metallic sensing plate in close proximity to an outer surface of the post-tensioned tendon; rotating the magnet and the metallic sensing plate around the outer surface of the post-tensioned tendon; measuring an amount of magnetic forces applied to the magnet during rotation of the magnet around the post-tensioned tendon; measuring an impedance between the metallic sensing plate and metallic strands within the post-tensioned tendon during rotation of the metallic sensing plate around the post-tensioned tendon; and generating an image of a cross-section of the post-tensioned tendon indicating one or more grout conditions in spatial proximity to the metallic strands within the post-tensioned tendon based on measurement data using the magnet and the metallic sensing plate.

Abstract: Systems and methods are described for estimating a state of a process and an input to the process using a sensor network. Each sensor node in the sensor network is directly to one or more adjacent sensor nodes and indirectly coupled to the remaining sensor nodes through the one or more adjacent sensor nodes. Each sensor node iteratively calculates a new estimated state based on estimations of the state and the input to the process calculated by the sensor node in a previous iteration. The new estimated state is then adjusted based on a difference between a predicted and actual output of a sensor and is further adjusted based on differences between a previous estimated state calculated by the sensor node and estimated states calculated by adjacent sensor nodes.

Abstract: Described herein are geomembranes with improved chemical, physical, and mechanical properties. In one aspect, the geomembrane includes polyethylene, a phenolic antioxidant, a phosphite antioxidant, a hindered amine light stabilizer, and carbon black. Also described herein are methods for making the geomembranes described herein.

Abstract: A 4D-perfused tumoroid-on-a-chip platform used in personalized cancer treatment. The platform includes a plate with a plurality of bottomless wells that resides atop a microfluidic channel layer, which in turn resides atop a surface acoustic wave (SAW) based sensor layer that is capable of measuring potential pH values of fluids disposed within the platform. The microfluidic channel layer includes a plurality of bioreactors, with each bioreactor including an inlet well, a culture well, and an outlet well. The inlet well, culture well, and outlet well form a closed system via fluid conduits spanning from the inlet well to the culture well, as well as from the culture well to the outlet well. Due to the fluid flow from the plate to the chip, and from the inlet well to the outlet well on the chip through the culture well, target cell (tumoroid) growth is promoted within the culture well.

Abstract: In one embodiment, a chromatic device includes a transparent conductive substrate, an active layer provided on the conductive substrate, the active layer comprising a conducting polymer, an electrolyte layer in contact with the conductive substrate and the active layer, the electrolyte comprising an oxidant and a salt but not comprising an acid, and a metal element configured to be selectively placed in and out of direct electrical contact with the conductive substrate or the active layer, wherein the active layer has a color that blocks light when the metal element is not in electrical contact with the conductive substrate but changes to a translucent color that transmits light when the metal element is placed in electrical contact with the conductive substrate or the active layer, wherein the active layer changes color without applying external energy to the active layer.

Abstract: A large area sintering platform, system, and methodology. The system includes a convection oven with a projection window disposed within a top surface of the oven. A platform is disposed within the oven below the window at a spaced distance away from the window. A powder is positioned on top of the platform, with a thermocouple positioned within the powder on the platform. A high intensity projector moves in sync with the platform, and uses low intensities and long exposure times to project an image through the window onto the powder and sinter the powder to fabricate the desired model layer by layer.

Abstract: The disclosed subject matter relates to method for increasing the molecular weight of a polymer material during an additive manufacturing process. The method can comprise disposing a first layer of the polymer material at a target surface; exposing the first layer of the polymer material to an energy source for a sufficient period of time to sinter or melt and undergo a condensation reaction at least at a portion of the polymer material; controlling the condensation reaction to allow a desired increased number average molecular weight of the polymer material; and repeating the method steps to form an object in a layerwise fashion. Controlling the condensation reaction can comprise controlling and/or adjusting an energy 10 source-related parameter, a polymer-related parameter, a temperature related parameter, a vacuum related parameter, a process duration, a processing gas, an air flow volume and/or speed, or a combination thereof.

Abstract: A system and method utilizing a novel waveform structure based on unique word (UW)—orthogonal frequency division multiplexing (OFDM) is proposed for the applications of joint radar-sensing and communication (JRC). A predetermined chirp sequence is used as the UW in the waveform. The predetermined chirp sequence is used to perform radar functionality, which also increases power efficiency of linear power amplifier that is critical for radar applications.

Abstract: In one implementation, a system for the prevention of malicious attack on a computing resource includes one or more processor; computer memory storing instructions that, when executed by the one or more processors, cause the one or more processors to perform operations including: observing traffic flow of a network; altering a SYN threshold value based on the observing of the traffic flow of the network; comparing a metric of SYN messages submitted to the network; and based on the comparison of the metric of SYN messages submitted, selectively engaging corrective action with the network.

Abstract: A device and method that supplements sensory input, thereby providing a supplemented sensory environment, to induce plasticity within the central nervous system that effectively overcomes sensory-neural processing deficits or strengthens specific sensory-neural abilities. In one implementation, ear-level hearing devices are used to deliver therapeutic sound with specific acoustic features that serve as archetypes of stimulus features for which sensory-neural processing is compromised by a sensory-neural deficit.

Abstract: Described herein are corrole-based frameworks and methods for making the same. The corrole-based frameworks have unique structural and physical properties, which lends them to be versatile in a number of different applications and uses such as in gas storage/separation, proton conduction, biomedicine, sensing, and catalysis. In one aspect, the corrole-based frameworks are organic frameworks. In other aspects, the corrole-based frameworks are metal-organic frameworks.

Abstract: A computer-based system and method for generating a current pain assessment of a neonate using facial expressions along with crying sounds, body movement, and vital signs changes and for using the current pain objective assessment to predict future pain objective assessment and assign a future pain probability score by incorporation spatiotemporal data into the multimodal assessment.

Abstract: Disclosed herein are compounds for activating the Reelin signaling system for the treatment of neurological disorders Further provided are compounds and methods for activating a lipoprotein receptor, such as ApoER2 or VLDLR.

Abstract: A novel electrode and associated method of manufacturing said novel electrode comprising a porous structure having absorbed polystyrene sulfonate (PSS), a self-assembled polypyrole (PPy) layer adjacent to the PSS absorbed porous structure, a self-assembled polyaniline (PANI) layer adjacent to the PPy layer, an electrochemically deposited PANI layer adjacent to the PPy layer and an electrochemically deposited PANI-molybdenum disulfide (PANI-MoS2) layer adjacent to the electrochemically deposited PANI layer. A supercapacitor and associated method of manufacturing a supercapacitor comprising a first novel electrode and a second novel electrode separated by a polyvinyl gel and a porous separator.

Abstract: Compositions are provided for efficient uranium extraction, for example from wastewater, seawater, or other water sources. The compositions can include a functionalized porous organic polymer functionalized with one or more uranium binding moieties, e.g. having a plurality of amidoxime or amidrazone groups covalently attached thereto. The compositions can include covalent organic frameworks, porous aromatic frameworks, and various porous organic polymers, especially those having a hierarchical pore size distribution over a range of pore sizes. The compositions can have functional groups such as amidoxime or an amidrazone covalently attached thereto. The hierarchical pore size distribution can be determined based upon at least 60% of the pore sizes in the range of pore sizes having a pore volume of at least 0.01 cm3 g?1 in the pore size distribution at 77 K. Methods of making the compositions and methods of using the compositions are also provided.